Abstract: The present disclosure relates to an artificial intelligence (AI) system which simulates functions such as cognition, judgment, and the like of the human brain by utilizing machine learning algorithms such as deep learning and the like, and to an application thereof.

Abstract: Removing a stimuli responsive polymer (SRP) from a substrate includes controlled degradation. In certain embodiments of the methods described herein, removing SRPs includes exposure to two reactants that react to form an acid or base that can trigger the degradation of the SRP. The exposure occurs sequentially to provide more precise top down control. In some embodiments, the methods involve diffusing a compound, or a reactant that reacts to form a compound, only to a top portion of the SRP. The top portion is then degraded and removed, leaving film the remaining SRP intact. The exposure and removal cycles are repeated.

Abstract: The present disclosure relates to a novel compound suitable for a metal-free primary explosive, and the method of making and using the novel compound. The novel compound can undergo a deflagration to detonation transition (DDT) to initiate detonation of a larger body of secondary explosive.

Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.

Abstract: The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of: assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules; amplifying the barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

Abstract: Provided herein are compounds that inhibit IDO1 and methods of use thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating sarcopenia or age-related muscle loss.

Abstract: Described herein are compositions and methods for waste-to-energy ash in engineered aggregate in road construction.

Abstract: A method and system of casting an integral multi-way valve based on 3D printing belong to the technical field of valve casting. The casting method and system determine, according to structural parameters of an integral multi-way valve to be cast, a plurality of ingates on a plurality of layers, a plurality of runners connecting the ingates on each layer, and a sprue connecting the plurality of runners, and an integral sand mold is printed by using the 3D printing technology to realize a multi-layer composite casting method and a corresponding casting system.

Abstract: The present disclosure relates to a method of removing a radioactive structure from a nuclear power plant. The method includes flattening at least a portion of an outer surface of a drilling portion of a wall of a nuclear reactor vessel when the portion of the outer surface is uneven, wherein the radioactive structure is buried in the wall and the drilling portion is adjacent to the radioactive structure, installing a drilling device in the flattened drilling portion and performing a drilling operation, extracting the radioactive structure from the wall, and cutting the extracted radioactive structure and storing pieces of the cut radioactive structure in a shielding container.

Abstract: Described here are systems and methods for generating and implementing a hybrid machine learning and mechanistic model to produce biological feature maps, or other measurements of biological features, based on an input of multiparametric magnetic resonance or other images. The hybrid model can include a combination of a machine learning model and a mechanistic model that takes as an input multiparametric MRI, or other imaging, data to generate biological feature maps (e.g., tumor cell density maps), or other measures or predictions of biological features (e.g., tumor cell density). The hybrid models have capabilities of learning individual-specific relationships between imaging features and biological features.

Abstract: Disclosed are a fault early-warning method and a fault early-warning system applied to a gas turbine unit, and an apparatus. The method includes: calculating, by means of a mechanism model, predicted data of prediction parameters in a gas turbine unit, and performing data comparison on the predicted data and real data of the prediction parameters, so as to obtain an error matrix; constructing several Kriging primary functions according to the mechanism model; screening an optimal Kriging primary function from the several Kriging primary functions according to the error matrix, and performing error compensation on the mechanism model by using the optimal Kriging primary function; and performing fault early warning on the gas turbine unit by means of the mechanism model after error compensation. By means of the present application, the problem of a large number of fault false alarms in fault early warning of an existing gas turbine is solved.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: A collapsible sample collection device with a novel, collapsible 3D capture open affinity net dispersed throughout the volume of the container, said net with tethered affinity moieties, is designed to address the need for low-cost, simple harvesting and concentration of diagnostic analytes that generally does not require any ancillary equipment. The collection device generally permits analytes of interest to be efficiently harvested from body fluid samples, in one step, concentrated, collapsed into a flat mailing size, and protected from degradation without the need for traditional cold chain technologies. The concentration factor will increase sensitivity by several orders of magnitude when coupled with any type of downstream analyte measurement, including point of care testing. The collection device, in various embodiments, obviates the need for handling transport or storage of the fluid portion of the body fluid sample (e.g. blood, urine, saliva, etc.

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

Abstract: A high voltage generator is provided. The high voltage generator includes an inverter circuit coupled to receive a direct-current (DC) input voltage, a resonant circuit coupled to the inverter circuit, a transformer coupled to the resonant circuit and also coupled to provide a high voltage output to a high voltage device, and a phase control circuit coupled to receive a voltage across and a current through the resonant circuit and also coupled to the inverter circuit. The phase control circuit generates control signals to drive the inverter circuit. The control signals drive the inverter circuit to keep the resonant circuit operating in an inductive region.

Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.

Abstract: Systems and methods of controlling a vehicle in a stable drift are provided. With the goal of enhancing the driver experience, the disclosed drift control systems provide an interactive drift driving experience for the driver of a vehicle. In some embodiments, a driver is allowed to take manual control of a vehicle after a stable drift is initiated. For safety reasons, an assisted driving system may provide corrective assistance to prevent the vehicle from entering an unstable/unsafe drift. In other embodiments, an autonomous driving system retains control of the vehicle throughout the drift. However, the driver may perform “simulated drift maneuvers” such as counter-steering, and clutch kicking in order to communicate their desire to drift more or less aggressively. Accordingly, the autonomous driving system will effectuate the driver's communicated desire in a manner that keeps the vehicle in a safe/stable drift.

Abstract: HVAC load can be shifted to change indoor temperature. A time series change in HVAC load data is used as input modified scenario values that represent an HVAC load shape. The HVAC load shape is selected to meet desired energy savings goals, such as reducing or flattening peak energy consumption load to reduce demand charges, moving HVAC consumption to take advantage of lower utility rates, or moving HVAC consumption to match PV production. Time series change in indoor temperature data can be calculated using only inputs of time series change in the time series HVAC load data combined with thermal mass, thermal conductivity, and HVAC efficiency. The approach is applicable for both winter and summer and can be applied when the building has an on-site renewable power system.

Abstract: The present invention relates to a lyophilized pharmaceutical composition of hydrolytically unstable pharmaceutical compounds, such as phenobarbital or salts thereof. The present invention also relates to an aqueous solution for injection of phenobarbital or salts thereof that is reconstituted from the lyophilized pharmaceutical composition. The pharmaceutical compositions of the present disclosure have an ethanol content in the range from about 5000 ppm to about 70000 ppm. The composition of the present disclosure, in certain embodiments, is stable following two years of storage, wherein the total impurities do not exceed 0.5%. The pharmaceutical compositions of the present disclosure may be used for the treatment of neonatal seizures.