Patents Assigned to SmithKline Corporation
  • 7-Amino intermediates for preparing 7-acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4068073
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Pharmaceutical compositions of .alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins
    Patent number: 4067978
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • .alpha.-AMINO-.alpha.-(UREIDOPHENYL)ACETAMIDOCEPHALOSPORINS AND THEIR PHARMACEUTICAL COMPOSITIONS
    Patent number: 4067977
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • Alpha-amino-alpha-(ureidophenyl)acetamidocephalosporins and their pharmaceutical compositions
    Patent number: 4067976
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-yl thiomethyl-3-cephem-4-carboxylic acid
    Patent number: 4066762
    Abstract: New semisynthetic cephalosporins are described whose structures are characterized by having an .alpha.-oxyimino group in the 7-acetamido moiety and a sulfosubstituted tetrazolylthiomethyl group at position 3. The compounds are active antibacterial agents especially against Gram negative organisms.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: January 3, 1978
    Assignee: SmithKline Corporation
    Inventor: George Lawrence Dunn
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4066761
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-[1-(2,3-dihydroxypropyl)tetrazole-5-ylthiomethyl]-3-ceph em-4-carboxylic acids
    Patent number: 4064242
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 1-dihydroxypropyltetrazole-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-[1-(2,3-dihyroxypropyl)tetrazole-5-ylthiomethyl]-3-cephe m-4-carboxylic and 7-(D-.alpha.-phenyl-.alpha.-aminoacetamido)-3-[1-(2,3-dihydroxypropyl)-tet razole-5-ylthiomethyl]-3-cephem-4-carboxylic acid.
    Type: Grant
    Filed: November 4, 1976
    Date of Patent: December 20, 1977
    Assignee: SmithKline Corporation
    Inventor: Stanley J. Schmidt
  • Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
    Patent number: 4062961
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.
    Type: Grant
    Filed: August 5, 1976
    Date of Patent: December 13, 1977
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton
  • Slide smearing device
    Patent number: 4061108
    Abstract: A device for smearing liquid on a slide has (1) a housing and means for supporting a pair of slides on top of the housing, (2) a carriage with a pair of spaced runners which slidably support the carriage on the top of the housing, (3) a spreader pivotally mounted on the carriage and free to rock transversely with respect to a slide, (4) a member to advance the carriage and spreader, (5) a spring and dashpot arrangement to retract the carriage, and (6) latch means to arrest the carriage after it retracts a short distance. The means for supporting the slides may support the slide at an angle of at least five degrees with respect to the plane in which the carriage moves reducing the thickness of the liquid smeared on the slide. The dashpot plunger moves in the direction of an open end of the dashpot cylinder. Advantageously the device has means to clean the spreader.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: December 6, 1977
    Assignee: SmithKline Corporation
    Inventors: Marshall S. Levine, Albert A. Faulkner
  • Pharmaceutical compositions comprising 7-acyl-3-(substituted triazolyl thiomethyl)-cephalosporins and methods of treating bacterial infections
    Patent number: 4060610
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: November 29, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Substituted mercaptoacetamido cephamycins
    Patent number: 4059578
    Abstract: 7.beta.-Substituted mercaptoacetamido-7.alpha.-methoxycephalosporanic acid and derivatives thereof are prepared. These compounds are antibacterial agents with improved properties.
    Type: Grant
    Filed: January 13, 1975
    Date of Patent: November 22, 1977
    Assignee: SmithKline Corporation
    Inventors: Robert M. DeMarinis, Jerry A. Weisbach
  • Ureidoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins
    Patent number: 4059591
    Abstract: The uriedoalkyl substituted tetrazolethiol compounds of this invention are used for preparing 7-acyl-3-(uriedoalkyl substituted tetrazolythiomethyl)-cephalosporins.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: November 22, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Skeletal muscle relaxant compositions comprising .alpha.,.alpha.-diphenyl-3-tropidineethanol and methods of producing skeletal muscle relaxation
    Patent number: 4058615
    Abstract: Pharmaceutical compositions having direct acting skeletal muscle relaxant activity comprising .alpha.,.alpha.-diphenyl-3-tropidineethanol and methods of producing skeletal muscle relaxant activity by administering internally said compositions.
    Type: Grant
    Filed: September 28, 1976
    Date of Patent: November 15, 1977
    Assignee: SmithKline Corporation
    Inventors: Peter Tone Ridley, Edwin Frank Weidley
  • 7-Dithioacetamido cephalosporins
    Patent number: 4058609
    Abstract: Novel cephalosporins having a dithioacetamido substituent at the 7-position are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: June 28, 1976
    Date of Patent: November 15, 1977
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Antiarthritic compositions comprising bis-coordinated gold(1+) salts and methods of producing antiarthritic activity
    Patent number: 4057630
    Abstract: Pharmaceutical compositions having antiarthritic activity comprising phosphine or phosphite bis-coordinated gold(1+) salts and methods of producing antiarthritic activity by administering internally, preferably orally, said compositions.
    Type: Grant
    Filed: August 2, 1976
    Date of Patent: November 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David Taylor Hill
  • Method of preparing 2,3-dichloroanisole
    Patent number: 4057585
    Abstract: A new process for preparing 2,3-dichloroanisole comprises reacting 1,2,3-trichlorobenzene with an alkali metal methoxide preferably in the presence of methanol.
    Type: Grant
    Filed: September 2, 1976
    Date of Patent: November 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Wilford Lee Mendelson, Robert Lee Webb
  • 7-(.alpha.-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-c ephem-4-carboxylic acids
    Patent number: 4057631
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-ceph em-4-carboxylic acid disodium salt.
    Type: Grant
    Filed: September 2, 1976
    Date of Patent: November 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Electrochemical reduction of imidazolecarboxylic esters
    Patent number: 4055573
    Abstract: Lower alkyl 4-imidazolecarboxylates are electro-chemically reduced to give the corresponding alcohol and lower alkyl ethers. This mixture is reacted directly with cysteamine to give the important thioamine intermediates.
    Type: Grant
    Filed: May 6, 1976
    Date of Patent: October 25, 1977
    Assignee: SmithKline Corporation
    Inventor: Wilford Lee Mendelson
  • Live Newcastle disease virus vaccines
    Patent number: 4053583
    Abstract: The improved live Newcastle disease virus vaccines of the invention contain a cold or cold and temperature-sensitive strain of Newcastle disease virus obtained by U.V. or nitrous acid mutation. The vaccines are administered to chickens in the form of an aerosol.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
    Patent number: 4053468
    Abstract: A process for preparing 7-oxo cephalosporins and 6-oxo penicillins by reaction of a 7-amino cephalosporin or 6-amino penicillin with a carbonyl-containing oxidizing agent is disclosed.
    Type: Grant
    Filed: February 25, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventor: Kenneth G. Holden