Patents Assigned to SANDOZ
  • Patent number: 4699626
    Abstract: Complexes of the formula ##STR1## or a water-soluble salt thereof each cation of which is independently a non-chromophoric cation, wherein X is chloro or hydroxy,m is 1 or 2, andn is 0 or 1, with the proviso that m + n is 2, with the proviso that one of the asterisked bonds is in the 1-position and the other asterisked bond is in the 2-position, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, preferably textile material consisting of or containing cellulose fibers, most preferably cotton, alone or blended with other suitable textile fibers. The resulting dyed or printed textile material may be aftertreated with a polymeric polybasic amino compound in order to improve the wet fastness of these dyeings and printings.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: October 13, 1987
    Assignee: Sandoz Ltd.
    Inventors: Hans-Rudolf von Tobel, Paul Doswald
  • Patent number: 4698331
    Abstract: Compounds of formula I ##STR1## wherein R.sub.2 and R.sub.3 are the same or different and each represent unsubstituted or substituted acyl,and(a) R.sub.1 represents lower alkyl, aralkyl or the phosphate, pyrophosphate, phosphorylethanolamine or pyrophosphorylethanolamine group, R.sub.4 represents the phosphate, pyrophosphate, phosphorylethanolamine or pyrophosphorylethanolamine group and one of R.sub.1 and R.sub.4 may additionally represent hydrogen and R.sub.5 represents hydrogen or a glycosyl radicalor(b) R.sub.1 represents hydrogen, lower alkyl or aralkyl and R.sub.4 and R.sub.5 represent hydrogen,which compounds are indicated for use as pharmaceuticals, in particular as immunostimulants.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: October 6, 1987
    Assignee: Sandoz Ltd.
    Inventors: Ingolf Macher, Frank M. Unger
  • Patent number: 4697033
    Abstract: Certain novel derivatives of carbamates and their use for the control of pests.
    Type: Grant
    Filed: December 24, 1985
    Date of Patent: September 29, 1987
    Assignee: Sandoz Ltd.
    Inventor: Clive A. Henrick
  • Patent number: 4696962
    Abstract: A cationic polymer composition suitable for use as a flocculating agent and as a retention aid and dewatering agent in paper making consists of a mixture of(a) a hydrophilic cationic polymer of(a.sub.1) acrylamide and/or methacrylamide and(a.sub.2) dialkylamino-C.sub.2-3 alkylene-(meth)acrylamidethe molar quantity of cationic monomer units (a.sub.2) being from 0.2 to 9 mol % of the total(b) an anionic surfactant(c) a water-immiscible oil in which the polymer (a) is insoluble, andoptionally (d) a lipophilic non-ionic surfactant,optionally (e) waterand optionally (f) an oil-miscible polar solvent.The compositions may be prepared by water-in-oil emulsion copolymerization and are readily diluted with water.
    Type: Grant
    Filed: July 24, 1984
    Date of Patent: September 29, 1987
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, James R. Ruynon
  • Patent number: 4695600
    Abstract: These compounds are useful as light stabilizers in polymeric systems. ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are organic radicals.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: September 22, 1987
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4692544
    Abstract: Certain substituted diaryl amines are used to inhibit the polymerization of ethylenically unsaturated monomers; for example, unsaturated carboxylic acids and derivatives thereof.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: September 8, 1987
    Assignee: Sandoz Ltd.
    Inventors: Richard N. Goerner, J. Michael Hipp, Ruth H. Hipp
  • Patent number: 4692453
    Abstract: A 6- or 8-monooxy- or 6,8-dioxy-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline in which the 3-position is unsubstituted, is useful as a pharmaceutical, in particular as a prolactin secretion inhibitor, dopaminergic agent and dopamine receptor stimulating agent.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: September 8, 1987
    Assignee: Sandoz Ltd.
    Inventor: Max P. Seiler
  • Patent number: 4687842
    Abstract: Compounds of the formula ##STR1## wherein each of R and R.sub.1 is independently hydrogen, C.sub.1-4 alkyl, phenyl or phenyl substituted by 1 to 3 C.sub.1-4 alkyl, C.sub.1-4 alkoxy or halo substitutents orR and R.sub.1 taken together are trimethylene or tetramethylene,each of R.sub.2 and R.sub.3 is independently allyl, C.sub.1-4 alkyl, phenyl (C.sub.1-4 alkyl) or C.sub.2-4 alkyl monosubstituted by hydroxy, cyano or carbamoyl, ##STR2## wherein R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined in the specification, andA.sup..crclbar. is an anion, and mixtures thereof with cationic 5-hydroxypyrazole dyes, are useful for dyeing and printing materials dyeable with basic dyes, e.g., homopolymers and copolymers of acrylonitrile and asymmetrical dicyanoethylene, polyamides and polyesters modified to contain acidic groups, leather and paper.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: August 18, 1987
    Assignee: Sandoz Ltd.
    Inventor: Beat Henzi
  • Patent number: 4686237
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-3 alkyl, andZ is ##STR2## wherein R.sub.7 is hydrogen, R.sub.8 or M, whereinR.sub.8 is a physiologically acceptable and hydrolyzable ester group, andM is a pharmaceutically acceptable cation,the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: August 11, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: Paul L. Anderson
  • Patent number: 4685934
    Abstract: Monoazo compounds of formula ##STR1## wherein R.sub.1 is a coupling component radical,R.sub.1 is C.sub.1-6 alkyl; C.sub.1-6 alkyl substituted by 1 or 2 substituents selected from chloro, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl and phenyl substituted by 1 or 2 substituents selected from chloro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, carboxy, sulfo, sulfamoyl and acetamido; C.sub.5-7 cycloalkyl; C.sub.5-7 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups; phenyl; phenyl substituted by 1 to 3 substituents selected from chloro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetamido (maximum of 1), carboxy (maximum of 1), sulfo (maximum of 1) and --SO.sub.2 NR.sub.7 R.sub.8 (maximum of 1); 1- or 2-naphthyl or 1- or 2-naphthyl substituted by sulfo,whereineach of R.sub.7 and R.sub.8 is independently hydrogen; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by hydroxy or phenyl; cyclohexyl; phenyl or phenyl monosubstituted by chloro, methyl or methoxy, or--NR.sub.7 R.sub.
    Type: Grant
    Filed: July 12, 1985
    Date of Patent: August 11, 1987
    Assignee: Sandoz Ltd.
    Inventors: Francois Benguerel, Roland Mislin
  • Patent number: 4686285
    Abstract: (i) Metal-free compounds of the formula ##STR1## (ii) tautomers thereof, (iii) 1:1 and 1:2 metal complexes of (i) and (ii),(iv) salts of (i), (ii), and (iii), and(v) mixtures of (i), (ii), (iii), and (iv),wherein the symbols are as defined in the Specification, are useful as dyes for, for example, polymers and copolymers of acrylonitrile, polyesters modified to contain acid groups, polyamides such as wool, leather, cotton, bast fibers such as hemp, flax, sisal jute, coir and straw, regenerated cellulose, glass fibers and paper (those wherein R.sub.o is other than hydrogen) or as intermediates for the synthesis of dyes.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: August 11, 1987
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4685960
    Abstract: The subject matter of this invention is the use of propanoic esters of the following structural formula: ##STR1## wherein R is an alkyl group having 10 to 16 atoms to increase the recoverable sugar in sugarcane.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: August 11, 1987
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard J. Stach, Takeo Hokama
  • Patent number: 4684661
    Abstract: The invention relates to novel homopropargylamines of formula I ##STR1## wherein n is 2 or 3,R.sub.1 is a group of formula IIa, IIb or IIc ##STR2## in which R.sub.6 and R.sub.7 independently are H, halogen, CF.sub.3, lower alkyl or lower alkoxy,s is a number of 3 to 5,X is O, S, OCH.sub.2, SCH.sub.2, CH.sub.2 or NR.sub.8, andR.sub.8 is H or lower alkyl,R.sub.2 is H or lower alkyl, eitherR.sub.3 and R.sub.4, independently, are H or lower alkyl, orR.sub.3 and R.sub.4 together are (CH.sub.2).sub.u, in which u is a number of 3 to 5, andR.sub.5 is H, alkenyl or is a group selected from alkyl, trialkylsilyl, dialkylphenylsilyl, phenyl, phenylalkyl and cycloalkyl, in which alkyl, phenyl and cycloalkyl groups or moieties are unsubstituted or substituted by OH, lower alkyl, lower alkoxy, phenyl or halogen,in free base form or acid addition salt form thereof, their preparation, their chemotherapeutical and agricultural use and to compositions comprising such novel compounds and suitable for such use.
    Type: Grant
    Filed: November 20, 1985
    Date of Patent: August 4, 1987
    Assignee: Sandoz Ltd.
    Inventor: Anton Stuetz
  • Patent number: 4681754
    Abstract: Improved cyclosporin therapy in particular for counteracting cyclosporin (e.g. Cyclosporine) organ toxicity, comprises adjunct administration of co-dergocrine.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: July 21, 1987
    Assignee: Sandoz Ltd.
    Inventor: Helene Siegl
  • Patent number: 4681898
    Abstract: Compounds of the formula ##STR1## where n is 0 or 1,R is alkyl, phenyl or R.sub.4 -substituted phenyl,R.sub.2 and R.sub.3 are, independently, alkyl orR.sub.2 and R.sub.3 together with N is ##STR2## m is 1, 2 or 3, R.sub.1 and R.sub.4 are, independently hydrogen, halo, alkyl or alkoxy, andR.sub.5 is hydrogen or alkyl of 1 to 6 carbon atomsor their pharmaceutically acceptable salts are useful as anti-diabetic agents, in particular, as hypoglycemic agents or inhibitors of post-prandial hypoglycemia.
    Type: Grant
    Filed: May 8, 1984
    Date of Patent: July 21, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: Jeffrey Nadelson
  • Patent number: 4681880
    Abstract: 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: July 21, 1987
    Assignee: Sandoz Ltd.
    Inventors: Hans Kobel, Jean-Jacques Sanglier, Hans Tscherter, Georg Bolliger
  • Patent number: 4680291
    Abstract: The present invention provides propenylamines useful as anti-mycotic agents.
    Type: Grant
    Filed: August 18, 1978
    Date of Patent: July 14, 1987
    Assignee: Sandoz Ltd.
    Inventors: Helmut Hamberger, Adrian Stephen, Anton Stutz, Peter Stutz
  • Patent number: 4677211
    Abstract: 7-Substituted lower alkyl hept-6-enoates and 4-hydroxytetrahydropyran-2-ones bearing 6-olefinic substituents (e.g.,) ethyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enoates are prepared by a multi-step process. The process involves 3-protected-lower alkyl 3,5-dihydroxy-hept-6-enoates, which are obtained by cleaving corresponding 6.alpha.-vinyl-4.beta.-protected hydroxy-tetrahydro 2H-pyran-2-ones. The final products are useful as anti hypercholesteremic agents.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: June 30, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing
  • Patent number: 4675022
    Abstract: Textile substrates are impregnated with a aqueous disperison of a fine crystalline wax containing carboxy and carboxylic acid ester groups, a paraffin wax and a non-ionic emulsifier, optionally together with an optical brightener and/or a resin finish, and then submitted to a heat treatment. The treated textile substrates have improved sewability.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: June 23, 1987
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Patent number: 4675330
    Abstract: A compound of formula I ##STR1## wherein R.sub.1 represents ethyl or vinyl andR.sub.2 represents a five membered saturated heterocycle or aminoalkyl unsubstituted or substituted in its alkyl moiety by hydroxy,in free or in the form of an acid addition or quaternary salt, which compounds are indicated for use as chemotherapeutic agents e.g. as anti-bacterially active antibiotics and as veterinary agents e.g. in combatting microorganism infections and promoting growth in domestic animals.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: June 23, 1987
    Assignee: Sandoz Ltd.
    Inventors: Heinz Berner, Hermann Vyplel