Abstract: A workpiece carrier for transporting and/or storing components of a drug delivery device. The workpiece carrier includes a body including a planar-shaped bottom area. The planar-shaped bottom area includes an upper side and a bottom side opposite to the upper side. The bottom area includes a number of longitudinally extending hollow protuberances protruding from the bottom side and forming longitudinally extending cavities in the upper side. A longitudinal end of at least one of the protuberances or cavities faces away from the bottom side comprises an aperture.

Abstract: Described is an electronics assembly with pressure or force sensing capabilities for use in a drug delivery device. The electronics assembly includes a processor, a sensor arranged to measure the force applied by a drive mechanism to drive a medicament from a cartridge, a wireless module to which an external device can be paired, a power module arranged to supply power to the assembly, and memory storing instructions for the processor to perform. The instructions include receiving a measurement signal during the drug delivery operation, and determining if the dose of the medicament was expelled from the drug delivery device based on the received measurement signal.

Abstract: An arrangement of drug delivery devices is provided with interchangeable members and non-interchangeable members.

Abstract: The present disclosure is directed to an electronic add-on module configured for attachment to a drug delivery device and to an assembly comprising a drug delivery device and an electronic add-on module. The electronic add-on module may comprise a first portion with a main housing defining a longitudinal axis. The module comprises a gripping mechanism allowing attachment to drug delivery device dose dial user interfaces, e.g., a dial grip, and/or drug delivery device injection user interfaces, e.g., a dose button of varying diameters and shapes. The first portion comprises on an inner side of the main housing at least two elastically deformable arms each having a clamping section which is configured to be elastically deflected radially outwards with respect to the longitudinal axis from a unstressed, nominal position to a strained, deflected position.

Abstract: Embodiments of the present disclosure include systems, methods, and non-transitory computer-readable storage media for automated determination of a patient tumor-immune phenotype from immunofluorescence (IF) image analysis of pathology slides based on a tumor infiltrating lymphocytes score, a non-tumor infiltrating lymphocytes score, and a non-tumor infiltrating lymphocytes at tumor margin score.

Abstract: The present technology relates to polypeptides binding to the neonatal Fc receptor. More particularly, the present technology provides polypeptides binding to the neonatal Fc receptor and comprising (i) at least one domain comprising a serum albumin protein and/or at least one domain specifically binding to a serum albumin protein and (ii) an Fc domain of an immunoglobulin G (IgG).

Abstract: A machine-learned model to diagnose patients with a rare disease based on medical data/records, and methods of training such a model are disclosed. A computer implemented method is disclosed for generating a training dataset for training a machine-learning model to identify individuals with a rare disease. the method comprises: generating, from medical literature associated with the rare disease and using natural language processing, an embedding vector for each of a plurality of terms associated with the rare disease; receiving an initial dataset comprising medical data relating to a plurality of individuals with the rare disease; combining the initial dataset with a control dataset comprising a plurality of individuals without the rare disease; and generating, for each individual in the combined dataset, an embedding vector representing the individual based on features associated with the individual and the embedding vectors for the plurality of terms associated with the rare disease.

Abstract: A packaging assembly includes a case configured to at least partially contain injection devices for delivering a medicament; a light sensor configured to detect light incident on the packaging assembly; and a status indicator configured to generate an output which indicates a status of the packaging assembly conditional on an intensity of light detected by the light sensor exceeding a threshold light intensity.

Abstract: The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thi-azol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

Abstract: Provided herein are methods of purifying messenger RNA (mRNA) by subjecting a preparation comprising in vitro synthesized mRNA to one or more steps of enzymatic digestion with a proteinase, optionally with a further oligo dT affinity chromatography step. Also provided are mRNA purified by the methods described herein.

Abstract: A computing device comprises a memory and a data interface for connecting to a corresponding interface in a storage assembly. The memory comprises instructions which, on connection with the storage assembly, cause a processor of the storage assembly to: detect, using a device sensor of the storage assembly, one or more medicament delivery devices stored in the storage assembly; and display, on a display screen provided on the storage assembly, information relating to a medicament stored in the storage assembly.

Abstract: A data collection device for attachment to an injection device and for collecting medicament dosage information therefrom.

Abstract: This disclosure relates to antigenic EBV polypeptides and their use in eliciting antibodies against EBV. Also disclosed are antigenic polypeptides comprising an EBV polypeptide and a ferritin protein.

Abstract: The invention relates to a lateral flow assay device for the detection of a target peptide in a liquid sample, comprising: (a) a solid support, (b) a sample pad for initially receiving and optionally pre-treating the sample at a first end of the solid support, (c) an absorbent pad at a second end of the solid support, (d) a conjugate pad comprising in a dry state a mobilizable conjugate of a particle and the target peptide, wherein the target peptide conjugated to said particle is biotinylated and the particle comprises on its surface a biotin-binding protein, (e) a target peptide reaction membrane comprising, (i) a capture region comprising an immobilized first capture reagent against the target peptide, and (ii) optionally a control region comprising an immobilized second capture reagent against particle control conjugate, wherein the sample pad, the conjugate pad, the reaction membrane and the absorbent pad are mounted to the solid support to permit capillary flow from the sample pad to the reaction membra

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.

Abstract: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile-associated disease.

Abstract: The present disclosure relates to a closure cap for sealing an outlet end of a barrel of a medicament container, the outlet end having a radially widened rim and the outlet end being sealable by an elastomeric seal, wherein the elastomeric seal comprises a flange portion configured to abut in a longitudinal direction with the outlet end, the closure cap comprising: a cap body comprising a retainer portion and a fastening portion, wherein the retainer portion is configured to engage with the elastomeric seal, wherein the fastening portion comprises a resiliently and radially deformable fastener comprising a snap feature configured to releasably engage with the radially widened rim of the outlet and, and wherein a longitudinal distance between the retainer portion and the snap feature is sized to receive the radially widened rim and the flange portion of the elastomeric seal between the retainer portion and the snap feature.

Abstract: A packaging assembly comprises a case configured to contain a plurality of injection devices for delivering a medicament and a lid coupled to the case. The lid is movable between an open position and a closed position. The packaging assembly further includes a countdown timer configured to monitor a time remaining to a scheduled time and a sensor configured to output a signal representative of a change in position of the lid from the closed position to the open position. The packaging assembly also includes a reminder alert configured to activate once the scheduled time has been reached, and deactivate based on the signal received from the sensor. The packaging assembly further comprises a reset input device. The packaging assembly is configured to respond to operation of the reset input device by a user to set the scheduled time.