Patents Assigned to SANDOZ
  • Patent number: 4273930
    Abstract: Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.
    Type: Grant
    Filed: August 9, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4272244
    Abstract: A process for dyeing without shrinkage with a disperse dyestuff or an optical brightening agent a fibrous substrate whose fibres comprise a mixture of polyvinyl chloride and acetalized polyvinyl alcohol, in which the substrate is dyed at a temperature from 60.degree. to 90.degree. C. in the presence of a levelling carrier, this levelling carrier being removable when the dried substrate is subsequently submitted to a dry heat treatment for a period up to 120 seconds and at a temperature from 95.degree. to 135.degree. C.
    Type: Grant
    Filed: March 6, 1979
    Date of Patent: June 9, 1981
    Assignee: Sandoz Ltd.
    Inventor: Bernhard Schlick
  • Patent number: 4272533
    Abstract: 2-aminoethyl-1-phenylindolines are useful as anti-diabetic and anti-obesity agents.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: June 9, 1981
    Assignee: Sandoz Ltd.
    Inventors: Fulvio Gadient, Rudolf Suess
  • Patent number: 4267321
    Abstract: Novel Cephalosporin C derivatives, their production and their use in isolating Cephalosporin C from culture filtrates for subsequent conversion to 7-aminocephalosporanic acid.
    Type: Grant
    Filed: January 22, 1980
    Date of Patent: May 12, 1981
    Assignee: Sandoz Ltd.
    Inventor: Gerd Ascher
  • Patent number: 4267115
    Abstract: Water-soluble anthraquinone dyes which bear one or two 3,5,5-trimethylcyclohexylamino groups in the 1- and/or 4-positions and one or two -SO.sub.3 H groups bound either directly to a carbon atom of an aromatic ring or indirectly over an oxygen atom to a carbon atom of an aliphatic chain.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: May 12, 1981
    Assignee: Sandoz Ltd.
    Inventors: Wolfgang Frey, Wolfgang Schoenauer
  • Patent number: 4264602
    Abstract: Anti-allergic 4-hydroxy-3-nitro-pyrido[2,3-b]pyridines-2(1H)-ones are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitro acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: July 21, 1976
    Date of Patent: April 28, 1981
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4264324
    Abstract: A process for dyeing or printing with a fibre-reactive dyestuff a substrate consisting of or comprising cellulosic fibres, which process comprises treating the dyed or printed substrate, at a temperature from 20.degree. to 105.degree. C. with an aqueous solution of a polymer containing carboxylic acid groups at least partially neutralized in salt form.
    Type: Grant
    Filed: July 3, 1979
    Date of Patent: April 28, 1981
    Assignee: Sandoz Ltd.
    Inventors: Jean-Pierre Chavannes, Rene Fischer, Saverio Fornelli, Francis Palacin
  • Patent number: 4264323
    Abstract: Disclosed are stable, concentrated, aqueous dyestuff preparations comprising water, an anionic dispersing agent and at least one cold-dyeing water soluble fibre reactive dye, said dye having an average particle diameter of less that 20 .mu., other optional constituents being one or more disperse dyes, acid, such as acetic acid, to adjust the pH of the preparation to a preferred value of 4 to 6, and organic solvents. The preparations are useful for the convenient production of dyebaths for dyeing substrates containing a fibre reactive dyeable component.
    Type: Grant
    Filed: September 12, 1979
    Date of Patent: April 28, 1981
    Assignee: Sandoz Ltd.
    Inventors: Miro Capponi, Urs Ruf, Franz Somm
  • Patent number: 4263298
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is amino, or ##STR2## wherein each of R.sub.3 and R.sub.4 is independently alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms or phenyl,R.sub.8 is hydrogen or alkyl of 1 to 4 carbon atoms, andA is --(CH.sub.2).sub.n --,wherein n is an integer from 1 to 3, with the proviso that when R.sub.1 is amino, R.sub.2 is methyl or phenyl and R.sub.8 is hydrogen,n is 2 or 3,or .dbd.N--CO--R.sub.5,wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, a --(CH.sub.2).sub.m --R.sub.6 group,whereinm is an integer from 0 to 2, andR.sub.6 is phenyl, or phenyl monosubstituted by fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or alkylmercapto of 1 to 4 carbon atoms,or an --OR.sub.7 group,wherein R.sub.
