Abstract: The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.

Abstract: The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(tri-fluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.

Abstract: A liquid crystal display apparatus including a plurality of pixels, including a pair of substrates and a liquid crystal having a negative dielectric anisotropy inserted between the pair of substrates. First and second electrodes are formed on the pair of substrates, respectively. A first alignment control structure is formed linearly on one of the pair of substrates for controlling an alignment of the liquid crystal, and a second alignment control structure is formed linearly on the other of the pair of substrates for controlling an alignment of the liquid crystal. The first and second alignment control structures are bent in a zigzag fashion and extend parallel with each other, and at least one of the first and second alignment control structures includes a linear portion and a narrow portion having a width narrower than a width of the linear portion.

Abstract: An active matrix substrate has: scanning lines extending in row direction and image data lines extending in column direction, formed in display area; semiconductor islands at each cross point and in peripheral circuit area; a first gate insulating film formed on each pixel semiconductor island; a first gate made of a first wiring layer and formed on said first gate insulating film; a second gate insulating film thinner than the first gate insulating film formed on peripheral circuit semiconductor island; and a second gate electrode made of a second wiring layer and formed on the second gate insulating film, wherein the pixel transistor semiconductor island, first gate insulating film and first gate electrode constitute a pixel transistor, and the scanning line includes a lower layer made of the second wiring line and an upper layer made of the first wiring line connected to the lower layer.

Abstract: An optical pickup apparatus and a drive apparatus having the same are provided. Second light-receiving elements or third light-receiving elements for receiving ±first-order diffraction light beams from a polarization hologram are arranged outwardly of a circular region having the optical axis of a zero-order diffraction light beam on a light detector as its center, a radius of which is expressed by (2×t/n)×(f2/f1), where f1 denotes a focal length of an objective lens, f2 denotes a focal length of a coupling lens, t denotes a maximum value of a light transmitting layer thickness, n denotes a refractive index of a light transmitting layer.

Abstract: It is an object to prevent distortions and deviations of images caused by the eccentricity of a driven gear mounted to a rotational shaft of a photosensitive drum. There are provided a driving gear which is secured to a rotational shaft of a rotational driving power source and is rotated at a constant peripheral speed, a driven gear secured coaxially to a rotational shaft of a cylindrical-shaped photosensitive member, a phase control gear having the same diameter as that of the driven gear and having the same rotational speed variation characteristic as that of the driven gear, and a transmission gear, and a driving force from the driving gear is transmitted to the driven gear through the phase control gear and the transmission gear.

Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I).

Abstract: Using the attribute “priority” to achieve a stronger Forward Error Correction (FEC) for Radio Link Control (RLC) Control Protocol Data Units (PDUs) transmitted via the High Speed Downlinik Shared Channel (HS-DSCH) also entails prioritized handling so that an RLC Control PDU is likely to overhaul an RLC Data PDU. As a consequence the RLC protocol operation can severely be disturbed, since it relies on in-sequence delivery of control and data PDUs. According to an exemplary embodiment of the present invention, two types of containers are provided in which data packets may be transmitted, wherein the first type of container is provided with a stronger error coding than the second type of container and wherein data packets which comprise control instructions are only transmitted in the first container type with the stronger error correction. Due to this, an improved forward error correction for control PDUs of the AM RLC protocol of Universal Mobile Telecommunications System (UMTS) may be provided.

Abstract: The present invention provides methods for analyzing exon expression profiles of a cell or type of cell. In the invention, the expression levels of a plurality of individual exons or multiexons for each of a plurality of genes in the genome of an organism are measured and analyzed to determine the biological state, such as the exon expression state or transcriptional state, of the cell or type of cell. The methods of the invention are useful for determination of alternative RNA splicing in a plurality of genes. The invention also provides nucleic acid probe arrays for determining in parallel the expression levels of a plurality of exons or multiexons for each of a plurality of genes in the genome of an organism. The invention further provides methods for determining the effects of perturbations, such as perturbations by drugs, on exon expression and alternative RNA splicing pathways.

Abstract: The present invention provides a coating liquid which is excellent in stabilities and capable of being stably ejected by an ejection equipment and suppressing variation in film thickness inside a film or between films, in application for various uses, a film production method, a production method of a functional device, and a functional device, using the coating liquid. The present invention is a coating liquid comprising a mixed solvent and a functional material, wherein the mixed solvent comprises a first solvent constituted by a compound having two or more aromatic rings such as diphenyl sulfide, diphenylmethane, diphenyl ether, and a symmetric structure and another solvent constituted by a compound having an aromatic ring such as xylene, and a proportion by volume of the another solvent is 90% or less in the mixed solvent.

Abstract: Provided is a method of manufacturing a nitride semiconductor light-emitting device including the step of contacting a surfactant material with the surface of an n-type nitride semiconductor layer or the surface of a p-type nitride semiconductor layer before the growth of an active layer, or, with a grown crystal surface during or after the growth of the active layer. According to this manufacturing method, a nitride semiconductor light-emitting device having higher light-emitting efficiency can be obtained.

Abstract: Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Abstract: An image forming apparatus (100) includes a photoreceptor drum (1), a development unit (2), a pressing member (7), and a vibration absorption member (8). The development unit (2) is disposed adjacent to the photoreceptor drum (1), and supported movably toward and away from the photoreceptor drum (1). The pressing member (7) urges the development unit (2) toward the photoreceptor drum. The vibration absorption member (8) frictionally suppresses the movement of the development unit (2) toward and away from the photoreceptor drum (1). The vibration absorption member (8) attenuates a self-excited vibration of the development unit (2), by suppressing the movement of the development unit (2).

Abstract: The present invention provides an image processing apparatus which can promptly detect whether or not a jam has been removed in the case of occurrence of the jam such as a paper jam. A paper feeding apparatus 1b includes a paper feed tray 11, a pickup roller 61, a paper roller 63, a sorting roller 64, feeding rollers 66a, resist rollers 67, a paper ejection roller 73, a passage detection sensor 69, an overlapped feeding detection sensor 68 and a second detection apparatus 71. An image processing apparatus 100 includes a position detection portion 41 for detecting a location of a jam which occurs during feeding of recording paper, a determination portion 42 for determining a jam state based on a detection result of the position detection sensor 69, an examination portion 43 for examining whether the jam has been resolved and a resuming portion 44 for resuming the processing when an examination of the jam location by the examination portion 43 is finished.

Abstract: A portable information terminal includes a first casing having a manipulation unit at its surface, a second casing having a display unit at its surface, and a rotation link mechanism linking the first casing and the second casing such that the second casing rotates slidably with respect to the first casing. The rotation link mechanism is configured to allow transition, by one rotating operation, from one to another of a closed state in which the second casing entirely covers the manipulation unit of the first casing and an open state in which the manipulation unit of the first casing is exposed as a result of movement of the second casing that takes an axially symmetric orientation to the center line of the first casing in the open state. Thus, the operation from a closed state up to an open state can all be readily conducted with one hand.

Abstract: A method and system optimizes the transmission of a downlink reference signal (DLRS) in a wireless communication system that uses orthogonal division multiple access (OFDMA) for the downlink. Each Node-B (base station) is capable of transmitting the DLRS reference symbols in different subframes of the OFDM radio frame and changing both the number and location of the subframes in response to changing network conditions. The network conditions include the number of terminals being served by the Node-B and multiple access interference (MAI) from adjacent Node-Bs.

Abstract: A group of phosphor particles for a light-emitting device contains a plurality of types of phosphor particles having different emission peak wavelengths, while phosphor particles of a type having a relatively longer emission peak wavelength have a relatively larger median diameter as compared with phosphor particles of a type having a relatively shorter emission peak wavelength.

Abstract: An image processing apparatus in which image data is transformed to spatial frequencies to obtain multiple frequency components, the obtained frequency components are processed, the processed frequency components are inversely transformed to image data, and the number of gray levels of the inversely transformed image data is decreased, and the image processing apparatus comprising a frequency component judgment section for comparing the absolute value of each of specific multiple frequency components in the multiple frequency components obtained after transformation to spatial frequencies with a predetermined value in terms of magnitude, a frequency component changing section for changing each of specific frequency components on the basis of the result of the comparison, and a noise addition section for adding a specific value to each of the specific frequency components having been changed and other frequency components.

Abstract: An embodiment of a printed circuit board according to the present invention is provided with an insulating layer, a conductive layer that is laminated on the insulating layer and that has a connecting portion and a circuit pattern portion formed connected to the connecting portion, and a film cover layer that covers the insulating layer and the conductive layer via an adhesive layer and that has an opening for connecting a mounted component to the connecting portion. The circuit pattern portion is provided with a recessed portion that is concave with respect to the connecting portion.

Abstract: A high-density plasma method is provided for forming a SiOXNY thin-film. The method provides a substrate and introduces a silicon (Si) precursor. A thin-film is deposited overlying the substrate, using a high density (HD) plasma-enhanced chemical vapor deposition (PECVD) process. As a result, a SiOXNY thin-film is formed, where (X+Y<2 and Y>0). The SiOXNY thin-film can be stoichiometric or non-stoichiometric. The SiOXNY thin-film can be graded, meaning the values of X and Y vary with the thickness of the SiOXNY thin-film. Further, the process enables the in-situ deposition of a SiOXNY thin-film multilayer structure, where the different layers may be stoichiometric, non-stoichiometric, graded, and combinations of the above-mentioned types of SiOXNY thin-films.