Patents Assigned to SmithKline Corporation
  • Antiarthritic compositions comprising bis[(trialkyl-phosphine)gold(I)]sulfides and methods of producing antiarthritic activity
    Patent number: 4093719
    Abstract: Pharmaceutical compositions having antiarthritic activity comprising Bis[(Trialkylphosphine)Gold(I)]Sulfides and methods of producing antiarthritic activity by administering internally, preferably orally, said compositions.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: June 6, 1978
    Assignee: SmithKline Corporation
    Inventor: David Taylor Hill
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4092480
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: May 30, 1978
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation thereof
    Patent number: 4092352
    Abstract: A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.
    Type: Grant
    Filed: October 4, 1976
    Date of Patent: May 30, 1978
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Robert Lee Webb
  • Multiple dose paste dispenser
    Patent number: 4090639
    Abstract: A multiple dose paste dispenser has a frame with a handle secured thereto. A piston rod having a piston on the front end is mounted in said frame for longitudinal movement. A cartridge is secured to the frame in alignment with the piston. A gripping ring is slidable along said rod and grippably engages the rod when it is tilted with respect to the rod. A return spring urges the ring in a direction away from the piston. A trigger pivotally mounted on the frame is adapted to tilt the ring and advance the ring, the rod and the piston into the cartridge. A stop is pivoted to the frame for movement from an inoperative position to a position for limiting the advance of the ring. Advantageously the stop is stepped to provide for at least two different stop positions.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: May 23, 1978
    Assignee: SmithKline Corporation
    Inventors: James A. Campbell, R. Richard Unangst
  • Protected .alpha.-amino-.alpha.-ureido(thioureido)phenylacetic acids
    Patent number: 4091227
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: October 10, 1976
    Date of Patent: May 23, 1978
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
    Patent number: 4089956
    Abstract: A new series of 7-acylamino-8-oxo-3-oxa-1-azabicyclo-[4.2.0]octane-2-carboxylic acid derivatives is described which compounds have antibacterial activity especially against certain Gram negative organisms.
    Type: Grant
    Filed: September 8, 1976
    Date of Patent: May 16, 1978
    Assignee: SmithKline Corporation
    Inventors: Thomas Francis Buckley, John Gerald Gleason
  • Antipsychotically useful quinolizidylidene derivatives of xanthenes, thioxanthenes and dibenzoxepins
    Patent number: 4089961
    Abstract: Tricyclic quinolizidine derivatives administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity essentially free of extrapyramidal symptoms.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 16, 1978
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, John Joseph Lafferty
  • Method of inhibiting platelet aggregation
    Patent number: 4089970
    Abstract: Method of inhibiting platelet aggregation by administering 4-(2-thenoyl)-2,3-dichlorophenoxyacetic acid or its salts.
    Type: Grant
    Filed: September 7, 1977
    Date of Patent: May 16, 1978
    Assignee: SmithKline Corporation
    Inventor: Mirza M. A. Beg
  • Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
    Patent number: 4086350
    Abstract: Tricyclic piperidylidene derivatives administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity without extrapyramidal symptoms. Certain of the active ingredients are novel compounds per se.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: April 25, 1978
    Assignee: SmithKline Corporation
    Inventor: Charles Leon Zirkle
  • Intermediate for dephthaloylation of azetidinone compounds
    Patent number: 4085100
    Abstract: A method for dephthaloylation of azetidinone compounds which contain a phthalimido group to produce useful aminoazetidinone intermediates comprises reaction with methyl hydrazine at low temperatures.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: April 18, 1978
    Assignee: SmithKline Corporation
    Inventor: William D. Kingsbury
  • 7 -Acylamino-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4-carb oxylic acids
    Patent number: 4083975
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4- carboxylic acid disodium salt.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: April 11, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Substituted aurones
    Patent number: 4083952
    Abstract: Substituted aurones useful as inhibitors of certain antigen-antibody reactions, particularly in alleviating allergic manifestations such as asthma, are prepared by reaction of a 3-coumaranone with an appropriately substituted benzaldehyde followed by treatment with aqueous mineral acid and an alkanol.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: April 11, 1978
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • Process using alkali fusion for decyanation of tert.-nitriles
    Patent number: 4079061
    Abstract: An improvement in the decyanation of tertiary nitriles comprises the alkali fusion of the nitriles. Exemplary are the preparation of chlorpheniramine and brompheniramine by heating the respective nitriles in liquid sodium or potassium hydroxide at from 100.degree.-200.degree..
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: March 14, 1978
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Donald E. Rivard
  • 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-y lthiomethyl)-3-cephem-4-carboxylic acids
    Patent number: 4079134
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl group at position 3. Exemplary is the anti-bacterially effective 7-D-mandelamido-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem -4-carboxylic acid disodium salt.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: March 14, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Uricosuric composition and method of producing uricosuria and hypouricemia
    Patent number: 4076839
    Abstract: Uricosuric compositions containing 2,3-dichloro-4-carboxyphenoxyacetic acid or its alkali metal salts and methods of producing uricosuria and hypouricemia by administering said compounds.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: February 28, 1978
    Assignee: SmithKline Corporation
    Inventor: Alfred Roland Maass
  • Substituted acetamidocephalosporins
    Patent number: 4075338
    Abstract: Novel cephalosporins with the trifluoroethylmercaptoacetamido, trifluoroethylsulfinylacetamido, and trifluoroethylsulfonylacetamido groups at position 7 are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: February 21, 1978
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
    Patent number: 4073912
    Abstract: Novel piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins administered internally to an animal host, in therapeutically effective amounts, produce antipsychotic activity essentially free of extrapyramidal symptoms.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 14, 1978
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, John J. Lafferty
  • Cis-4-oxoazetidine intermediates and methods of preparing them
    Patent number: 4072674
    Abstract: The stereospecific cycloaddition of nitrogen containing acetic acid halides or anhydrides with Schiff bases having a carbalkoxy group substituted on the methine carbon atom offers new intermediates and methods for preparing synthetic cephalosporin congeners having antibacterial activity.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: February 7, 1978
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • Preparation of trifluoromethylthioacetic acid and its esters
    Patent number: 4069243
    Abstract: A new method of preparing trifluoromethylthioacetic acid using a tertiary phosphine in a sulfur extrusion of lower alkyl trifluoromethyldithioacetate with optional is situ alkaline hydrolysis of said acetate using a biphasic hydrolysis system in the presence of a phase transfer catalyst.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: January 17, 1978
    Assignee: SmithKline Corporation
    Inventor: Robert Michael DeMarinis
  • Intermediates for preparing 7-acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl)cephalosporins
    Patent number: 4067880
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges