Abstract: C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the definitions of each variable group are described in the specification. Also provided are methods of preparing and using the C, O-spiro aryl glycoside compounds. The C, O-spiro aryl glycoside compounds can be used as SGLT2 inhibitors and for treating diseases, such as diabetes, atherosclerosis, and adiposity.
Type:
Grant
Filed:
June 23, 2016
Date of Patent:
February 4, 2020
Assignee:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Abstract: A method for treatment of a hexachlorodisilane and its hydrolyzed product is disclosed. It comprises adding a hexachlorodisilane or its hydrolyzed product into a sulfuric acid solution for reaction.
Type:
Grant
Filed:
May 23, 2018
Date of Patent:
February 4, 2020
Assignee:
National Kaohsiung University of Science and Technology
Abstract: A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
February 4, 2020
Assignee:
Gilead Sciences, Inc.
Inventors:
Benjamin Micah Collman, Lei Hong, Joanna M. Koziara
Abstract: A stereo type distance recognition apparatus and method are provided. The stereo type distance recognition apparatus may include a plurality of sensors to generate a plurality of infrared (IR) signals, a communication unit to insert a set first pattern into each of the plurality of generated IR signals and to transmit the IR signals to an object, and a processor to extract a second pattern from each of signals reflected from the object by the plurality of IR signals, to cancel an interference signal from each of the reflected signals based on a result of a comparison between the first pattern and the second pattern, and to compute a distance from the object based on signals from which the interference signal is cancelled.
Type:
Grant
Filed:
July 10, 2017
Date of Patent:
February 4, 2020
Assignee:
Daegu Gyeongbuk Institute of Science and Technology
Inventors:
Moon Jong Choi, Rock Hyun Choi, Jae Sung Choi, Won Seok Kang, Dong Ha Lee
Abstract: A carbon material-polymer strain sensitive film and its preparation method are disclosed. The carbon material-polymer strain sensitive film includes multiple layers of carbon sensitive films and multiple layers of polymer films, wherein the multiple layers of carbon sensitive films and the multiple layers of polymer films form a multi-layer composite film in sequence through a layer-by-layer assembly process. The preparation method includes steps of: cleaning, processing a hydrophilic treatment and processing a hydrophobic treatment on a rigid substrate in sequence; preparing a carbon material in dispersion solution and a polymer dispersion solution; through a layer-by-layer self-assembly process, growing the polymer and the carbon material in a form of layer-by-layer on the rigid substrate; transferring the composite film from the rigid substrate to a flexible substrate; and pasting two electrodes at two ends of the composite film and encapsulating with a flexible film.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
February 4, 2020
Assignee:
University of Electronic Science and Technology of China
Inventors:
Huiling Tai, Xueliang Ye, Zhen Yuan, Rui Guo, Yadong Jiang, Weizhi Li, Xiaosong Du
Abstract: A video resource file acquisition method includes: acquiring, by a terminal, a resource decryption key of a target video from a key management server; transmitting, by the terminal, a resource download request for the target video to a resource server of the target video; after receiving the resource download request for the target video, acquiring, by the resource server, a resource encryption key of the target video from the key management server; encrypting, by the resource server, a resource file of the target video by using the resource encryption key and feeding back, by the resource server, the encrypted resource file to the terminal; and after receiving the encrypted resource file, decrypting, by the terminal, the encrypted resource file using the resource decryption key.
Abstract: According to one embodiment, a magnetic memory device includes a stacked body and a controller. The stacked body includes a first conductive layer, a second conductive layer, a first magnetic layer provided between the first conductive layer and the second conductive layer, a second magnetic layer provided between the first magnetic layer and the second conductive layer, and a nonmagnetic layer provided between the first magnetic layer and the second magnetic layer. A resistance value per unit area of the nonmagnetic layer exceeds 20 ??m2. The controller is electrically connected to the first conductive layer and the second conductive layer, and supplies a write pulse to the stacked body in a first operation.
Type:
Application
Filed:
April 4, 2018
Publication date:
January 30, 2020
Applicant:
National Institute of Advanced Industrial Science and Technology
Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.
Type:
Application
Filed:
February 27, 2018
Publication date:
January 30, 2020
Applicant:
Oregon Health & Science University
Inventors:
David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
Abstract: Systems and methods for continuous insect pupae sensing are described. One example method includes receiving a flow at a singulator, the flow comprising one or more insect pupae; singulating the insect pupae into a single-file flow of insect pupae; sensing, using a sensor, insect pupae within the single-file flow of insect pupae; and incrementing a counter based on each sensed insect pupae in the single-file flow of insect pupae.
Type:
Application
Filed:
July 23, 2019
Publication date:
January 30, 2020
Applicant:
Verily Life Sciences LLC
Inventors:
Martin Sheridan, Jianyi Liu, Matthew Metlitz
Abstract: According to one or more embodiments presently disclosed, a method of catalytically converting polystyrene may include contacting polystyrene with a catalyst to form a product comprising ethylbenzene. The catalyst may include oxidized iron, oxidized cobalt, and oxidized copper. The catalyst may further include a mesoporous support material with pores having an average pore diameter of from 2 nm to 50 nm.
Type:
Application
Filed:
July 17, 2019
Publication date:
January 30, 2020
Applicants:
Saudi Arabian Oil Company, King Abdullah University of Science and Technology
Abstract: An InGaN-based resonant cavity enhanced detector chip based on porous DBR, including: a substrate (10); a buffer layer (11) formed on the substrate (10); a bottom porous DBR layer (12) formed on the buffer layer (11); an n-type GaN layer (13) formed on the bottom porous DBR layer (12), wherein one side of the n-type GaN layer (13) is recessed downward to form a mesa (13?), and the other side of the n-type GaN layer (13) is protruded; an active region (14) formed on the n-type GaN layer (13); a p-type GaN layer (15) formed on the active region (14); a sidewall passivation layer (20) formed on an upper surface of the p-type GaN layer (15) and sidewalls of the protruded n-type GaN layer (13), the active region (14), and the p-type GaN layer (15), wherein the sidewall passivation layer (20) on the upper surface of the p-type GaN layer (15) has a window in a middle; a transparent conductive layer (16) formed on the sidewall passivation layer (20) and the p-type GaN layer (15) at the window; an n-type electrode (18
Type:
Application
Filed:
June 1, 2017
Publication date:
January 30, 2020
Applicant:
Institute of Semiconductors, Chinese Academy of Sciences
Inventors:
Lixia Zhao, Lei Liu, Chao Yang, Jing Li, Kaiyou Wang
Abstract: A method of catalytically cracking a petroleum hydrocarbon may include contacting a petroleum hydrocarbon feed with a catalyst to form an upgraded petroleum hydrocarbon. The catalyst may include oxidized iron, oxidized cobalt, and oxidized copper. Also discloses are methods for reducing the viscosity of a subterranean petroleum hydrocarbon by utilizing the presently disclosed catalysts.
Type:
Application
Filed:
July 17, 2019
Publication date:
January 30, 2020
Applicants:
Saudi Arabian Oil Company, King Abdullah University of Science and Technology
Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.
Type:
Application
Filed:
August 6, 2019
Publication date:
January 30, 2020
Applicant:
BioDelivery Sciences International, Inc.
Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.
Type:
Application
Filed:
March 28, 2018
Publication date:
January 30, 2020
Applicant:
Imperial College of Science, Technology and Medicine
Abstract: According to one or more embodiments presently disclosed, a catalyst for converting hydrocarbons may include catalytic oxidized metal materials comprising oxidized iron, oxidized cobalt, and oxidized copper. At least 95 wt. % of the catalytic oxidized metal materials may be a combination of oxidized iron, oxidized cobalt, and oxidized copper. The catalyst may additionally include a mesoporous support material comprising pores having an average pore diameter of from 2 nm to 50 nm. At least 95 wt. % of the mesoporous support material may comprise alumina. At least 95 wt. % of the catalyst may be the combination of the catalytic oxidized metal materials and the mesoporous support material. Additional embodiments are included, such as methods for making the presently disclosed catalysts.
Type:
Application
Filed:
July 17, 2019
Publication date:
January 30, 2020
Applicants:
Saudi Arabian Oil Company, King Abdullah University of Science and Technology
Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
Type:
Application
Filed:
July 29, 2019
Publication date:
January 30, 2020
Applicant:
Gilead Sciences, Inc.
Inventors:
Elbert Chin, Darryl Kato, John O. Link, Nathan Shapiro, Zheng-Yu Yang
Abstract: A monitoring and forewarning method for coal-rock dynamic disasters based on an electromagnetic radiation and an earth-sound monitoring includes the following steps: (1) calculating the weighted average value of research parameter P(t) during a time period according to the monitoring data collected by the electromagnetic radiation and the earth-sound monitoring system in real time; (2) calculating D(t), the deviation value of P(t); (3) calculating |D(t)| as the deviation threshold value, the average value of |D(t)| during period of normal mining of the working surface; (4) calculating DS, the number of times that D(t) is greater than |D(t)| in one day; (5) normalizing DS to obtain the monitoring and forewarning index ?; (6) forewarning the hazard state of dynamic disaster of the working surface in real time according to ? and forewarning method, determining hazard level.
Type:
Application
Filed:
March 30, 2018
Publication date:
January 30, 2020
Applicants:
University of Science and Technology Beijing, Zhong-an Academy of safety Engineering
Abstract: An object of the present invention is to provide a novel myocardial stem cell for transplantation which enables maintenance of a therapeutic effect on and/or preventive effect against cardiac failure for a prolonged period, a method for producing the myocardial stem cell, and a cell preparation containing the myocardial stem cell. [Solution] The present invention relates to a method for producing a myocardial stem cell to be used for treatment and/or prevention of cardiac failure, the method comprising the step of introducing a complex of a mitochondria-targeting carrier and a mitochondria activating agent into a myocardial stem cell; a cell produced by the method and a cell preparation containing the cell; and a liposome to be used for producing the cell. According to the present invention, there can be provided a myocardial stem cell which is capable of maintaining a therapeutic effect and/or preventive effect by cell transplantation for a prolonged period.