Patents Assigned to SANDOZ
  • Patent number: 4288227
    Abstract: Disclosed is a process for imparting coloration of good light fastness to a substrate comprising or consisting of homo- and co-polymers of acrylonitrile or of dicyanoethylene, or acid modified synthetic polyamide or polyester, which process comprises mass dyeing, dyeing or printing such substrate, employing, as dyestuff, a compound or mixture of compounds of formula I, ##STR1## wherein either R is hydrogen, or a straight or branched chain C.sub.1--8 alkyl radical, unsubstituted or mono-substituted by OH, CN, Cl, Br, CONH.sub.2, C.sub.1--4 -alkoxy, phenyl, phenoxy, --O--CO--R.sub.5 or --CO--O--R.sub.5,and R.sub.1 is a straight or branched chain C.sub.1--8 alkyl radical, unsubstituted or mono-substituted by OH, CN, Cl, Br, --CONH.sub.2, C.sub.1--4 alkoxy, phenyl, phenoxy, --O--CO--R.sub.5 or --CO--O--R.sub.5 ; or phenyl, unsubstituted or monosubstituted by halogen, C.sub.1--4 alkyl or C.sub.1--4 alkoxy,or R and R.sub.
    Type: Grant
    Filed: May 16, 1979
    Date of Patent: September 8, 1981
    Assignee: Sandoz Ltd.
    Inventors: Berthold Gertisser, Beat Henzi
  • Patent number: 4287355
    Abstract: Carbalkoxy-phenyl (or tolyl)-dialkyl-or alkyl-phenyl-sulfonium salts, e.g. p-(.alpha.-carbethoxy) tolyl-n-octadecyl-phenyl sulfonium tetrafluoroborate, are useful as pharmaceuticals. The compounds are obtainable by reaction of a carbalkoxy-phenyl (or-tolyl)-dialkyl-or-alkyl-phenyl-sulfide with an alkylhalide in the presence of a metal salt, e.g. silver tetrafluoroborate.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: September 1, 1981
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4286961
    Abstract: The present invention relates to an after-dyeing treatment process for synthetic/cellulosic fibre mixed substrates which have been dyed with at least one disperse and at least one reactive dye in which after fixation, the dyed or printed substrate is reductively treated at a neutral to alkaline pH with an aqueous solution containing reducing agent, whereby non-bound disperse dyestuff is decomposed such that it does not re-build up on the substrate whilst the fixed reactive dyestuff remains substantially unaffected.
    Type: Grant
    Filed: August 2, 1979
    Date of Patent: September 1, 1981
    Assignee: Sandoz Ltd.
    Inventors: Rolf Buser, Francis Palacin, Georg Robert, Franz Somm
  • Patent number: 4287196
    Abstract: Certain known pyrimido[2,1-a]isoindoles and diazepino[2,1-a]isoindoles, e.g., 7-(p-chlorophenyl)-7-hydroxy-2,3,4,5-tetrahydro-7H-[1,3]-diazepino[2,1-a]i soindoles, are useful for inhibiting prolactin secretion.
    Type: Grant
    Filed: February 26, 1980
    Date of Patent: September 1, 1981
    Assignee: Sandoz, Inc.
    Inventors: Ronald G. Babington, F. Eugene Harrington, William J. Houlihan
  • Patent number: 4285840
    Abstract: A detergent composition comprises an aqueous solution of the following components:A: 3 to 6 parts by weight of a nitrilocarboxylic acid in free acid or salt form,B: 2 to 11 parts by weight of a higher (C.sub.8-24) alkyl phenyl polyglycol ether having from 5 to 25 glycol residues,C: 5 to 15 parts by weight of an alkanolamine,D: 1 to 3 parts by weight of a block copolymer of propylene oxide and ethylene oxide of an average molecular weight from 1500 to 2500 and containing from 5 to 15% by weight of ethylene oxide end units,E: 0 to 3 parts by weight of a higher (C.sub.8-14) alcohol,F: 0 to 1 parts by weight of a water-soluble silicone oil,and optionally one of the following solvents:G: 10 to 40 parts by weight of an organic solvent based on aliphatic or aromatic hydrocarbon or chlorinated hydrocarbon orH: 5 to 20 parts by weight of a (C.sub.13) alcohol or a water-soluble glycol.
    Type: Grant
    Filed: February 5, 1980
    Date of Patent: August 25, 1981
    Assignee: Sandoz Ltd.
    Inventor: Rene Fricker
  • Patent number: 4285691
    Abstract: The present invention provides a process for dyeing an anionic dyeable substrate with reserve and/or multicolored effects, which process comprises(1) impregnating the substrate with a dyeing liquor containing an anionic dye having a K'-value.gtoreq.5(2) directly thereafter applying locally to the substrate a liquor or paste containing an alkoxylated fatty amine or polyamine having affinity for anionic dyes with a K'value.gtoreq.5 and optionally a disperse dye and/or an anionic dye or an anionic optical brightening agent with the proviso that the anionic dye or optical brightening agent has a K-value at least one unit lower than the K'value of the anionic dye used in step (1), and(3) subsequently submitting the substrate to a heat treatment to effect fixation of the dye(s) and, if used, optical brightening agent.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: August 25, 1981
    Assignee: Sandoz Ltd.
    Inventors: Hermann Egli, Emil Engeler
  • Patent number: 4285996
    Abstract: The present invention relates to a process for producing a non-woven fabric comprising impregnating a non-woven fibrous web with an aqueous binding agent dispersion containing, as coagulation agent, a polyurethane having a weight average molecular weight of from 500 to 20,000 which is the reaction product of(i) a polyoxyalkylated aliphatic amine containing d nitrogen atoms, where d is 1 to 5, and where d is greater than 1, each nitrogen atom is connected with the next by a (C.sub.2-4) alkylene moiety and from d+1 to d+2 polyoxy(C.sub.2-4)alkylene units, with the proviso that the molecule contains C.sub.2 alkyleneoxy units and C.sub.3 and/or C.sub.4 alkyleneoxy units with the C.sub.3 and/or C.sub.4 units forming the majority of alkyleneoxy units, and(ii) from 0.1 mols to 2 mols per mol of (i) but not exceeding the stoichiometric amount of a polyisocyanate,which product is optionally in quaternized form and, is present in an amount of from 0.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: August 25, 1981
    Assignee: Sandoz Ltd.
    Inventor: Hans Gerber
  • Patent number: 4285944
    Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andR.sub.3 represents hydrogen or lower alkyl, andX represents ##STR2## which are useful as sleep inducers.
    Type: Grant
    Filed: April 10, 1980
    Date of Patent: August 25, 1981
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Patent number: 4284554
    Abstract: Compounds of the formula ##STR1## in which D is ##STR2## where R.sub.1 is hydrogen, (C.sub.1-4)alkyl or (C.sub.1-4)alkoxy,m and n are 1 or 2, andp is 0 or 1, with the proviso that n+p is 2 or 3,R.sub.2 is hydrogen or (C.sub.1-4)alkyl,R.sub.3 is (C.sub.1-4)alkyl, andHal is fluorine, chlorine or bromine,and mixtures thereof, which compounds are in free acid or salt form, their production and use as reactive dyestuffs for hydroxy group-containing and amide group-containing organic substrates such as leather and textiles consisting of or comprising natural or synthetic polyamides (e.g., wool, silk and nylon) or natural or regenerated cellulose (e.g., cotton, viscose and spun rayon).
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: August 18, 1981
    Assignee: Sandoz Ltd.
    Inventor: Paul Doswald
  • Patent number: 4284790
    Abstract: 3-Hydroxylbenzyl compounds of formula, ##STR1## in which each of R.sub.1, R.sub.2 and R.sub.3 is a hydrocarbon group, e.g. alkyl, R.sub.4 is hydrogen or alkyl, or forms with R.sub.1 --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --, and Z is either an oxygen- or sulphur-containing group featuring at least one ester or amide moiety, or a disubstituted amino group, Z being bound to the rest of the molecule via the oxygen or sulphur atom, or nitrogen atom, respectively, are useful as antioxidants. Organic materials which are susceptible to the degradative effects of oxygen are treated with one or more of such compounds, e.g. by incorporation into the body of the organic material, in order to be stabilized against such effects.
    Type: Grant
    Filed: January 23, 1979
    Date of Patent: August 18, 1981
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller
  • Patent number: 4282251
    Abstract: Cinnamylalkyl-1-naphthylmethylamines, useful as antimycotic agents, and processes for their production.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: August 4, 1981
    Assignee: Sandoz Ltd.
