Patents Assigned to Sandoz Ltd.
  • Patent number: 5776941
    Abstract: This invention relates to 2-(4-alkylthio-pyrimidin-5-yl)-acetic acid derivatives; fungicidal compositions comprising such compounds and a method of combating phytopathogenic fungi comprising applying such compounds to the fungi or their habitat.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: July 7, 1998
    Assignee: Sandoz Ltd
    Inventors: Gerald Wayne Craig, Martin Eberle, Fritz Schaub
  • Patent number: 5770741
    Abstract: The invention provides a process for the preparation of a compound of the general formula (I): ##STR1## wherein X, Y and R.sup.1 to R.sup.7 are as defined. In the process, the olefinic analog of the compound of general formula (I) is treated with a halogen-bearing compound in the presence of metallic zinc.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: June 23, 1998
    Assignee: Sandoz Ltd.
    Inventors: Patrick Jelf Crowley, Christopher John Urch, Paul Anthony Worthington
  • Patent number: 5739080
    Abstract: Co-application of auxin agonist herbicides such as dicamba and amino acid synthesis inhibitor herbicides such as ALS inhibitor herbicides reduces the incidence of phytotoxic effects, particularly in grassy crops.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: April 14, 1998
    Assignee: Sandoz Ltd.
    Inventors: Mark C. Boyles, John M. Fenderson, Bart Brinkman
  • Patent number: 5736131
    Abstract: The present invention provides, inter allia, a B.t. hybrid toxin fragment comprising at its C-terminal domain III of a first Cry protein or a part of the domain or a protein substantially similar to the domain, with the proviso that the N-terminal region of the fragment is the N-terminal region of a second Cry protein or a part of the region or a protein substantially similar to the region.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: April 7, 1998
    Assignee: Sandoz Ltd.
    Inventors: Hendrik Jan Bosch, Willem Johannes Stiekema
  • Patent number: 5733848
    Abstract: Microparticulate agrochemicals based on crosslinked polyester polymers particularly suited to rapidly leaching herbicides.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: March 31, 1998
    Assignee: Sandoz Ltd.
    Inventor: George F. Luteri
  • Patent number: 5731194
    Abstract: A novel insecticidal protein isolated from Bacillus thuringiensis var. galleria is described and its DNA sequence is given. This protein, called CryIC(b), is toxic to Lepidoptera, including Spodoptera.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 24, 1998
    Assignee: Sandoz Ltd.
    Inventors: Sue S. Kalman, Kristine L. Kiehne
  • Patent number: 5728831
    Abstract: A process for preparing a compound of formula III ##STR1## which comprises decarboxylating a compound of formula V ##STR2## wherein R.sup.20 is alkoxy and R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen or C.sub.1-8 alkyl.
    Type: Grant
    Filed: June 12, 1996
    Date of Patent: March 17, 1998
    Assignee: Sandoz Ltd.
    Inventor: Shy-Fuy Lee
  • Patent number: 5721191
    Abstract: Co-application of dimethenamid with sulfonylurea herbicides provides improved herbicidal activity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 24, 1998
    Assignee: Sandoz Ltd.
    Inventors: John M. Fenderson, William B. O'Neal, Theo Quaghebeur, Karl-Christoph Schumm, Walter Van Loocke
  • Patent number: 5719123
    Abstract: Pulmonary administration of Ciclosporin in orthorhombic crystal form (designated "CY-A/X-III"), e.g. for the treatment of obstructive or inflammatory airways disease, e.g. asthma, as well as crystalline Ciclosporin, e.g. CY-A/X-III, in spheroidal particulate form, processes for its preparation and its pharmaceutical use, e.g. for pulmonary administration. Pharmaceutical compositions comprising CY-A/X-III and crystalline Ciclosporin, e.g. CY-A/X-III, in spheroidal particulate form as well as Ciclosporin in solution in aerosol propellants are also provided.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: February 17, 1998
    Assignee: Sandoz Ltd.
    Inventors: John Morley, Andreas Rummelt, Martin List
  • Patent number: 5716901
    Abstract: Co-application of dimethenamid with other herbicides provides improved herbicidal activity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 1998
    Assignee: Sandoz Ltd.
    Inventors: John M. Fenderson, William B. O'Neal, Theo Quaghebeur, Karl-Christoph Schumm, Walter Van Loocke
  • Patent number: 5712248
    Abstract: A novel insecticidal protein isolated from Bacillus thuringiensis var. galleria is described and its DNA sequence is given. This protein, called CryIC(b), is toxic to Lepidoptera, including Spodoptera.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: January 27, 1998
    Assignee: Sandoz LTD.
    Inventors: Sue S. Kalman, Kristine L. Kiehne
  • Patent number: 5700762
    Abstract: Substituted aryl or heteroaryl in particular benzoyl bicycloalkanediones and related compounds, intermediates therefor, synthesis thereof, and the use of said diones for the control of weeds.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 23, 1997
    Assignee: Sandoz Ltd.
    Inventors: Shy-Fuh Lee, Takashi Nishizaka, Kenichi Komatsubara
  • Patent number: 5698694
    Abstract: A process for preparation of substituted phthalides, heterocyclic phthalides and derivatives thereof by reacting an aromatic carboxylic acid mono- or di-anion with a reactive derivative of a pyrimidine carboxylic acid.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: December 16, 1997
    Assignee: Sandoz Ltd.
