Patents Assigned to SANDOZ
  • Alkyl-substituted-tricyclic quinazolinones as bronchodilators
    Patent number: 3982000
    Abstract: The compounds are alkyl-substituted-tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones and pyrimido[2,1-b]quinazolin-6-one, e.g., 2-methyl-2,3-dihydro-10-(4'-fluorobenzyl)-imidazo[2,1-b]quinazolin-5(1OH)- one, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with an alkyl substituted cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole or a 2-organomercapto-3,4,5,6-tetrahydropyrimidine and the cyclization of a 2-(.omega.-hydroxy(branched) alkylamino)-4-quinazolone.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: September 21, 1976
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 2-(N-thiocarbamoyl-n-substituted-amino)-3,4-methylenedioxy benzhydrols
    Patent number: 3981890
    Abstract: 1,4 disubstituted-methylenedioxy-quinazoline-2(1H)-thiones are provided which are useful as pharmaceutical agents, e.g. anti-inflammatory agents. The title compounds are intermediates in their preparation.
    Type: Grant
    Filed: January 20, 1975
    Date of Patent: September 21, 1976
    Assignee: Sandoz, Inc.
    Inventors: George A. Cooke, William J. Houlihan
  • Basic azo dyes having a quaternized s-triazolo-[2,3-a]-pyrimidine diazo component radical
    Patent number: 3980632
    Abstract: Basic azo dyes free from sulphonic acid groups of the formula ##EQU1## in which R signifies an alkyl or alkenyl radical, R.sub.1 and R.sub.3 independently signify hydrogen, hydroxyl, halogen, an alkyl, aryl, cycloalkyl, alkoxy, aryloxy, amino or alkylthio radical,R.sub.2 signifies hydrogen, an alkyl, aryl or cycloalkyl radical,R.sub.4 signifies the radical of a coupling component of the aliphatic, benzene, naphthalene or heterocyclic series, andA.sup.- signifies an organic or inorganic anion,Which compounds are useful for dyeing synthetic materials, leather and paper and for pigmenting plastics.
    Type: Grant
    Filed: May 16, 1974
    Date of Patent: September 14, 1976
    Assignee: Sandoz Ltd.
    Inventor: Beat Henzi
  • Amino-containing polymers
    Patent number: 3980682
    Abstract: The invention relates to synthetic polymers obtainable by condensingA. a carboxyl-group-bearing polymer having a molecular weight of between 300 and 10,000,B. a primary aliphatic amine containing 1 to 6, preferably 1 to 3, particularly 1, hydroxyl group,C. an epihalohydrin, andD. an alkyl(C.sub.11 -C.sub.22) or alkenyl(C.sub.11 -C.sub.22) group-containing mono or poly amine, unsubstituted or substituted on the alkyl or alkenyl chain by hydroxyl and/or substituted on the amino function(s) by alkyl(C.sub.1 -C.sub.3), unsubstituted or substituted by hydroxyl and/or a group(--CH(Ro)--CH.sub.2 --O).sub.r --Hor (--CH.sub.2 --CH(Ro)--O)--O).sub.r Hwherein Ro is hydrogen, methyl or ethyl, and r is an integer 2 to 30, that are water dispersible and in disperse form are useful as wash softeners for synthetic fibers especially polyamide fibers.
    Type: Grant
    Filed: April 1, 1974
    Date of Patent: September 14, 1976
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Richard Hochreuter
  • Dyeing process
    Patent number: 3980428
    Abstract: The present invention relates to a process for dyeing or printing organic substrates in the presence of lactone, the amount of which is sufficient to adjust the pH value of the dyeing or printing medium from a neutral or basic value to a value from 4.0 to 6.5.
    Type: Grant
    Filed: October 31, 1973
    Date of Patent: September 14, 1976
    Assignee: Sandoz Ltd.
    Inventors: Sergio Fabbri, Josef Frauenknecht
  • Sulphonated coumarin derivatives
    Patent number: 3979389
    Abstract: The present invention provides compounds of formula I, ##SPC1##in which,Either R.sub.1 signifies an unsubstituted or substituted (C.sub.1.sub.-4) alkyl radical,R.sub.2 signifies a hydrogen atom or an unsubstituted or substituted (C.sub.1.sub.-4) alkyl radical,Or, R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, form a pyrrolidine, piperidine or morpholine ring,R signifies a group of formula (a) or (b), ##SPC2##In whichR.sub.3 signifies a condensed further unsubstituted or substituted pyrimidine, pyridine or benzene ring or a condensed further unsubstituted naphthalene ring, andM signifies a hydrogen ion or a cation equivalent, which compounds are useful as anionic dyes.
    Type: Grant
    Filed: October 15, 1974
    Date of Patent: September 7, 1976
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Para-amino-.beta.-cyano-bis-styryl compounds
    Patent number: 3979429
    Abstract: The present invention relates to para-substituted-amino-.beta.,.beta.-dicyano- or .beta.-cyano-,.beta.-acyl-distyryl disperse dyes in which the benzene nuclei of the two styryl radicals are connected by a bridge member.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: September 7, 1976
    Assignee: Sandoz Ltd.
    Inventor: Ulrich Zirngibl
  • Cyclic substituted tricyclic quinazolinones
    Patent number: 3978059
    Abstract: The compounds are biologically active tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones, pyrimido[2,1-b]quinazolin-6-ones and diazepino[2,1-b]quinazolin-7-ones substituted by a thienyl or furyl group, e.g., 10-(2-thienylmethyl)-2,3-dihydro-imidazo[2,1-b] quinazolin-5(10)-one, and useful, for example, as broncho-dilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with a cyclic pseudothiourea such as 2-organomercapto-4,5-dihydroimidazole or 2-organomercapto-3,4,5,6-tetrahydropyrimidine.
    Type: Grant
    Filed: November 6, 1972
    Date of Patent: August 31, 1976
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 17.beta.-SUBSTITUTED-ALLENE-BEARING STEROIDS
    Patent number: 3978048
    Abstract: Steroidal compounds of the invention bear a 17.beta.-oxygenated group and a 17.alpha.-.PSI.-alkyl substituted allene group, e.g., 17.alpha.-(penta-1'-2'-dienyl)-estra-4,9-dien-17.beta.-ol-3-one, and are prepared by a procedure, e.g., involving reacting a corresponding intermediate bearing a 17.alpha.-(3'-dialkylamino-3'-alkyl-substituted-1'-propynyl)-group with a complex hydride. The steroidal compounds are useful as pharmaceuticals, e.g., as progestational agents.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: August 31, 1976
    Assignee: Sandoz, Inc.
    Inventor: Imre Bacso
  • Acyl benzyl ethers
    Patent number: 3978132
    Abstract: Acyl substituted or unsubstituted benzyl ethers, e.g., p-(phenoxymethyl)pivalophenone, are prepared by reacting a corresponding .alpha.-bromo-p-pivaloyl toluene with a corresponding phenol and are useful as hypolipidemic agents.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: August 31, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Substituted amino-hydrazinopyridazines
    Patent number: 3978057
    Abstract: Amino and substituted amino-hydrazinopyridazines, e.g., 4-methyl-amino-3-hydrazinopyridazine and 4-ethylamino-6-chloro-3-hydrazinopyridazine, are prepared from 3,4,6-trihalopyridazines and are active as hypotensive/antihypertensive agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: August 31, 1976
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, William J. Houlihan, Robert E. Manning
  • Acridone compounds
    Patent number: 3978062
    Abstract: Disclosed are anthraquinonylamino-nitroacridones, their production and their use as pigments, particularly their use in pigmenting paper, plastics and as pigments in surface coating media.
    Type: Grant
    Filed: January 9, 1974
    Date of Patent: August 31, 1976
    Assignee: Sandoz Ltd.
    Inventors: Rodolf Altiparmakian, Hans Bohler
  • 2-Amino-4,5-methylenedioxyphenyl nitriles
    Patent number: 3978086
    Abstract: 2-Amino-4,5-methylenedioxyphenyl nitriles are useful as intermediates for 2-amino-4,5-methylenedioxybenzophenonimines when reacted with a phenyl lithium or phenyl magnesium halide.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: August 31, 1976
    Assignee: Sandoz, Inc.
    Inventors: George A. Cooke, William J. Houlihan
  • Ether and thioether substituted 3,4-alkylenedioxybenzenes
    Patent number: 3978097
    Abstract: The present invention concerns novel aromatic long chain alkenyl ethers and thioethers of the formula: ##EQU1## wherein R.sub.1 is a hydrocarbon group,R.sub.2, r.sub.3 and R.sub.4 are each H or alkyl,R.sub.6 is an aromatic radical,Z is a divalent hydrocarbon group,Y is o or s, andw and n are zero or integers.The compounds are useful insecticides and acaricides.
    Type: Grant
    Filed: August 6, 1973
    Date of Patent: August 31, 1976
    Assignee: Sandoz Ltd.
    Inventors: Fritz Schaub, Hans-Peter Schelling
  • Ether of thioether substituted benzaldehydes
    Patent number: 3978134
    Abstract: The present invention concerns novel compounds of the formula: ##EQU1## wherein R.sub.1 to R.sub.9 have various significances including e.g. alkyl, X and Y include O and S and s, v, w and z are O or whole numbers and Ar.sub.1 is a formyl phenyl radical.The compounds possess insecticidal properties.
    Type: Grant
    Filed: May 21, 1974
    Date of Patent: August 31, 1976
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Schelling, Fritz Schaub
  • Organic compounds
    Patent number: 3976427
    Abstract: The present invention provides a method of dyeing with aqueous dispersed dyes which comprises using as dye carrier a composition comprising 30 to 60 parts by weight of diphenyl, 5 to 35 parts by weight of a phenyl toluene and 5 to 25 parts by weight of fluorene, provided the total of said parts by weight does not exceed 100.The invention also provides a dye carrier composition as specified above and comprising also an emulsifier.The invention is particularly useful in the dyeing of polyester fibers.
    Type: Grant
    Filed: November 30, 1973
    Date of Patent: August 24, 1976
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Substituted 7,12-methano dibenzazocines and 8,13-methano dibenzazonines
    Patent number: 3976634
    Abstract: Substituted 7,12-methano-dibenzazocines and 8,13-methanodibenzazonines, e.g., 7,12-dihydro-6,13-dimethyl-7,12-methano-6H-dibenz [c,f] azocine, are prepared by cyclizing 3-benzylamino or 3-phenethylamino -2-alkyl-indan-1-ols and are useful as anti-inflammatory agents.
    Type: Grant
    Filed: March 25, 1974
    Date of Patent: August 24, 1976
    Assignee: Sandoz, Inc.
    Inventors: Jeffrey Nadelson, William J. Houlihan
  • Pyrazole derivatives
    Patent number: 3976658
    Abstract: New ultraviolet light-absorbing compounds of the formula ##SPC1##In whichR.sub.1 is a substituent, e.g. alkyl,R.sub.2 is a substituent, e.g. alkyl,R.sub.3 is hydrogen or a substituents, e.g. alkyl,n is 1, 2 or 3, andR is an n-valent, optionally substituted benzene radical, or a 1- or 2-valent naphthalene or heterocyclic radical,Which are producible by known processes.Such compounds are useful as stabilizers of organic materials, particularly plastics materials, against the degrading action of ultraviolet light and can be either applied as a coating on the organic material, or incorporated therein.
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: August 24, 1976
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer, Martin Preiswerk
  • 1-Succinoyl-2,4-disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-ph enanthrenes and compositions and methods for treating lipodemia
    Patent number: 3976684
    Abstract: 1-succinoyl-2,4-disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthre nes, e.g., 1-succinoyl-2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are prepared by treating a corresponding 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene with a Friedel Crafts catalyst in the presence of an organic solvent, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: April 4, 1975
    Date of Patent: August 24, 1976
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Pyrazol(5)/pyrazolone(5)metal complexes as stabilizers for organic materials
    Patent number: 3975382
    Abstract: The present invention concerns novel pyrazole (5) pyrazolone (5) metal complexes of the formula ##SPC1##Wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are substituents and Me is a transition metal,Useful in stabilizing sensitive organic material against the degradative effect of U.V. light.
    Type: Grant
    Filed: March 14, 1975
    Date of Patent: August 17, 1976
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer