Abstract: In order to develop and optimize metering strategies for fed-batch fermentations in two or more reaction vessels, release systems containing nutrients are attached to the inner surfaces of the reaction vessels in areas that will come into contact with culture liquid placed in the vessels.

Abstract: S-Adenosyl-L-methionine analogs of formula (I) wherein R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond or an aromatic carbocyclic or heterocyclic system in ?-position to the sulfonium center, X— is an organic or inorganic anion carrying one or more negative charges, Z is —CR1R2—, —O—, —S— or —NR3— and R1, R2 and R3 are independently selected from H, D and C1-C12 alkyl. Also disclosed are complexes of the compound with a methyltransferase, pharmaceutical compositions comprising the same, methods for modifying biomolecule using the compound, and methods for detecting sequences specific methylation of biomolecules using the compound.

Abstract: The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment.

Abstract: Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be specifically introduced into biomolecules, polymers, and surfaces in mild conditions.

Abstract: In order to improve a surgical holding device for holding a surgical instrument, with a frame, with a first linkage comprising at least two links, which articulatedly connects the frame to a first articulation point associated with the instrument, and with a second linkage comprising at least two links, which articulatedly connects the frame to a second articulation point associated with the instrument, so that a large range of action of the surgical instrument held by the holding device is adjustable as simply as possible, it is proposed that the links of the first linkage be mounted for pivotal movement about pivot axes relative to one another and relative to the frame, and that the pivot axes extend parallel to one another.

Abstract: The invention provides an analogue of a pharmaceutical active whose molecular weight is less than 25,000 Daltons, the analogue comprising a pharmaceutical active whose molecular weight is less than 25,000 Daltons covalently linked to a pendant molecular group wherein as a result of the administration of the composition to the human or animal body an active complex having a molecular weight of 25,000 Daltons or greater is present in the human or animal circulatory system. The analogue is hepatoselective when administered to the circulatory system. Preferably the analogue is an insulin analogue comprising an insulin or functional equivalent thereof covalently linked to the pendant molecular group wherein the active complex is an insulin complex. Such an insulin analogue may be used in a method of insulin replacement therapy.

Abstract: A porous, flow-through molded body, designed specifically for use in the removal of diesel soot particles from the exhaust gas of diesel engines. It includes a reciprocally closed honeycombed body made of silicon carbide and possessing the following features.wall thickness: 1.25.+-.0.5 mm;porosity: 55 to 60%;average pore diameter: 25 to 70 .mu.m;specific permeability: 20 to 100 nPm.In the production method, a starting powder of silicon or a mixture of silicon with portions of silicon carbide and/or carbon is combined with an organic binding agent that can be coked and molded into a green body. This is then subjected to a coking fire in an inert-gas atmosphere; the molded body obtained in this manner is then heated in the presence of nitrogen or a nitrogenous inert gas to a temperature where free silicon is converted with the carbon, in a reaction firing, to silicon carbide. Additionally, a recrystallization firing at greater than 2000.degree. C. is implemented.