    Type: Grant
    Filed: July 3, 1979
    Date of Patent: April 21, 1981
    Assignee: Sandoz Ltd.
    Inventor: Erhard Schenker
  • Patent number: 4261888
    Abstract: The invention provides polypeptides of formula I,A-B-Gly-D-E Iwherein A is Tyr or substituted Tyr,B is -Gly- or -(D)Ala-,D is, for example, Phe or MePhe andE is, for example, -Met-X, -Leu-X, -Nle-X, -Nva-X, -Ile-X, methioninesulhoxide-X, methioninesulphone-X wherein X is --NR'R" or --OR'" and each of R', R" and R'" independently signifies hydrogen or alkyl of 1 to 5 carbon atoms,which compounds possess pharmacological activity, for example, analgesic activity.
    Type: Grant
    Filed: November 27, 1979
    Date of Patent: April 14, 1981
    Assignee: Sandoz Ltd.
    Inventors: Wilfried Bauer, Francois Cardinaux, Rene Huguenin, Janos Pless, Edmond Sandrin
  • Patent number: 4261895
    Abstract: The compounds of formula I ##STR1## wherein R is(a) hydrogen,(b) cycloalkyl of 3 to 7 carbon atoms,(c) alkyl of 2 to 5 carbon atoms monosubstituted by hydroxy, with the proviso that the hydroxyl radical is separated by at least 2 carbon atoms from the carbonylthio moiety to which R is bound,(d) phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted in the phenyl ring by alkyl of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35, or phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted or independently trisubstituted in the phenyl ring by alkoxy of 1 to 4 carbon atoms, or(e) furyl, benzo[b]furyl, thienyl, benzo[b]thienyl, pyridyl, quinolyl, isoquinolyl, 2- or 3-pyrrolyl or indolyl other than 1-indolyl,R.sub.1 and R.sub.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: April 14, 1981
    Assignee: Sandoz Ltd.
    Inventor: Erik Wiskott
  • Patent number: 4261894
    Abstract: An improved process for the preparation of optionally substituted 2,3-indolinediones which are useful as intermediates in the preparation of compounds having pharmacological activity which comprises reacting a 3,1-benzoxazine with an alkali or alkaline earth metal cyanide or a tetra-(C.sub.1-4) alkylammonium cyanide to obtain a 2-imino-3-indolinone, which is then subjected to hydrolysis.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: April 14, 1981
    Assignee: Sandoz, Inc.
    Inventor: Gary M. Coppola
  • Patent number: 4260389
    Abstract: A finishing process for porous fibrous materials, especially for textiles, especially a dyeing process, in the presence of relatively small amounts of water and a foaming agent, is carried out at a liquor to material ratio of about 0.25:1 to 5:1. This water-saving finishing process leads to equal and level finishings especially important in the dyeing area.
    Type: Grant
    Filed: September 30, 1974
    Date of Patent: April 7, 1981
    Assignee: Sandoz Ltd.
    Inventor: Gordon H. Lister
  • Patent number: 4259523
    Abstract: This invention provides new mono-deuterated prostaglandins having prolonged uterotonic activity.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: March 31, 1981
    Assignee: Sandoz Ltd.
    Inventors: Pietro Bollingen, Manfred Krieger
  • Patent number: 4256635
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, cyano, --COR.sub.4 or --CONR.sub.5 R.sub.6,whereinR.sub.4 is C.sub.1-4 alkyl or phenyl,R.sub.5 is hydrogen, C.sub.1-4 alkyl or phenyl, andR.sub.6 is hydrogen or primary or secondary C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl, phenyl, benzyl or phenylethyl,R.sub.3 is a straight or branched C.sub.2-8 alkylene or alkenylene bridge, optionally interrupted by one oxygen atom,R is a radical ##STR2## wherein each R.sub.13, independently, is hydrogen or halogen, and either Q has a first significance selected from the groups of the formulae ##STR3## wherein R.sub.7 and R.sub.8, independently, are C.sub.1-8 alkyl,R.sub.9 is C.sub.1-4 alkyl, unsubstituted or mono-substituted by halogen, C.sub.1-4 alkoxy, C.sub.1-4 alkylcarbonyl or benzoyl,R.sub.10 is hydrogen or C.sub.1-4 alkyl, and A.sup..crclbar. is an anion,or Q has a second significance selected from the groups of the formulae ##STR4## wherein R.sub.7, R.sub.8, R.sub.10 and A.sup..crclbar.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: March 17, 1981
    Assignee: Sandoz Ltd.
