Abstract: The present description relates to an emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to such an emulsion for use as an improving agent in ultrasound ablation surgery (FIG. 3).
Type:
Application
Filed:
June 14, 2019
Publication date:
August 19, 2021
Applicants:
AVIGNON UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, SORBONNE UNIVERSITE, UNIVERSITE DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventors:
Christiane Contino-Pepin, Stéphane Desgranges, Nicolas Taulier
Abstract: Method for increasing the ability of at least one droplet to slide over a medium. An ultrasonic surface wave is generated in the medium with a sufficient amplitude to cause the droplet to deform in an inertio-capillary eigen-vibration mode, thus decreasing the attachment of the droplet to the medium, so as to make it easier for the droplet to move under the effect of an external force, the amplitude of the ultrasonic surface wave being insufficient to cause the droplet to deform asymmetrically to the point that it moves in the absence of the external force in the direction of propagation of the ultrasonic surface wave.
Type:
Grant
Filed:
December 6, 2016
Date of Patent:
August 17, 2021
Assignees:
UNIVERSITÉ DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE LILLE
Inventors:
Adrien Bussonniere, Olivier Bou Matar-Lacaze, Michaël Baudoin, Philippe Brunet
Abstract: The present invention relates to a polyvalent culture medium for anaerobic bacteria under aerobic conditions in blood culture bottles. The present invention provides a polyvalent culture medium for culture in aerobic atmosphere of anaerobic bacteria or aerobic bacteria comprising a basal culture medium for bacteria characterized in that it further comprises a mixture of the following antioxidant compounds: sodium hydrosulphide (Na2S), L-cysteine, ascorbic acid, glutathione, catalase, ubiquinol and lipoic acid.
Type:
Grant
Filed:
August 1, 2018
Date of Patent:
August 17, 2021
Assignees:
FONDATION MEDITERRANEE INFECTION FACULTÉ DE MÉDECINE, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Inventors:
Didier Raoult, Saber Khelaifia, Marion Bonnet
Abstract: A rigid foam or composition allowing a rigid foam to be obtained made from polyurethane and/or polyisocyanurate. The rigid foam or composition includes polyols selected from polyester polyols and polyether polyols; the polyols include: 5 to 50% of a polyester polyol A by weight relative to the total weight of the polyols; and a polyol B selected from polyester polyols B and polyether polyols B. The polyester polyol A is of general formula Rx-Ry-Z-Ry?-Rx? in which Z is a C3 to C8 alcohol sugar chosen from glycerol, sorbitol, erythritol, xylitol, araditol, ribitol, dulcitol, mannitol and volemitol. Ry and Ry? are diesters of formula —OOC—Cn-COO— in which n is between 2 and 34, and Rx and Rx? are identical or different C2 to C12 monoalcohols.
Type:
Application
Filed:
January 22, 2019
Publication date:
August 12, 2021
Applicants:
TEREOS STARCH & SWEETENERS BELGIUM, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SOPREMA, UNIVERSITÉ DE STRASBOURG
Inventors:
Pierre Etienne BINDSCHENDLER, Alexandru SARBU, Rémi PERRIN, Pierre FURTWENGLER, Luc AVÉROUS, Andréas REDL
Abstract: The present invention relates to mutated factor (FX) polypeptides and uses thereof for the treatment of haemophilia. In particular, the present invention relates to a mutated factor X (FX) polypeptide which comprises a heavy chain wherein at least one amino acid residue at position 401 or 408 is mutated.
Type:
Grant
Filed:
April 13, 2020
Date of Patent:
August 10, 2021
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITA DI PERUGIA, AMERICAN UNIVERSITY OF BEIRUT, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
Inventors:
Olivier Christophe, Cecile Denis, Peter Lenting
Abstract: A method for producing at least one type of nanostructures comprises the following steps: partially covering a surface of a single-crystal layer or multilayer structure with a discontinuous mask, forming discrete islets having at least one submicrometric lateral dimension and made of a material having an evaporation temperature above that of the layer or multilayer structure; and heating the layer or multilayer structure under vacuum to a so-called etching temperature, above the evaporation temperature of the layer or multilayer structure but below that of the mask, so as to cause evaporation of the layer or multilayer structure outside of the regions covered by the mask. Structures that may be produced by such a method are also provided.
Type:
Grant
Filed:
June 3, 2016
Date of Patent:
August 10, 2021
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Stéphane Vezian, Benjamin Damilano, Julien Brault
Abstract: The invention relates to a method for the non-destructive testing of a mechanical part (2) by propagation of ultrasonic waves accomplished by means of a multi-element transducer (3) placed opposite the mechanical part and comprising a plurality of piezoelectric elements e(1), e(2), . . . , e(N), N>1. It comprises: for each element e(i) of the transducer, the emission of an ultrasonic wave at a given frequency and measurement, by each element e(j) distinct from the element e(i), of a time-varying signal kij(t) representing the back-scattered ultrasonic wave received by the element e(j); the determination of a first matrix of time-varying components based on the measured signals kij(t), i,j=1, . . .
Type:
Application
Filed:
April 19, 2019
Publication date:
August 5, 2021
Applicants:
SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: Some embodiments are directed to an elementary acoustic metamaterial cell, including a body made of solid material and at least one resonator defining a groove of width l and depth p, the groove being open on the surface of the body, wherein the depth p is set by a resonant frequency (f) of the cell according to a relationship x, c being the speed of sound in air and the width l is set by an energy density confined in the cell according to a logarithmic relationship Emax ?log (l) determined experimentally, the groove having an acoustic absorption controlled by a ratio between the depth p and the width l of the groove. Some embodiments are also directed to an acoustic screen including such an elementary cell.
Type:
Grant
Filed:
December 2, 2016
Date of Patent:
August 3, 2021
Assignees:
UNIVERSITÉ DE FRANCHE-COMTÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Abdelkrim Khelif, Mahmoud Addouche, Aliyasin El Ayouch
Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.
Type:
Grant
Filed:
January 4, 2018
Date of Patent:
August 3, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ETABLISSEMENT FRANCAIS DU SANG
Inventors:
François Morvan, Albert Meyer, Jean-Jacques Vasseur, Julie Mayen, Carole Chaix, Carole Farre, Chantal Fournier-Wirth, Jean-François Cantaloube, Myriam Lereau
Abstract: The invention relates to a method for determining active concentrations of an analyte and optionally kinetic constants for the interaction of the analyte with a ligand in complex biological samples by means of surface plasmon resonance comprising the use of an auto-blank.
Type:
Grant
Filed:
March 28, 2017
Date of Patent:
August 3, 2021
Assignees:
UNIVERSITÉ DE BORDEAUX, CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Inventors:
Jonathan Visentin, Carmelo Di Primo, Jean-Luc Taupin
Abstract: The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.
Type:
Grant
Filed:
July 6, 2018
Date of Patent:
August 3, 2021
Assignees:
Centre National d'Etudes Spatiales, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITY
Abstract: Disclosed is a method for pattern recognition in a plurality of received time signals of different types, the method includes: b) for each received signal, creating an asynchronous time signal including events; c) for each created asynchronous signal, creating an activity profile of the asynchronous signal which decreases as a function of the time elapsed since the last event of the asynchronous signal; d) for a given time t0: d1) determining a context defined as the set of activity profiles of the created asynchronous signals, d2) determining a standard context among predetermined standard contexts, having a minimum distance to the context determined in step d1, d3) determining the pattern as a function of the determined standard context.
Type:
Grant
Filed:
September 8, 2017
Date of Patent:
August 3, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Inventors:
Kevin Gehere, Germain Haessig, Ryad Benosman, Sio Hoi Ieng, José-Alain Sahel, Guillaume Chenegros, Nicolas Libert
Abstract: An optical fibre for an ultrafast laser endoscope including at least the following structures: a hollow core, the periphery of which has an order of symmetry of at least six when considering axes of symmetry passing through the centre of the core and through the centre of convex shapes, seen from the centre of the core, the convex shapes at least partly making up the periphery of the core; an intermediate layer of cellular structure surrounding the core; a light conducting peripheral structure surrounding the intermediate layer of cellular structure; and an outer sheath surrounding the light-conducting peripheral structure. A particular advantage of the optical fibre is that it optimizes the emission of a high-power flux associated with fluorescence collection.
Type:
Grant
Filed:
July 11, 2018
Date of Patent:
August 3, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LIMOGES
Abstract: The invention relates to a method for treating a silicate-type glass comprising alkali and alkaline-earth metal oxides or d10 or IIIA metal oxides, said method comprising at least the following steps: (a) incorporation of nitrogen into the surface of the glass; and (b) thermal poling treatment of the material obtained in (a), under a chemically inert controlled atmosphere. The invention also relates to the material produced by said method.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
August 3, 2021
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Maxime Paraillous, Thierry Cardinal, Angeline Poulon, Evelyne Fargin, Marc Dussauze
Abstract: The invention relates to novel glycosidase substrates of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R?9, V, X, Y and Z are as defined in claim 1, and a method for detecting the presence of a catalytically active glycosidase by means of one of said substrates.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
August 3, 2021
Assignees:
ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute myeloid leukemia. In particular, the present invention relates to a method for treating NPM-1-driven acute myeloid leukemia (AML) in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one arsenic compound and with a therapeutically effective amount of at least one retinoid.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
August 3, 2021
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITA DI PERUGIA, AMERICAN UNIVERSITY OF BEIRUT, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
Inventors:
Hugues De The, Ali Bazarbachi, Hiba El Hajj, Maria Paula Martelli, Brunangelo Falini
Abstract: The invention relates to a method for increasing the yield and biomass of a plant, by means of an increase in the expression of the L-aspartate oxidase in the plant. The method according to the invention allows an increase in the photosynthetic capacities of the plants as a result of an increase in the quantities of NAO and the derivatives thereof in said plants. The invention relates to the plants produced by such a method.
Type:
Application
Filed:
April 14, 2021
Publication date:
July 29, 2021
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD
Abstract: The present disclosure relates to a stable copper-based core-shell nanoparticle and its process of manufacture. Further, the present disclosure relates to the use of the copper-based core-shell nanoparticles as plasmonic photocatalysts in photocalysis and hydrogen production.
Type:
Application
Filed:
December 21, 2020
Publication date:
July 29, 2021
Applicant:
INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE