Patents Assigned to SANDOZ
  • Patent number: 4434196
    Abstract: A process for accelerating the drying of a wet hydrophilic substrate, e.g. in a washing process, comprising the steps of(i) applying to the wet substrate by an exhaust process 0.05 to 1.0 per kg dry weight of substrate of a mixture comprising a cationic agent having affinity for the fibres and an emulsified polyethylene wax in an aqueous medium, and(ii) subsequently drying the substrate.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: February 28, 1984
    Assignee: Sandoz Ltd.
    Inventors: Tibor Robinson, Charles Voegtlin
  • Patent number: 4434161
    Abstract: Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding sulfur and silicon-containing carboxylic acid (or active form thereof).
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: February 28, 1984
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4434176
    Abstract: This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is phenyl; phenyl monosubstituted with fluorine; phenyl mono- or disubstituted with chlorine; phenyl mono-, di- or trisubstituted with methyl or methoxy, secondary 1-phenoxyalkyl, the secondary alkyl residue of which is of 3 to 5 carbon atoms and in which the phenyl residue is unsubstituted or monosubstituted with chlorine, andeither R.sub.2 is hydrogen,and R.sub.3 is methyl,or R.sub.2 is methyland R.sub.3 is hydrogen or methyl,which are useful, for example, for treating coronary conditions.
    Type: Grant
    Filed: May 6, 1982
    Date of Patent: February 28, 1984
    Assignee: Sandoz Ltd.
    Inventors: Franz Troxler, Fritz Seemann
  • Patent number: 4434171
    Abstract: Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging agents.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: February 28, 1984
    Assignee: Sandoz Ltd.
    Inventor: Werner M/u/ ller
  • Patent number: 4432989
    Abstract: Fungicides of the formula: ##STR1## wherein R.degree. is alkyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl in which the cycloalkyl is of 3 to 6 carbon atoms and the alkyl portion of 1 to 3 carbon atoms, said cycloalkyl and cycloalkylalkyl being optionally ring substituted by one or two alkyl groups of 1 to 3 carbon atoms, andR is hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms or nitro, andR' is hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, --CF.sub.
    Type: Grant
    Filed: April 27, 1982
    Date of Patent: February 21, 1984
    Assignee: Sandoz, Inc.
    Inventor: Homer K. Spencer
  • Patent number: 4432770
    Abstract: Disclosed is a method of rapid dyeing a substrate comprising polyester fibres at a temperature above 100.degree. C. comprising bringing into contact with the substrate an aqueous dyebath containing a mixture of at least two disperse dyes having each individually specific physicochemical properties.
    Type: Grant
    Filed: November 17, 1982
    Date of Patent: February 21, 1984
    Assignee: Sandoz Ltd.
    Inventors: Rolf Hasler, Beat Henzi, Ernst Schnider, Hermann Ulshoefer
  • Patent number: 4428953
    Abstract: Novel pleuromutilin derivatives of formula I, ##STR1## in which R.sub.1 is ethyl or vinyl,m is 0 or 1, andR.sub.2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated heterocyclic ring containing one or more hetero atoms selected from oxygen, sulphur and nitrogen, is attached to the --S(CH.sub.2).sub.m --group,provided that when m is 0, R.sub.2 is other than pyridyl,their production and use as antimicrobial agents are described.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: January 31, 1984
    Assignee: Sandoz, Ltd.
    Inventors: Heinz Berner, Friederike Turnowsky, Georg Laber, Johannes Hildebrandt
  • Patent number: 4429133
    Abstract: Disclosed are compounds of Formula I, ##STR1## where either R.sub.1, R.sub.2, R.sub.3 and R.sub.4, independently, are hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, cyano, carboxy, alkoxy(C.sub.1-4)carbonyl, --CONR.sub.6 R.sub.7, --SO.sub.2 NR.sub.6 R.sub.7, --SO.sub.2 R.sub.8, alkyl(C.sub.1-4)carbonyloxy, or C.sub.1-4 alkoxy monosubstituted by phenyl, alkoxy(C.sub.1-4)carbonyl, cyano, carboxy or --CONR.sub.6 R.sub.7,with the proviso that a maximum of one of R.sub.1 and R.sub.2 and a maximum of one of R.sub.3 and R.sub.4 can signify a group selected from cyano, carboxy, alkyl (C.sub.1-4)carbonyloxy, --CONR.sub.6 R.sub.7, --SO.sub.2 NR.sub.6 R.sub.7 and --SO.sub.2 R.sub.8,or one or both pairs R.sub.1 and R.sub.2, and R.sub.3 and R.sub.4, are on adjacent carbon atoms and form a fused benzene ring, any pair not forming a ring being as defined above,R.sub.5 is C.sub.1-4 alkyl, unsubstituted or mono-substituted by hydroxy, cyano, phenyl, C.sub.2-4 alkenyl, carboxy, C.sub.1-4 alkoxycarbonyl or --CONR.sub.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: January 31, 1984
    Assignee: Sandoz Ltd.
    Inventor: Peter S. Littlewood
  • Patent number: 4425362
    Abstract: The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.
    Type: Grant
    Filed: November 4, 1981
    Date of Patent: January 10, 1984
    Assignee: Sandoz Ltd.
    Inventors: Richard Berthold, William J. Louis
  • Patent number: 4421752
    Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub.2 and R.sub.3 together with N represent ##STR2## wherein n is 1, 2 or 3, andR.sub.4 and R.sub.5 each independently represent hydrogen or lower alkyl as defined above,or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: December 20, 1983
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4420475
    Abstract: Compounds of the formula I: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each R' and R" is independently a hydrogen atom, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, or halo having an atomic weight of from about 19 to 127; and R is of an aralkyl-, phenyl- tryptophanyl- or benzo-cycloalkyl-type, are obtained by hydrogenating corresponding .alpha.-.beta. ethylenically-unsaturated analogs (II), which in turn are obtained by hydrogenating corresponding .alpha.-.beta. acetylenically-unsaturated analogs. Compounds I and II are useful as anti-atheroslerotic agents.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: December 13, 1983
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Damon, II
  • Patent number: 4419353
    Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, orR.sub.3 and R.sub.4 together with N represent ##STR2## wherein n is 1, 2 or 3, andR.sub.5 and R.sub.6 each independently represent hydrogen or lower alkyl as defined above,or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents, in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: December 6, 1983
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4416816
    Abstract: Disclosed are the 1:2 chromium complex of the formula ##STR1## and the alkali metal salts thereof which are useful for the coloration of oxide layers produced on aluminum and alloys thereof and for dyeing natural and synthetic polyamides.
    Type: Grant
    Filed: November 29, 1978
    Date of Patent: November 22, 1983
    Assignee: Sandoz Ltd.
    Inventor: Hans Grossmann
  • Patent number: 4416876
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;each of R.sup.2 and R.sup.3 is, independently, a hydrogen atom or lower alkyl having from 1 to 3 carbon atoms;n is 0 or 1; andM is a hydrogen atom, an equivalent of a cation which forms a non-toxic, pharmaceutically acceptable salt, or a non-toxic pharmaceutically acceptable monovalent radical which is hydrolyzable or saponifiable to an alkali metal cation, eg sodium 4-(4,4-dimethyl-4-sila-tetradecylamino)-benzoate, are useful as pharmaceutical agents.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: November 22, 1983
    Assignee: Sandoz, Inc.
    Inventors: Sandor Barcza, Faizulla G. Kathawala
  • Patent number: 4417014
    Abstract: The present invention provides dyestuffs of formula I, ##STR1## in which R.sub.1 is a mono- or bicyclic aromatic radical, and the ring A may bear up to 4 substituents conventional for dyestuffs, in which the dyestuff is free from sulphonic and carboxylic acid groups, and mixtures of such dyestuffs and their use as disperse dyestuffs.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: November 22, 1983
    Assignee: Sandoz Ltd.
    Inventor: Paul Buecheler
  • Patent number: 4416894
    Abstract: 5-phenyl-5-hydroxy-2,3-dihydro-5H-imidazo [2,1-.alpha.]-isoindole derivatives for the treatment of urinary frequency, urgency and incontinence.
    Type: Grant
    Filed: January 25, 1982
    Date of Patent: November 22, 1983
    Assignee: Sandoz Ltd.
    Inventor: Christopher R. J. Woodhouse
  • Patent number: 4417013
    Abstract: A solid pigment composition comprises an intimate mixture of a pigment and a copolymer of an alkyl or cycloalkyl methacrylate ester and a lesser amount of an aminoalkyl methacrylate ester. The compositions are compatible with a wide range of substrates such as paints, printing inks and bulk polymers.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: November 22, 1983
    Assignee: Sandoz Ltd.
    Inventor: Johann Schuster
  • Patent number: 4415568
    Abstract: This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, andR.sub.3 and R.sub.4 together with N represent ##STR3## or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: November 15, 1983
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4415560
    Abstract: Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4"-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding silicon-containing carboxylic acid (or active form thereof).
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: November 15, 1983
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4415687
    Abstract: 1,3-dihydroxy-4,6-bis-4'-(2',2',6',6',-tetramethylpiperidyl) benzene, its 1'-alkyl or 1'-(substituted alkyl) derivatives and monomeric or polymeric products derived from these compounds by substitution of 1- and 3-hydroxy groups and/or by the linking of hydroxy groups on adjacent units through a bridging groups, are useful as light and heat stabilizers for polymeric organic materials.Corresponding bis(3',4'-dehydro) unsaturated compounds are useful as intermediates.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: November 15, 1983
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Evelyne Kalt, Hellmuth Reinshagen