Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g.

Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.

Abstract: The present disclosure provides novel vancomycin derivatives that act as antimicrobials against Gram-negative bacteria. The compounds of the present disclosure are believed to be useful for the treatment of diseases caused by antimicrobial resistant bacteria, including Acinetobacter baumannii and Escherichia coli.

Abstract: An anode material for a lithium ion battery comprises a carbonaceous silicon composite material. The composite material comprises Si nanoparticles, and nanostructured and microporous graphitic carbon and/or silicon carbide, wherein the graphitic carbon and/or silicon carbide are derived at least in part from carbonized metal organic framework.

Abstract: A metal organic framework (MOF)-polymer composite for detoxifying a chemical warfare agent (CWA) comprises MOF nanoparticles having catalytically active Lewis acid sites and at least one polymer having catalytically active basic sites. The composite is configured such that the at least one polymer is in surrounding relation to the MOF nanoparticles such that at least a portion of the Lewis acid sites of the MOF nanoparticles are in proximal relation to at least a portion of the basic sites of the at least one polymer thereby forming a plurality of proximal acid-base interfaces thus enabling a bifunctional catalytic mechanism for detoxifying the CWA. The MOF-polymer composite can provide CWA detoxification without the presence of a basic compound.

Abstract: A reservoir device comprising an active agent formulation contained within a reservoir is described. The reservoir is defined by a biodegradable, permeable polymer membrane having a thickness of at least 45 ?m. The membrane allows for diffusion of an active agent of the formulation there through when positioned subcutaneously in a body of a subject.

Abstract: A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.

Abstract: An internal combustion engine is operated at fuel-rich conditions by adjusting one or more operating parameters such as, for example, a throttle, an ignition timing, a load coupled to the engine, a fuel pressure, power to a supercharger, and power to a preheater to maintain a specified engine speed and a temperature of an exhaust gas. Operating the engine under these conditions allows the engine to function as a reformer producing a synthesis gas comprising hydrogen and carbon monoxide.

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

Abstract: A suspension comprises a nano-crystalline metal organic framework suspended in a polymeric solution. The nano-crystalline metal organic framework comprises micropores having an average diameter in the range of 0.5-5 nm, and the nano-crystalline metal organic framework is substantially homogenously dispersed in the polymeric solution, which comprises a first polymeric material dissolved in a non-aqueous solvent.

Abstract: A chromium-free catalyst for use in a fluidized bed reactor is described. The catalyst comprises 45-70 wt % Fe2O3, 5-15 wt % CuO, 20-35 wt % Al2O3, 10-20 wt % ZnO, and 1-15 wt % K2CO3. The catalyst has a Davison Index (DI %) of less than or equal to 15. A method for converting carbon monoxide (CO) into carbon-dioxide (CO2) using the catalyst is described. The method includes introducing H2O and CO into a fluidized bed reactor having an operating temperature between about 375° C. and about 450° C. and comprising the chromium free catalyst. The CO conversion is at least 60%.

Abstract: The present disclosure provides novel solid sorbents synthesized by the reaction of polyamines with polyaldehyde phosphorus dendrimer (P-dendrimer) compounds for metal sequestration. The sorbents are highly stable and exhibit desirable thermodynamics and reaction kinetics with a wide variety of metals including heavy metals and rare earth elements. The sorbents can be easily regenerated for repeated use to extract metals from an aqueous solution. The materials are stable to aqueous and organic media, as well as strong acid and bases. The sorbents maintain full capacity over many cycles of use.

Abstract: The present disclosure provides novel 4-substituted-phenyl acetamide and arylurea derivatives that act as agonists against GPR88. The compounds of the present disclosure are believed to be useful for the treatment of diseases and conditions caused by physiological processes implicating the orphan receptor GPR88, including diverse brain and behavioral functions such as cognition, mood, movement control, and reward-based learning. GPR88 is emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson's disease, anxiety, and addiction. One particular indication for which GPR88 agonists hold promise is alcohol use disorder (AUD).

Abstract: An air filtration media with integrated disinfection capability. The media has a collection filter for capture of pathogens, and an ultraviolet (UV) radiation source integrated into the collection filter such that the pathogens collected by the collection filter are exposed to UV radiation from the UV radiation source.

Abstract: A method, comprising i) contacting an aqueous solution of an organic ligand salt of the formula Ax(L?x) with a mesoporous material (MPM) to form an impregnated mesoporous salt material of the formula Ax(L?x)/MPM, ii) treating the impregnated mesoporous salt material with an aqueous acidic solution to form an impregnated mesoporous acid material of the formula Hx(L?x)/MPM, iii) contacting an aqueous solution of a metal precursor of the formula M+y(B)y with the impregnated mesoporous acid material to form an impregnated mesoporous metal organic framework precursor of the formula [M+y(B)y][Hx(L?x)]/MPM, and iv) at least one of 1) heating the impregnated mesoporous metal organic framework precursor in the absence of a solvent or 2) exposing the impregnated mesoporous metal organic framework precursor to a volatile vapor in the absence of a solvent such that the heating or the exposing forms a hybrid material of the formula (M+yL?x)/MPM, wherein the hybrid material comprises a nano-crystalline metal organic framew

Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.

Abstract: A method for making a metal organic framework suspension is described herein. The method includes providing a hybrid material comprising a nano-crystalline metal organic framework comprising micropores and a mesoporous polymeric material comprising mesopores, wherein the nano-crystalline metal organic framework is homogeneously dispersed and substantially present only within the mesopores or void spaces of the mesoporous polymeric material; and wherein the hybrid material has a weight percentage of the metal organic framework in the range of 5-50% relative to the total weight of the hybrid material. The method includes contacting the hybrid material with a solvent in which the mesoporous polymeric material is soluble, thereby forming a polymeric solution in which the nano-crystalline metal organic framework is substantially homogeneously dispersed and suspended.

Abstract: Apparatus for testing an electronic smoking (e-smoking) device includes an electronic circuit for electronically activating an e-smoking device and causing the e-smoking device to generate a plurality of puffs by converting a wicking fluid therein into a plurality of puffs without a need for a human to physically contact the e-smoking device during puff generation, and a wireless controller for controlling the electronic circuit. The electronic circuit is configured for activating the e-smoking device to generate the plurality of puffs based on wireless signals received at the wireless controller. The apparatus is further configured for measuring a characteristic of the e-smoking device, which may include a rate of conversion of the wicking fluid to vapor as a function of time for the plurality of puffs.

Abstract: Described herein is a nanostructured silicon carbonaceous composite material and methods for producing the same. The methods include formation of a metal organic framework/silica (MOF/SiO2) intermediate material and conversion of the MOF/SiO2 intermediate material to the nanostructured silicon carbonaceous composite material. Relatively inexpensive and/or recycled materials can be used as precursors in manufacturing the nanostructured silicon carbon composition material, which can be used in various applications, including as silicon anode material in a lithium-ion battery.

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.