Abstract: Novel N-substituted ergoline- and 9,10-didehydro-8-carboxamide- and -8-aminomethyl-derivatives for the treatment of vascular headaches, especially migraine, and of orthostatic hypotension.
Abstract: A liquid concentrate comprising an oxamide and a 2,2,6,6-tetraalkylpiperidine compound dissolved in an organic solvent is useful for the UV-stabilization of hardenable liquid finishes, particularly automotive finishes.
Abstract: A water soluble or water dispersible composition containing(a) at least one phosphoric acid partial ester(b.sub.1) at least one mono- or di-(C.sub.2-3 alkylene) glycol mono-(C.sub.1-4 -alkyl) ether or at least one aliphatic C.sub.4-6 alcohol or a mixture thereof(b.sub.2) mono- or diethylene glycol or a mixture thereof(c) at least one aromatic-free or aromatic-poor hydrocarbon oil, and(d) a water miscible alkanolamine,the phosphoric acid partial ester (a) being dispersed or dissolved in the mixture (b.sub.1)+(b.sub.2)+(c), and component (a) being at least partially neutralized in salt form, with the proviso that the composition has a water content .ltoreq.5% by weight.It is useful as fatting agent for fatting leather.
Abstract: An aqueous dispersion comprising one or more 2,2,6,6-tetraalkylpiperidine compounds having a molecular weight 2000 or less than 2000 and a melting point of 100.degree. C. or more, one or more cationic, non-ionic and/or anionic dispersing agents and an aqueous medium. These dispersions are suitable for use as light stabilizers in aqueous systems.
Abstract: Metal-free compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, and acid addition salts of metal-free compounds of said formula and 1:1 and 1:2 metal complexes thereof, whereinB is hydrogen; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by C.sub.1-4 alkoxy; C.sub.2-4 alkyl substituted by hydroxy; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups; phenyl(C.sub.1-3 alkyl); phenyl(C.sub.1-3 alkyl) the phenyl group of which is substituted by 1 to 3 substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halo; --A--NH--R.sub.2 ; --A'.sub.4 --N(R.sub.7).sub.2 ; --A.sub.4 --N.sup..sym. (R.sub.8).sub.2 R.sub.9 A.sup..crclbar. or --N(R.sub.7).sub.2,R is hydrogen; C.sub.1-4 alkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 or 2 C.sub.
Type:
Grant
Filed:
June 10, 1987
Date of Patent:
October 25, 1988
Assignee:
Sandoz Ltd.
Inventors:
Helmut Moser, Manfred Greve, Reinhard Pedrazzi, Roland Wald
Abstract: A method of fatting tanned leather substrates comprising(a) applying to the substrate as the fatting agent an aqueous solution or dispersion of an ortho-phosphoric acid partial ester having attached to the phosphorus atom an average 1 to 2 (which may be a non-integral number) groups of the formula I ##STR1## where each A independently is ##STR2## and n is a number from 2 to 10 with the proviso that 2 to 6 groups A are --(CH.sub.2).sub.2,R is an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkyl group or an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkenyl group,the phosphoric acid partial ester being in free acid or salt form;(b) treating with an agent selected from polyvalent metal oxide, hydroxide and salt, at the same time as fatting or after fatting.
Abstract: [2-Halo-10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]acetic acids, for example of formula I ##STR1## wherein R.sub.1 is H or C.sub.1-4 alkyl and R.sub.2 is halogen, their physiologically-hydrolysable and -acceptable esters, and salts thereof. Such compounds, esters and salts possess valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic, properties.
Abstract: The subject matter of this invention involves 2-[4-(2-pyridinyloxy)phenoxy]propionyl-2-oxazolidinones which are substituted in the pyridinyl ring by trifluoromethyl and/or chloro. The compounds are useful for increasing the recoverable sugar in sugarcane.
Type:
Grant
Filed:
February 24, 1987
Date of Patent:
October 4, 1988
Assignee:
Sandoz Ltd.
Inventors:
Louis G. Nickell, Leonard Stach, Takeo Hokama
Abstract: A compopund containing one or more units of formula I ##STR1## in which R.sub.1 is --CH.sub.2 C.sub.1-4 alkyl or --CH.sub.3 or both groups R.sub.1 form --(CH.sub.2).sub.5 --;R.sub.2 is --CH.sub.2 C.sub.1-4 alkyl or --CH.sub.3 or both groups R.sub.2 form --(CH.sub.2).sub.5 --;R.sub.3 is furylmethyl, unsubstituted C.sub.1-18 alkyl; C.sub.1-4 alkyl monosubstituted by phenyl, the phenyl group of which is unsubstituted or substituted by 1 to 3 groups selected from --OH and C.sub.1-8 alkyl; C.sub.2-8 alkyl monosubstituted by C.sub.1-4 alkoxy; phenyl, unsubstituted or substituted by 1 to 3 groups selected from C.sub.1-8 alkyl and --OH; or cyclohexy, unsubstituted or monosubstituted by C.sub.1-8 alkyl or --OH.These compounds are useful as light stabilizers for polymeric material.
Abstract: Cylosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- andY is -.alpha.Abu-, -Thr-, -Val- or -Nva-,wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, .alpha.-N-methylated .alpha.-amino acid residue of the (D)-configuration, possess pharmaceutical, in particular immunosuppressive, anti-inflammatory and anti-parasitic activity, Intermediate cyclosporin poly-anions having a de-protonated sarcosyl residue at the 3-position, e.g. polyanions of cyclosporins of formula II above wherein X and Y have the meanings given above and Z is -Sar-, in which the said residue Z is de-protonated, are also novel and part of the invention.
Abstract: The invention relates to novel alkyl polyoxyalkylene carboxylate esters and to their use as surface active agents. The novel esters are especially useful as emollients in skin care compositions.
Abstract: Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--.alpha.Abu--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or --Nva-- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH-- wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
Abstract: The invention relates to a method for preventing the brightening effect of an optical brightening agent on a textile substrate comprising applying on the textile substrate a water-soluble, cationic, optical brightener quencher either before or together with a resin precursor and submitting the treated substrate to a heat treatment. This method imparts an antibrightening effect to goods when they are washed with an optical brightener containing detergent.
Abstract: Cationic fixing agents based on the reaction products of(a) a monofunctional or polyfunctional amine having one or more primary and/or secondary and/or tertiary amino groups and(b) cyanamide, dicyandiamide, guanidine or bisguanidinegive improved results when the reaction takes place in the presence of a catalyst (K) selected from metals, metal salts and heterocyclic nitrogen-containing organic bases, particularly zinc chloride.
Type:
Grant
Filed:
September 15, 1987
Date of Patent:
August 16, 1988
Assignee:
Sandoz Ltd.
Inventors:
Jurg Heller, Bruno Kissling, Curt Muller, Tibor Robinson, Salvatore Valenti
Abstract: A compound of formula I ##STR1## wherein R.sub.1 is n-propyl,R.sub.2 is hydrogen or alkyl(C.sub.1-3),R.sub.3 is alkyl(C.sub.1-3), andR.sub.4 is hydrogen or methylin free base form or in pharmaceutically acceptable acid addition salt form is useful as a prolactin secretion inhibitor, anti-parkinson and anti-depressant agent.
Abstract: Metal-free compounds of the formula, ##STR1## and 1:1 copper complexes of metallizable metal-free compounds of said formula and internal and external salts of metal-free compounds of said formula and of 1:1 copper complexes of metallizable metal-free compounds of said formula, whereineach Q is independently linear or branched C.sub.2-6 alkylene; linear or branched C.sub.2-6 alkylene interrupted by --O--, --S-- or --NR.sub.4 --; linear or branched C.sub.3-6 alkylene monosubstituted or disubstituted by hydroxy or --*NHCO--CH.sub.2 --, wherein the * denotes the atom attached to the --NR.sub.4 -- radical,each R.sub.1 is independently hydrogen, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (C.sub.1-4 alkyl)carbonylamino, --SO.sub.2 NR.sub.3 R.sub.4, --CONR.sub.4 --C.sub.6 H.sub.5 or benzamido,R.sub.2 is hydrogen, hydroxy, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (C.sub.1-4 alkyl)carbonylamino or --NHCONR.sub.3 R.sub.4,X is --NR.sub.5 R.sub.6 or --N.sup..sym. R.sub.7 R.sub.8 R.sub.9 An.sup..crclbar.
Abstract: A method for preparing a pigment preparation comprising kneading a pigment presscake (comprising a pigment and water and/or one or more organic liquids) at a temperature in the range 80.degree. to 200.degree. C. under vacuum together with a thermoplastic material, thereby at the same time removing the water and/or any organic liquids present. These preparations are useful for coloring polymeric material.
Abstract: A compound of formula I ##STR1## wherein R is H or R'CO wherein R'CO is an acyl radical of a carboxylic acid,Y.sub.1 is the radical linked to an alpha carbon atom an .alpha.-amino acid,Y.sub.2 is the radical linked to an alpha carbon atom of an .alpha.-amino acid, ##STR2## --CH.sub.2 --S--S--CH.sub.2 --CH.sub.2 --COOH, --(CH.sub.2).sub.p --COOH or --CH.sub.2 --S--Y.sub.3,Y.sub.3 is (C.sub.1-4)alkyl or benzyl optionally substituted by methyl or methoxy,or CH.sub.3 CO--NH--CH.sub.2 --,n is 1 to 4,A.sub.6 is Thr or D-Thr,p is 3 to 5,A.sub.8 is the aminoacyl radical of a neutral, lipophilic L-.alpha.-aminoacid,A.sub.9 is the aminoacyl radical of a neutral, lipophilic L- or D-.alpha.-aminoacid,Z is a polypeptide radical corresponding to the polypeptide radical in positions 10 to 31 of a natural calcitonin or a derivative or analogue thereof having a hypocalcemic effect,wherein, when there is more than one Y.sub.1 radical, these are the same or different, and with the exception of radical A.sub.
Type:
Grant
Filed:
December 3, 1986
Date of Patent:
July 19, 1988
Assignee:
Sandoz Ltd.
Inventors:
Francois Cardinaux, Janos Pless, Robert H. Buck