    Inventors: Takeo Hokama, Ian S. Cloudsdale, Werner Langer, Hermann Schneider
  • Patent number: 5683963
    Abstract: The present invention relates to herbicidal ribofuranose derivatives, particularly hydantocidin derivatives, compositions comprising said derivatives and methods of use.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: November 4, 1997
    Assignee: Sandoz Ltd.
    Inventors: Shy-Fuh Lee, Richard J. Anderson
  • Patent number: 5679363
    Abstract: Method for the preparation of an insect attractant composition which includes a trialkylamine salt, an alkali salt of a carboxylic acid and a pheromone in a suitable aqueous solution.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: October 21, 1997
    Assignee: Sandoz Ltd.
    Inventors: Kim W. Yang, David R. Kinzer, Ronald B. Winslow
  • Patent number: 5679640
    Abstract: Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptide compositions of the present invention comprise various isosteres of naturally occurring amino acid sequences. Such compositions may be used to treat diseases associated with particular DR alleles, including autoimmune diseases such as rheumatoid arthritis.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: October 21, 1997
    Assignees: Cytel Corporation, Sandoz Ltd.
    Inventors: Federico C. A. Gaeta, Michael F. Powell, Howard M. Grey, Alessandro D. Sette, Thomas S. Arrhenius
  • Patent number: 5670648
    Abstract: The invention discloses a novel process for the preparation of a compound of formula II ##STR1## wherein R.sub.1 is C.sub.1-5 alkyl,R.sub.2 is hydrogen or C.sub.1-5 alkyl, andR.sub.3 is optionally substituted phenyl,comprising the reaction of a 4-hydroxypyrazole of formula III ##STR2## wherein R.sub.1 and R.sub.2 are as defined for formula II, with a benzylhalide of formula IVHal--CH.sub.2 --R.sub.3 (IV)wherein Hal is halogen, preferably bromine or chlorine, and R.sub.3 is as defined for formula II, in the presence of a base. The invention further comprises a novel process for the preparation of the 4-hydroxypyrazole of formula III. The compounds of formulae II and III are intermediates for highly effective systemic fungicides of the class of pyrazolyl acetic acid derivatives.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: September 23, 1997
    Assignee: Sandoz Ltd.
    Inventors: Erwin Waldvogel, Eugen Eichenberger
  • Patent number: 5670456
    Abstract: N-carbamoyl-2-carboxyaryl-heterocyclic and hydrazinecarboximidamidehydrazone derivatives, intermediates and processes for their preparation, agricultural compositions containing them and their use as agricultural chemicals, in particular herbicides.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: September 23, 1997
    Assignee: Sandoz Ltd.
    Inventors: Richard J. Anderson, Joe T. Bamberg, Michael M. Leippe
  • Patent number: 5667340
    Abstract: A method for placing concrete underwater comprising pumping a flowable cementitious mixture comprising cement, water and one of either BNS or a cellulosic polymer to the underwater point of discharge of the cementitious mixture from a delivery tube and adding into the flowable cementitious mixture at the point of discharge, the other of the BNS or a cellulosic polymer resulting in a cementitious mixture having zero flow characteristics.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: September 16, 1997
    Assignee: Sandoz Ltd.
    Inventor: Jeffrey Bury
  • Patent number: 5665681
    Abstract: The invention discloses compounds of formula I ##STR1## wherein X is oxygen or sulfur,R is hydrogen, chlorine or fluorine,R.sub.1 is fluorine, chlorine, bromine, cyano or methyl,R.sub.2 is halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylcarbonyloxy, C.sub.3-6 cycloalkoxy, C.sub.3-6 alkynyloxy, C.sub.3-6 alkenyloxy, --COOH, --CO--R.sub.3, --CO--NR.sub.4 R.sub.5, --NR.sub.6 R.sub.7, C.sub.2-6 alkenyl, N-pyrrolyl, 2-oxo-3-tetrahydrofuranyl or isC.sub.1-6 alkyl substituted with halogen, COOH, --CO--R.sub.3, --CO--NR.sub.8 R.sub.9, .dbd.N--OH, .dbd.N--C.sub.1-4 alkoxy, --O--CO--R.sub.3 or --O--C.sub.2-3 alkylene-O--; or isC.sub.2-6 alkenyl substituted with halogen, COOH, --CO--R.sub.3, --CO--NR.sub.8 R.sub.9 or C.sub.1-4 alkoxy; or isC.sub.1-6 alkoxy substituted with cyano, --CO--R.sub.3, C.sub.1-4 alkoxy, C.sub.3-6 cycloalkyl, oxiranyl, orC.sub.1-4 alkoxy or halogen; or isC.sub.3-6 alkenyloxy substituted by C.sub.2-5 alkynyl;R.sub.3 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 cyanoalkyl, C.sub.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: September 9, 1997
    Assignee: Sandoz Ltd.
    Inventors: Karl Seckinger, Sasank Sekhar Mohanty, Karlheinz Milzner, Fred Kuhnen