Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4- carboxylic acid disodium salt.
Abstract: A new method for preparing ticrynafen comprises reacting 2,3-dichloro-4-hydroxyphenyl-2-thienylmethanone with an alkali metal salt of chloro or bromo acetic acid in aqueous solvent. An advantageous aspect of the reaction is that yields are increased with the addition of an alkali metal iodide to the reaction mixture.
Abstract: A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in an anti-hypertensive effect in humans. Particular species of this group include 6-chloro-7,8-dihydroxy-1-p-methylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzaz epine and its derivatives which have dopaminergic activity.
Type:
Grant
Filed:
January 19, 1977
Date of Patent:
August 1, 1978
Assignee:
SmithKline Corporation
Inventors:
Gregory Gallagher, Jr., Francis R. Pfeiffer, Joseph Weinstock
Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.
Type:
Grant
Filed:
May 24, 1977
Date of Patent:
August 1, 1978
Assignee:
SmithKline Corporation
Inventors:
Clifford Steven Labaw, Robert Lee Webb, George Robert Wellman
Abstract: Novel bicyclic .beta.-lactams and intermediates useful in their preparation are disclosed. In particular, 7.beta.-acyl-amino- and 7.beta.-amino-8-oxo-4-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids are prepared. The acylated compounds are antibacterial agents.
Type:
Grant
Filed:
June 8, 1976
Date of Patent:
July 25, 1978
Assignee:
SmithKline Corporation
Inventors:
John G. Gleason, Kenneth G. Holden, William F. Huffman
Abstract: 7.beta.-Substituted mercaptoacetamido-7.alpha.-methoxycephalosporanic acid and derivatives thereof are prepared. These compounds are antibacterial agents with improved properties.
Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an alkanesulfonamidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
Abstract: A device for smearing on slides a drop of liquid placed on a predetermined point on each slide has slide magazines containing a plurality of slides with the uppermost slide in each magazine having its upper face exposed for the reception of a drop of liquid towards one end thereof. Spreaders are adjacent the other ends of the slides. Means advance the spreaders out of contact with the slides, lower the spreaders into contact with the slides as they approach said predetermined points on the slides and slow the advance of the spreaders as they approach said points. The spreaders are retracted and the angle between each spreader and slide decreases to thin the smear of liquid. Means advance the uppermost slide in each magazine forwardly out of the magazine a predetermined distance to facilitate the removal of the slide by hand after the desired smear is made.
Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
Abstract: A nasal inhaler has a body with an open end and containing a frangible fluid containing ampul. A nozzle is mounted in the open end for movement relative to the body and the ampul. Structure responsive to the movement of the nozzle relative to the body and the ampul ruptures the ampul and releases the contained fluid.
Abstract: The compounds are trialkylphosphinegold(I)2,3,4,6-tetra-O-(N-loweralkylcarbamoyl)-1-thio-.be ta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.
Abstract: A new series of lower alkyl sulfonyl esters of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranosides has been prepared and found to have anti-arthritic activity and, in particular, are of use in treating rheumatoid arthritis.
Abstract: The compounds are tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally substituted phenyl and the others are lower alkyl or lower alkoxy.
Abstract: A new series of lower alkyl ethers of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranoside has been prepared and found to have anti-arthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.
Abstract: Novel process for preparing aryloxybenzoic and arylthiobenzoic acids by reacting 2-chlorobenzoic acid with substituted phenols or thiophenols in the presence of an alkali metal iodide and a base.
Abstract: 1,2,3-Triazole-4(5)-thiol is prepared by treating 1-benzyl-1,2,3-triazole with a strong base, treating the resulting anion with sulfur, removing the benzyl group by reductive means, and acidifying the resulting thiolate with strong acid.
Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
Abstract: A new .beta.-lactam system containing a tricyclic ring nucleus is disclosed. In addition to the .beta.-lactam, the new nucleus contains a cyclic hydrazide moiety. The compounds have antibacterial activity.