Abstract: A pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells are described herein. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.

Abstract: A multi-layer lens stack includes first liquid crystal material enclosed between a first diffractive lens structure and a first substrate surface having a first alignment layer disposed thereon, and second liquid crystal material enclosed between a second diffractive lens structure and a second substrate surface having a second alignment layer disposed thereon. The first and second liquid crystal materials assume a homeotropic alignment relative to the first and second substrate surfaces, respectively, in a first mode. The first alignment layer is configured to align the first liquid crystal material along a first direction and the second alignment layer is configured to align the second liquid crystal material along a second direction, substantially orthogonal to the first direction, in a second mode. The multi-layer lens stack has a first optical power in the first mode and a second optical power, different from the first optical power, in the second mode.

Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer or infectious disease or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with a preferred embodiment of a bispecific antibody against TIM-3 and CD3.

Abstract: The invention provides a positive/negative phase shift bimetallic zone plate and production method thereof, wherein the positive/negative phase shift bimetallic zone plate comprises: a first metallic material having a positive phase shift; a second metallic material having a negative phase shift at a working energy point; wherein the first metallic material and the second metallic material are alternately arranged, so that the second metallic material replaces the blank portion in a cycle of a traditional zone plate.

Abstract: Systems and methods are described that relate to an optical system including an image sensor optically-coupled to at least one nanophotonic element. The image sensor may include a plurality of superpixels. Each respective superpixel of the plurality of superpixels may include at least a respective first pixel and a respective second pixel. The at least one nanophotonic element may have an optical phase transfer function and may include a two-dimensional arrangement of sub-wavelength regions of a first material interspersed within a second material, the first material having a first index of refraction and the second material having a second index of refraction. The nanophotonic element is configured to direct light toward individual superpixels in the plurality of superpixels, and to direct light toward the first or second pixel in each individual superpixel based on a wavelength dependence or a polarization dependence of the optical phase transfer function.

Abstract: A polyamide/hybrid carbon filler composite is disclosed. The composite includes a polyamide as a matrix and a hybrid carbon filler dispersed in and bonded to the polyamide matrix. The hybrid carbon filler is composed of a nano carbon and a carbon fiber. Also disclosed is a method for preparing the polyamide/hybrid carbon filler. The method includes simultaneously subjecting a mixture of a polyamide and a hybrid carbon filler to mechanofusion and plasma treatments.

Abstract: A luminaire comprising a base, a circuitry housing attached to the base and comprising circuitry, a first rotational structure attached to the circuitry housing, a second rotational structure attached to the first rotational structure, and a lighting apparatus attached to the second rotational structure. The circuitry is positioned in electrical communication with each of the base and the lighting apparatus. The first rotational structure is attached to the circuitry housing so as to rotate about a first rotational axis that is parallel to a longitudinal axis of the luminaire. The second rotational structure is attached to the first rotational structure so as to rotate about a second rotational axis that is parallel to a transverse axis of the luminaire.

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.

Abstract: Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest.

Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

Abstract: The plate pulsating heat spreader according to the present disclosure may lower the degree of superheat to thereby allow nucleation to easily occur by including the cavities, thereby preventing a sudden temperature rise of an evaporator and having improved thermal performance. The pulsating heat spreader includes fluid channels and cavities.

Abstract: An implant includes an anterior plate defining a first end of the implant and a posterior plate defining a second end of the implant opposite the first end of the implant. The implant also includes a central support portion extending between the anterior plate and the posterior plate. The implant further includes a side wall extending between the anterior plate and the posterior plate and defining a portion of the outside perimeter of the implant; a first exterior arced member disposed proximate the side wall and the posterior plate; and a first interior arced member is disposed proximate the central support member and the posterior plate. The exterior arced member and the interior arced member curve in a superior direction such that portions of the exterior and interior arced members form portions of a bone contacting superior surface of the implant.

Abstract: Antenna systems and related methods are disclosed. An antenna system includes an antenna controller configured to operably couple to control inputs of an antenna including an array of electromagnetic (EM) scattering elements. A method includes controlling an array of EM scattering elements to operate according to holographic modulation patterns, and modulating at least one effective EM property of the antenna over space, time, or a combination thereof to, in the average and/or the aggregate, cause side lobes of an antenna gain of the antenna to be reduced.

Abstract: The present invention provides a method for the functionalization of a polymeric surface with a protein by physical adsorption. The method enables a membrane spanning protein to be used as an anchor for proteins and/or peptides for display. Also provided are polymeric substrates for protein or peptide display, and related kits and methods of use.

Abstract: A walk assist robot for lower body walking of a walking trainee, including a joint angle signal measurement unit disposed on a joint of the walking trainee, an electromyogram (EMG) signal measurement unit disposed on a muscle related to ankle joint extension of the walking trainee, a plantar pressure signal measurement unit disposed on a sole of the walking trainee, and a control unit to recognize signals measured from the joint angle signal measurement unit, the EMG signal measurement unit and the plantar pressure signal measurement unit and process the signals to recognize a walking speed intention of the walking trainee, wherein the control unit controls a walking speed of the walk assist robot from the walking speed intention of the walking trainee.

Abstract: Disclosed is a system for controlling acoustic radiation from an aircraft. The system comprising a plurality of rotor systems (one or more) and a noise controller configured to regulate acoustic radiation from the plurality of rotor systems. The noise controller can be configured to regulate a commanded flight setting from the flight control system and to output a regulated flight setting to the plurality of rotor systems. Based on the regulated flight setting, the plurality of rotor systems are configured to generate, individually and in aggregate, acoustic radiation having a target acoustic behavior. The target acoustic behavior may be achieved using beamforming techniques to, for example, change the directionality of acoustic radiation from the plurality of rotor systems, or otherwise tune the acoustic radiation to reduce detectability and/or annoyance.

Abstract: Methods, systems, and media for review content traffic are provided. In accordance with some embodiments of the present invention, a method, implemented on a processor, for reviewing advertisement placement on webpages is provided.

Abstract: An operation method of a controller includes: generating a predetermined number of sub-messages by dividing an original message; generating a first parity added message by adding a cyclic redundancy check (CRC) parity message of a predetermined length to each of the sub-messages; and generating an encoded message by performing a polar encoding operation to the first parity added message.

Abstract: A method for registering a tooth image with a tooth structure according to an embodiment includes a first registering step for registering a tooth image model obtained from a medical image taken when an object bites a bite including a marker with a bite scanning model obtained by scanning the bite, a second registering step for registering the bite scanning model with a tooth scanning model obtained by scanning a tooth shape of the object, and a third registering step for registering the tooth image model with the tooth scanning model based on the results of the first registering step and the results of the second registering step. As a result, a model including an accurate shape of tooth part difficult to obtain from a medical imaging apparatus can be easily obtained.

Abstract: The present disclosure relates to a method for separating sugars and acids with reduced energy consumption, including a step of diffusively dialyzing a first acid hydrolysate obtained by saccharifying biomass with an acid solution, thereby preparing a second acid hydrolysate wherein the concentration of the acid solution contained in the acid hydrolysate is decreased; and a step of electrolyzing the second acid hydrolysate, thereby separating sugars from the acid solution, which is advantageous in that less energy is consumed, the separated acid solution can be recycled directly without further treatment due to high concentration and loss of sugars can be minimized.