Patents Assigned to SANDOZ
  • Patent number: 4755534
    Abstract: A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR2## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, andR.sub.6 is a radical of formula IIIa--C.tbd.C--R.sub.11 IIIawhere R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof;processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 4, 1984
    Date of Patent: July 5, 1988
    Assignee: Sandoz Ltd.
    Inventor: Anton Stuetz
  • Patent number: 4755606
    Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below,the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: July 5, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: James R. Wareing
  • Patent number: 4754032
    Abstract: Compounds of formula I ##STR1## can be used as optical brighteners.
    Type: Grant
    Filed: February 26, 1986
    Date of Patent: June 28, 1988
    Assignee: Sandoz Ltd.
    Inventors: David L. Connell, John M. Farrar, Jurg Heller, Hans-Rudolf Schmid
  • Patent number: 4753959
    Abstract: The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: June 28, 1988
    Assignee: Sandoz Ltd.
    Inventors: Hans Tscherter, Hans Hofmann, Roy Ewald, Michael M. Dreyfuss
  • Patent number: 4752299
    Abstract: A process for dyeing a mixed fibrous substrate comprising applying to the substrate at least one disperse dye and at least one metal containing direct and/or reactive dye in the presence of a complexing agent having a stability constant K value with the metal of the direct or reactive dye of from 6 to 17 inclusive.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: June 21, 1988
    Assignee: Sandoz Ltd.
    Inventors: Oskar Annen, John A. Hook
  • Patent number: 4752301
    Abstract: A biomass containing biologically produced indigo or a derivative thereof which is used for dyeing without isolating the indigo dye from the rest of the solid biomass before dyeing. Cotton dyeings of clean pure shade can be obtained by a vat dyeing procedure which have the usual fastness properties associated with the active substance.
    Type: Grant
    Filed: June 23, 1987
    Date of Patent: June 21, 1988
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Patent number: 4751235
    Abstract: 7-(indolizin-2-yl)hept-6-enoic acids of the formula I: ##STR1## wherein each of R.sup.1 and R.sup.2 is, independently, H, alkyl, cycloalkyl, aralkyl or aryl, ##STR2## in which R.sup.8 is H, an ester residue or cation; or the lactone thereof. The compounds are useful as hypocholesteremic agents.
    Type: Grant
    Filed: December 23, 1986
    Date of Patent: June 14, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: Paul L. Anderson
  • Patent number: 4749696
    Abstract: The invention discloses hydroxy-[1-substituted carbonyl-2-(or 3-) piperidinyl methoxy]phosphinyloxy]-N,N,N-trilkylalkaneaminium hydroxide inner salt oxides useful as antitumor agents, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for treating tumors.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 7, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: Mark L. Lee
  • Patent number: 4749456
    Abstract: An electrolytic cell which has at least one three-dimensional cathode of non-galvanizable material, which cell is useful in removing metal ions or complexed metals from industrial waste water for example such as produced in the production and use of complex metal dyestuffs.
    Type: Grant
    Filed: August 6, 1987
    Date of Patent: June 7, 1988
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Samhaber
  • Patent number: 4743660
    Abstract: A quaternized aminoamide-modified wax obtainable by amidating, with a polyamine containing a single primary amino group, a carboxy group-containing, oxidized hydrocarbon wax which may be partially saponified, and quaternizing at least one amino group of the resulting aminoamide-modified wax, optionally in admixture with a non-oxidized paraffin wax may be applied, preferably in the form of an aqueous dispersion containing a dispersing agent, to a fibrous substrate to improve its workability in mechanical processes.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: May 10, 1988
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Eckart Schleusener
  • Patent number: 4742077
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 represents a group of formula ##STR2## whereby R.sub.4 and R.sub.5 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl and X represents oxygen, sulfur, imino, lower alkylimino, --(CH.sub.2)--, --(S.CH.sub.2)-- or --(O.CH.sub.2)--,R.sub.2 represents hydrogen or lower alkyl,R.sub.3 represents a group of formula ##STR3## whereby R.sub.6, R.sub.7 and R.sub.8 are the same or different and represent hydrogen or alkyl or R.sub.6 together with R.sub.7 or R.sub.7 together with R.sub.8 represent --(CH.sub.2).sub.m -- wherein m is 3 to 6,R.sub.9 represents alkyl, alkenyl, trialkylsilyl or alkyl substituted by hydroxy, lower alkoxy, lower halogenalkyl or aryl andn stands for 1, 2 or 3,which possess pharmaceutical in particular antimycotic activity as well as activity against phytopathogenic fungi.
    Type: Grant
    Filed: September 8, 1986
    Date of Patent: May 3, 1988
    Assignee: Sandoz Ltd.
    Inventor: Anton Stutz
  • Patent number: 4742160
    Abstract: Metal-free compounds of the formula ##STR1## and 1:1 and 1:2 metal complexes thereof, and salts of the metal-free compounds and 1:1 and 1:2 metal complexes, whereR is hydrogen, --SO.sub.3 H or --NR.sub.5 R.sub.6 ;R.sub.a is hydrogen or --NR.sub.5 R.sub.6 ;R.sub.1 is hydrogen, halogen, --OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or --SO.sub.3 H;R.sub.3 is hydrogen or C.sub.1-4 alkyl;R.sub.4 is halogen, --OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl, --NH.sub.2, an aliphatic, cycloaliphatic or aromatic amino group, a heterocyclic amino group containing 1 to 3 hereto atoms or a hydrazino group,R.sub.5 is hydrogen or C.sub.1-4 alkyl; andR.sub.6 is an organic radical, are useful as cationic dyes for dyeing and printing fibers, threads and textile materials comprising, for example, a natural or regenerated cellulosic material such as cotton, a modified synthetic polyamide or polyester, and a homo- or co-polymer of acrylonitrile or 1,1-dicyanoethylene, bast fibers such as hemp and particularly paper and leather.
    Type: Grant
    Filed: February 28, 1986
    Date of Patent: May 3, 1988
    Assignee: Sandoz Ltd.
    Inventors: Jacky Dore, Reinhard Pedrazzi
  • Patent number: 4742161
    Abstract: Disazo and trisazo compounds of the formula ##STR1## and salts thereof, wherein in each B is independently hydrogen; C.sub.1-4 alkyl; (C.sub.1-4 alkoxy) C.sub.1-4 alkyl; C.sub.2-4 hydroxyalkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cyloalkyl substituted by 1 to 3 C.sub.1-4 alkyls; phenyl (C.sub.1-3 alkyl); phenyl (C.sub.1-3 alkyl) the phenyl group of which is substituted by 1 to 3 substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halo; --A--NH--R.sub.2 ; --A.sub.2 --N(R.sub.7).sub.2 ; --A.sub.N.sup..crclbar. (R.sub.8).sub.2 R.sub.9 A.sup..sym. or --N(R.sub.7).sub.2,whereinA, A.sub.1, A.sub.2 and R.sub.7 -R.sub.9 are as defined in the specification,each R is independently hydrogen; amino C.sub.1-4 alkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 or 2 C.sub.1-4 alkyls; phenyl; benzyl; phenylethyl; or phenyl, benzyl or phenylethyl the phenyl group of which is substituted by 1 or 2 substituents selected from methyl, ethyl, methoxy and ethoxy,each R.sub.5 is independently hydrogen or C.
    Type: Grant
    Filed: May 20, 1985
    Date of Patent: May 3, 1988
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • Patent number: 4742079
    Abstract: The present invention relates to the use of a compound (a), an oomycetes controlling fungicide having the structure element of formula I ##STR1## in which X is CH or N,in association witha compound (b), selected frm CYMOXANIL and Phosetyl-Al in combatting or preventing fungal diseases, and fungicidal composition comprising such compounds.
    Type: Grant
    Filed: December 2, 1986
    Date of Patent: May 3, 1988
    Assignee: Sandoz Ltd.
    Inventors: Andre Devoise-Lambert, Ulrich Gisi
  • Patent number: 4740518
    Abstract: .alpha.-[5H-dibenzo[a,d]cyclohepten-5-ylidene]-carboxylic acids e.g. of formula I ##STR1## wherein R.sub.1 is H, C.sub.1-4 alkyl or phenyl-(C.sub.1-4 alkyl), R.sub.2 is H or C.sub.1-4 alkyl and ring A is unsubstituted or halo- or hydroxy-substituted, as well as the physiologically-hydrolysable and -acceptable esters thereof have valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic properties.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: April 26, 1988
    Assignee: Sandoz Ltd.
    Inventor: Pietro Bollinger
  • Patent number: 4740210
    Abstract: Process for the fatting and hydrophobizing of tanned leather and pelts, wherein the tanned leather or pelt is fatted with an aqueous dispersion containing a natural optionally chemically modified leather fatting agent and a surface-active phosphoric acid partial ester and optionally a non-ionic and/or an anionic carboxy group and/or sulfo group containing surfactant and subsequently treating the fatted leather or pelt in aqueous medium with a polyvalent metal cation; the treated substrates and the dispersions suitable for carrying out the process.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: April 26, 1988
    Assignee: Sandoz Ltd.
    Inventors: Werner Amati, Markus Badertscher
  • Patent number: 4739073
    Abstract: Compounds of the formula ##STR1## wherein one of R and R.sub.o is ##STR2## and the other is primary or secondary C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-6 cycloalkyl or phenyl(CH.sub.2).sub.m --, whereinR.sub.4 is hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl, t-butyl, C.sub.1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy,R.sub.5 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy,R.sub.5a is hydrogen, C.sub.1-2 alkyl, C.sub.1-2 alkoxy, fluoro or chloro, andm is 1, 2 or 3, with the provisos that both R.sub.5 and R.sub.5a must be hydrogen when R.sub.4 is hydrogen, R.sub.5a must be hydrogen when R.sub.5 is hydrogen, not more than one of R.sub.4 and R.sub.5 is trifluoromethyl, not more than one of R.sub.4 and R.sub.5 is phenoxy, and not more than one of R.sub.4 and R.sub.5 is benzyloxy,R.sub.2 is hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl, t-butyl, C.sub.3-6 cycloalkyl, C.sub.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: April 19, 1988
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4737499
    Abstract: An ergot 5'S-(2R-butyl) peptide alkaloid and its acid addition salts is a useful pharmaceutical for use as a prolactin secretion inhibitor, for increasing vigilance or for the treatment of senile dementia, hypertension, or stroke.
    Type: Grant
    Filed: November 18, 1986
    Date of Patent: April 12, 1988
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger
  • Patent number: 4737500
    Abstract: Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: April 12, 1988
    Assignee: Sandoz Pharm. Corp.
    Inventor: Dieter Sorg
  • Patent number: 4737516
    Abstract: Benzothienyldialkylallylamines wherein the amine side chain is attached to the ring via an alkyl radical and is either in 4-, 5-, 6- or 7-position or if not bears tertiary alkylethynyl or alkenylethynyl as its terminal group, which are useful, in particular, as anti-mycotic agents.
    Type: Grant
    Filed: May 1, 1986
    Date of Patent: April 12, 1988
    Assignee: Sandoz Ltd.
    Inventor: Anton Stutz