Patents Assigned to SANDOZ
  • Patent number: 4783464
    Abstract: Novel N-substituted ergoline- and 9,10-didehydro-8-carboxamide- and -8-aminomethyl-derivatives for the treatment of vascular headaches, especially migraine, and of orthostatic hypotension.
    Type: Grant
    Filed: November 19, 1987
    Date of Patent: November 8, 1988
    Assignee: Sandoz Ltd.
    Inventors: Rene Ziegler, Peter Stutz
  • Patent number: 4780492
    Abstract: A liquid concentrate comprising an oxamide and a 2,2,6,6-tetraalkylpiperidine compound dissolved in an organic solvent is useful for the UV-stabilization of hardenable liquid finishes, particularly automotive finishes.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4780222
    Abstract: A water soluble or water dispersible composition containing(a) at least one phosphoric acid partial ester(b.sub.1) at least one mono- or di-(C.sub.2-3 alkylene) glycol mono-(C.sub.1-4 -alkyl) ether or at least one aliphatic C.sub.4-6 alcohol or a mixture thereof(b.sub.2) mono- or diethylene glycol or a mixture thereof(c) at least one aromatic-free or aromatic-poor hydrocarbon oil, and(d) a water miscible alkanolamine,the phosphoric acid partial ester (a) being dispersed or dissolved in the mixture (b.sub.1)+(b.sub.2)+(c), and component (a) being at least partially neutralized in salt form, with the proviso that the composition has a water content .ltoreq.5% by weight.It is useful as fatting agent for fatting leather.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventor: Werner Amati
  • Patent number: 4780494
    Abstract: An aqueous dispersion comprising one or more 2,2,6,6-tetraalkylpiperidine compounds having a molecular weight 2000 or less than 2000 and a melting point of 100.degree. C. or more, one or more cationic, non-ionic and/or anionic dispersing agents and an aqueous medium. These dispersions are suitable for use as light stabilizers in aqueous systems.
    Type: Grant
    Filed: April 11, 1985
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventors: Erwin Hess, Rainer Wolf
  • Patent number: 4780106
    Abstract: Metal-free compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, and acid addition salts of metal-free compounds of said formula and 1:1 and 1:2 metal complexes thereof, whereinB is hydrogen; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by C.sub.1-4 alkoxy; C.sub.2-4 alkyl substituted by hydroxy; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups; phenyl(C.sub.1-3 alkyl); phenyl(C.sub.1-3 alkyl) the phenyl group of which is substituted by 1 to 3 substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halo; --A--NH--R.sub.2 ; --A'.sub.4 --N(R.sub.7).sub.2 ; --A.sub.4 --N.sup..sym. (R.sub.8).sub.2 R.sub.9 A.sup..crclbar. or --N(R.sub.7).sub.2,R is hydrogen; C.sub.1-4 alkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 or 2 C.sub.
    Type: Grant
    Filed: June 10, 1987
    Date of Patent: October 25, 1988
    Assignee: Sandoz Ltd.
    Inventors: Helmut Moser, Manfred Greve, Reinhard Pedrazzi, Roland Wald
  • Patent number: 4778476
    Abstract: A method of fatting tanned leather substrates comprising(a) applying to the substrate as the fatting agent an aqueous solution or dispersion of an ortho-phosphoric acid partial ester having attached to the phosphorus atom an average 1 to 2 (which may be a non-integral number) groups of the formula I ##STR1## where each A independently is ##STR2## and n is a number from 2 to 10 with the proviso that 2 to 6 groups A are --(CH.sub.2).sub.2,R is an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkyl group or an unsubstituted linear or branched (preferably linear) C.sub.14-20 alkenyl group,the phosphoric acid partial ester being in free acid or salt form;(b) treating with an agent selected from polyvalent metal oxide, hydroxide and salt, at the same time as fatting or after fatting.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: October 18, 1988
    Assignee: Sandoz Ltd.
    Inventor: Werner Amati
  • Patent number: 4775691
    Abstract: [2-Halo-10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]acetic acids, for example of formula I ##STR1## wherein R.sub.1 is H or C.sub.1-4 alkyl and R.sub.2 is halogen, their physiologically-hydrolysable and -acceptable esters, and salts thereof. Such compounds, esters and salts possess valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic, properties.
