Patents Assigned to SCIENTIFIQUE (CNRS)
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Publication number: 20210164126Abstract: A process for obtaining a nitride (N) layer preferably obtained from at least one of gallium (Ga), indium (In) and aluminium (Al), may include: on a stack including a substrate and at least the following layers successively disposed from the substrate: a creep layer having a glass transition temperature, Tglass transition, and a crystalline layer, forming pads by etching the stack so that each pad includes at least a creep segment formed by at least a portion of the creep layer, and a crystalline segment formed by the crystalline layer; and growing by epitaxy a crystallite on each of the pads and continuing the epitaxial growth of the crystallites so as to form the nitride layer. The epitaxial growth may be carried out at a temperature Tepitaxy, such that Tepitaxy?k1×Tglass transition, with k1 being 0.8.Type: ApplicationFiled: December 24, 2018Publication date: June 3, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Guy FEUILLET, Blandine ALLOING, Virginie BRANDLI, Benoit MATHIEU, Jesus ZUNIGA PEREZ
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Publication number: 20210163671Abstract: Method for preparing a compound having an alkoxysilyl group of formula (I), wherein X represents —O— or —NR4— with R4?H or C1-C4alkyl; R1 is a radical having from 1 to 20 carbon atoms; R2 and R3 are a C1-C4 alkyl radical; p is an integer equal to 0, 1 or 2; comprising a cross metathesis reaction in the presence (i) of a compound having a group of acrylate type and of formula: —X(C?O)—CH?CH2, (ii) of an ?-olefinic silane of formula (II): and (iii) of a metathesis catalyst chosen from GRUBBS catalysts and 2nd generation HOVEYDA-GRUBBS (HG2) catalysts. 2) Compound having said alkoxysilyl group, obtained by the method 1).Type: ApplicationFiled: July 19, 2019Publication date: June 3, 2021Applicants: BOSTIK SA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1Inventors: Frederic SIMON, Stephane FOUQUAY, Guillaume MICHAUD, Cyril CHAUVEAU, Jean-Francois CARPENTIER, Sophie GUILLAUME
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Publication number: 20210163974Abstract: The present invention relates generally to the field of plant molecular biology and relates to plants having a modified lipid metabolism and to methods for making such modified plants. In particular, the invention provides modified plants and parts thereof, including seeds, having an increased level of triacylglycerol (TAG), by means of a seed-specific expression in seed tissues during seed filling of a nucleic acid encoding a translocator protein (TSPO) in said modified plants or parts thereof. The invention further relates to methods for modulating lipid metabolism in plants and for producing plants with a modified lipid metabolism. The invention also provides constructs, vectors and host cells useful in the methods of the invention, and further relates to products obtained from the modified plants.Type: ApplicationFiled: August 24, 2018Publication date: June 3, 2021Applicants: UNIVERSITÉ CATHOLIQUE DE LOUVAIN, UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Henri BATOKO, Patrick MOREAU
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Patent number: 11020473Abstract: The invention is in the field of prevention or treatment of diseases, in particular infectious diseases, and more particularly in the field of multivalent vaccines. The inventors characterized 5? copy-back DI-RNAs produced by recombinant MV strains, including rMV-based vaccines and wild-type MV (wt-MV). The efficiency of these DI-RNAs productions in different cell types was compared. For the first time 5? copy-back DI-RNAs specific binding to RIG-I, MDA5 and LGP2 was assessed and linked to functional outcome in type-I IFN signalling. The inventors provide a composition of products comprising at least (i) a mixture of particles of a rescued recombinant MV-derived virus encoding at least one antigen (ii) a recombinant and/or purified protein, comprising at least one antigen. Regardless of the presentation of the products, and in particular regardless of whether the products are separated or readily separable or presented as a mixture.Type: GrantFiled: June 23, 2017Date of Patent: June 1, 2021Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MINISTÈRE DES ARMÉES—Direction Centrale du Service de Sante des ArméeInventors: Frederic Tangy, Anastassia Komarova, Marie Mura, Chantal Combredet
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Patent number: 11023628Abstract: The present invention relates to a method of simulating the operation of an electronic circuit modelled by a numerical model comprising successive steps consisting in updating parameters of the model, periodically, at variable or constant simulated time step, when the battery is in a state of non-linear operation, and at each change of state of operation of one of the functional electronic components, when the battery is in a state of quasi-linear operation.Type: GrantFiled: July 7, 2016Date of Patent: June 1, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITEInventors: Wilfried Dron, Khalil Hachicha, Patrick Garda
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Patent number: 11021496Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.Type: GrantFiled: January 18, 2017Date of Patent: June 1, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, NANOMEDSYNInventors: Jean Olivier Durand, Jimenez Chiara Mauriello, Sebastien Richeter, Laurence Raehm, Magali Gary-Bobo, Marcel Garcia, Marie Maynadier
