Patents Assigned to SCIENTIFIQUE (CNRS)
  • METHOD FOR EXECUTING A MACHINE CODE OF A SECURE FUNCTION
    Publication number: 20200257805
    Abstract: This execution method comprises the supplying of the machine code, this machine code being formed by a succession of base blocks, each base block being associated with a signature and comprising instructions to be protected, each instruction to be protected being immediately preceded or followed by an instruction for constructing the value of the signature associated with this base block, wherein: each construction instruction is coded on strictly less than N bits, and each word of the machine code which comprises at least one portion of one of said instructions to be protected also comprises one of said construction instructions so that it is not possible to load an instruction to be protected into an execution file, without at the same time loading a construction instruction which modifies the value of the signature associated with this base block when it is executed.
    Type: Application
    Filed: March 20, 2018
    Publication date: August 13, 2020
    Applicants: COMMISSARIAT A L'ENERGIE ATGMIGUE ET AUX ENERGIES ALTERNATIVES, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Damien COUROUSSE, Karine HEYDEMANN, Thierno BARRY
  • Methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza
    Patent number: 10736937
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza. In particular, the present invention relates to a method of treating a bacterial superinfection post-influenza in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide optionally in combination with at least one antibiotic.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE LILLE, INSTITUT PASTEUR DE LILLE
    Inventors: Jean-Claude Sirard, Christophe Carnoy, François Trottein, Rémi Porte
  • Pharmaceutical compositions for preventing or treating inflammatory bowel diseases
    Patent number: 10736927
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Harry Sokol, Mathias Lavie-Richard, Marie-Laure Michel, Bruno Michel Lamas, Philippe Langella
  • Variants of exoglucanases having improved activity and uses thereof
    Patent number: 10738291
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates to variants of the exoglucanase 2 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: August 11, 2020
    Assignees: IFP Energies nouvelles, Proteus, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Cecile Persillon, Christophe Ullmann, Celine Ayrinhac, Olivier Bonzom, Antoine Margeot, Hugues Mathis, Sebastien Fort, Sylvie Armand, Stephanie Pradeau
  • Organic/inorganic hybrid nanoparticulates made from iron carboxylates
    Patent number: 10738068
    Abstract: The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity of loading with medicaments and in biocompatibility.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: August 11, 2020
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Patricia Horcajada-Cortes, Gérard Ferey, Christian Serre, Ruxandra Gref, Patrick Couvreur
  • Device for electromagnetic dosimetry and associated method
    Patent number: 10739392
    Abstract: Some embodiments relate to a device for simulating characteristics of human tissues in electromagnetic dosimetry. The device includes a substrate bearing a metallised shielding, a layer of a dielectric material arranged on or preferentially beneath the substrate and the device including a plurality of openings made in the shielding and at least one array of sensors in the layer of dielectric material.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: August 11, 2020
    Assignees: UNIVERSITÉ DE RENNES 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Maxim Zhadobov, Artem Boriskin
  • “4D” dynamic tomography system
    Patent number: 10739281
    Abstract: A tomography scanner includes at least one first emission source (GX1), one first matrix detector (D1), and a computer (C) arranged to produce an initial tomography of an object (E) based on radiographs arising from the first matrix detector, taken from various angles. The tomography scanner further includes a second emission source (GX2) and a second matrix detector (D2) arranged so that, when the object is subjected to a loading that is known at a given instant in time, the computer determines the changes in the object subjected to said loading based only on the information from the first radiograph of the object under loading arising from the first matrix detector, from the second radiograph of the object under loading arising from the second matrix detector and the initial tomograph, the first radiograph and the second radiograph being taken simultaneously at the same given instant in time.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: August 11, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: François Hild, Hugo Leclerc, Stéphane Roux
  • Non-linear dynamic absorber and use thereof for acoustic insulation
    Patent number: 10738464
    Abstract: A building element includes a sheet of a rigid material and at least one nonlinear energy sink including a blade with two end parts and a nonlinear spring function intermediate part, a mass fixed to the nonlinear spring function intermediate part of the blade, and a fixing element allowing the two end parts of the blade to be fixed to a solid support in such a way that the nonlinear spring function intermediate part can oscillate about its position of equilibrium or its positions of equilibrium. The nonlinear energy sink is fixed rigidly to the sheet by the fixing element. The building element can be contained in a partition wall. Additionally, such an energy sink or building element can be used for reducing the acoustic transparency of a wall.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: August 11, 2020
    Assignees: SAINT-GOBAIN PLACO, SAINT-GOBAIN ISOVER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre-Olivier Mattei, Sergio Bellizzi, Marc Pachebat, Remi Poncot, Sylvain Berger
  • PRINT HEAD OF A PRINTER, PRINTER AND PRINTING METHOD
    Publication number: 20200247046
    Abstract: A microfluidic print head of a printer has a distal face, an injection channel, a suction channel, a groove, and a light source or an optical waveguide. The injection channel is configured to inject an ink onto a substrate and leads onto the distal face by an injection opening The suction channel is configured to suck up the ink and leads onto the distal face by a suction opening. The groove is defined on the distal face and into which the suction opening leads.
    Type: Application
    Filed: August 3, 2018
    Publication date: August 6, 2020
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, SORBONNE UNIVERSITE
    Inventors: Laurent Malaquin, Jean Louis Viovy, Sandrine Souleille, Xavier Dollat, Victor Fournie
  • CARTILAGE GEL FOR CARTILAGE REPAIR, COMPRISING CHITOSAN AND CHONDROCYTES
    Publication number: 20200248144
    Abstract: The present invention concerns a method for obtaining an implantable cartilage gel for tissue repair of hyaline cartilage, comprising particles of chitosan hydrogel and cells that are capable of forming hyaline cartilage, said method comprising a step for amplification of primary cells in a three-dimensional structure comprising particles of physical hydrogel of chitosan or a chitosan derivative, then a step for re-differentiation and induction of the synthesis of extracellular matrix by said amplified cells, in the same three-dimensional structure, wherein said cells are primary articular chondrocytes and/or mesenchymal stem cells differentiated into chondrocytes. The present invention also concerns the cartilage gel obtained thereby, and its various uses for cartilage repair following a traumatic lesion or an osteoarticular disease such as osteoarthritis.
    Type: Application
    Filed: March 25, 2020
    Publication date: August 6, 2020
    Applicants: ADVANCED CHITOSAN SOLUTIONS BIOTECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Pascale HAZOT, Frédéric MALLEIN GERIN
  • DEVICE FOR INSERTING A SURGICAL IMPLANT
    Publication number: 20200246053
    Abstract: A device for forcibly inserting a surgical implant into a receiving bone (4), by impaction, comprising an impactor (10) which exerts an impact force on the implant and is associated with at least one sensor (12). The sensor (12) measures the deformation of the impactor (10), and provides a measurement signal representing the temporal variation of the deformation during an impact. The sensor (12) is connected to a processing unit (30) configured to calculate, on the basis of the temporal variation of the deformation of the impactor (10) during the impact, an indicator representative of the level of contact between the implant and the receiving bone (4).
    Type: Application
    Filed: September 27, 2018
    Publication date: August 6, 2020
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Université Paris XII Val de Marne
    Inventors: Guillaume Haiat, Giuseppe Rosi, Antoine Tijou
  • Molecules presenting dual emission properties
    Patent number: 10734591
    Abstract: A compound is provided which has dual emission properties and which is useful in light devices, and which has formula (I): wherein: A represents an electron-withdrawing group; D represents an electron-donating group; X is selected from the group consisting of: O, S and NR, wherein R is selected from the group consisting of: H, an alkyl group preferably comprising from 1 to 20 carbon atoms, an aryl group preferably comprising from 6 to 22 carbon atoms, and a heteroaryl group; n is an integer from 1 to 4; m is an integer from 1 to 6; and represents a condensed bicyclic aromatic radical comprising from 6 to 22 carbon atoms, and from 1 to 3 heteroatom(s) selected from the group consisting of: N, S and O; the OH group being in ortho position of the condensed bicyclic aromatic radical relative to the radical.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: August 4, 2020
    Assignees: UNIVERSITÉ DE STRASBOURG, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Karima Benelhadj, Julien Massue, Gilles Ulrich, Raymond Ziessel, Denis Jacquemin, Adèle Laurent
  • Terahertz laser source and method for emitting terahertz radiation
    Patent number: 10732484
    Abstract: A THz laser source includes a first generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a first reference frequency; a second generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a second reference frequency different from the first reference frequency; the THz laser source furthermore comprises a nonlinear crystal suitable for forming, from the first light emissions emitted by each of the first and second generators, a THz light emission generated by difference-frequency generation, of frequency comprised between 0.3 THz and 10 THz; and at least one first frequency-stabilizing module allowing the frequency of one of the second emissions emitted by one of the first and second generators to be stabilized to an atomic transition.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 4, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, OBSERVATOIRE DE PARIS
    Inventor: Mohand Ouali Acef
  • Nanostructured amorphous boron material
    Patent number: 10730035
    Abstract: A nanostructured material consisting essentially of boron. The material is in amorphous form and comprising aggregates of boron nanoparticles. A method of preparation thereof and the uses thereof.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 4, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COLLEGE DE FRANCE
    Inventors: Clément Sanchez, Christel Gervais Stary, David Portehault, Guillaume Gouget
  • System and method for measuring a physical parameter of a medium
    Patent number: 10732114
    Abstract: Method and system for measuring a physical parameter of a target region of a medium are provided, wherein: an excitation wave having a periodic modulation over time of a physical characteristic is emitted, a return wave is periodically deflected with a controllable deflecting element so that the deflected wave scans a transducer array, each transducer being associated with a predefined phase range of the periodic modulation, a phase image is recorded during at least one period of the periodic modulation, a phase shift between a periodic modulation of the return wave and the periodic modulation of the excitation wave is determined from the phase image, a physical parameter of the target region is determined from the phase shift.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 4, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Emmanuel Fort, Sandrine Leveque-Fort, Nicolas Bourg
  • COMPOUNDS USEFUL FOR TREATING CANCER
    Publication number: 20200239444
    Abstract: A compound of formula (I): wherein A and A? independently represent a phenylene group or a pyridylene group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R4 is a carbonyl group or a sulfonyl group; and R5 is a —NH—(CH2)a—NR6R7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R6 and R7 representing independently a (C1-C4)alkyl group, or R6 and R7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 30, 2020
    Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
    Inventors: Pierre ROUX, Florence MAHUTEAU, Romain NAJMAN, Gilles GADEA, Jamal TAZI, Didier SCHERRER, Carsten BROCK, Nathalie CAHUZAC
  • IN SITU ENZYMATIC DEGRADATION OF HYDROCARBON-POLLUTED SOILS
    Publication number: 20200239343
    Abstract: The present invention provides crude enzyme extracts, cocktails and compositions from Alkanivorax borkumensis and methods for the enzymatic treatment and bioremediation of petroleum hydrocarbon polluted ecosystems.
    Type: Application
    Filed: January 30, 2020
    Publication date: July 30, 2020
    Applicant: INSTITUT NATIONAL DE RECHERCHE SCIENTIFIQUE
    Inventors: Satinder KAUR BRAR, Tayssir GUEDRI, Tarek ROUISSI
  • Process for implementing in vitro spermatogenesis and associated device
    Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Preparation of nanoparticles by flash evaporation
    Patent number: 10722813
    Abstract: A method of preparing organic or inorganic nanoparticles is useful in the manufacture of of fertilizers, pharmaceutical or phytopharmaceutical active ingredients, or insensitive energy materials. The method includes preparing a solution of a compound in a solvent, heating the solution under a pressure ranging from 3 to 300 bars at a temperature higher than the boiling point of the solvent, atomizing the solution in an spray drying chamber using at least one dispersion device and at an angle ranging from 30 to 150° under pressure ranging from 0.0001 to 2 bars, separating the solvent in gaseous form, and recovering the nanoparticles.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: July 28, 2020
    Assignees: ISL—INSTITUT FRANCO-ALLEMAND DE RECHERCHES DE SAINT-LOUIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Benedikt Risse, Dominique Hassler, Denis Spitzer
  • Method of fabricating a ceramic from a chemical reaction
    Patent number: 10723658
    Abstract: A method of fabricating a ceramic material, the method including forming a ceramic material by performing a first chemical reaction at least between a first powder of an intermetallic compound and a reactive gas phase, a liquid phase being present around the grains of the first powder during the first chemical reaction, the liquid gas phase being obtained from a second powder of a metallic compound by melting the second powder or as a result of a second chemical reaction between at least one element of the first powder and at least one metallic element of the second powder, a working temperature being imposed during the formation of the ceramic material, which temperature is low enough to avoid melting the first powder.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: July 28, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN CERAMICS
    Inventors: Laurence Maille, Jérôme Roger, Yann Le Petitcorps, Bernard Reignier