Abstract: The novel 3,4-dihydro-1,3 dioxo-1,4 pyrido-(2,3-d)(1,3) oxazine compounds of this invention are useful as intermediates in the preparation of pharmaceutically active pyridopyrimidine-one compounds.
Abstract: Dyes of the formula ##SPC1##WhereinEach of R, R.sub.1, R.sub.2 and R.sub.3 is independently hydrogen, halo, nitro, unsubstituted or substituted alkyl or alkoxy, carboxy or sulfo,R.sub.4 is a diazo component radical, and Me is a metal atom,Are useful for dyeing and printing of leather. They exhaust well on leathers of low affinity and give level dyeings. The dyeings exhibit good fastness to light, water, washing, perspiration, ironing and formaldehyde.
Abstract: N-substituted-4-t-butyl-1-pyridinethiocarboxamides, e.g. N-methyl-4-t-1,2,3,6-tetrahydro-1-pyridinethiocarboxamides, are prepared by treating 4-t-butyl-1,2,3,6-tetrahydropyridine with a substituted isothiocyanate and are useful as anti-inflammatory and non-narcotic analgesic agents.
Abstract: Disclosed are pigment dyes containing the basic structure of formula I, ##SPC1##in which R.sub.1 is alkyl,R.sub.2 is alkylcarbonyl, alkoxycarbonyl or -CONR.sub.6 R.sub.7,R.sub. 3 is hydrogen or alkylR.sub.4 is an aromatic carbo- or heterocyclic bivalent radical bound through ortho or peri-positionsR.sub.5, together with >C=C< group, signifies an aromatic carbo- or heterocyclic ring,R.sub.6 is hydrogen or alkyl,R.sub.7 is hydrogen, alkyl or a mono- or bi-nuclear aromatic carbo- or heterocyclic ring, andMe is a bivalent transition metal atom or zinc,Their production and use in pigmenting, for example, plastics, synthetic resins, paints, varnishes, paper, viscose and cellulose acetate.
Abstract: Disclosed are stilbene compounds of formula I, ##SPC1##in whichR.sub.1 signifies hydrogen, halogen or C.sub.1-6 alkyl,R.sub.2 signifies hydrogen or methyl,R.sub.3 signifies cyano or a radical --CONR.sub.7 R.sub.8 in which either R.sub.7 and R.sub.8, independently, each signifies hydrogen, C.sub.1-6 alkyl or C.sub.2-6 hydroxyalkyl, or R.sub.7 and R.sub.8, together with the nitrogen atom, signify a pyrrolidine, piperidine or morpholine radical,Either R.sub.4 and R.sub.5, independently, each signifiesC.sub.1-6 alkyl or C.sub. 2-6 hydroxyalkyl, or R.sub.4 and R.sub.5, together with the nitrogen atom, form a radical (a) ##EQU1## in which --X-- signifies --CH.sub.2 --, --O--, --S--, a direct bond, or --NR.sub.9 --, in which R.sub.9 signifies C.sub. 1-6 alkyl or C.sub.2-6 hydroxy-alkyl,R.sub.6 signifies hydrogen or C.sub.1-6 alkyl, unsubstituted or substituted by hydroxy, cyano or aminocarbonyl,M signifies hydrogen or a non-chromophoric cation,A.sup.
Type:
Grant
Filed:
February 11, 1974
Date of Patent:
July 20, 1976
Assignee:
Sandoz Ltd.
Inventors:
Hans Balzer, Fritz Fleck, Hans-Rudolf Schmid
Abstract: A method of administering large dosages of potassium and chloride ions in an effervescent drink, wherein the ratio of potassium ion to chloride is maintained in a ratio of 1 to 1 with hydrochloride salts of basic amino acids.
Type:
Grant
Filed:
May 30, 1975
Date of Patent:
July 20, 1976
Assignee:
Sandoz, Inc.
Inventors:
Eugene W. Brockemeyer, Michael B. Rodell
Abstract: The invention concerns a novel deaerating arrangement for deaerating dialysis liquid in dialysis equipment of the type comprising a dialysis liquid feed line leading to a dialysis device and a dialysis liquid take off line leading from the dialysis device, wherein the deaerating arrangement comprises at least one deaerating chamber having a dialysis liquid inlet and dialysis liquid outlet in the dialysis liquid feed line, and a deaerating line which leads off from the head of the deaerating chamber through a first liquid flow rate restrictor to an evacuation pump which, in operation, creates a negative pressure in the deaerating chamber and withdraws air or gas formed in said deaerating chamber.
Abstract: Softening agents, especially useful for treatment of synthetic fiber shag carpeting, to impart softening and anti-soiling properties and which do not increase the inherent flammability of the carpeting are provided by reacting a fatty acid or fatty ester amide-amine with tris-(2,3-dibromopropyl)-phosphate.
Abstract: The compounds are biologically active tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones, pyrimido[2,1-b]quinazolin-6-ones and diazepino[2,1-b]quinazolin-7-ones, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with a cyclic pseudothiourea such as 2-organomercapto-4,5-dihydroimidazole or 2-organomercapto-3,4,5,6-tetrahydropyrimidine.
Abstract: Disclosed are compounds of the class 1-naphthyl-2,3-butadien-1-ol e.g. 2-(6'-methoxy-2-naphthyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g. as anti-inflammatory agents. Said compounds can be readily prepared by reduction of a corresponding 4-substituted-1-naphthyl-2-butyne-1-ol with a complex hydride such as lithium aluminium hydride.
Abstract: Disclosed is a process for the removal of liquid from an absorbent substrate, comprising passing the substrate through the nip between a pair of rollers, at least one of said rollers having an effective surface of a sponge material, the sponge material having capillary pores, the average diameter of which is less than 1 mm and at least 50% of said pores having a diameter in the range of 0.1 to 0.001 mm, the pressure applied at the nip between said rollers being less than 1 kg per cm roller length.
Abstract: The present invention concerns the use of the compounds of the formula: ##EQU1## wherein R.sub.1 to R.sub.9 have various significances including e.g. alkyl, X and Y include O and S, and s, v, w and z are O or whole numbers and Ar.sub.1 is substituted phenyl, as insecticides, and insecticidal compositions containing said compounds as active agent.
Abstract: The invention concerns a novel method of reducing the tendency of material to accumulate static electricity which comprises antistatically treating said material with a water soluble or readily water-dispersible salt having a cation of the formula: ##EQU1## WHEREIN R.sub.1, R.sub.2, and R.sub.3 are substituents e.g. alkyl and m, n, and x are integers.
Abstract: The invention concerns new 4a,10b-cis-substituted benzo-naphthyridines of the formula: ##SPC1##WhereinR.sub.1 is hydrogen, alkyl, alkoxy, alkylthio, fluorine, chlorine, bromine, nitro, trifluoromethyl, amino or acylamino,R.sub.2 is hydrogen, chlorine, alkyl or alkoxy, andR.sub.3 and R.sub.4 are both hydrogen or both methoxy, orR.sub.3 and R.sub.4 together are methylenedioxy.A process for the production thereof and intermediates therefor are also described.The compounds inhibit blood platelet aggregation.
Abstract: The present invention concerns novel N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives of the formula: ##EQU1## wherein R.sub.1 is hydrogen or alkyl, R.sub.2 is alkyl and Ar.sub.1 and Ar.sub.2 are each phenyl or a substituted phenyl, which compounds are useful as herbicides.The present invention relates to N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives.The present invention provides compounds of formula I, ##EQU2## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms, and eitherAr.sub.1 and Ar.sub.2 are the same, and are each phenyl or a substituted phenyl group selected from ##SPC1##WhereinR.sub.3 is chlorine, bromine, methyl, methoxy, or dimethyl or diethylsulphonamide andR.sub.4 is chlorine, bromine, methyl, methoxy or trifluoromethyl, orAr.sub.2 is phenyl andAr.sub.1 is a substituted phenyl group selected from ##SPC2##WhereinR.sub.3 ' is chlorine or methyl andR.sub.4 ' is chlorine, methyl or trifluoromethyl,With the proviso that Ar.sub.
Abstract: The present invention concerns a novel improvement in the catalytic hydrogenation of nitroanthraquinones to produce aminoanthraquinones, comprising over-hydrogenating the resulting aminoanthraquinone to the corresponding nuclear hydrogenated aminoanthraquinone and, after removal of the aminoanthraquinone, oxidising the remaining nuclear-hydrogenated aminoanthraquinone to aminoanthraquinone. Aminoanthraquinones are useful as intermediates in the production of anthraquinone dyestuffs.
Abstract: The present invention concerns novel oxindole derivatives of the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are saturated or unsaturated substituted or unsubstituted hydrocarbon radicals, useful as antiarrhythmic and .beta.-blocking agents.
Abstract: 2-amino-5-(substituted or unsubstituted phenylalkyl)-1,3,4-thiadiazoles, e.g., 2-amino-5-(3-trifluoromethylbenzyl)-1,3,4-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thio-semicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sleep inducers.
Abstract: N,N'-disubstituted-p-phenylenediamines, e.g., N-(3-isopropoxypropyl)-N'-(2-octyl)-p-phenylenediamine or N-phenethyl-N'-(2-octyl)-p-phenylenediamine, are prepared by condensing phenylenediamines with an alkyl carbonyl in the presence of a reducing catalyst, and are useful as hypolipidemic and anti-obesity agents.