Patents Assigned to SmithKline Corporation
  • Pharmaceutical compositions and method of producing anti-Parkinsonism activity
    Patent number: 4052506
    Abstract: Pharmaceutical compositions and method of producing anti-Parkinsonism activity by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal.
    Type: Grant
    Filed: August 5, 1975
    Date of Patent: October 4, 1977
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton, Paulette E. Setler
  • Automatic fraction collector
    Patent number: 4049031
    Abstract: A liquid fraction collector has a first series of containers and a second series of containers, each of the first and second series of containers being arranged in a plurality of groups with means to support each group at a different elevation. A conduit leads upwardly from each container in said first series with the upper ends of the conduits lying in a first row and a conduit leads upwardly from each container in said second series with the upper end of the conduits lying in a second row parallel to the first row. A carriage is mounted above said conduits. The carriage has means to discharge a liquid having an inverted V guide member with one trough over one row and the other trough over the other row and a discharge tube having its discharge end movable from a position over one trough of the guide member to a position over the other trough of the guide member.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: September 20, 1977
    Assignee: SmithKline Corporation
    Inventors: David J. Cooper, George W. Gebhardt, Joseph R. Valenta, Francis E. Wdzieczkowski
  • Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole compounds
    Patent number: 4049669
    Abstract: A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: September 20, 1977
    Assignee: SmithKline Corporation
    Inventors: Bing Lun Lam, Joseph James Lewis, Robert Lee Webb, George Robert Wellman
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4048311
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • .alpha.-AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS
    Patent number: 4048229
    Abstract: .alpha.-Aminomethyl-4-hydroxy-3-methylsulfonyl benzyl alcohols having .beta.-adrenergic antagonist activity are prepared generally from 4-benzyloxy-3-methylsulfonylacetophenone by, for example, bromination and treatment of the resulting .alpha.-bromo derivative with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove protective benzyl groups and reduce the ketone moiety.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Mercaptopseudotrisaccharides
    Patent number: 4048430
    Abstract: Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as intermediates to pseudotrisaccharides.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventors: David J. Cooper, John R. E. Hoover, Jerry A. Weisbach
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4044047
    Abstract: Cephalosporia compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: August 23, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4041162
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 11, 1976
    Date of Patent: August 9, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4034092
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: July 5, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Aromatic prostaglandin derivatives
    Patent number: 4032656
    Abstract: Aromatic prostaglandin derivatives are prepared. These compounds have valuable antiprostaglandin activity specifically inhibiting prostaglandin synthesis and antagonizing diarrhea induced by prostaglandin E.sub.2 (PGE.sub.2).
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: June 28, 1977
    Assignee: SmithKline Corporation
    Inventors: William G. Groves, Bernard Loev, Carl D. Perchonock
  • Substituted 2H-pyran-2,6(3H)-dione derivatives, pharmaceutical compositions comprising such derivatives and methods of inhibiting the antigen-antibody reaction
    Patent number: 4032652
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives, pharmaceutical compositions comprising such derivatives and methods of inhibiting the antigen-antibody reaction by administering said compositions. The active ingredients are the products formed by the reaction of acetonedicarboxylic acid with acetic anhydride followed by reaction with an appropriate amine. Certain of the dione derivatives are novel compounds per se.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: June 28, 1977
    Assignee: SmithKline Corporation
    Inventors: Lawrence W. Chakrin, Kenneth M. Snader, Chester R. Willis
  • Novel preparation of trifluoromethylthioacetic acid
    Patent number: 4028408
    Abstract: Methods and intermediates are disclosed for the preparation of trifluoromethylthioacetic acid using the reaction of trifluoromethylsulfenyl halides with certain orthoesters.
    Type: Grant
    Filed: April 15, 1976
    Date of Patent: June 7, 1977
    Assignee: SmithKline Corporation
    Inventors: Sidney Harry Levinson, Wilford Lee Mendelson
  • Cephalosporin purification process
    Patent number: 4028355
    Abstract: A process for purifying semisynthetic cephalosporins is disclosed which uses alumina and/or a polymeric nonionic resin as adsorbents at a controlled pH. The process is more efficient than previously used methods.
    Type: Grant
    Filed: July 18, 1975
    Date of Patent: June 7, 1977
    Assignee: SmithKline Corporation
    Inventor: Dale W. Blackburn
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4025626
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of allergic reactions
    Patent number: 4025614
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • Methods and compositions using 5-cycloalkylthio- and oxy-2-carbalkoxy-aminobenzimidazole
    Patent number: 4025638
    Abstract: New anthelmintic compositions and methods of use are described utilizing 5-cycloalkylthio and oxy-2-carbalkoxyaminobenzimidazoles as active ingredients.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Robert J. Gyurik, William D. Kingsbury
  • Substituted 2H-pyran-2, 6(3H)-dione derivatives
    Patent number: 4025642
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
    Patent number: 4024281
    Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
    Patent number: 4024273
    Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
    Type: Grant
    Filed: November 17, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, John M. Petta, Stephen T. Ross
  • Substituted phenylglycylcephalosporins
    Patent number: 4022895
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 10, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason