Patents Assigned to Sciences
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Patent number: 10454462Abstract: A Quadrature-In, Quadrature-Out (QIQO) clock divider divides by an odd divisor, such as three. An IQ input clock has in-phase and quadrature differential signals. Four stages of dynamic logic are arranged into a loop, with each stage output being one of four IQ output signals that have 90-degree phase separations. Each stage output drives the gates of a p-channel charging transistor and an n-channel discharging transistor of a next stage. Two p-channel charging logic transistors are in series between the next stage output and the p-channel charging transistor, and two n-channel evaluation transistors are in series between the next stage output and the n-channel discharging transistor. Different pairs of the four IQ input clock signals are applied to their gates. When the prior stage output is low, the stage output is charged. When the prior stage output is high, the stage output discharge timing is determined by the IQ signals.Type: GrantFiled: April 18, 2019Date of Patent: October 22, 2019Assignee: Hong Kong Applied Science and Technology Research Institute Company LimitedInventor: Tat Fu Chan
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Patent number: 10450225Abstract: The present invention relates to a glass having a surface with improved water-repellency or hydrophobicity and low reflectance, and a fabrication method thereof. A technology is employed, in which a thin film containing silicon or silicon oxide is formed on the glass surface, the nano-structures are formed by selective etching treatment using a reactive gas such as CF4 or the like to provide superhydrophobicity and low reflectance properties, and a material with low surface energy is coated onto the nano-structures. The fabrication method of the low-reflective and superhydrophobic or super water-repellent glass may execute deposition and etching processes for the glass having the superhydrophobicity and the low reflectance, and provide excellent superhydrophobicity and low reflectance to the surface of the glass which was difficult to be treated. Also, the method is sustainable due to non-use of a toxic etching solution during these processes.Type: GrantFiled: December 2, 2014Date of Patent: October 22, 2019Assignee: Korea Institute of Science and TechnologyInventors: Myoung Woon Moon, Heon Ju Lee, Jeong Sim Lee, Tae Jun Ko, Kyu Hwan Oh, Do Hyun Kim, Eu Sun Yu
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Patent number: 10449037Abstract: A flexible intraocular lens including a flexible, transparent conductor disposed on a sidewall is disclosed herein. An example flexible intraocular lens includes an annular body and a transparent and flexible conductor. The annular body having at least one inner surface, where the annular body is formed from a flexible biocompatible material amenable to implantation into an eye. The transparent and flexible conductor formed on the at least one inner surface, the transparent and flexible conductor being one of a conductive polymer or a conductive nanowire-based mesh.Type: GrantFiled: August 8, 2016Date of Patent: October 22, 2019Assignee: Verily Life Sciences LLCInventors: Daniel B. Otts, Kristopher A. Lavery
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Patent number: 10453351Abstract: An automated detection and avoidance system that provides a pilot with high-fidelity knowledge of the aircraft's physical state, and notifies the pilot of any deviations in expected state based on predictive models. The automated detection and avoidance system may include a processor and a sensor payload operatively coupled to the processor to detect a non-cooperative obstacle within a first airspace adjacent the aircraft. The sensor payload may comprise a radar to radially scan the first airspace, and a camera to scan a second airspace within said first airspace.Type: GrantFiled: July 17, 2017Date of Patent: October 22, 2019Assignee: Aurora Flight Sciences CorporationInventors: Jae-Woo Choi, Jeffrey Saunders, James D. Paduano
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Patent number: 10450270Abstract: Inhibitors of HBV replication of Formula (IA) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.Type: GrantFiled: July 25, 2014Date of Patent: October 22, 2019Assignee: Janssen Sciences Ireland UCInventors: Koen VanDyck, Bart Rudolf Romanie Kesteleyn, Serge Maria Aloysius Pieters, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
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Patent number: 10454115Abstract: Provided is a porous carbon material having carbon nano-rods on the surface thereof. The porous carbon material has an increased specific surface area and an increased electrochemically active area, and thus may be expected to provide improved performance, when used as an electrode for electrochemical reactions. In addition, the carbon nano-rods of the porous carbon material are formed through an etching process using a catalyst for etching formed on the carbon material, and thus the carbon material may have various functions.Type: GrantFiled: October 27, 2016Date of Patent: October 22, 2019Assignee: Korea Institute of Science and TechnologyInventors: Heung Yong Ha, Hyuck Lee, Jinyeon Hwang
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Patent number: 10449051Abstract: An implant includes a body having a leading edge portion, a trailing edge portion, and an intermediate portion extending between the leading edge portion and the trailing edge portion. The leading edge portion includes a substantially smooth surface forming a substantial majority of a leading edge surface of the leading edge portion. The trailing edge portion includes a monolithic structure including at least one receptacle configured to receive an insertion tool. In addition, the intermediate portion includes a plurality of elongate curved structural members.Type: GrantFiled: October 23, 2017Date of Patent: October 22, 2019Assignee: Institute for Musculoskeletal Science and Education, Ltd.Inventors: Rami Hamzey, Robert Morris, William Duffield, Edward J. McShane, III, Megan A. Stauffer, Mathew Gordon, Joseph M. Nyahay
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Patent number: 10450348Abstract: The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents.Type: GrantFiled: November 6, 2014Date of Patent: October 22, 2019Assignee: Norwegian University of Science and TechnologyInventors: Marit Otterlei, Siri Bachke
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Patent number: 10451863Abstract: Apparatuses and methods for an interposer for integration of multiple image sensors are disclosed herein. An example apparatus includes an interposer including laterally spaced first and second windows, and first and second image sensors disposed on the interposer over the first and second windows, respectively. The interposer including conductive conduits formed in or on to provide electrically conductive paths there through with the first and second image sensors coupled to the conductive conduits. The first and second image sensors laterally spaced by a gap, and an active area of the first and second image sensors to receive incident light through the respective first and second windows, where a perspective of the first image is different than a perspective of the second image sensor based at least in part on the gap.Type: GrantFiled: August 5, 2016Date of Patent: October 22, 2019Assignee: Verily Life Sciences LLCInventors: Sam Kavusi, Brian M. Pepin
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Patent number: 10451745Abstract: A muon detector system capable of determining muon direction and flight trajectory or path is disclosed. The muon detector system includes scintillators for determining muon direction, and an array of muon detectors arranged in orthogonal layers for determining flight trajectory. The system can be used for tomographic and telescopic mode imaging, and may be used for imaging concealed and/or subterranean objects.Type: GrantFiled: December 10, 2015Date of Patent: October 22, 2019Assignees: National Technology & Engineering Solutions of Sandia, LLC, National Security Technologies LLC, Decision Sciences International CorporationInventors: Nedra D. Bonal, Leiph A. Preston, David Schwellenbach, Wendi Dreesen, J. Andrew Green, Michael Sossong
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Patent number: 10450364Abstract: In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens ?-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.Type: GrantFiled: February 13, 2018Date of Patent: October 22, 2019Assignees: Arkion Life Sciences, LLC, United Sates of America, as Represented by the Secretary of AgricultureInventors: Hyun S. Lillehoj, Earnest W. Porta, Samuel V. Walker, Leslie A. Confer, Ujvala Deepthi Gadde, Cyril Gay
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Patent number: 10449191Abstract: Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 29, 2019Date of Patent: October 22, 2019Assignees: Myovant Sciences GmbH, Takeda Pharmaceutical Company LimitedInventors: Vijaykumar Reddy Rajasekhar, Brendan Mark Johnson, David B. MacLean, Lynn Seely, Paul N. Mudd, Jr.
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Patent number: 10452113Abstract: A programmable-threshold power supply selector has two power-supply inputs VDD1 and VDD2. The higher of these two voltages is pre-selected as a common supply that powers all transistors and circuitry in the programmable-threshold power supply selector, including substrates under transistors. An open-loop decision circuit is very stable since it uses no feedback. A tunable voltage divider divides VDD1 by a programmable divisor. The divided VDD1 is compared to a reference voltage to generate switch-control signals. The switch-control signals drive the gates of p-channel switch transistors that connect either VDD1 or VDD2 to an output supply voltage. The different programmable divisor values effectively cause VDD1 to be compared to a programmable threshold voltage VTH. The switch transistors switch the output supply voltage to VDD2 only when VDD1 falls below VTH. The output supply voltage remains at VDD1 even when VDD1 falls below VDD2, eliminating unnecessary power switching.Type: GrantFiled: November 20, 2017Date of Patent: October 22, 2019Assignee: Hong Kong Applied Science and Technology Research Institute Company LimitedInventors: Chung Fai Au Yeung, Chi Hong Chan, Hok San Yu
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Patent number: 10448843Abstract: Methods and systems are provided for measuring the flow of fluid (e.g., blood) in vasculature of a human by heating the fluid in a portion of the vasculature and detecting the temperature of fluid in and/or tissue proximate to a downstream portion of the vasculature. The blood is heated by emitting energy through an external body surface into the portion of vasculature. The temperature of the downstream portion of vasculature is detected by an infrared sensor receiving infrared light from the body and/or a temperature sensor in thermally conductive contact with the body. The flow of fluid in the portion of vasculature can be determined by determining a latency between a change in the detected temperature relative to a change in the emitted energy, by determining a difference between the detected temperature and a detected temperature of another portion of the body, or by some other method.Type: GrantFiled: July 16, 2014Date of Patent: October 22, 2019Assignee: Verily Life Sciences LLCInventor: Eric Peeters
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Publication number: 20190315742Abstract: New compositions of matter useful for the treatment of human diabetes and cancers comprise the reaction products of thymoquinone and harmaline or harmaline-like compounds, such as ?-carboline compounds, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.Type: ApplicationFiled: April 10, 2019Publication date: October 17, 2019Applicant: Ankh Life Sciences LimitedInventors: Gene H. Zaid, Cameron E. West
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Publication number: 20190314489Abstract: The present invention provides cells which have a high ability to propagate influenza virus, are suitable for use in production of an influenza virus for preparing a vaccine, and are able to be cultured in vitro, and a method for producing an influenza virus using the cells. That is, the present invention provides cells for producing an influenza virus in which expression of one or more genes that encode proteins involved in an effect of suppressing influenza virus production in a cell is suppressed and the gene is at least one selected from the group including ACTG1 gene and the like, and a method for producing an influenza virus that includes infecting the cells for producing an influenza virus with an influenza virus and then culturing.Type: ApplicationFiled: June 26, 2019Publication date: October 17, 2019Applicant: Japan Science and Technology AgencyInventors: Yoshihiro KAWAOKA, Tokiko Watanabe, Eiryo Kawakami, Shinji Watanabe
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Publication number: 20190319096Abstract: Disclosed are a two-dimensional semiconductor in which an energy band gap changes with thickness, a manufacturing method therefor, and a semiconductor device comprising the same. A two-dimensional semiconductor according to an embodiment comprises: a first layer having a first thickness; and a second layer having a second thickness, wherein the first thickness and the second thickness are different from each other, the first layer forms a first junction with a first electrode, and the second layer forms a second junction with a second electrode.Type: ApplicationFiled: July 4, 2016Publication date: October 17, 2019Applicants: KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP, Korea Advanced Institute of Science and TechnologyInventors: Hyun Jong CHUNG, Hyun Cheol KIM, Han Byeol LEE, Hak Seong KIM, Sung Yool CHOI
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Publication number: 20190317066Abstract: Provided is a novel analysis method that enables identification of a sample even when any sample is introduced during measurement carried out by using a chemical sensor. An input in which the amount of an unknown sample changes over time is provided to the chemical sensor, a response which is from the chemical sensor and which changes over time is measured, a sensor function (transmission function) of the chemical sensor with respect to the unknown sample is calculated on the basis of the input and the response, and the unknown sample is identified on the basis of the sensor function of the chemical sensor with respect to the unknown sample.Type: ApplicationFiled: November 22, 2017Publication date: October 17, 2019Applicant: National Institute for Materials ScienceInventors: Gaku Imamura, Genki Yoshikawa, Takashi Washio
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Publication number: 20190315663Abstract: The invention relates to the field of controlled release fertilizer technology, and in particular to a special film-coated controlled release fertilizer for peanut in a high yield field, which comprises an outer layer, an intermediate layer and an inner layer, integrates the ingredients for disease and pest control, chemical control, growth promotion and premature senescence prevention, controls the release period, improves the fertilization efficiency without the need of top application throughout the growth period, saves labor cost, and has positive effects on improving peanut yield and quality.Type: ApplicationFiled: July 20, 2018Publication date: October 17, 2019Applicant: Biotechnology Research Center, Shandong Academy of Agricultural SciencesInventors: Shubo Wan, Jialei Zhang, Feng Guo, Xinguo Li, Sha Yang, Zheng Zhang, Yun Geng, Haijun Zhao, Jingjing Meng
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Publication number: 20190314508Abstract: A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.Type: ApplicationFiled: November 13, 2017Publication date: October 17, 2019Applicant: Tokyo University of Science FoundationInventors: Etsuko MIYAMOTO, Masaaki OZAWA