Patents Assigned to SmithKline Corporation
  • 7.beta.-Acyloxy cephalosporins
    Patent number: 4020057
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: April 26, 1977
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • 3-Heterocyclicthiomethylcephalosporins
    Patent number: 4018759
    Abstract: Cephalosporins containing a heterocyclicthiomethyl group at position 3 are prepared. The heterocyclic group is 5-oxo-.DELTA..sup.2 -1,2,4-triazolinyl, 5-thiono-.DELTA..sup.2 -1,2,4-triazolinyl, 5-oxo-.DELTA..sup.2 -1,2,4-thiadiazolinyl or 5-thiono-.DELTA..sup.2 -1,3,4-thiadiazolinyl. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: April 19, 1977
    Assignee: SmithKline Corporation
    Inventor: David Alan Berges
  • Substituted phenylglycylcephalosporins
    Patent number: 4018921
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: April 19, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Stable oxidase reagent solutions
    Patent number: 4017420
    Abstract: Stable oxidase reagent solutions containing N,N,N',N'-tetramethyl-p-phenylenediamine or N,N-dimethyl-p-phenylenediamine for determining the presence of oxidase in microbial colonies.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: April 12, 1977
    Assignee: SmithKline Corporation
    Inventors: Betty Anne Bowie, Joseph F. Pagano
  • Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones
    Patent number: 4017633
    Abstract: Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones useful as inhibitors of certain antigen-antibody reactions, particularly in alleviating allergic manifestations such as asthma, are prepared by reaction of a 3-(1-aminoethylidene)-5-acetyl-2H-pyran-2,6(3H)-dione with an appropriately substituted benzaldehyde.
    Type: Grant
    Filed: February 18, 1976
    Date of Patent: April 12, 1977
    Assignee: SmithKline Corporation
    Inventor: Chester Rhodes Willis
  • Pharmaceutical compositions comprising substituted 3-cinnamoyl-2H-pyran-2,6(3H)-diones
    Patent number: 4015009
    Abstract: Pharmaceutical compositions comprising a substituted 3-cinnamoyl-2H-pyran-2,6(3H)-dione and methods of inhibiting the antigen-antibody reaction by administering said compositions. Certain of the 3-cinnamoyl-2H-pyran-2,6(3H)-diones are novel compounds per se.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: March 29, 1977
    Assignee: SmithKline Corporation
    Inventors: Lawrence William Chakrin, Kenneth Means Snader, Chester Rhodes Willis
  • Bis-phenoxypropanolamines
    Patent number: 4013777
    Abstract: Bis-phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.
    Type: Grant
    Filed: August 22, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Pharmaceutical compositions comprising substituted phenylglycylcephalosporins and methods of treating bacterial infections
    Patent number: 4013764
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporinic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Compositions and methods for treating bacterial infections with substituted acetamidocephalosporins
    Patent number: 4013765
    Abstract: Novel cephalosporins with the trifluoroethyl-mercaptoacetamido, trifluoroethylsulfinylacetamido, and trifluoroethylsulfonylacetamido groups at position 7 are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • .alpha.-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS HAVING .beta.-ADRENERGIC STIMULANT ACTIVITY
    Patent number: 4012528
    Abstract: .alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: March 15, 1977
    Assignee: SmithKline Corporation
    Inventors: Timothy Yu-Wen Jen, Carl Kaiser, Joe R. Wardell
  • 4-Sulfanilamidothiazole
    Patent number: 4011210
    Abstract: 4-Sulfanilamidothiazole having antibacterial activity is prepared from the previously unknown 4-aminothiazole.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: March 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., William D. Kingsbury
  • Pharmaceutical compositions and methods involving benzazepine derivatives
    Patent number: 4011319
    Abstract: Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed.
    Type: Grant
    Filed: July 2, 1975
    Date of Patent: March 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton
  • .alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins
    Patent number: 4007173
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: May 7, 1973
    Date of Patent: February 8, 1977
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • O-acyl-7-acylaminocephalosporadesic acids
    Patent number: 4007178
    Abstract: A method for O-acylating the 3-hydroxymethyl group of 7-acylaminocephalosporadesic acids by reaction with an azolide and new O-acyl-7-acylaminocephalosporadesic acids in which the O-acyl group is derived from an alkoxyalkanoic acid or an amino acid.
    Type: Grant
    Filed: May 15, 1975
    Date of Patent: February 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Epoxidation of .alpha.,.beta.-ethylenic ketones
    Patent number: 4006169
    Abstract: A method of preparing .alpha.,.beta.-epoxy ketones by reacting water-soluble .alpha.,.beta.-ethylenic ketones with sodium hypochlorite. Especially useful for preparing 3,4-epoxy-butanone.
    Type: Grant
    Filed: February 26, 1976
    Date of Patent: February 1, 1977
    Assignee: SmithKline Corporation
    Inventors: Elvin L. Anderson, Bing L. Lam, George R. Wellman
  • N-Heterocyclic-9-xanthenylamines
    Patent number: 4005208
    Abstract: The compounds are N-piperidinyl and pyrrolidinyl-9-xanthenylamines which are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: May 16, 1975
    Date of Patent: January 25, 1977
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, Bernard Loev
  • Phenoxypropanolamines
    Patent number: 4004028
    Abstract: Phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: January 18, 1977
    Assignee: SmithKline Corporation
    Inventor: Carl Kaiser
  • 2,3-Bis-(3-lower alkanoyl-2-thioureido)-pyridines
    Patent number: 4002761
    Abstract: New 2,3-bis-(3-acyl-2-thioureido)-pyridines having anthelmintic activity are prepared by reacting a diaminopyridine with acylthiocyanates.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: January 11, 1977
    Assignee: SmithKline Corporation
    Inventor: Roger C. Parish
  • Substituted benzofurans and benzothiophenes
    Patent number: 4001426
    Abstract: The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • 2-Alkoxy(and 2-alkoxyalkyl)-2-quinolyl-thioacetamides
    Patent number: 4001241
    Abstract: The compounds are 2-alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides which are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: June 12, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: Helene E. Bowman Van Hoeven, L. Martin Brenner, Bernard Loev