Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.

Abstract: The invention relates to a process for manufacturing a laminated material (S) comprising a fibrillated cellulose layer, characterized in that it comprises the following steps: (a) depositing a suspension (1) of fibrillated cellulose on a filtration membrane (2) and draining the suspension through that membrane so as to form a wet layer of fibrillated cellulose (A) having a dryness, that is to say a ratio between the mass of dry matter and the total mass of the fibrillated cellulose layer, of between 5% and 18%; (b) transferring the wet layer (A) under pressure to an at least partially hydrophilic surface of a substrate (B), so as to form the laminated material (S); (c) drying the laminated material. The invention also relates to a device for implementing the process.

Abstract: The invention relates to a magnetic memory cell (30), comprising: a stack (31) including a magnetic layer section (34) between a conductive layer section (32) and a section (36) of a layer that is different from the conductive layer, the magnetic layer having a magnetisation (35) perpendicular to the plane of the layers; a metallisation section (42) on which the stack is placed; and first, second, third and fourth metallisation arms (44D to 44G), each arm having a median axis (45D to 45G), wherein, for each arm, a current flowing towards the stack in the direction of the median axis sees that portion of the stack which is closest the arm mostly on its left for the first and second arms (44E, 44G), and mostly on its right for the third and fourth arms (44D, 44F).

Abstract: The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.

Abstract: The present invention concerns a method for obtaining an implantable cartilage gel for tissue repair of hyaline cartilage, comprising particles of chitosan hydrogel and cells that are capable of forming hyaline cartilage, said method comprising a step for amplification of primary cells in a three-dimensional structure comprising particles of physical hydrogel of chitosan or a chitosan derivative, then a step for re-differentiation and induction of the synthesis of extracellular matrix by said amplified cells, in the same three-dimensional structure, wherein said cells are primary articular chondrocytes and/or mesenchymal stem cells differentiated into chondrocytes. The present invention also concerns the cartilage gel obtained thereby, and its various uses for cartilage repair following a traumatic lesion or an osteoarticular disease such as osteoarthritis.

Abstract: A porous electrolyte membrane including a first main surface and a second main surface that are separated by a thickness, where carbon nanotubes, defining through-pores or through-channels that are open at their two ends, have a diameter smaller than or equal to 100 nm, are oriented in the direction of the thickness of the membrane, and are all substantially parallel over the entire thickness of the membrane, connect the first main surface and the second main surface; the carbon nanotubes are separated by a space, and the space between the carbon nanotubes is completely filled with at least one solid material, and an electrolyte is confined inside the carbon nanotubes. A method for preparing the membrane and an electrochemical device, such as a lithium accumulator or battery, including the electrolyte membrane.

Abstract: A method for measuring the height of a forest of carbon nanotubes, containing: a) providing a substrate having a growth area containing at least one measurement zone containing a growth zone and a sterile zone, the growth zone being defined by a segment of the substrate containing a growth catalyst of the nanotubes, and b) growing catalytically by CVD the forest of nanotubes in the growth zone, wherein, at least in step b) contains: irradiating the measurement zone with an incident light beam; measuring, at various times, the intensity of the beam reflected by the measurement zone; and determining the height of the forest of nanotubes from the reflected-beam intensities measured at the various times.

Abstract: The present invention provides new peptides useful as skin whitening agents and their uses in cosmetic or therapeutic applications.

Abstract: The present invention relates to the field of organic lithium batteries having high energy and power densities. In particular, the present invention relates to an organic lithium battery comprising a positive electrode based on redox organic compounds and a porous separator made of biaxially oriented polypropylene, and to its process of manufacture.

Abstract: A quantum device with spin qubits, comprising: a first semiconducting layer comprising a first matrix of data qubits and measurement qubits connected to each other through tunnel barriers; means of addressing qubits configured for controlling conduction of each tunnel barrier by the field effect and comprising: first and second conducting portions arranged in first and second superposed metallisation levels respectively; first and second conducting vias each comprising a first end connected to one of the first and second conducting portions respectively, and a second end located facing one of the tunnel barriers; a first dielectric layer interposed between the tunnel barriers and the second ends of the first and second conducting vias.

Abstract: A generating device includes at least one pulsed laser source that delivers primary photons having at least one wavelength in a single spatial mode and in pulses having a high pump energy, forming means that act on the primary photons to deliver an input beam, and at least one optical fiber having at least ten modes between which the pump energy is initially distributed, and able to relocate the latter via a non-linear effect into a fundamental mode, before generating secondary photons of various wavelengths by wavelength conversions from the wavelength of the primary photons in the fundamental spatial mode.

Abstract: The present invention relates to a lentiviral vector-based Japanese encephalitis (JE) immunogenic composition. The present invention is directed to a recombinant lentiviral vector expressing the precursor of membrane (prM) and the envelope (E) protein, in particular glycoprotein of a Japanese encephalitis virus (JEV) or immunogenic fragments thereof. The present invention also provides cells expressing the lentiviral vector, uses and methods to prevent a JEV infection in a mammalian host, especially in a human or an animal host, in particular a pig or a piglet, preferably a domestic pig or a domestic piglet.

Abstract: A miniaturized electrochemical cell and a method for making it are provided. The method includes preparing at least one inner electrode of an electron conducting or semi-conducting material M1; providing a hollow support made of an electrically insulating material M6 and having at least one internal hollow channel; depositing on the external surface of the support a layer of an electrically conducting material M2; forming a template of colloidal particles of an electrically insulating material M3, on the M2 layer; depositing a layer of an electrically conducting material M4 on the M2 layer; depositing a layer L1 of an electron conducting or semi-conducting material M5 on the M4 layer, introducing the at least one inner electrode into the at least one internal hollow channel of the obtained structure; stabilizing the structure at its two open ends with an electrically insulating material M7; and removing M2, M3, M4 and M6 materials.

Abstract: Disclosed is a composition based on copolymers including at least one A-B block copolymer, wherein block A is a polyester and block B is a polyoxyethylene (PEG), and wherein the total molecular mass in weight of the PEG is higher than or equal to 50 kDa, and the ethylene oxide motif/ester motif molar ratio is between 0.5 and 5. The invention also relates to an anti-adhesive material including such a composition, used for the prevention of tissue adhesions and especially for the prevention of intrauterine synechiae.

Abstract: The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

Abstract: The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog.

Abstract: A mixed oxide of sodium and transition metals having the formula (1): Nax[MnaNibCoc]O2+y??(1) wherein: 0.5?x?0.9, ?0.1?y?0.1, a+b+c=1, 4a+2b+3c=4?x+2y, and 0<c?0.5. Further a process for producing such a mixed oxide, a positive electrode including such a mixed oxide and a sodium ion secondary battery including such a positive electrode.

Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2991+1655 A>G CEP290 mRNA.

Abstract: The invention relates to complexing agents of formula (I) in which A1, A2, A3 and R1 are as defined in the description. The invention also relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.

Abstract: The present invention concerns an in vitro process for diagnosing joint disease in a mammal and/or determining the type of joint disease and/or determining the stage of said disease and/or predicting the course of said disease, comprising the following steps: a) depositing a drop of a synovial fluid sample from said mammal onto a flat substrate made of an inorganic material, such as glass; b) drying the drop deposited in step a); c) measuring at least one parameter indicative of the morphological features of the drop dried in step b), whereby a value for said parameter is obtained, and d) comparing each value measured in step c) with a reference value representative of a reference synovial fluid, characterized in that said parameter is selected from (i) the maximum height (H) of the bead formed on the surface of the drop, (ii) the area of the drop and (iii) the surface profile (Z) of the drop.