Abstract: Method of inhibiting luteinising hormone secretion in a subject, said method comprising administering an optionally 5-alkyl- or -phenyl- and/or 2'-hydroxy-, -alkoxy- or -acyloxy-substituted 9,9-dimethyl-6,7-benzomorphan derivative having an oxygen containing substituent at the N-atom.
Abstract: Compounds of the formula ##STR1## wherein F is the residue of a monoazo or disazo compound, each X is independently --NR.sub.2 --Q--NR.sub.3 R.sub.4 or --NR.sub.2 --Q--N.sup..sym. R.sub.5 R.sub.6 R.sub.7,wherein Q is linear or branched C.sub.2-6 alkylene, R.sub.2 is hydrogen or C.sub.1-4 alkyl,each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is independently hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkyl substituted by hydroxy or cyano; C.sub.1-3 alkyl substituted by phenyl or substituted phenyl having 1 to 3 substituents selected from chloro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; C.sub.5-6 cycloalkyl or C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups, with the proviso that neither R.sub.5 and R.sub.6 can be hydrogen, orR.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 taken together and with the nitrogen atom to which they are joined from a 5- or 6-membered ring containing at most one further hetero atom, andR.sub.7 is C.sub.1-4 alkyl or benzyl,each Z.sub.1 is independently --CO--, --SO.sub.
Abstract: A composition containing(A) 10 parts by weight of an anionic product obtained by addition of 5 to 20 mols of ethylene oxide to an aliphatic saturated or unsaturated alcohol of 10 to 24 carbon atoms, followed by carboxymethylation(B) 1 to 15 parts by weight of a cationic addition product of 50 to 150 mols of ethylene oxide to a fatty amino-(C.sub.2-3)alkylene-amine(C) 1 to 10 parts by weight of a non-ionic addition product of 20 to 150 mols of ethylene oxide to castor oil, or a non-ionic sequenced addition product of 20 to 150 mols of ethylene oxide and 1 to 10 mols of propylene oxide to castor oil, and(D) 1 to 20 parts by weight of a N-(.beta.-hydroxy-(C.sub.2-4)alkyl)-fatty acid amide,is a dyeing auxiliary useful for the dyeing in one bath or printing of a mixed textile substrate comprising cationic dyeable fibres and anionic or disperse dyeable fibres.
Abstract: The myotonolytic use of compounds of formula I ##STR1## wherein R is hydrogen, acetyl or a group of formula IIR'--O--CO-- IIwherein R' is alkyl(C.sub.1-8); phenyl; phenyl substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4); phenylalkyl; or phenylalkyl in which the phenyl group is substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4).
Abstract: Herbicidal and algaestatic and algaecidal compositions and use thereof comprising copper salts; both soluble acid salts as copper sulfate, chloride, nitrate, acetate, sulfamate, gluconate, citrate, etc. and basic copper salts such as basic copper sulfate, cupric hydroxide, basic copper carbonate, basic copper chloride and the like for a method for treating bodies of water to arrest or eliminate the growth of algae and aquatic weeds by giving a more efficient algaestat, algaecide and/or herbicide, when the copper salts or insoluble basic copper salts are used as a complex with an alkylene diamine, such as ethylenediamine, propylenediamine and substituted derivatives of these; or poly (aminoalkylene).sub.n --NH.sub.
Abstract: The compounds of formula I ##STR1## where R.sub.1, R.sub.2 and R have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardiotonic, anti-arrhythmic, .alpha.- and .beta.-adrenoceptor blocking agents.
Abstract: Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging agents.
Abstract: The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are prepared by cyclization of a phenyl hydrazine compound with a 1,1,3,3-tetra-C.sub.1-4 -alkoxy-propane compound.
Abstract: 1:2 Metal complexes of the formula ##STR1## in which each of X.sub.1 and X.sub.2, independently, is --COO-- or --O--,each of B.sub.1 and B.sub.2, independently, is a radical of a coupling component of the benzene or oxyquinoline series,M is a metal capable of forming a 1:2 complex and,each of ##STR2## independently, is the radical of a diazo component of the benzene series, with the proviso that at most one of such diazo component radicals contains a single sulpho group,and mixtures thereof with one or more of the corresponding symmetrical 1:2 metal complexes,which complexes and mixtures of complexes are in free acid or salt form and are useful as anionic dyes for dyeing and printing substrates such as natural and regenerated cellulose, natural and synthetic polyamides, polyurethanes and polymers modified to contain basic groups, especially leather.
Abstract: A liposome medicament delivery system wherein the medicament is encapsulated in a liposome comprising an aliphatic liquid-sterol-water lamellae. The lipid may be a sodium or potassium salt of a C.sub.4 to C.sub.18 fatty acid, and the sterol may be cholesterol.
Abstract: The invention provides compounds of formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl, R.sub.3 is hydrogen, alkyl, alkenyl, phenylalkyl or a group --(CH.sub.2 --CH.sub.2 --O).sub.n --R.sub.4 in which n is 1 to 3 and R.sub.4 is hydrogen or an acid residue, and the ring A is unsubstituted or substituted, with the proviso that when R.sub.3 is methyl the ring A is substituted. The compounds are useful in the treatment and prophylaxis of allergic conditions.
Abstract: The invention provides indole compounds useful for the treatment of hypertension, processes for the preparation of said compounds and pharmaceutical compositions containing these compounds.The compounds of the invention have the formula ##STR1## wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R.sub.1 is H or alkyl, or A together with NR.sub.1 is 4-piperidyl, R.sub.2 is hydrogen or alkyl, R.sub.3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R.sub.4 is hydrogen, chlorine, bromine or alkyl, R.sub.5 is hydrogen, alkyl, alkoxy or alkylthio, and X is --CO-- or --CS.
Abstract: The present invention provides a composition for dyeing or printing with disperse dyestuffs comprising(a) 70-87.5% by weight of an aromatic hydrocarbon mixture containing more than 30% by weight of a mixture of alkylbenzenes having two or more methyl groups or at least one ethyl, propyl or butyl group on the benzene nucleus, which aromatic hydrocarbon mixture has a boiling point range of from 160.degree. to 280.degree. C.;(b) 10 to 20% by weight of the condensation product of castor oil with 30 to 50 mols ethylene oxide;(c) 0.5 to 5% by weight of the condensation product of a fatty acid wih 5 to 8 mols ethylene oxide and(d) 2 to 5% by weight paraffin oiland the preparation is free from any anionic dispersing agent.
Abstract: The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,R.sub.1 is methyl or ethyl,R.sub.2 is alkyl of 1 to 4 carbon atoms or allyl,R.sub.3 is CH.sub.2 CN or a group --NR.sub.4 R.sub.5, wherein R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and R.sub.5 is alkanoyl of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms in the aggregate thereof, or mono-, di- or tri-haloalkoxycarbonyl of 3 to 5 carbon atoms, wherein the alkoxy group is substituted by halogen other than in the .alpha. position to the oxygen atom, or R.sub.5 is SO.sub.2 R.sub.6, wherein R.sub.6 is alkyl of 1 to 4 carbon atoms, mono-, di- or tri-haloalkyl of 1 to 4 carbon atoms, phenyl, phenyl mono-substituted by halogen or alkoxy of 1 to 4 carbon atoms, or pyridyl, or R.sub.6 is a group NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, or R.sub.7 and R.sub.8 together form --[CH.sub.2 ].sub.n -- or --[CH.sub.2 ].sub.2 --A--[CH.
Type:
Grant
Filed:
September 22, 1980
Date of Patent:
September 7, 1982
Assignee:
Sandoz Ltd.
Inventors:
Peter Stutz, Theodor Fehr, Paul Stadler
Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,R.sub.1 is methyl or ethyl, andR.sub.2 is CH.sub.2 --CN, or a group NR.sub.3 R.sub.4, whereinR.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is SO.sub.2 R.sub.5, wherein R.sub.5 is alkyl of 1 to 4 carbon atoms, mono- to tri-halogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen or alkoxy of 1 to 4 carbon atoms, or a group NR.sub.6 R.sub.7, wherein each ofR.sub.6 and R.sub.7 is independently hydrogen or alkyl of 1 to 4 carbon atoms, orR.sub.6 and R.sub.7 together are one of the groups (CH.sub.2).sub.n or (CH.sub.2).sub.2 --A--(CH.sub.2).sub.2, whereinn is a number from 3 to 7, andA is oxygen, sulphur or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl,useful as prolactin secretion agents and antiparkinson agents.
Type:
Grant
Filed:
September 22, 1980
Date of Patent:
September 7, 1982
Assignee:
Sandoz Ltd.
Inventors:
Theodor Fehr, Paul Stadler, Peter Stutz
Abstract: The invention provides fungicidal compositions comprising a N-amino-2-oxo-3-oxazolidine derivative (component a) such as 2-methoxy-N-(2,6-dimethylphenyl)-N-(2-oxo-3-oxazolidinyl)-acetamide and a component (b) selected from a copper fungicide, folpet, captan, mancozeb or maneb. A further object of the invention are methods of combating phytopathogenic fungi in plants, seeds or soil with the aid of fungicidally effective amounts of a component (a) and a component (b).
Abstract: The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
Abstract: Compounds of the formula ##STR1## in which R.sub.1 is hydrogen or an aliphatic or aromatic substituent conventional for diazo component radicals of disperse dyes and which is bound to a N-atom in the 1- or 2-position of the triazole nucleus through a carbon atom, with the proviso that when R.sub.1 is in the 1-position, the broken line represents double bonds in the 2,3- and 4,5-positions and when R.sub.1 is in the 2-position, the broken line represents double bonds in the 3,4- and 1,5-positions,R.sub.2 is an electron withdrawing or inductive group, andK is a coupling component radical of the aniline series,with the proviso that the molecule is free from cationic groups, sulphonic acid groups, metals and metallizable groups, which compounds are useful as disperse dyes for textile substrates consisting of or comprising synthetic or semi-synthetic, hydrophobic, high molecular weight organic materials such as linear aromatic polyesters, cellulose 21/2 acetate, cellulose triacetate and synthetic polyamides.
Abstract: This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is phenyl; phenyl monosubstituted with fluorine; phenyl mono- or disubstituted with chlorine; phenyl mono-, di- or trisubstituted with methyl or methoxy, secondary 1-phenoxyalkyl, the secondary alkyl residue of which is of 3 to 5 carbon atoms and in which the phenyl residue is unsubstituted or monosubstituted with chlorine, andeither R.sub.2 is hydrogen, and R.sub.3 is methyl,or R.sub.2 is methyl and R.sub.3 is hydrogen or methyl,which are useful, for example, for treating coronary conditions.
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or amino, R.sub.2 is hydrogen or alkyl of 1 to 6 carbon atoms, with the provisos that (1) at least one of R.sub.1 and R.sub.2 is not a tertiary alkyl group and (2) R.sub.2 is hydrogen when R.sub.1 is amino, orR.sub.1 and R.sub.2 taken together and with the nitrogen atom to which they are joined are pyrrolidino, piperidino or N'-2-hydroxyethylpiperazino,each X' is independently alkyl or 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halo, or two X's on adjacent carbon atoms together are methylenedioxy, andn is 0, 1, 2 or 3,and the pharmaceutically acceptable acid addition salts thereof, are useful as anti-obesity and anti-diabetic agents. The compounds wherein R.sub.1 is alkyl and R.sub.2 is hydrogen are synthesized by a two-step synthesis from 2-alkyl-5-arylisoxazolium salts and ethylenediamine. The compounds wherein R.sub.1 and R.sub.