Patents Assigned to Smith Kline & French Laboratories Limited
  • N-phenylpyridone type III phosphodiesterases
    Patent number: 4906628
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: March 6, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Benzene compounds having two pyridazinone substituents
    Patent number: 4904664
    Abstract: The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): ##STR1## wherein: R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 1, 1986
    Date of Patent: February 27, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Hunter D. Prain, Brian H. Warrington
  • Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub. 2
    Patent number: 4902698
    Abstract: The invention provides a class of alkanoic acids substituted with a benzenesulphonamidopyridyl group. The compounds have activity as thromboxane A.sub.2 -antagonists.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: February 20, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David G. Cooper
  • Pyridine compounds which have useful histamine-H.sub.2 antagonist activity
    Patent number: 4894372
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: January 16, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities
    Patent number: 4885301
    Abstract: This invention relates to purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)-6-purinone.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: December 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Biologically active compounds
    Patent number: 4866076
    Abstract: The invention provides a class of sulphonamide-containing tetrahydroisoquinolinyl compounds having thromboxane antagonist activity.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: September 12, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Andrew D. Gribble
  • 3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h.sub.1 -antagonist activity
    Patent number: 4863936
    Abstract: Various substituted aminoalkylamino-2-pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: October 21, 1986
    Date of Patent: September 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 3-hydroxypyridines
    Patent number: 4863933
    Abstract: The disclosure relates to a class of 2-(pyridylalkylamino)-3-hydroxypyridines which are active as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: September 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, Peter D. Miles, Rodney C. Young
  • Heterocyclic compounds
    Patent number: 4861773
    Abstract: The invention relates to thiadiazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 7-(1H-imidazol-1-yl)-9,9a-dihydroindeno[1,2-e][1,3,4]-thiadiazin-2(3H)-one .
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: August 29, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Lawrence I. Kruse
  • Chemical compounds having selective thyromimetic activity
    Patent number: 4826876
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 2, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
  • Treatment of Parkinsons disease
    Patent number: 4824860
    Abstract: The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: April 25, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David A. A. Owen
  • 5-phenyl-3[2H]-pyridazinone derivatives
    Patent number: 4820819
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: April 11, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman
  • Pyrimidone derivatives
    Patent number: 4808589
    Abstract: This invention provides 5-substituted-4-pyrimidones having in the 2-position a heterocyclic (or substituted phenyl) alkyl group. These compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: February 9, 1983
    Date of Patent: February 28, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Thomas H. Brown
  • 4-amino-3-carbonyl substituted quinolines
    Patent number: 4806549
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: February 21, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Process for preparing beta-methyl-gamma-oxo-4-(4-oxo-1(4H)-pyridinyl) derivative of benzene butanoic acid
    Patent number: 4782159
    Abstract: A process for the prepartion of 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid which comprises the reaction of 3-(4-fluorobenzoyl)butanoic acid with 4-hydroxypyridine under aqueous conditions in the presence of a base.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: November 1, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Michael B. Mitchell, Kiritkant D. Pancholi
  • Pyrimidylalkylthio benzimidale compounds, pharmaceutical compositions and use
    Patent number: 4777172
    Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: October 11, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown
  • 3,4-diamino-1,2,5-thiadiazole-1-oxides having histamine H.sub.1 -antagonist activity
    Patent number: 4771058
    Abstract: The invention relates to a class of 3,4-diamino-1,2,5-thiadiazole-1-oxides which have histamine H.sub.1 -antagonist activity. A preferred compound of the invention is 3-[3-(5-bromo-3-methylpyrid-2-ylamino)-propylamino]-4-amino-1,2,5-thiadiaz ole-1-oxide.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: September 13, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Methylamidine compounds
    Patent number: 4766123
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanoethanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Cyanoamidine compounds and derivatives thereof
    Patent number: 4766122
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanopropanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Pharmaceutical tablet
    Patent number: D303160
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: August 29, 1989
    Assignee: Smith Kline & French Laboratories, Limited
    Inventor: Geoffrey D. Tovey