Patents Assigned to SANDOZ
  • Patent number: 4340385
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.3 is hydrogen or C.sub.1-4 alkyl, andM is hydrogen or a monovalent non-chromophoric cation,and mixtures of such compounds, stable, concentrated, aqueous compositions consisting essentially of, by weight,5-20% Compound of said formula in salt form or a mixture thereof2-25% 2-(2-Methoxyethoxy)ethanol0-8% Propylene glycolBalance Water,and the use of such compounds, mixtures and stable, concentrated, aqueous compositions for dyeing and printing anionically dyeable substrates such as natural and synthetic polyamides, especially nylon carpet.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: July 20, 1982
    Assignee: Sandoz, Inc.
    Inventors: Silvio A. Rodriguez, Sigmund C. Catino, deceased
  • Patent number: 4338244
    Abstract: The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran(2)one compound or indolin(2)one compound containing at least two benzofuran(2)one or indolin(2)one nuclei.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: July 6, 1982
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider
  • Patent number: 4338092
    Abstract: Compounds of the formula ##STR1## in which each of R.sub.1 and R.sub.3, independently, is hydrogen, methyl, methoxy or --NHCOR.sub.6,each of R.sub.2 and R.sub.4, independently, is hydrogen, methyl or methoxy, with the proviso that at least one of R.sub.1 to R.sub.4 is hydrogen,R.sub.5 is hydrogen, 2-, 3- or 4-hydroxy-C.sub.2-4 alkyl, carboxy-C.sub.1-4 alkyl, sulpho-C.sub.1-4 alkyl, sulphophenyl or carboxyphenyl andR.sub.6 is methyl or NH.sub.2, salts thereof,and mixtures of such compounds which compounds and mixtures are useful as reactive dyes for nitrogen-containing and hydroxy group-containing organic substrates such as leather and textile materials comprising or consisting of natural or synthetic polyamides such as wool, silk and nylon and natural or regenerated cellulose such as cotton, viscose and spun rayon.
    Type: Grant
    Filed: December 17, 1980
    Date of Patent: July 6, 1982
    Assignee: Sandoz Ltd.
    Inventor: Lukas Schneider
  • Patent number: 4337198
    Abstract: either(i) X is --CH.sub.2 -- and n is 0, 1, 2 or 3 or(ii) X is --CO-- and n is 1, 2 or 3 or(iii) X is --O-- and n is 2 or 3,R.sub.2 is hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms,R.sub.3 is hydrogen, halogen, trifluoromethyl, or alkyl or alkoxy of 1 to 4 carbon atoms,R.sub.4 is hydrogen, or alkyl or alkoxy of 1 to 4 carbon atoms,andR.sub.5 is hydrogen, alkyl of 1 to 4 carbon atoms or alkenyl of 3 or 4 carbon atoms, with the proviso that, when R.sub.2 is hydrogen, R.sub.5 is hydrogen,are useful for inducing sleep and treating psychoses and depressions.
    Type: Grant
    Filed: April 24, 1980
    Date of Patent: June 29, 1982
    Assignee: Sandoz Ltd.
    Inventors: Dieter Sorg, Albert Leutwiler
  • Patent number: 4336378
    Abstract: This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents lower alkyl or ##STR2## where R.sub.5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, andR.sub.3 and R.sub.4 together with N represent ##STR3## or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: June 22, 1982
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4336391
    Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 and R.sub.3 each independently represent lower alkyl as defined above, orR.sub.2 and R.sub.3 together with N represent ##STR2## wherein n is 1, 2 or 3, andR.sub.4 and R.sub.5 each independently represent hydrogen or lower alkyl as defined above,or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.
    Type: Grant
    Filed: April 6, 1981
    Date of Patent: June 22, 1982
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4336379
    Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, orR.sub.3 and R.sub.4 together with N represent ##STR2## wherein n is 1, 2 or 3, andR.sub.5 and R.sub.6 each independently represent hydrogen or lower alkyl as defined above,or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents, in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.
    Type: Grant
    Filed: March 18, 1981
    Date of Patent: June 22, 1982
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4335259
    Abstract: The present invention relates to quaternized polyamines having the basic structure of formula I, ##STR1## in which each R independently, is (C.sub.10-22)alkyl, (C.sub.10-22)alkenyl, phenyl(C.sub.1-3)alkyl or naphthyl(C.sub.1-3)alkyl,each R.sub.1, independently, is phenyl(C.sub.1-3)alkyl or naphthyl(C.sub.1-3)alkyl,z, is 1 to 5,each y.sub.1, independently is an integer from 2 to 8,y.sub.2, is an integer from 2 to 8, with the proviso that when z=1, y.sub.1 .noteq.y.sub.2 and when z>1 and the y.sub.1 's are the same y.sub.2 .noteq.y.sub.1and wherein an average of 0.5 to 2.0 nitrogen atoms are quaternized with alkyl radicals containing from 1 to 6 carbon atoms and mixtures of such quaternized polyamimes with further quaternized polyamines, such polyamines and mixtures being useful as dye retarders/levelling agents.
    Type: Grant
    Filed: January 5, 1981
    Date of Patent: June 15, 1982
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Patent number: 4335124
    Abstract: The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: June 15, 1982
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4333945
    Abstract: This invention provides a new tranquillizing use of thiazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: June 8, 1982
    Assignee: Sandoz Ltd.
    Inventor: Erwin Ringwald
  • Patent number: 4331667
    Abstract: Disclosed is a method of controlling ectoparasites of the order Acari in animal livestock which comprises applying to the animal an effective amount of a 4-alkylaminoquinazoline, e.g. 4(n-C.sub.9 H.sub.19 NH)quinazoline or 4-(n-C.sub.10 H.sub.21 NH)quinazoline.
    Type: Grant
    Filed: February 4, 1981
    Date of Patent: May 25, 1982
    Assignee: Sandoz Ltd.
    Inventor: Rupert Schneider
  • Patent number: 4330555
    Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl(C.sub.1-10), andR.sub.2 is alkyl(C.sub.1-10),and physiologically acceptable and hydrolysable esters thereof, useful as anti-allergic agents.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: May 18, 1982
    Assignee: Sandoz Ltd.
    Inventor: Trevor G. Payne
  • Patent number: 4330294
    Abstract: The present invention relates to compounds of formula ##STR1## in which R.sub.1 is an aliphatic or alicyclic hydrocarbon radical,R.sub.2 is hydrogen, halogen or C.sub.1-8 alkyl,M is hydrogen or an equivalent of a non-chromophoric cationand mixtures of such compounds with the corresponding ethers, which mixtures are useful as anionic dyestuffs.
    Type: Grant
    Filed: September 26, 1980
    Date of Patent: May 18, 1982
    Assignee: Sandoz Ltd.
    Inventor: Roland Wald
  • Patent number: 4330293
    Abstract: The present invention relates to a process for dyeing or printing a flat form textile substrate which comprises applying onto the substrate an aqueous dyeing or printing liquor having a viscosity below 500 cps and comprising a synthetic thickener precursor which contains carboxylic acid groups in free acid form, the substrate having been pretreated by depositing thereon a solution of a basic compound, the dyeing or printing liquor being converted on contact with the pretreated substrate into a gel having a viscosity from 3,000 to 60,000 cps.
    Type: Grant
    Filed: July 9, 1980
    Date of Patent: May 18, 1982
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Lindemann
  • Patent number: 4329349
    Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, whereinR.sub.1 is C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halo, trifluoromethyl, C.sub.1-4 alkylthio or --NR.sub.5 R.sub.6, wherein each of R.sub.5 and R.sub.6 is independently hydrogen or C.sub.1-3 alkyl,R.sub.3 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, halo or trifluoromethyl, andR.sub.4 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or halo,their use as muscle relaxants and as anti-inflammatory agents, pharmaceutical compositions comprising them, processes for their synthesis and compounds of the formulae ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, useful as intermediates in their synthesis.
    Type: Grant
    Filed: July 24, 1980
    Date of Patent: May 11, 1982
    Assignee: Sandoz, Inc.
    Inventors: Robert E. Damon, II, Jeffrey Nadelson
  • Patent number: 4329354
    Abstract: This invention provides a new antidepressive use of thiazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: May 23, 1980
    Date of Patent: May 11, 1982
    Assignee: Sandoz Ltd.
    Inventor: Erwin Ringwald
  • Patent number: 4329390
    Abstract: Aqueous dispersions of an oxidized microcrystalline wax, optionally together with one or more non-oxidized paraffins, in which a cationic surfactant is used as dispersing agent may be applied to textile substrates by impregnation or exhaust processes. The treated textile substrates, particularly knitted goods, have improved sewability and are less liable to damage by high-speed sewing machines.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: May 11, 1982
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Patent number: 4326879
    Abstract: Herbicides are of the formula ##STR1## wherein W is fluoro, bromo, chloro or CF.sub.3,each of X and X.degree. is independently H, fluoro, chloro, bromo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 or nitro,Z and Z.sub.1 are independently oxygen or sulfur, with the proviso that at least one is oxygen,each of Y and Y.degree. is independently H, fluoro, chloro, bromo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 or nitro,R.sub.1 and R.sub.4 are independently H, C.sub.1 -C.sub.4 alkyl and --COOR.sub.5 wherein R.sub.5 is H or C.sub.1 -C.sub.4 alkyl,R.sub.2 and R.sub.3 are independently H, C.sub.1 -C.sub.5 alkyl, fluoro, chloro, bromo or hydroxy, andR and R.degree. are independently H or C.sub.1 -C.sub.3 alkyl or both together form a covalent bond or an epoxy bridge (--O--),with the further proviso that no two adjacent ring members in either Rings A or B are from the group of t-butyl, t-butoxy and CF.sub.3.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: April 27, 1982
    Assignee: Sandoz, Inc.
    Inventors: Homer K. Spencer, Melvin M. Graben
  • Patent number: 4325862
    Abstract: A solid pigment composition comprises an intimate mixture of a pigment and a copolymer of an alkyl or cycloalkyl methacrylate ester and a lesser amount of an aminoalkyl methacrylate ester. The compositions are compatible with a wide range of substrates such as paints, printing inks and bulk polymers.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: April 20, 1982
    Assignee: Sandoz Ltd.
    Inventor: Johann Schuster
  • Patent number: 4325863
    Abstract: The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran (2) one or indolin (2) one compound as stabilizer. Such stabilized polymeric materials are stabilized against degradation during the polymer processing.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: April 20, 1982
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider