Patents Assigned to SmithKline Corporation
  • Phosphinegold (I) salts having antiarthritic activity
    Patent number: 4171360
    Abstract: The compounds are (pyridine) (trisubstituted phosphine) gold(I) salts which have antiarthritic activity.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4171359
    Abstract: A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi nes have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichloro-7,8-dihydroxy-1-(p-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H- 3-benzazepine in the form of an acid addition salt.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins
    Patent number: 4171433
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171368
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171362
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Methods and intermediates for preparing cis-4-oxoazetidine intermediates
    Patent number: 4166816
    Abstract: The stereospecific cycloaddition of nitrogen containing acetic acid halides or anhydrides with Schiff bases having a carbalkoxy group substituted on the methine carbon atom offers new intermediates and methods for preparing synthetic cephalosporin congeners having antibacterial activity.
    Type: Grant
    Filed: August 3, 1977
    Date of Patent: September 4, 1979
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
    Patent number: 4166061
    Abstract: A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.
    Type: Grant
    Filed: November 2, 1977
    Date of Patent: August 28, 1979
    Assignee: SmithKline Corporation
    Inventors: Antonietta R. Mastrocola, Robert L. Webb
  • Substituted 2H-pyran-2,6(3H)-dione derivatives
    Patent number: 4165365
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventor: Kenneth M. Snader
  • Bis(sulfide)gold(1+) salts
    Patent number: 4165380
    Abstract: The compounds are bis(sulfide)gold(1+) salts which have antiarthritic activity.
    Type: Grant
    Filed: June 2, 1978
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • 6-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use as dopaminergic agents
    Patent number: 4165372
    Abstract: A group of 1-phenyl-3-benzazepines with structures characterized by having a carboxy derived substituent at position 6 which are dopaminergic agents or are intermediates for preparing other dopaminergic agents. Particular illustrative species include 6-carbomethoxy-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-ben zazepine, 6-carboxy-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6-carbomethoxy-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3- benzazepine.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 3-Aminoazetidinone derivatives
    Patent number: 4162250
    Abstract: New lactam intermediates and methods for preparing a new series of 7-acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]-octane-2-carboxylic acid derivatives are described. The end product compounds have antibacterial activity especially against certain Gram negative organisms.An example of the compounds of this invention are cis-3-blocked amino-4-ketoazetidinyl-2-acetaldehydes and their acetal derivatives.
    Type: Grant
    Filed: June 6, 1978
    Date of Patent: July 24, 1979
    Assignee: SmithKline Corporation
    Inventors: Thomas F. Buckley, John G. Gleason
  • Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
    Patent number: 4160765
    Abstract: The preparation of 6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines is described by direct bromination of the nucleus.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: July 10, 1979
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Substituted 2H-pyran-2,6(3H)-dione derivatives
    Patent number: 4160021
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: July 3, 1979
    Assignee: SmithKline Corporation
    Inventor: Kenneth M. Snader
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4159373
    Abstract: The compounds of this invention are cephalosporins having a 3- or 4-aminomethylphenylacetamido substituent at the 7-position and a sulfonic acid substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 4, 1978
    Date of Patent: June 26, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Acyloxy-3-acetoxymethyl cephalosporins
    Patent number: 4158733
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: June 19, 1979
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • 3-Acyl-5-alkyl-2H-pyran-2,4,6-(3H,5H)-triones and their 4-hydroxy tautomers
    Patent number: 4153720
    Abstract: 3-Acyl-5-alkyltetrahydro-2,4,6-pyrantriones are prepared by catalytic hydrogenation of their 3,5-diacyl congeners. They have been found to have anti-allergic activity useful for treating the symptoms of asthma.
    Type: Grant
    Filed: January 19, 1978
    Date of Patent: May 8, 1979
    Assignee: SmithKline Corporation
    Inventor: Theodore M. Resnick
  • 6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles
    Patent number: 4153706
    Abstract: The compounds are 6-hydroxy-5,6-substituted-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles which have antiarthritic activity and are useful as intermediates for preparing 2,3-dihydroimidazo[2,1-b]thiazole antiarthritic compounds. A particular compound of this invention is 5,6-bis-(p-fluorophenyl)-6-hydroxy-2,3,5,6-tetrahydroimidazo[2,1-b]thiazol e.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: May 8, 1979
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, David T. Hill
  • Slide smearing device
    Patent number: 4151915
    Abstract: A device for smearing on slides a drop of liquid placed on a predetermined point on each slide has slide magazines containing a plurality of slides with the uppermost slide in each magazine having its upper face exposed for the reception of a drop of liquid towards one end thereof. Spreaders are adjacent the other ends of the slides. Means advance the spreaders out of contact with the slides, lower the spreaders into contact with the slides as they approach said predetermined points on the slides and slow the advance of the spreaders as they approach said points. The spreaders are retracted and the angle between each spreader and slide decreases to thin the smear of liquid. Means advance the uppermost slide in each magazine forwardly out of the magazine a predetermined distance to facilitate the removal of the slide by hand after the desired smear is made.
    Type: Grant
    Filed: March 3, 1978
    Date of Patent: May 1, 1979
    Assignee: SmithKline Corporation
    Inventors: Marshall S. Levine, Albert A. Faulkner
  • Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihalocarbinols
    Patent number: 4152517
    Abstract: A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: May 1, 1979
    Assignee: SmithKline Corporation
    Inventors: Sidney H. Levinson, Wilford L. Mendelson
  • 7-Acylamino-3-(1-car boxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acids
    Patent number: 4147701
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-ceph em-4-carboxylic acid disodium salt.
    Type: Grant
    Filed: November 2, 1977
    Date of Patent: April 3, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges