Abstract: The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.
Type:
Application
Filed:
April 26, 2019
Publication date:
July 29, 2021
Applicants:
UNIVERSITE PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Abstract: Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.
Type:
Grant
Filed:
December 23, 2016
Date of Patent:
July 27, 2021
Assignees:
SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Abstract: The subject matter of the present invention is a microfluidic process for treating and analysing a solution containing a biological material, comprising a step of introducing the solution into microchannels of a microfluidic circuit (1), a step of forming drops of this solution, under the effect of modifications of the surface tension of the solution, a step of moving the drops to one or more drop storage zones(s) (130), under the effect of modifications of the surface tension of the drops, a step of treating the drops and a step of analysing the drops.
Type:
Grant
Filed:
December 9, 2019
Date of Patent:
July 20, 2021
Assignees:
ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RESCHERCHE SCIENTIFIQUE
Inventors:
Charles Baroud, Remi Dangla, Paul Abbyad, Silvan Turkcan
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of systemic mastocytosis. The inventors showed the effect of KPT-251 treatment on SCF-dependent human Mast cell (MC) line without KIT mutation (WT ROSA) and on two factor-independent MC lines with KIT mutations : ROSA ? 417-419 insY and ROSA D816V. KPT is a Selective Inhibitor of Nuclear Export (SINE) that specifically inhibits the activity of the exportin-1 (XPO1). KPT-251 treatment induces minimal toxicity in non-cancerous hematopoietic cells both in vitro and in vivo. In particular, the present invention relates a method of treating systemic mastocytosis in patient in need thereof comprising administering to the patient a therapeutically effective amount of a XPO1 inhibitor.
Type:
Grant
Filed:
September 15, 2017
Date of Patent:
July 20, 2021
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN NORMANDIE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE CAEN
Abstract: Ionically conductive materials that can be used in electrochemical generators. A new ionically conductive material usable in an electrochemical generator, for example in separators, solid polymer electrolytes or electrodes, has good mechanical properties and good ionic conductivity and is able to prevent dendritic growth in lithium batteries. The material comprises at least one polymer A, different from B, having an ionic conductivity of between 10?5 and 10?3 S/cm, at least one polymer B having mechanical strength characterised by a storage modulus ?200 MPa and at least one reinforcing filler C.
Type:
Grant
Filed:
July 12, 2017
Date of Patent:
July 20, 2021
Assignees:
INSTITUT POLYTECHNIQUE DE GRENOBLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
Abstract: The present invention relates to inhibitors of gangliosides metabolism for treating motor neuron diseases, in particular hereditary spastic paraplegias.
Type:
Grant
Filed:
November 3, 2017
Date of Patent:
July 20, 2021
Assignees:
ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), ÉCOLE PRATIQUE DES HAUTES ÉTUDES
Inventors:
Frédéric Darios, Giovanni Stevanin, Fanny Mochel, Julien Branchu, Maxime Boutry
Abstract: The present Inventors demonstrated that the RelB subunit of NF?B plays a crucial role in promoting cell migration. More precisely, they identified that this pro-migratory activity is mediated by the activation of the NF?B pathway through RelB phosphorylation at serine 472. In a first aspect, the present invention proposes to monitor the activation of the NF?B pathway by following the phosphorylation status of said serine. Also, the present invention discloses methods and kits for prognosing the evolution of a disease involving cell migration in a subject—treated or not—suffering thereof, based on the detection of said RelB-S472 phosphorylation.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
July 20, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DESCARTES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Abstract: Micropeptides (miPEPs), or peptides coded by microRNAs, for promoting nodulation between a plant and a bacterium, as well as their use in this manner.
Type:
Application
Filed:
March 25, 2021
Publication date:
July 15, 2021
Applicants:
UNIVERSITE TOULOUSE III-PAUL SABATIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: A nanostructure transfer method is provided. The method includes providing a first substrate (10) having thereon a plurality of nanostructures (12), the nanostructures (12) extending away from the first substrate (10). A solder material (14) is deposited on distal ends of the nanostructures (12). A second substrate (18) having thereon a first metal layer (20) is provided. The solder material (14) is bonded to the first metal layer (20), thereby attaching the nanostructures (12) to the second substrate (18). The attached nanostructures (12) are then released from the first substrate (10).
Type:
Application
Filed:
August 29, 2019
Publication date:
July 15, 2021
Applicants:
THALES SOLUTIONS ASIA PTE LTD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, NANYANG TECHNOLOGICAL UNIVERSITY, UNIVERSITÉ DE LILLE
Inventors:
Jianxiong Wang, Philippe Coquet, Beng Kang Tay
Abstract: The invention relates to a nickel-based superalloy comprising, in percentages by mass, 5.0 to 6.0% aluminum, 6.0 to 9.5% tantalum, 0 to 1.50% titanium, 8.0 to 10.0% cobalt, 6.0 to 7.0% chromium, 0.30 to 0.90% molybdenum, 5.5 to 6.5% tungsten, 0 to 2.50% rhenium, 0.05 to 0.15% hafnium, 0.70 to 4.30% platinum, 0 to 0.15% silicon, the remainder being nickel and unavoidable impurities. The invention also relates to a single-crystal blade comprising such an alloy and a turbomachine comprising such a blade.
Type:
Application
Filed:
June 4, 2019
Publication date:
July 15, 2021
Applicants:
SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS, ECOLE NATIONALE SUPERIEURE DE MECANIQUE AEROTECHNIQUE
Abstract: An elementary antenna includes a planar radiating device comprising a substantially flat radiating element having a center and a plane defined by (i) a straight line passing through the center and (ii) another straight line perpendicular to the straight line and passing through the center, the radiating element comprising pairs of excitation points arranged in a quadruplet of excitation points located at a distance from the lines, comprising a first pair of excitation points arranged substantially symmetrically in relation to the straight line and a second pair of excitation points arranged substantially symmetrically in relation to the other line, the elementary antenna comprising processing to supply differential excitation signals for (i) exciting the excitation points and/or (ii) shaping signals emitted from the excitation points.
Type:
Grant
Filed:
February 1, 2018
Date of Patent:
July 13, 2021
Assignees:
THALES, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Patrick Garrec, Anthony Ghiotto, Gwenaël Morvan
Abstract: The invention relates to an ion thruster, comprising: a chamber, a reservoir, comprising a solid propellant (PS), housed in the chamber and comprising a conductive jacket provided with an orifice; means for forming an ion-electron plasma in the chamber, which means are able to sublime the solid propellant in the reservoir, then to generate said plasma in the chamber from the sublimed propellant coming from the reservoir through the orifice; a means for extracting and accelerating the ions and electrons of the plasma out of the chamber, which means comprises at least two grids at one end (E) of the chamber; a radiofrequency AC voltage source for generating a radiofrequency signal comprised between the plasma frequencies of the ions and of the electrons, arranged in series with a capacitor and connected, by one of its outputs and via this capacitor, to one of the grids, with the other grid being connected to the other output of said voltage source; said means for extracting and accelerating and said voltage
Type:
Grant
Filed:
August 30, 2016
Date of Patent:
July 13, 2021
Assignees:
ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: An optically transparent electromagnetic shield assembly comprising an electrical connection device with variable electrical resistance. The electrical connection device electrically connects a conductive two-dimensional structure, which covers a transparent substrate, to a shell portion which is electrically conductive. The resistance of the connection device can be adjusted, either initially for a detection system for which the shield assembly is intended or in real time while the shield assembly is in use, according to an RF radiation intensity.
Type:
Grant
Filed:
May 15, 2018
Date of Patent:
July 13, 2021
Assignees:
SAFRAN ELECTRONICS & DEFENSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE DE RENNES 1
Abstract: The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats.
Type:
Application
Filed:
February 10, 2021
Publication date:
July 8, 2021
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE NANTES, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
Inventors:
Mathieu MEVEL, David DENIAUD, Eduard AYUSO
Abstract: The present invention relates to the use of a nucleic acid molecule encoding a first reporter gene, bordered by at least one first pair and one second pair of sequences targeting a site-specific recombinase in order to detect cells of a mammal infected with a virus responsible for an immunodeficiency.
Type:
Grant
Filed:
December 17, 2015
Date of Patent:
July 6, 2021
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Abstract: A method includes placing a fluid guide forming composition in contact with the optical source and with the optical fiber, injecting a first light in the guide forming composition from the optical source and/or from the optical fiber, to harden a central region of the optical guide, illuminating the guide forming composition with the second light to harden a peripheral region of the optical guide by photopolymerization initiated by the second photoinitiator system. The difference between the first peak wavelength and the second peak wavelength being more than 100 nm.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
July 6, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE HAUTE ALSACE, UNIVERSITE PAUL SABATIER TOULOUSE III
Abstract: Some embodiments are directed to the design and manufacture of integrated circuits, and more particularly, some embodiments are directed to the electrical modeling of integrated circuits combining high voltage power devices with low voltage control logic blocks, and even more particularly, some embodiments are directed to the modeling of substrate coupling effects in these circuits.
Type:
Grant
Filed:
June 24, 2016
Date of Patent:
July 6, 2021
Assignees:
SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The application concerns a method of authenticating an object, the object comprising an identification substance including at least one amorphous phase, at least one crystalline phase and at least one complex metallic phase. The method includes the steps of: subjecting the identification substance of a candidate object to XRD analysis to determine an XRD signature thereof; comparing the XRD signature of the candidate object to a reference XRD signature, and concluding to the authenticity of the object when its XRD signature substantially matches the reference XRD signature.
Type:
Grant
Filed:
July 11, 2018
Date of Patent:
July 6, 2021
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: A method for reconstructing a colour image acquired by a photosensitive sensor covered with a mosaic of filters of different colours making up a base pattern, obtaining the product of a demosaicing matrix with a matrix representation of a mosaic image coming from the sensor following acquisition of the colour image by the sensor, the product of the demosaicing matrix with the matrix representation of the mosaic image performing an interpolation of the colour of each pixel of the mosaic image as a function of a pixel neighbourhood of a base pattern corresponding to the base pattern of the mosaic of filters.
Type:
Grant
Filed:
February 20, 2019
Date of Patent:
July 6, 2021
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: A unit (1?, 10?, 100?) for generating non-propulsive electrical power for use on board an aircraft, the unit (1?, 10?, 100?) comprising an electricity production device (3, 30) comprising a gas turbine (31) and an electricity generator (32) mechanically connected to an outlet shaft (33) of the gas turbine (31), said electricity generator (32) including output electrical connections (320) for being electrically connected to an electrical power supply network (2, 20, 200) on board an aircraft. The unit (1?, 10?, 100?) includes energy storage means (5) and regulator means (6) configured to control the speed of rotation of the gas turbine (31) as a function of the electrical power required by the on-board electrical power supply network (2, 20, 200).
Type:
Grant
Filed:
December 15, 2017
Date of Patent:
July 6, 2021
Assignees:
SAFRAN POWER UNITS, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Stephane Richard Dominique Vaillant, Mickael Faucher, Christophe Turpin