Abstract: Described is a medicament delivery device (1), comprising a body (2), a container carrier (7) for retaining a medicament container within the body (2) and being slidably disposed in the body (2), a sleeve (6) slidably coupled to body (2), and a piston rod (11) coupled to the body (2) and the container carrier (7). The piston rod (11) and the container carrier (7) provide a feedback as 10 the container carrier (7) moves from a first position (P1) to a second position (P2) relative to the body (2).

Abstract: The present invention relates to amino acid sequences that are directed against interleukin 23 (IL-23). The amino acid sequences of the present invention comprise two NANOBODY® molecules against IL-23 and one NANOBODY® molecule against serum albumin, linked by two linkers. In particular, the invention relates to the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3 (listed in Table 1 and FIG. 1) (also referred to herein as “anti-IL 23 polypeptides of the invention”).

Abstract: This disclosure relates to antigenic EBV polypeptides and their use in eliciting antibodies against EBV. Also disclosed are antigenic polypeptides comprising an EBV polypeptide and a ferritin protein.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set a delivery dose. An injector may include a housing, a cartridge containing a medicinal product, the cartridge being retained within the housing, means for selecting a dose of the medicinal product to be expelled, and means for expelling the selected dose of the medicinal product. The housing may be a unitary housing within which the means for selecting the dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston rod may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: Implementations of the present disclosure are directed to conserving energy of an injection device by using a sensor attached to the housing, the sensor configured to detect a signal associated with an amount of medicament within the injection device and to generate a sensor signal based on the signal, a control component coupled to the sensor, the control component configured to harvest energy to process the sensor signal and to generate injection device data, and an antenna coupled to the control component and configured to transmit a radio frequency signal based on the injection device data.

Abstract: The present disclosure relates to a sheath remover for removing a protective needle sheath from a drug cartridge. The sheath remover includes a resilient ring and one or more resilient legs attached to the ring and extending in a proximal direction. Each leg includes an inwardly directed ledge arranged at a proximal end of the leg. The ring consists of a resilient material allowing inward deflection of a proximal end of the ring. The present disclosure further relates to a method for assembling and a method for using the sheath remover.

Abstract: The disclosure refers to a medical device comprising a measurement unit adapted to measure a value of a physiological parameter, for example a blood glucose level, an energy storage unit providing energy supply for the measurement unit, an NFC antenna, an energy supply unit that controls the NFC antenna such that in the presence of an electromagnetic field of a pre-defined frequency range energy is withdrawn from the electromagnetic field surrounding the NFC antenna and stored in the energy storage unit, a charge control unit adapted to determine the electric charge contained in the energy storage unit, and a communication unit adapted to output a pre-defined visible, audible and/or tactile signal if the electric charge contained in the energy storage unit determined by the charge control unit is equal to or below a pre-defined minimum charge value.

Abstract: The invention relates to the novel products of formula (I): with p, q=0, 1 or 2; R1=phenyl, pyridyl; —(CH2)m—Ra; alkylene; cycloalkyl; heterocycloalkyl; alkyl; —SO2—Rb; —CO—Re; m=1 or 2; Ra=aryl, heteroaryl, —CO-cycloalkyl, —CO-heterocycloalkyl, —CO—Rb, —C(Rb)?N—ORc, —CO2Rd, —CONRxRy; Rb=alkyl, aryl, heteroaryl; Rc=H, alkyl; Rd=alkyl, cycloalkyl; Re=alkyl, cycloalkyl, aryl, heteroaryl; NRxRy with Rx,Ry=H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N; R2, R3=H, alkyl, CF3, or form with C a ring with optionally O, S and N; R4=H, F, Cl, CH3 or CN; the morpholine is substituted with Me, and optionally substituted with F, OH; or is and the isomer of configuration R,R these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: The invention relates to indane compounds of formula (I): to their preparation and to their therapeutic use.

Abstract: An injection device is presented. The injection device comprises a housing configured to receive a syringe which has a barrel and a plunger received in the barrel. The injection device further comprises a vibration generator operable to vibrate at least one of the barrel and plunger when said syringe is received in the housing. Methods of dispensing medicament from an injection device are also presented.

Abstract: Implantable device for measuring the glucose concentration of a body fluid when implanted, the device comprising a glucose measurement unit, the glucose measurement unit comprising a light source configured to emit light towards a light transmissive part of a housing of the device, the device further comprising an optical sensor configured to detect light returned through the transmissive part from the light source, and output an electrical signal based on the detected light, and a wireless communication module configured to wirelessly communicate with an external wireless communication device, wherein the wireless communication module is configured to wirelessly transmit a signal based on the electrical signal to the external wireless communication device.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.

Abstract: A computing device comprises a memory and a data interface for connecting to a corresponding interface in a storage assembly. The memory comprises instructions which, on connection with the storage assembly, cause a processor of the storage assembly to: detect, using a device sensor of the storage assembly, one or more medicament delivery devices stored in the storage assembly; and display, on a display screen provided on the storage assembly, information relating to a medicament stored in the storage assembly.

Abstract: A packaging assembly comprises a case configured to at least partially contain a plurality of injection devices for delivering a medicament; and a sensor arrangement comprising at least one device sensor; wherein the at least one device sensor is configured to detect one or more injection devices contained in the case, and to output a signal according to a result of the detection.

Abstract: Disclosed are methods of treating various disorders with anti-IL-4R? antibodies and fragments thereof.

Abstract: The invention is related to an apparatus comprising a switch configured to variably connect a device circuit of an electronic device to a battery, a cutout control circuit connected to the switch and comprising a supply power input and a cutout activation input, wherein the cutout control circuit is configured to turn the switch on when a supply voltage is connected to the supply power input. The invention is further related to a drug delivery device for delivering at least one drug agent comprising an apparatus of the aforementioned kind, a charging connector for a drug deliver device of the aforementioned kind, and a method for manufacturing a drug delivery device of the aforementioned kind.

Abstract: An injection device comprises a housing with a receptacle for a product, a dosing mechanism for setting a product dosage to be administered and for displaying the product dosage that has been set, and a dispensing mechanism for dispensing the product. The dosing mechanism comprises a dosing sleeve which is rotatable relative to the housing in a first direction for setting a product dosage and which is rotatable relative to the housing in a second, opposite direction for correcting or dispensing a product dosage. The dispensing mechanism comprises a piston rod, at least one sleeve, and a clutch. The device further comprises a first detector for detecting movement of the clutch relative to the dosing sleeve and/or the housing and/or the at least one sleeve and a data processing unit connected to the first detector for reading, storing, processing, transmitting, and/or displaying signals received from the first detector.

Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.