Abstract: Spiro compounds, comprising a five-membered carbocyclic ring interrupted by two heteroatoms in ring positions 1 and 3 chosen from oxygen and sulfur atoms and in which the carbon atom in ring position 4 is common to a 4 to 8-membered carbocyclic ring interrupted by a nitrogen atom, are useful as pharmaceuticals.
Abstract: Complexes of the formula ##STR1## wherein each R.sub.1 is independently a monocyclic or fused ring aromatic or heteroaromatic group free of water-solubilizing groups,each R.sub.2 is independently is phenyl or methyl, andMe is Ni, Cu, Co or Zn, are useful as pigments for, for example, the mass pigmenting of synthetic plastics and resins, surface coatings and inks, pigment printing, textile coating and pigmenting paper in the mass.
Type:
Grant
Filed:
August 8, 1986
Date of Patent:
March 29, 1988
Assignee:
Sandoz Ltd.
Inventors:
Peter Bitterli, Jurgen Goldmann, Bansi L. Kaul
Abstract: Disclosed are herbicidal compounds of the general formula I: ##STR1## wherein A is O-alkylene of 1 to 5 carbon atoms, O-alkenylene of 3 to 6 carbon atoms in which the unsaturation is non-adjacent the oxygen atom thereof or NH-alkylene in which the alkylene is of 1 to 5 carbon atoms, and --COZR is an acid function or forms certain ester or thioester functions, and the mono- and di-salt forms thereof.
Abstract: A compound useful as a light-stabilizer for polymeric material of formula I ##STR1## in which R is hydrogen, oxygen, C.sub.1-8 alkyl or --CO--R.sub.5, where R.sub.5 is --C(R.sub.10).dbd.CH.sub.2, C.sub.1-6 alkyl, phenyl, --CO--O--C.sub.1-4 alkyl or --NR.sub.7 R.sub.8 and where R.sub.7 is hydrogen, C.sub.1-12 alkyl, C.sub.5-6 -cycloalkyl, phenyl, phenylC.sub.1-4 alkyl or C.sub.1-12 alkylphenyl and R.sub.8 is C.sub.1-12 alkyl or hydrogen;each R.sub.1, independently, is --CH.sub.3 or --CH.sub.2 (C.sub.1-4 alkyl) or both groups R.sub.1 form a group --(CH.sub.2).sub.5 --;each R.sub.2, independently, is --CH.sub.3 or --CH.sub.2 (C.sub.1-4 alkyl) or both groups R.sub.2 form a group --(CH.sub.2).sub.5);R.sub.10 is hydrogen or C.sub.1-4 alkyl; andR.sub.4 is an amide- or ester-forming group.
Abstract: Compositions comprising(a) 30-70% by weight of one or more compounds of the formula ##STR1## wherein each R.sub.1 is independently C.sub.2-4 alkyl, and R.sub.3 is methyl or ethyl; and(b) 30-70% by weight of one or more compounds of the formula ##STR2## wherein R.sub.4 is chloro, bromo or iodo each R.sub.5 is independently C.sub.2-4 alkyl, and R.sub.6 is methyl or ethyl are useful for dyeing substrates comprising a synthetic or semi-synthetic hydrophobic organic material, e.g., polyester, by, for example, the rapid dyeing process.
Abstract: Somatostatine derivatives of the general formula ##STR1## wherein either (a)A is ##STR2## W is -CO-N(A.sub.4) or -N(A.sub.5)-CO- and Y.sub.1 and Y.sub.2 are H or together a bondor (b)A is H, alkyl, phenylalkyl or RCO andY.sub.1 and Y.sub.2 are acyl groups as defined in claim 1,A', B, C, D, E, F, A.sub.1, A.sub.2, A.sub.3, A.sub.4, A.sub.5, R and Z having the meanings recited in claim 1, have pharmacological, in particular GH-, gastric- and pancreatic secretion inhibiting activity.
Abstract: Compounds of formula I ##STR1## in which R is hydrogen, methyl or ethyl, R.sub.1 is methyl, ethyl, C.sub.1-4 alkoxy or halogenR.sub.2 is hydrogen, methyl or ethylR.sub.3 is hydrogen, methyl or ethylM is hydrogen or one equivalent of a cation andring A may be unsubstituted or substituted by up to three substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen and C.sub.2-4 acylaminoare useful anionic dyestuffs having superior alkali resistance for the dyeing and printing of natural and synthetic polyamides, especially nylon.
Abstract: Substituted 2-pyridinesulfonamide 1-oxides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.
Abstract: 6-(1'-fluorethyl)- and 6-(1'-fluoro-1'-methylethyl)-carbapenems such as (5RS,6RS)-1-aza-6-(1(RS)-fluorethyl)-3-(N'-dimethyl-N'-methylamidinomethyl thio)-7-oxobicyclo[3.2.0]hept-2-ene-2-carboxylic acid which are useful as chemotherapeutic agents in particular as anti-bacterially active anti-biotics.
Abstract: Compounds of formula I ##STR1## wherein, R.sub.1 represents hydrogen or methyl,R.sub.2 represents hydrogen or lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl each of which may be unsubstituted or mono- or poly-substituted by amino, mono- or di(lower)-alkylamino, lower acylamino, carboxy, lower alkoxycarbonyl or carbamoyl; a group of formula IIc(CH.sub.2).sub.p --R.sub.5 IIcwherein R.sub.5 represents phenyl or a 5- or 6-membered saturated or unsaturated heterocycle containing one or more heteroatoms selected from O, S and/or N and which may be unsubstituted or mono- or poly-substituted by fluoro, chloro, bromo, amino, mono- or di-(lower)-alkylamino, hydroxy, lower alkoxy, mercapto, alkylthio, phenylthio, sulfamoyl, guanidino, nitro, cyano, lower acylamino, carboxy, alkoxycarbonyl or carbamoyl and p is 0, 1, 2 or 3; or a group of formula ##STR2## wherein R.sub.6, R.sub.7 and R.sub.8 may be the same or different and each represents hydrogen or lower alkyl or R.sub.6 and R.sub.8 and/or R.sub.
Abstract: Polymeric compounds (A) obtained by the reaction of epihalo-hydrin with a polyalkylene polyamine are useful as textile treatment agents. As pretreatment agents they improve the color yield of the subsequent dyeing, as aftertreatment agents they improve fastness properties. Certain of the products (A) are novel.
Type:
Grant
Filed:
June 16, 1986
Date of Patent:
January 12, 1988
Assignee:
Sandoz Ltd.
Inventors:
Jurg Heller, Bruno Kissling, Tibor Robinson, Salvatore Valenti
Abstract: Aqueous optical brightener compositions consisting essentially of:(a) at least one optical brightener of formula ##STR1## in which R.sub.1 is hydrogen or --SO.sub.3 M;R.sub.2 is hydrogen or --SO.sub.3 M;R.sub.3 is hydrogen, C.sub.2-3 -hydroxyalkyl, C.sub.1-4 -alkyl, --CH.sub.2 --CH.sub.2 --CN or --CH.sub.2 --CH.sub.2 --CONH.sub.2 ;R.sub.4 is hydrogen, C.sub.1-4 -alkyl, C.sub.2-3 -hydroxyalkyl, hydroxy-ethoxy-ethyl, N,N-Bis-(C.sub.1-3 -alkyl)-amino-C.sub.2-6 -alkyl or benzyl;orR.sub.3 and R.sub.4 together with the neighboring nitrogen atom signify a morpholine, pyrrolidine, piperidine or N-methylpiperazine ring;andM is hydrogen or a colorless cation; provided that at most one of R.sub.3 and R.sub.
Abstract: A hair-reserving penetration dyeing of the leather side of wool- or fur-bearing skins is obtained by dyeing the wooled or fur skins in aqueous medium with hydrosoluble sulpho-group-containing sulphur dyes (a) in the presence of dye-substantive uptake assistant (b) and of non-ionic and/or anionic hydrophilic dispersants (c) and optionally in the presence of leather fatting agents (d).
Abstract: Tanned leather is penetration-dyed from aqueous medium with hydrospluble sulpho group-containing sulphur dyes in the presence of dye-substantive uptake assistants and may be used as a substrate for further coloration processes, mainly dyeings and printings, in particular with anionic or basic dyes; in a variation of the process for overdyeing, in particular of thin leathers, the penetration-dyeing may also be carried out in the absence of the dye-substantive uptake assistant.
Abstract: Virus insecticide compositions having good stability and wettability are free-flowing particles prepared by spray-drying techniques and having the virus insecticide encapsulated in a matrix comprising an intimate mixture of a protein and clay.
Abstract: both R.sub.1 's and CH.sub.3 or together form --CH.sub.2).sub.5 ;both R.sub.2 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;R.sub.3 has a significance of R, independently of R, except for oxygen;X is --O--, --NH-- or ##STR2## m is an integer from 1 to 4 inclusive; R.sub.4 is a saturated or unsaturated aliphatic group unsubstituted or substituted by one or two groups selected from --OH and C.sub.1-4 alkoxy and which can be interrupted by an oxygen or sulphur atom; or an aromatic group unsubstituted or substituted by one or two groups selected from --OH, C.sub.1-4 alkyl and C.sub.1-4 alkoxy are useful as U.V. light stabilizers in polymeric organic compounds.
Abstract: Water soluble polyacetals having molecular weights from about 5,000-30,000 are formed by condensing three monomers, e.g. a divinyl ether, a water soluble glycol and a diol. The invention is used for the bioerodible controlled release of therapeutic agents from the polyacetal hydrogel.
Abstract: 1,4-Dihydropyridine-3,5-dicarboxylic acid esters of formula I ##STR1## wherein the substitutents have various significances, are useful as calcium antagonists.
Abstract: Cyclosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- andY is -.alpha.Abu-, -Thr-, -Val- or -Nva-,wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, .alpha.-N-methylated .alpha.-amino acid residue of the (D)-configuration, possess pharmaceutical, in particular immunosuppressive, anti-inflammatory and anti-parasitic activity. Intermediate cyclosporin poly-anions having a de-protonated sarcosyl residue at the 3-position, e.g. polyanions of cyclosporins of formula II above wherein X and Y have the meanings given above and Z is -Sar-, in which the said residue Z is de-protonated, are also novel and part of the invention.
Abstract: The invention relates to a method of combatting fungal diseases with the aid of(a) an oomycetes controlling fungicide of formula I ##STR1## wherein R.sub.1, R.sub.2, independently, are H or CH.sub.3R.sub.3 is H, Cl, Br,X is CH(CH.sub.3)COOCH.sub.3, 2-oxo-tetrahydrofuran-3-yl, 2-oxo-tetrahydrothien-3-yl or 2-oxo-1,3-oxazolidin-3-yl andY is Ch.sub.2 OCH.sub.3, 2-furyl, benzyl, CH.sub.2 Cl, cyclopropyl or 3-isoxazolyl,in association with(b) Anilazine of formula II ##STR2## in admixture or separately in a fungicidally effective aggregate amount, and optionally other fungicides, and to fungicidal compositions comprising such fungicides.
Type:
Grant
Filed:
February 19, 1986
Date of Patent:
October 20, 1987
Assignee:
Sandoz Ltd.
Inventors:
Helmut Kaspers, Jiri Duben, Ulrich Gisi