Patents Assigned to Siemens Healthcare Diagnostics Inc.
  • Publication number: 20240085686
    Abstract: A method, device and system for enhancing image quality of an image is provided. In one aspect, the method includes illuminating a sample with a light source associated with an imaging device. Further, the method includes simulating a transmission wave at a sensor plane of the imaging device for a light wave from illuminating the sample. Additionally, the method includes determining a phase and amplitude information associated with the light wave based on the transmission wave. The method also includes determining at least one microscope transfer function associated with the imaging device based on the phase and amplitude information. Furthermore, the method includes generating a modified mi-croscope transfer function using a Zernike function based on the at least one microscope transfer function in an iterative procedure and enhancing the image quality associated with the im-age using the modified microscope transfer function.
    Type: Application
    Filed: March 8, 2021
    Publication date: March 14, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Abhijeet A. Joshi, Mohiudeen Azhar
  • Patent number: 11927736
    Abstract: A method of characterizing a serum or plasma portion of a specimen in a specimen container provides a fine-grained HILN index (hemolysis, icterus, lipemia, normal) of the serum or plasma portion of the specimen, wherein the H, I, and L classes may each have five to seven sub-classes. The HILN index may also have one un-centrifuged class. Pixel data of an input image of the specimen container may be processed by a deep semantic segmentation network having, in some embodiments, more than 100 layers. A small front-end container segmentation network may be used to determine a container type and boundary, which may additionally be input to the deep semantic segmentation network. A discriminative network may be used to train the deep semantic segmentation network to generate a homogeneously structured output. Quality check modules and testing apparatus configured to carry out the method are also described, as are other aspects.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 12, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Kai Ma, Yao-Jen Chang, Terrence Chen, Benjamin S. Pollack
  • Patent number: 11927598
    Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: March 12, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: David Stein, Roy Barr, Mark Edwards, Colin Mellars, Thomas J. Bao, Charles V. Cammarata, Benjamin S. Pollack, Baris Yagci, Beri Cohen
  • Patent number: 11920976
    Abstract: A system for coupling photometers to an incubation ring for use in in vitro diagnostics comprises one or more light sources, and an incubation ring assembly, and two photometers. An incubation ring assembly comprises an internal trough and an external trough. Each trough comprises (a) an internal wall comprising an internal aperture and (b) an external wall comprising an external aperture. A first photometer comprises: a first optics housing directing light from the light sources through the external aperture of the internal trough, and a first detector positioned to receive the light through the internal aperture of the internal trough. A second photometer comprises a second optics housing directing the light from the light sources through the internal aperture of the external trough, and a second detector positioned to receive the light through the external aperture of the external trough.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: March 5, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: John P. Mizzer, Donald Wood
  • Patent number: 11921124
    Abstract: Aqueous calibration or quality control reagents that include urea are disclosed; the reagents may further include at least one amino acid-containing composition to provide pH stability thereto. Methods of production and use thereof are also disclosed.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: March 5, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Laura Uretsky, Kevin Horan
  • Publication number: 20240068984
    Abstract: The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 29, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: John Benco, Robert Bergquist
  • Patent number: 11913817
    Abstract: Embodiments provide a fluid metering device, including: a first fluid supply port for receiving a first fluid; a first fluid dispense port for dispensing the first fluid; a second fluid supply port for receiving a second fluid; a second fluid dispense port for dispensing the second fluid; a waste discharge port for discharging a mixture of the first fluid and the second fluid; a valve assembly including a plurality of valves; a manifold connected to the metering pump, wherein the manifold includes a plurality of fluid channels, and the manifold is used for communicating between the valve assembly and each port; a first tube connected between the second valve and the third valve for accommodating the mixture or the first fluid; and a second tube connected between the third valve and the fourth valve for accommodating the second fluid.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: February 27, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: William D. Dunfee, Robert Hopely, Jr., Colin Ingersoll, Yudis Moreta
  • Patent number: 11913965
    Abstract: Methods are disclosed for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,500. The method comprises the use of a first antibody that binds to the small molecule and a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a hapten that is not the small molecule or a derivative of the small molecule wherein the hapten comprises a moiety that is structurally similar to that of the second portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: February 27, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Tie Wei
  • Publication number: 20240061005
    Abstract: A pipette assembly configured to aspirate liquid from a well having a cover includes: a pipette including a terminal end; a pipette tip detachably coupled to the terminal end; and a vibration inducer configured to vibrate the pipette tip when at least a portion of the pipette tip is located in the well thus reducing stiction between the cover and the pipette tip. This minimizes the pipette tip from getting detached from the pipette and stuck in the cover. Other systems and methods including vibrating a pipette tip are disclosed.
    Type: Application
    Filed: October 6, 2020
    Publication date: February 22, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Simin Yao
  • Publication number: 20240061003
    Abstract: A pipette tip configured to aspirate and dispense liquids. The pipette has a tip comprising an opening, wherein the pipette has one or more blades having a length extending at least partway from the tip, and at least some of the one or more blades include an acute-angled cutting edge along the length. In some embodiments, the pipette tip is part of a detachable pipette tip having a tip body with a first end configured to detachably couple to a pipette. Other detachable pipette tips, pipette tips, pipette assemblies, aspiration and dispense systems, testing apparatus, and methods of accessing a well through a well cover are disclosed.
    Type: Application
    Filed: October 6, 2020
    Publication date: February 22, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Simin Yao
  • Publication number: 20240037723
    Abstract: Methods of identifying a defect in a machine vision system. Embodiments of the method include providing a first imaging device having a first field of view; moving a reflective tool through the first field of view; capturing a plurality of images of the reflective tool at different locations in the first field of view using the first imaging device; and analyzing at least one of the plurality of images to identify one or more defects in the machine vision system. Systems and apparatus configured to carry out the methods are provided, as are other aspects.
    Type: Application
    Filed: February 2, 2022
    Publication date: February 1, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Rayal Raj Prasad Nalam Venkat, Yao-Jen Chang, Benjamin S. Pollack, Ankur Kapoor
  • Publication number: 20240035980
    Abstract: A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.
    Type: Application
    Filed: February 1, 2022
    Publication date: February 1, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Tivadar Mach
  • Publication number: 20240036029
    Abstract: Non-limiting embodiments of a system(s) of generating interfering flags to reduce false diagnosis due to interfering conditions present in urinalysis results, and method(s) related thereto.
    Type: Application
    Filed: April 26, 2021
    Publication date: February 1, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Kausik Das
  • Publication number: 20240027438
    Abstract: Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.
    Type: Application
    Filed: September 22, 2023
    Publication date: January 25, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Kayla Cortese, Saji Cherian, Paul D'Agostino, Gabriel Hammarquist, Aili Han, Kuldeep Jaggi, Maral Poladian, Niver Sahakian, Seema Sinha, Prakash Tewari, Haekyung Lee
  • Publication number: 20240021301
    Abstract: Methods of troubleshooting non-event malfunctions include providing a database including pre-populated non-event issues and associated corrective actions, receiving search criteria regarding a particular non-event issue via entry of a search string at a user interface, parsing and normalizing the search string into a meta-data schema to produce a normalized search string, searching the database with the normalized search string to generate a listing of one or more particular corrective actions, and receiving the listing of one or more particular corrective actions that are associated with the normalized search string. Apparatus configured to carry out the methods are provided, as are other aspects.
    Type: Application
    Filed: July 26, 2023
    Publication date: January 18, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Arnold Rudorfer, Steven Magowan, Joel Cambron
  • Publication number: 20240010841
    Abstract: Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and/or conjugates are also disclosed, along with microfluidics devices containing same.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 11, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yali Yang, David Wen, Bogdan Draghici, Yi Feng Zheng, Raphael Bartz, Qingping Jiang, Roland Janzen, Joshua Whalen, Ling Ngo, William Bedzyk
  • Patent number: 11859734
    Abstract: A microfluidic device has a first substrate, a resilient diaphragm, an actuator, and a second substrate. The first substrate has an opening extending therethrough. The resilient diaphragm is secured to a second side and surrounds the opening. The actuator is secured to a first side and surrounds the opening. The first substrate, the resilient diaphragm, and the actuator cooperate to form a gas-tight chamber. The second substrate has a channel formed therein having a first end and a second end. The second substrate is secured to the first substrate. A volume of gas disposed in the gas-tight chamber pressurizes the gas-tight chamber and expands the resilient diaphragm such that the resilient diaphragm is disposed in the channel between the first end and the second end. The resilient diaphragm retracts from the channel to open the channel from the first end and the second when the gas-tight chamber is depressurized.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: January 2, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Patent number: 11852642
    Abstract: A method of characterizing a serum or plasma portion of a specimen in a specimen container provides an HILN (hemolysis, icterus, lipemia, normal) determination. Pixel data of an input image of the specimen container is processed by a classification network to identify whether the specimen contains plasma or serum. Pixel data representing a plasma sample are forwarded to a segmentation/classification/regression network trained with plasma samples for HILN determination. Pixel data representing a serum sample are forwarded to a transformation network, wherein the serum sample pixel data is transformed into pixel data that matches pixel data of a corresponding previously-collected plasma sample by changing sample color, contrast, intensity, and/or brightness. The transformed serum sample pixel data are forwarded to the segmentation/classification/regression network for HILN determination. Quality check modules and testing apparatus configured to carry out the method are also described, as are other aspects.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: December 26, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Venkatesh NarasimhaMurthy, Vivek Singh, Yao-Jen Chang, Benjamin S. Pollack, Ankur Kapoor
  • Patent number: 11850585
    Abstract: In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: December 26, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer A. Samproni
  • Patent number: 11850583
    Abstract: Devices, kits, and methods separating and metering a plasma sample from a patient's liquid test sample.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: December 26, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Aaron Kauffmann, David Ledden