Patents Assigned to Smith Kline & French Laboratories Limited
  • Substituted quinoline derivatives
    Patent number: 5420135
    Abstract: Substituted quinoline derivatives are described as inhibitors bone resorption with in particular, the compound 1-(2-methylphenyl)imidazo[4,5-c]quinoline hydrochloride.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: May 30, 1995
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach, David J. Keeling
  • Medicaments
    Patent number: 5326781
    Abstract: Benzylimidazole derivatives are described as anxiolytic agents.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: July 5, 1994
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Ann J. Hunter, Rodney C. Young, Lars M. Wood
  • Thiadiazinones for stimulating cardiac activity
    Patent number: 5246928
    Abstract: This invention relates to N-phenylpyridone derivatives which have inotropic, vasodilator and bronchodilator activity. A compound of the invention is 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)pyri dazinone.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: September 21, 1993
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Polystyrene anion exchange polymer pharmaceutical composition
    Patent number: 5230885
    Abstract: Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer, chloride salt.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: July 27, 1993
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey
  • Pyrimido[4,5-d]pyrimidine derivatives for use as bronchodilators
    Patent number: 5162316
    Abstract: This invention relates to pyrimidopyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 7-cyclopropylamino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d] pyrimidine.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: November 10, 1992
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Phenylpyrimidones
    Patent number: 5118686
    Abstract: This invention relates to phenylpyrimidone derivatives which have bronchodilator activity. A compound of the invention is 4-cyano-6-hydroxy-2-(2-propoxyphenyl)pyrimidine.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: June 2, 1992
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Derek A. Rawlings
  • Pharmaceutical compositions
    Patent number: 5082651
    Abstract: Pharmaceutical compositions suitable for intra-rectal administration in the form of a foam are described which comprise a therapeutically effective amount of 5-aminosalicylic acid, a pharmaceutically acceptable aqueous carrier therefor, and means for generating a foam.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: January 21, 1992
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: John N. C. Healey, Marshall Whiteman
  • Chemical compounds
    Patent number: 5066653
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## wherein R.sup.4 is hydrogen and A is a dihydro-1,2,4-triazin-3-one group or a dihydro-1,2,4-triazin-6-one group which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: November 19, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Method of stimulating histamine H.sub.3 -receptors
    Patent number: 5047418
    Abstract: A pharmaceutical composition is described which comprises a pharmaceutically acceptable carrier and a compound of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof wherein X is CH.sub.2 or S, in an amount sufficient to stimulate selectively histamine H.sub.3 -receptors.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: September 10, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William Howson
  • Biologically active compounds
    Patent number: 4997847
    Abstract: The invention relates to phenylsulphonamidolkanoic acids which have thromboxane A.sub.2 receptor antagonist activity.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: March 5, 1991
    Assignees: Smith Kline & French Laboratories Limited, Boehringer Mannheim GmbH
    Inventors: Robert J. Ife, David G. Cooper, Robert A. Slater, Karlheinz Stegmeier, Ernst-Christian Witte
  • Process for preparing substituted isoindolinone derivatives
    Patent number: 4997954
    Abstract: This invention relates to an improved process for the preparation of substituted indolinone derivatives using reductive cyclization conditions.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: March 5, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Joseph M. Fortunak
  • Pharmaceutical formulations
    Patent number: 4996222
    Abstract: The invention provides pharmaceutical suspension compositions of cimetidine wherein substantially all of the cimetidine is in the polymorph B crystalline form.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: February 26, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Brian A. C. Carlin, John N. C. Healey, Graham S. Leonard, Geoffrey D. Tovey
  • Pyrrolocinnolines for use as inhibitors of gastric acid secretion
    Patent number: 4988695
    Abstract: Pyrrolo- and dihydropyrrolocinnolines, and their use as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-2,3-dihydropyrrolo-[3,2-c]-cinnoline.
    Type: Grant
    Filed: January 23, 1990
    Date of Patent: January 29, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Peter Blurton
  • Pyridazinone derivatives
    Patent number: 4962110
    Abstract: The invention relates to 2-aminopyrimidinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(1,4-dihydro-4-oxo-2-pyrimidinylamino)phenyl]-5-methyl-4,5-dihydro-3( 2H)-pyridazinone.
    Type: Grant
    Filed: August 10, 1989
    Date of Patent: October 9, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: John C. Emmett, William J. Coates
  • Novel polystyrene anion exchange polymers
    Patent number: 4954339
    Abstract: Polystyrene polymers having a quaternized ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is N,N-dimethyl-N-dodecylammoniomethyl-substituted polystyrene.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: September 4, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey
  • Pyridine compounds
    Patent number: 4952589
    Abstract: This invention relates to aminoalkylphenoxyalkyl substituted heterocycles. These compounds antagonize the action of histamine on histamine H.sub.2 -receptors in the brain. A compound of the invention is 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]benzthiazole.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: August 28, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert C. Mitchell, Ian R. Smith, Rodney C. Young
  • Process
    Patent number: 4950765
    Abstract: This invention relates to a catalytic transfer hydrogenation process using water as a solvent in the preparation of substituted indolinone derivatives.
    Type: Grant
    Filed: August 24, 1987
    Date of Patent: August 21, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Timothy C. Walsgrove, Paul Oxley
  • Novel guanidino pyridazinones as cardiac stimulants
    Patent number: 4946842
    Abstract: The invention relates to phenyl dihydropyridazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.3 -benzyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: August 7, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, John C. Emmett, Robert A. Slater
  • Producing anxiolytic activity and treating depression with 3(H)-indolones
    Patent number: 4912126
    Abstract: The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 27, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David A. A. Owen
  • Pyridyl and pyridazinyl substituted thyronine compounds
    Patent number: 4910305
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: March 20, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson