Abstract: The use of certain herbicidal semicarbazones and salts thereof as potentiators or enhancers of herbicidal and/or plant growth regulating substances.

Abstract: Novel derivatives of rapamycin, particularly 9-deoxorapamycins, 26-dihydro-rapamycins, and 40-0-substituted and 28,40-0,0-di-substituted rapamycins, are found to have pharmaceutical utility, particularly as an immunosuppressants.

Abstract: The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

Abstract: The present invention provides a sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.

Abstract: The use, in sequence, of a cytotoxic, but stem cell sparing, agent and granulocyte-macrophage colony stimulating factor as a means to harvest very high numbers of multipotential haemopoietic precursor cells and in reducing the period of myeloid recovery after high dose chemo- or radiotherapy of cancer.

Abstract: Somatostatin peptides bearing a chelating group selected from a bifunctional N.sub.4 -chelating group particularly suitable for Tc, Rh, Cu, Co or Re-labelling, and a bifunctional polyamino-polycarboxylic acid chelating group are complexed with a .alpha.-, .beta.-, .gamma.- or positron-emitting nuclide or a nuclide with Auger-e.sup.- -cascades and are useful as radiopharmaceuticals.

Abstract: Process for oxidizing 1,4-dichlorobenzene using a secondary synthesized zeolites or zeolite-like metallosilicates or a primary synthesized zeolite-like metallosilicate and a peroxide.

Abstract: Monoclonal antibodies effective for the diagnosis and treatment of hepatitis B have been prepared from a cell line obtained by fusing a xenogeneic hybridoma designated SPAZ 4 with blood cells of a patient immunized with hepatitis B vaccine. The chimeric human monoclonal antibody, PE1-1, (ATCC HB 9234), is used in a method of treating patients infected with hepatitis B virus.

Abstract: A cyclosporin of the formula ##STR1## wherein A is a residue of the formula ##STR2## wherein R is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or C.sub.1-3 alkylthio; halo-substituted-C.sub.1-3 alkyl, -C.sub.1-3 alkoxy or -C.sub.1-3 alkylthio; hydroxy-substituted-C.sub.1-3 alkyl, -C.sub.2-3 alkoxy or -C.sub.2-3 alkylthio; or amino or mono- or di-(C.sub.1-2 alkyl)-amino,X is oxygen or sulphur,--x--y-- is --CH.dbd.CH-- (trans) or --CH.sub.2 --CH.sub.2 --,B is -.alpha.Abu-, -Val-, -Thr- or -Nva- andQ is -(D)Ala-; -(D)Ser-; -[O-(2-hydroxyethyl)(D)Ser]-; or -[O-acyl(D)Ser]- or -[O-(2-acyloxy ethyl)(D)Ser]-in which the acyl residue is physiologically hydrolysable and acceptable, are useful in the topical treatment of asthma.

Abstract: Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I ##STR1## wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761).They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.

Abstract: The present invention provides, inter alia, the use in the screening of haploid or doubled haploid plants or seeds of at least one dominant gene selected from the group consisting of conditional lethal genes, screenable marker genes and selectable marker genes. Preferably the haploids are induced by haploid inducing genes, such as "indeterminate gametophyte". The invention still further provides haploid plants comprising said at least one dominant gene, and a process for the production thereof, together with plants which result from said use and said process.

Abstract: The invention provides a process for the production of azodyes and their derivatives by diazotization and coupling reactions and optionally further modification reactions, wherein a compound of formula ##STR1## in which E signifies an aromatic bivalent radical,X.sub.1 signifies hydroxy or a primary amino group,Y.sub.1 signifies hydroxy or a primary amino group and in which the aminogroup linked to the --SO.sub.2 -bound phenyl radical may optionally be acylated,or a mixture of compounds of formula (I), is employed as a coupling component or/and--in the non-acylated form--as a diazo component,the invention in particular relates also to the novel dyes and their use and to the novel intermediates.

Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.

Abstract: A method of controlling the hydration of a cementitious composition comprising the steps of:i) providing a cementitious composition containing an amount of a neutralized salt of an alpha-monohydroxy carboxylic acid effective to retard the cementitious composition, said carboxylic acid containing two or more carboxylic acid groups, and subsequently,ii) adding an additional amount of said neutralized salt of an alpha monohydroxy carboxylic acid or a second neutralized salt of an alpha monohydroxy carboxylic acid in an amount sufficient to activate hydration of the retarded cementitious composition, said cementitious composition comprising hydraulic binder and water.

Abstract: A modified steamer (D) comprising a heatable conduit (5), through which a substrate (S) can be introduced into the steamer (D) so that the substrate (S) can be preheated directly prior to contact with the steam.

Abstract: The disperse dyes of formula I ##STR1## wherein the symbols D, K, R.sub.3-5, R.sub.10, m, z, n and Y possess the significances given in claim 1, are eminently suitable for dyeing or printing hydrophobic, fully or semi-synthetic, organic fiber materials.

Abstract: The present invention provides a novel gene and enzyme isolated from cocklebur (Xanthium sp.) which confers resistance to several structurally unrelated classes of herbicides in plants, plant tissues and seeds. In particular, the class of herbicides consists of herbicides wherein acetolactate synthase (ALS) is the site of action and includes sulfonylureas, imidazolinones, triazolopyrimidines, pyrimidyloxybenzoates and phthalides.

Abstract: A novel thiol protease inhibitor peptide is isolated from Diabrotica virgifera designated virgiferin. The DNA encoding virgiferin and modified virgiferin peptides are claimed. These sequences maybe cloned into vectors and used to transform plants conferring reduced susceptibility to damage by plant pests that have thiol proteases as digestive enzymes including insects and nematodes and particularly Coleopteran insects.