Patents Assigned to Sanofi
  • Humidity control in chemical reactors
    Patent number: 11725176
    Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: August 15, 2023
    Assignees: Sanofi, Massachusetts Institute Of Technology
    Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
  • Modified lipidated relaxin B chain peptides and their therapeutic use
    Patent number: 11725036
    Abstract: A biologically active single chain Relaxin peptide having the formula Nter-Ac-L-E-G-R-E-K-V-R-A-X19-I-X21-X22-E-G-X25-S-T-F-S-X30-R-A-X33-NH2-Cter, or a salt of solvate thereof, is described.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: August 15, 2023
    Assignee: Sanofi
    Inventors: Olivier Duclos, Stéphane Illiano, Sergio Mallart, Claire Minoletti-Hochepied, Elisabetta Bianchi, Raffaele Ingenito, Paola Magotti, Alessia Santoprete
  • Drug delivery device with electromagnetic drive unit
    Patent number: 11717607
    Abstract: The disclosure relates to a drug delivery device having a drive unit includes a stator comprising a plurality of coils consecutively arranged in an axial direction, and an armature axially movable within the stator, the armature including a number of magnets and pole shoes consecutively arranged in the axial direction. A respective pole shoe is arranged between respectively neighbouring magnets. At least one axial end of the armature comprises a terminal pole shoe.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: August 8, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Christian Nessel, René Richter, Robert Witt, Richard Guenther
  • TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20230242620
    Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay).
    Type: Application
    Filed: April 13, 2023
    Publication date: August 3, 2023
    Applicants: Ablynx N.V., Sanofi
    Inventors: Judith Baumeister, Marie-Paule Lucienne Armanda Bouche, Carlo Boutton, Marie-Ange Buyse, Veerle Snoeck, Stephanie Staelens, Bruno Dombrecht, Peter Schotte, Cedric Jozef Néotère Ververken, Gerald Beste, Guy Hermans, Soren Steffensen, Alexander Szyroki, Tinneke Denayer
  • Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-l-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate and preparation process thereof
    Patent number: 11713296
    Abstract: Herein are provided novel salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate namely the oxalate salt and the dibenzoyltartrate salt
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: August 1, 2023
    Assignee: SANOFI
    Inventors: Joël Malpart, José Ruiz Montes
  • Immunoglobulin variable domains
    Patent number: 11708404
    Abstract: VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: July 25, 2023
    Assignees: Ablynx N.V., Sanofi
    Inventors: Marie-Ange Buyse, Carlo Boutton
  • Electronic module and drug delivery device
    Patent number: 11707573
    Abstract: The invention relates to an electronic module for recording information of a drug delivery device, the electronic module comprising at least one connector, wherein at least one connector is adapted to be connected to a port of the drug delivery device and wherein at least one connector is adapted to be connected to a port of a computer. Furthermore, the invention relates to a drug delivery device, comprising a port for connecting to the connector of the electronic module.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: July 25, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Samuel Steel, Paul Richard Draper, Joseph Butler, George Cave, David Richard Mercer
  • Neisseria meningitidis vaccine
    Patent number: 11707514
    Abstract: Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: July 25, 2023
    Assignee: Sanofi Pasteur Inc.
    Inventors: Richard David Kensinger, Jr., Steven L. Hauser
  • Medical pump
    Patent number: 11707565
    Abstract: The present disclosure relates to a medical pump for dispensing a liquid. The medical pump includes a housing, a receptacle and a piston. The housing includes an inlet for receiving said liquid and an outlet for dispensing said liquid. The receptacle includes a chamber and a passage that is in fluid communication with the chamber. The receptacle is received in the housing and is axially movable relative to the housing from a filling position, wherein the passage fluidly communicates the chamber with the inlet, to a dispensing position, wherein the passage fluidly communicates the chamber with the outlet. The piston is received in the chamber and is configured such that when the receptacle is in the filling position the piston is axially moveable relative to the receptacle and when the receptacle is in the dispensing position the piston is axially moveable relative to the receptacle.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: July 25, 2023
    Assignee: Sanofi
    Inventors: René Richter, Sebastian Pech, Jens Lienig
  • WEARABLE INJECTION DEVICE
    Publication number: 20230211082
    Abstract: The present disclosure relates to wearable injection devices that comprise flexible elements. Exemplary devices can comprise flexible reservoirs, flexible housings, and flexible metering mechanisms. The flexible elements of the present disclosure provide improved wearable injection devices with small heights, low profiles, and streamlined, flexible cases that can withstand impact without experiencing adverse performance effects or tearing off of the patient.
    Type: Application
    Filed: May 19, 2021
    Publication date: July 6, 2023
    Applicant: Sanofi
    Inventors: Bernd Kuehn, Florian Schauderna
  • Compositions for booster vaccination against dengue
    Patent number: 11690903
    Abstract: The present invention is directed to a method of booster vaccination and to a vaccine composition for use in such a method, for inducing in a human subject a neutralizing antibody response, wherein said subject has previously received a primary vaccination against each of serotypes 1 to 4 of dengue virus and was dengue naïve before said primary vaccination, said composition comprising a dengue antigen of at least one of serotypes 1 to 4 or a nucleic acid construct capable of expressing said antigens in the subject, wherein said booster vaccination results in a 2-fold increase in the neutralizing antibody titre against each of serotypes 1 to 4.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: July 4, 2023
    Assignee: SANOFI PASTEUR
    Inventors: Diana Coronel, Betzana Zambrano, Fernando Noriega, Tram Anh Wartel, Yves Girerd-Chambaz
  • Methods to estimate effectiveness of a medical treatment
    Patent number: 11694773
    Abstract: Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for estimating treatment effect of medical treatments.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: July 4, 2023
    Assignee: Sanofi
    Inventors: Qi Tang, Wodan Ling, Youran Qi
  • Drive mechanism for a drug delivery device
    Patent number: 11672915
    Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: June 13, 2023
    Assignees: Terumo Corporation, Sanofi-Aventis Deutschland GMBH
    Inventor: Masaru Saiki
  • Data collection device
    Patent number: 11672913
    Abstract: A data collection device for attachment to an injection device and for collecting medicament dosage information therefrom.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Michael Helmer
  • Sensor device for attachment to an injection device
    Patent number: 11672916
    Abstract: A supplementary device configured to be releasably attached to a distal end of a drug delivery device. The supplementary device comprising primary electronics, a non-contact acceleration sensor and a low power processor. The non-contact acceleration sensor is directed towards a proximal end of the drug delivery device and the low power processor is configured to: receive the signals output from the non-contact acceleration sensor; determine based on the signals that an outer needle cap of the drug delivery device has been removed; and in response to determining that an outer needle cap of the drug delivery device has been removed, send a wake-up signal to the primary electronics of the supplementary device.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Michael Helmer
  • Packaging assembly
    Patent number: 11672923
    Abstract: A packaging assembly comprises a case configured to contain at least one injection device for delivering a medicament; a cooling unit configured to lower an internal temperature of the case; a processing arrangement; a device sensor configured to detect at least one injection device contained within the case, and to receive device storage information from the at least one detected injection device; and a data storage device. The processing arrangement is configured to record an injection history on the data storage device. The processor arrangement is configured to control the cooling unit to set an internal temperature of the case according to the received device storage information.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Michael Helmer
  • RFID dose tracking mechanism for injection devices
    Patent number: 11672914
    Abstract: Described is a dose tracking mechanism for a drug delivery device, including an RFID device with an electric circuit and a switch operable to open and close the electric circuit to transmit a wireless signal to a receiving device when the electric circuit is closed by the switch. The switch is configured to open and close in response to operation of a dose setting and/or a dose dispensing mechanism of the drug delivery device, and the closing and opening of the electric circuit generates a pulse of the wireless RFID signal. In one embodiment, each pulse corresponds to a unit of a dose of medicament set by the dose setting mechanism or dispensed by the dose dispensing mechanism from a drug container of the drug delivery device, depending on if the dose setting or dose dispensing mechanism is arranged to toggle the switch.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Maurice Toporek
  • Drive mechanism with noise reduction
    Patent number: 11666709
    Abstract: A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector. The pawl element and/or gear element comprises a noise reduction characteristic at a surface which dampens the noise produced.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 6, 2023
    Assignee: Sanofi
    Inventors: Ralph Donald Quentin Collings, James Robert Coop, James Anthony West, Stephen Francis Gilmore, Daniel David Higgins, Mark Digby Teucher, Jack Carroll, Timothy Robin Quigg, Laura Stein, Stefan Blancke, Sophie Sladen
  • Medical injection device
    Patent number: D988507
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: June 6, 2023
    Assignee: Sanofi
    Inventors: Christian Rogge, Philipp Oster, Carolin Frontzek, Uwe Dasbach, Alex Zuyev, William Timmis
  • Pen-shaped injector
    Patent number: D995762
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: August 15, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Simon Araia, Ingo Fritz