    Type: Grant
    Filed: January 20, 1988
    Date of Patent: October 4, 1988
    Assignee: Sandoz Ltd.
    Inventor: Albert Leutwiler
  • Patent number: 4775410
    Abstract: The subject matter of this invention involves 2-[4-(2-pyridinyloxy)phenoxy]propionyl-2-oxazolidinones which are substituted in the pyridinyl ring by trifluoromethyl and/or chloro. The compounds are useful for increasing the recoverable sugar in sugarcane.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: October 4, 1988
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard Stach, Takeo Hokama
  • Patent number: 4774332
    Abstract: A compopund containing one or more units of formula I ##STR1## in which R.sub.1 is --CH.sub.2 C.sub.1-4 alkyl or --CH.sub.3 or both groups R.sub.1 form --(CH.sub.2).sub.5 --;R.sub.2 is --CH.sub.2 C.sub.1-4 alkyl or --CH.sub.3 or both groups R.sub.2 form --(CH.sub.2).sub.5 --;R.sub.3 is furylmethyl, unsubstituted C.sub.1-18 alkyl; C.sub.1-4 alkyl monosubstituted by phenyl, the phenyl group of which is unsubstituted or substituted by 1 to 3 groups selected from --OH and C.sub.1-8 alkyl; C.sub.2-8 alkyl monosubstituted by C.sub.1-4 alkoxy; phenyl, unsubstituted or substituted by 1 to 3 groups selected from C.sub.1-8 alkyl and --OH; or cyclohexy, unsubstituted or monosubstituted by C.sub.1-8 alkyl or --OH.These compounds are useful as light stabilizers for polymeric material.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: September 27, 1988
    Assignee: Sandoz, Ltd.
    Inventor: Lajos Avar
  • Patent number: 4771122
    Abstract: Cylosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- andY is -.alpha.Abu-, -Thr-, -Val- or -Nva-,wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, .alpha.-N-methylated .alpha.-amino acid residue of the (D)-configuration, possess pharmaceutical, in particular immunosuppressive, anti-inflammatory and anti-parasitic activity, Intermediate cyclosporin poly-anions having a de-protonated sarcosyl residue at the 3-position, e.g. polyanions of cyclosporins of formula II above wherein X and Y have the meanings given above and Z is -Sar-, in which the said residue Z is de-protonated, are also novel and part of the invention.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: September 13, 1988
    Assignee: Sandoz Ltd.
    Inventor: Dieter Seebach
  • Patent number: 4766153
    Abstract: The invention relates to novel alkyl polyoxyalkylene carboxylate esters and to their use as surface active agents. The novel esters are especially useful as emollients in skin care compositions.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: August 23, 1988
    Assignee: Sandoz Ltd.
    Inventor: Robert V. Casciani
  • Patent number: 4764503
    Abstract: Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--.alpha.Abu--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or --Nva-- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH-- wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: August 16, 1988
    Assignee: Sandoz Ltd.
    Inventor: Roland Wenger
  • Patent number: 4764176
    Abstract: The invention relates to a method for preventing the brightening effect of an optical brightening agent on a textile substrate comprising applying on the textile substrate a water-soluble, cationic, optical brightener quencher either before or together with a resin precursor and submitting the treated substrate to a heat treatment. This method imparts an antibrightening effect to goods when they are washed with an optical brightener containing detergent.
    Type: Grant
    Filed: July 16, 1986
    Date of Patent: August 16, 1988
    Assignee: Sandoz Ltd.
    Inventor: Toshinobu Sakamoto
  • Patent number: 4764585
    Abstract: Cationic fixing agents based on the reaction products of(a) a monofunctional or polyfunctional amine having one or more primary and/or secondary and/or tertiary amino groups and(b) cyanamide, dicyandiamide, guanidine or bisguanidinegive improved results when the reaction takes place in the presence of a catalyst (K) selected from metals, metal salts and heterocyclic nitrogen-containing organic bases, particularly zinc chloride.
    Type: Grant
    Filed: September 15, 1987
    Date of Patent: August 16, 1988
    Assignee: Sandoz Ltd.
    Inventors: Jurg Heller, Bruno Kissling, Curt Muller, Tibor Robinson, Salvatore Valenti
  • Patent number: 4764517
    Abstract: A compound of formula I ##STR1## wherein R.sub.1 is n-propyl,R.sub.2 is hydrogen or alkyl(C.sub.1-3),R.sub.3 is alkyl(C.sub.1-3), andR.sub.4 is hydrogen or methylin free base form or in pharmaceutically acceptable acid addition salt form is useful as a prolactin secretion inhibitor, anti-parkinson and anti-depressant agent.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: August 16, 1988
    Assignee: Sandoz Ltd.
    Inventor: Peter Gull
  • Patent number: 4764175
    Abstract: Metal-free compounds of the formula, ##STR1## and 1:1 copper complexes of metallizable metal-free compounds of said formula and internal and external salts of metal-free compounds of said formula and of 1:1 copper complexes of metallizable metal-free compounds of said formula, whereineach Q is independently linear or branched C.sub.2-6 alkylene; linear or branched C.sub.2-6 alkylene interrupted by --O--, --S-- or --NR.sub.4 --; linear or branched C.sub.3-6 alkylene monosubstituted or disubstituted by hydroxy or --*NHCO--CH.sub.2 --, wherein the * denotes the atom attached to the --NR.sub.4 -- radical,each R.sub.1 is independently hydrogen, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (C.sub.1-4 alkyl)carbonylamino, --SO.sub.2 NR.sub.3 R.sub.4, --CONR.sub.4 --C.sub.6 H.sub.5 or benzamido,R.sub.2 is hydrogen, hydroxy, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, (C.sub.1-4 alkyl)carbonylamino or --NHCONR.sub.3 R.sub.4,X is --NR.sub.5 R.sub.6 or --N.sup..sym. R.sub.7 R.sub.8 R.sub.9 An.sup..crclbar.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: August 16, 1988
    Assignee: Sandoz Ltd.
    Inventors: Jacky Dore, Reinhard Pedrazzi
  • Patent number: 4759801
    Abstract: A method for preparing a pigment preparation comprising kneading a pigment presscake (comprising a pigment and water and/or one or more organic liquids) at a temperature in the range 80.degree. to 200.degree. C. under vacuum together with a thermoplastic material, thereby at the same time removing the water and/or any organic liquids present. These preparations are useful for coloring polymeric material.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: July 26, 1988
    Assignee: Sandoz Ltd.
    Inventors: Jurgen Goldmann, Bansi L. Kaul
  • Patent number: 4758263
    Abstract: Disclosed are herbicides of the formula: ##STR1## wherein R is H or halo of atomic weight of from 18 to 80.
    Type: Grant
    Filed: October 27, 1986
    Date of Patent: July 19, 1988
    Assignee: Sandoz Ltd.
    Inventors: John Krenzer, Leonard J. Stach
  • Patent number: 4758550
    Abstract: A compound of formula I ##STR1## wherein R is H or R'CO wherein R'CO is an acyl radical of a carboxylic acid,Y.sub.1 is the radical linked to an alpha carbon atom an .alpha.-amino acid,Y.sub.2 is the radical linked to an alpha carbon atom of an .alpha.-amino acid, ##STR2## --CH.sub.2 --S--S--CH.sub.2 --CH.sub.2 --COOH, --(CH.sub.2).sub.p --COOH or --CH.sub.2 --S--Y.sub.3,Y.sub.3 is (C.sub.1-4)alkyl or benzyl optionally substituted by methyl or methoxy,or CH.sub.3 CO--NH--CH.sub.2 --,n is 1 to 4,A.sub.6 is Thr or D-Thr,p is 3 to 5,A.sub.8 is the aminoacyl radical of a neutral, lipophilic L-.alpha.-aminoacid,A.sub.9 is the aminoacyl radical of a neutral, lipophilic L- or D-.alpha.-aminoacid,Z is a polypeptide radical corresponding to the polypeptide radical in positions 10 to 31 of a natural calcitonin or a derivative or analogue thereof having a hypocalcemic effect,wherein, when there is more than one Y.sub.1 radical, these are the same or different, and with the exception of radical A.sub.
    Type: Grant
    Filed: December 3, 1986
    Date of Patent: July 19, 1988
    Assignee: Sandoz Ltd.
    Inventors: Francois Cardinaux, Janos Pless, Robert H. Buck
  • Patent number: D298061
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: October 11, 1988
    Assignee: Sandoz Ltd.
    Inventors: Urs Flury, Detlef Lenkeit, Markus Tanner, Werner Thommen, Othmar Zuger