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Publication number: 20210156884Abstract: The invention relates to the field of localized surface analysis, characterization and modification by electrochemistry. It particularly relates to a portable electrochemical microscopy device, to kits comprising such a portable device, and to uses of the portable device and kits. According to the invention, the portable device comprises: a body having a gripping surface for a user and a bearing surface that can be applied to a surface of a substrate to be analyzed; an electrolytic chamber formed in the body and arranged so as to receive an electrolyte, the electrolytic chamber comprising an opening leading to the bearing surface; and a working probe having a distal end arranged in the electrolytic chamber.Type: ApplicationFiled: July 5, 2019Publication date: May 27, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, PROTEC INDUSTRIEInventors: Gaëlle CHARRIER, Aurélien DOUBLET, Guy DENIAU, Renaud CORNUT
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Publication number: 20210154514Abstract: A method for destructing and valorizing an asbestos waste including the steps of: determining the asbestos mineralogical group contained in the waste, performing a treatment on the waste which includes of: an acid treatment when the waste comprises only a chrysotile, a base treatment when the waste comprises only an amphibole, the acid treatment followed by the base treatment when the asbestos waste includes a mixture of a chrysotile and an amphibole, and valorizing at least one of the products obtained on completion of the performing of the treatment. An embodiment also concerns a treatment of a chrysotile waste through an acid treatment followed by a thermal treatment.Type: ApplicationFiled: August 21, 2018Publication date: May 27, 2021Applicants: Université de Montpellier, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ENSCM - ECOLE NATIONALE SUPERIEURE DE CHIMIEInventors: Gaël TALBI, Olivier CAMBON, Martine CAMBON
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Publication number: 20210159348Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.Type: ApplicationFiled: January 19, 2021Publication date: May 27, 2021Applicants: SAFRAN ELECTRONICS & DEFENSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE RENNES 1Inventors: Cyril DUPEYRAT, Patrice FOUTREL, Philippe BESNIER, Xavier CASTEL, Yonathan CORREDORES
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Publication number: 20210153485Abstract: A transgenic non-human animal model for Neurofibromatosis type 1, wherein the Nf1 gene is specifically inactivated in BC cells and derivatives thereof. Also, an in vitro method of producing cutaneous and plexiform Neurofibromas (NFBs) and/or for studying the development and composition of plexiform NFBs, including culturing in vitro Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model. Further, a method for screening a candidate compound for use as a drug to treat Neurofibromatosis type 1, cutaneous NFBs and/or plexiform NFBs including contacting the candidate compound Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model or administering the candidate compound to the transgenic non-human animal model.Type: ApplicationFiled: June 29, 2018Publication date: May 27, 2021Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Piotr TOPILKO, Patrick CHARNAY, Fanny COULPIER, Aurélie GRESSET, Katarzyna RADOMSKA
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Patent number: 11014918Abstract: The present disclosure is generally directed to the manufacture and use of compounds described herein for preventing, inhibiting or treating cancer, AIDS and/or premature aging, or the manufacture and use of a pharmaceutical composition comprising at least one of the compounds, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier for preventing, inhibiting or treating cancer, AIDS and/or premature aging.Type: GrantFiled: February 11, 2020Date of Patent: May 25, 2021Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIERInventors: Jamal Tazi, Florence Mahuteau, Romain Najman, Didier Scherrer, Julien Santo
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Patent number: 11014856Abstract: A process for manufacturing a composite material part including a particulate reinforcement densified by a ceramic matrix, the process including: formation of a blank of the part to be manufactured by shaping a mixture including a binder, first ceramic or carbon particles intended to form the particulate reinforcement of the part and second ceramic or carbon particles distinct from the first particles, removal or pyrolysis of the binder present in the blank to obtain a porous preform of the part to be manufactured, and infiltration of the porosity of the preform by a molten composition including a metal in order to obtain the part.Type: GrantFiled: December 20, 2018Date of Patent: May 25, 2021Assignees: SAFRAN CERAMICS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUXInventors: Arnaud Delehouze, Eric Bouillon, Yann Lepetitcorps
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Patent number: 11017526Abstract: A method for performing real-time detection and displaying of polyps in optical colonoscopy, includes a) acquiring and displaying a plurality of real-time images within colon regions to a video stream frame rate, each real-time image comprising a plurality of color channels; b) selecting one single color channel per real-time image for obtaining single color pixels; c) scanning the single color pixels across each the real-time image with a sliding sub-window; d) for each position of the sliding sub-window, extracting a plurality of single color pixels local features of the real-time image; e) passing the extracted single color pixels local features of the real-time image through a classifier to determine if a polyp is present within the sliding sub-window; f) real-time framing on display of colon regions corresponding to positions of the sliding sub-window wherein polyps are detected. A system for carrying out such a method is also provided.Type: GrantFiled: June 19, 2017Date of Patent: May 25, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CERGY PONTOISE, ECOLE NAT SUP ELECTRONIQUE APPLICATION, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITEInventors: Quentin Angermann, Xavier Dray, Olivier Romain, Aymeric Histace
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Patent number: 11014871Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.Type: GrantFiled: January 5, 2017Date of Patent: May 25, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUDInventors: Mouâd Alami, Abdallah Hamze, Jean-Daniel Brion, Jérôme Bignon, Joëlle Dubois
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Publication number: 20210147899Abstract: Method for determining the sensitivity of a bacterial strain of interest to a viral strain of bacteriophages, the method comprising: a) preparing a sample, this comprising bringing bacteria, belonging to the bacterial strain of interest, into contact with bacteriophages, each bacteriophage belonging to the same viral strain, the bacteria being either in a liquid medium, or in an agar medium; b) placing the sample between a light source and an image sensor, the light source emitting a light wave in an emission spectral band comprised between 500 nm and 600 nm; c) illuminating the sample using the light source and acquiring at least one image of the sample, with the image sensor, in the emission spectral band, no image-forming optic being placed between the sample and the image sensor; d) on the basis of the acquired images, determining a sensitivity of the bacterial strain of interest to the viral strain.Type: ApplicationFiled: November 13, 2020Publication date: May 20, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPESInventors: Prisca PERLEMOINE, Thomas BORDY, Pierre MARCOUX, Emmanuel PICARD, Rémi TOUTAIN, Marc ZELSMANN, Alexis MAIRE
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Publication number: 20210151846Abstract: This microwave component (10) comprises a waveguide (12) comprising an upper layer, a lower layer, and a central layer (18) intermediate between the upper layer and the lower layer, said layers defining a zone (19) of propagation of an electromagnetic wave, the propagation zone (19) extending along a propagation axis, and comprising a cavity (32) bounded by the upper layer, the lower layer, and, laterally, by two opposite lateral edges (36) of the central layer (18). The waveguide (12) comprises at least one dielectric strip (28) placed in the propagation zone (19), the dielectric strip (28) being defined in one of the upper layer and the lower layer or being placed in the cavity (32) away from the lateral edges (36) of the cavity (32).Type: ApplicationFiled: December 5, 2018Publication date: May 20, 2021Applicants: UNIVERSITÉ DE BORDEAUX, CENTRE NATIONAL D'ETUDES SPATIALES, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Anthony GHIOTTO, Frédéric PARMENT
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Patent number: 11006620Abstract: The invention concerns a gallinacean embryo in which cancer cells have been grafted within the embryo tissue, characterised in that the embryo is at a developmental stage between the HH10 and HH25 stages at the time of the grafting, wherein said cancer cells are not neuroblastoma cells and said cells form tumors inside the embryo.Type: GrantFiled: December 15, 2016Date of Patent: May 18, 2021Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Valerie Castellani-Lincontang, Celine Delloye-Bourgeois
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Patent number: 11008582Abstract: The invention relates to a method for increasing the yield and biomass of a plant, by means of an increase in the expression of the L-aspartate oxidase in the plant. The method according to the invention allows an increase in the photosynthetic capacities of the plants as a result of an increase in the quantities of NAD and the derivatives thereof in said plants. The invention relates to the plants produced by such a method.Type: GrantFiled: February 24, 2015Date of Patent: May 18, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUBInventors: Linda De Bont, Bertrand Gakiere
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Patent number: 11008217Abstract: The invention relates to an installation and a method for treating hydrogen sulphide. In particular, the invention relates to an installation and a method comprising at least one system for oxidizing hydrogen sulfide to sulfur (S) and water (H2O) with a solid reagent and at least one oxidizing system with an agent for oxidizing the solid reagent present in the reduced state, wherein the system of oxidizing the hydrogen sulfide to sulfur and the system for oxidizing the solid reagent, are so arranged that the hydrogen sulfide is not brought into contact with the agent oxidizing the solid reagent.Type: GrantFiled: May 19, 2017Date of Patent: May 18, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLEInventors: Axel Lofberg, Jesus Guerrero
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Publication number: 20210139943Abstract: The present invention relates to a specific culture medium for the culture and selective isolation of an Enterococcus hirae bacterium consisting of nutrients other than sugars from a basic culture medium for the culture of enterococci without aesculin, comprising inhibitors of Gram-negative and Gram-positive bacteria other than enterococci and preferably at least one antifungal compound characterized in that it comprises: as inhibitor of Gram-positive bacteria other than enterococci, sodium chloride at a concentration of at least 20 g/L and not more than 60 g/L, and as the only sugar, mannitol, and as the only dye, an indicator dye that changes colour at a pH lower than the pH of said specific culture medium corresponding to the acidification of said specific is culture medium resulting from the consumption of mannitol.Type: ApplicationFiled: May 30, 2018Publication date: May 13, 2021Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier RAOULT, Saber KHELAIFIA, Marion BONNET