    Inventor: Daniel Berney
  • Patent number: 4281131
    Abstract: Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof, e.g., 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid, useful as anti-allergic agents, and prepared by hydrolysis of the corresponding carboxylic acid esters.
    Type: Grant
    Filed: July 16, 1979
    Date of Patent: July 28, 1981
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4281115
    Abstract: The present invention relates to disperse dyes containing a group of formula I, ##STR1## in which R.sub.1 signifies the atoms necessary to complete an arylene radical, their production and intermediates therefor.
    Type: Grant
    Filed: July 25, 1979
    Date of Patent: July 28, 1981
    Assignee: Sandoz Ltd.
    Inventor: Werner Baumann
  • Patent number: 4278674
    Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein either R.sub.1 is ethyl or vinyl,n is an integer from 2 to 5,x is sulphur,a group ##STR2## or a group .dbd.N--R.sub.4 .sup.I, wherein eitherY and Z are both sulphur, orone of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.I is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, each of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members containing one nitrogen atom or one nitrogen atom and a further hetero member selected from sulphur, oxygen and a group .dbd.N--R.sub.5.sup.I,wherein R.sub.5.sup.I is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a piperazinyl radical, the second nitrogen atom of which is substituted by a radical R.sub.5.sup.II,whereby R.sub.5.sup.
    Type: Grant
    Filed: November 29, 1979
    Date of Patent: July 14, 1981
    Assignee: Sandoz Ltd.
    Inventors: Helmut Egger, Hellmuth Reinshagen
  • Patent number: 4277481
    Abstract: 6-methyl-8.beta.-(2-pyridylthiomethyl)ergolene is useful in treating senile cerebral insufficiency and bladder incontinence.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: July 7, 1981
    Assignee: Sandoz Ltd.
    Inventor: Jean-Marie Vigouret
  • Patent number: 4273780
    Abstract: The present invention provides anti-9,10-dihydro-4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]-cyclohepta[1 ,2-b]thiophen-10(9H)-one oxime of formula ##STR1## useful for the treatment of allergic conditions.
    Type: Grant
    Filed: January 8, 1980
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventors: Erwin Waldvogel, Jean-Michel Bastian, Gustav Schwarb
  • Patent number: 4273707
    Abstract: Compounds of the formula ##STR1## wherein F is the residue of a monoazo or disazo compound,each X is independently --NR.sub.2 --Q--NR.sub.3 R.sub.4 or --NR.sub.2 --Q--N.sup..sym. R.sub.5 R.sub.6 R.sub.7,whereinQ is linear or branched C.sub.2-6 alkylene,R.sub.2 is hydrogen or C.sub.1-4 alkyl,each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is independently hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkyl substituted by hydroxy or cyano; C.sub.1-3 alkyl substituted by phenyl or substituted phenyl having 1 to 3 substituents selected from chloro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; C.sub.5-6 cycloalkyl or C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyl groups, with the proviso that neither R.sub.5 nor R.sub.6 can be hydrogen, orR.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 taken together and with the nitrogen atom to which they are joined form a 5- or 6-membered ring containing at most one further hetero atom, andR.sub.7 is C.sub.1-4 alkyl or benzyl,each Z.sub.1 is independently --CO--, --SO.sub.
    Type: Grant
    Filed: April 20, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4273784
    Abstract: The present invention concerns prostaglandins having a cyclopropane ring in the 2,3 position.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventor: Pietro Bollinger
  • Patent number: 4273787
    Abstract: The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
    Type: Grant
    Filed: August 9, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4273720
    Abstract: The present invention relates to anionic dyestuffs of the 1-amino-4-aryl- or -4-alkylamino anthraquinone series which are unsubstituted in the 3-position and bear in the 2-position an arylalkyleneoxy group, and in which at least one aryl group bears a sulpho group, with the proviso that when the substituent in the 4-position is alkylamino such alkyl is linear, branched or cyclic and contains at least 9 carbon atoms and the sum of the carbon atoms of the alkylamino group in the 4-position and the alkylene group in the 2-position is at least 12, which dyestuffs are in the free acid or salt form.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventor: Roland Wald