    Inventor: Manfred Greve
  • Patent number: 4255153
    Abstract: Textile materials containing at least 50% by weight triacetate fibers are dyed with disperse dyes in an aqueous dyebath containing an emulsifier and, as carrier, an aliphatic dicarboxylic acid diester having 6 to 24 carbon atoms, such as dibutyl maleate.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: March 10, 1981
    Assignee: Sandoz, Inc.
    Inventors: Eric Altherr, Ronald L. Hafer, Richard L. Pepin
  • Patent number: 4252604
    Abstract: Bis-(triazinylamino)-stilbenesulphonic acids ##STR1## wherein X is optionally substituted NH.sub.2 ##STR2## Y is a radical of formula Z is --COOR.sub.4, --CO--C.sub.m H.sub.2m+1, --CN or ##STR3## R.sub.1 is H, halogen, alkyl or alkoxy, R.sub.2 is H or alkyl,R.sub.3 is H, optionally substituted alkyl, cycloalkyl or phenyl or ##STR4## R.sub.4 is optionally substituted alkyl, R.sub.3 and R.sub.6 are H, alkyl, hydroxyalkyl or form together with N a heterocyclem is a whole number from 1 to 5 andn is 1 or 2,are optical brighteners suitable for cellulosic fibres, polyamide and polyurethane fibres and paper.
    Type: Grant
    Filed: August 30, 1977
    Date of Patent: February 24, 1981
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans R. Schmid
  • Patent number: 4252817
    Abstract: This invention provides new compounds of the formula, ##STR1## wherein R.sub.1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or phenyl,R.sub.2 is hydrogen or lower alkyl, andR.sub.3 is halogen, nitro, lower alkyl, methylthio, hydroxy, lower alkoxy, acyloxy or acylamino, with the proviso that when R.sub.3 is in the 5 position, and R.sub.1 and R.sub.3 are identical and signify a straight alkyl chain of 1 to 5 carbon atoms, R.sub.2 is lower alkyl,useful as anti-phlogistics.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: February 24, 1981
    Assignee: Sandoz Ltd.
    Inventors: Annemarie Closse, Walter Haefliger, Daniel Hauser
  • Patent number: 4251952
    Abstract: Plant seeds designed for germination without substantial delay are coated with a first layer of a mixture of sugar and a water insoluble polymeric material, and have a particulate coating adhered to the first layer while the first layer is still tacky, the first layer being preferably formed from an aqueous coating composition which is cured by simple removal of water therefrom.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: February 24, 1981
    Assignee: Sandoz Ltd.
    Inventors: Frederic E. Porter, James M. Scott
  • Patent number: 4251440
    Abstract: Monoazo dyes of the formula ##STR1## is optionally substituted thiazolyl, benzothiazolyl, 1,2,4-triazolyl, indazolyl, imidazolyl or pyridyl or naphtho-[2,1-d]-thiazolyl,R.sub.1 is optionally substituted alkyl, phenylalkyl, cycloalkyl or alkenyl,each of R.sub.2 and R.sub.3 is independently optionally substituted alkyl,R.sub.4 is hydrogen or optionally substituted alkyl, phenylalkyl, cycloalkyl or phenyl,R.sub.5 is hydrogen or optionally substituted alkyl, orR.sub.4 and R.sub.5 taken together and with the nitrogen atom to which they are joined are optionally substituted saturated heterocyclyl,R.sub.6 is hydrogen or methyl, andA.sup..crclbar. is an anion,with the proviso that the molecule is free of sulfo groups,are useful for the dyeing and printing of basic dyeable substrates, e.g., materials comprising or consisting of homo- or mixed-polymers of acrylonitrile or asymmetrical dicyanoethylene or synthetic polyamides or polyesters modified to contain acid groups, leather and paper.
    Type: Grant
    Filed: April 29, 1975
    Date of Patent: February 17, 1981
    Assignee: Sandoz Ltd.
    Inventor: Viktor Kaeppeli