Abstract: The present disclosure relates to engineered microorganisms capable of producing gadusol. The engineered microorganisms contain a nucleotide sequence encoding 2-epi-5-valione synthase (EEVS) and a nucleotide sequence encoding methyltransferase-oxidoreductase (MT-Ox). Methods of using the engineered microorganisms to produce gadusol, including the culturing of such microorganisms, are also described.
Type:
Grant
Filed:
December 19, 2019
Date of Patent:
July 27, 2021
Assignee:
Oregon State University
Inventors:
Taifo Mahmud, Alan Bakalinsky, Andrew Osborn, Garrett Holzwarth
Abstract: An apparatus is provided which comprises pressure pass-thru means, which includes: an optic fiber having a first end and a second end; a first connector coupled to the first end; a second connector coupled to the second end; a housing between the first and second ends, wherein the housing covers a portion of the optic fiber, wherein a portion of the optic fiber in the housing is bare; a filing material inside the housing; and a swaged gland fitting on the housing to secure the apparatus to a pressure boundary.
Type:
Grant
Filed:
March 18, 2019
Date of Patent:
July 27, 2021
Assignees:
Oregon State University, Battelle Energy Alliance, LLC
Inventors:
Wade R. Marcum, Aaron W. Weiss, Daniel P. Labrier, Casey Jesse, Warren F. Jones, John Kennedy, Ann Marie Phillips, Chad Nixon
Abstract: A method of controlling a data center having a cold air cooling system, and at least one containment structure, comprising: determining a minimum performance constraint; determining optimum states of the cold air cooling system, a controlled leakage of air across the containment structure between a hot region and a cold air region, and information technology equipment for performing tasks to meet the minimum performance constraint, to minimize operating cost; and generating control signals to the cold air cooling system, a controlled leakage device, and the information technology equipment in accordance with the determined optimum states.
Type:
Grant
Filed:
January 24, 2018
Date of Patent:
July 27, 2021
Assignee:
The Research Foundation for the State University
Abstract: An information processing system, which includes a control system and an artificial neural network, is disclosed. The artificial neural network includes a group of neurons and a group of synapses, which includes a first portion and a second portion. The control system selects one of a group of operating modes. The group of neurons processes information. The group of synapses provide connectivity to each of the group of neurons. During a first operating mode of the group of operating modes, the first portion of the group of synapses is enabled and the second portion of the group of synapses is enabled. During a second operating mode of the group of operating modes, the first portion of the group of synapses is enabled and the second portion of the group of synapses is disabled.
Type:
Grant
Filed:
April 13, 2017
Date of Patent:
July 27, 2021
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: Methods and recombinant vectors for increasing resistance to Fusarium head blight (FHB) infection in plants. Exogenous Fhb1 nucleic acids are described to generate transgenic plants having increased resistance to FHB relative to a control plant. The nucleotide sequence of the exogenous nucleic acid comprises SEQ ID NO:1, 2, 4, 5, or 6; has at least 95% sequence identity to SEQ ID NO:1, 2, 4, 5, or 6; encodes a protein comprising the amino acid sequence of SEQ ID NO: 3, 7, 8, or 9; or encodes a protein having at least 95% amino acid identity to SEQ ID NO: 3, 7, 8, or 9.
Type:
Grant
Filed:
July 8, 2019
Date of Patent:
July 27, 2021
Assignees:
Kansas State University Research Foundation, Regents of The University Of Minnesota
Inventors:
Bikram Gill, Nidhi Rawat, Eduard Akhunov, Michael Pumphrey, James A. Anderson, Sixin Liu
Abstract: Provided are aromatic oligoamide foldamers and self-assembled compositions of the same. The aromatic oligoamide foldamers and compositions can form tube-like structures that can form pores in membranes. The pores can be used to transport ions and molecules, such as, for example, cryoprotective agents or therapeutic agents, through the membrane. The tube-like structures exhibit desirable stability at low temperatures.
Type:
Grant
Filed:
February 26, 2020
Date of Patent:
July 27, 2021
Assignee:
The Research Foundation for The State University of New York
Abstract: A system for generating an RFPWM signal comprises a delta sigma modulator having a plurality of outputs, a phase-locked loop comprising a plurality of phase quantization outputs, at least one multiplexer having a plurality of signal inputs, a plurality of selector inputs, and at least one output, the signal inputs communicatively connected to the phase quantization outputs of the phase-locked loop and the selector inputs electrically connected to the outputs of the delta sigma modulator, and a driver having an input communicatively connected to the output of the multiplexer and an output generating an RFPWM signal. A method of generating an RFPWM signal is also described.
Type:
Application
Filed:
January 21, 2021
Publication date:
July 22, 2021
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
Type:
Application
Filed:
February 12, 2021
Publication date:
July 22, 2021
Applicant:
The Research Foundation for The State University of New York
Abstract: Embodiments of the present disclosure pertain to methods of evaluating a meat sample by measuring electricity conducted from water in the meat sample and correlating the evaluation to a property of the meat sample. The water forms (e.g., free water, immobilized water, and bound water) can be evaluated by measuring electricity conducted from water in the meat sample. The property of the meat sample can include, without limitation, a color of the meat sample, or a tenderness of the meat sample.
Abstract: The present disclosure provides biomarkers for the detection of coronary artery disease. The biomarkers comprise oxylipins and the detection, identification, and quantification can provide a means to diagnose, prognose, and manage subject at risk for cardiovascular disease. Methods of also provided for the detection and quantification of the oxylipins, for treating, and for predicting the survival of a subject at high risk for coronary artery disease.
Type:
Application
Filed:
January 22, 2021
Publication date:
July 22, 2021
Applicants:
Oregon State University, Oregon Health & Science University
Inventors:
Manuel Garcia-Jaramillo Rodriguez, Gerd Bobe, Claudia Susanne Maier, Donald Bradley Jump, Armando Alcázar-Magaña, Dai-Trang Elizabeth Le, Sanjiv Kaul, Nabil J. Alkayed
Abstract: Gait, the walking pattern of individuals, is one of the most important biometrics modalities. Most of the existing gait recognition methods take silhouettes or articulated body models as the gait features. These methods suffer from degraded recognition performance when handling confounding variables, such as clothing, carrying and view angle. To remedy this issue, a novel AutoEncoder framework is presented to explicitly disentangle pose and appearance features from RGB imagery and a long short-term memory integration of pose features over time produces the gait feature.
Type:
Application
Filed:
January 22, 2021
Publication date:
July 22, 2021
Applicants:
Board of Trustees of Michigan State University, Ford Global Technologies, LLC
Inventors:
Xiaoming LIU, Jian WAN, Kwaku PRAKAH-ASANTE, Mike BLOMMER, Ziyuan ZHANG, Luan TRAN, Xi YIN, Yousef ATOUM
Abstract: Described herein are compounds and compositions for electrolytes based on bidentate and monodentate fluorinated alcohols. Also described are batteries that include the compounds and electrolytes described herein.
Abstract: The present disclosure describes genetically-modified plants having enhanced tolerance to multiple abiotic stressors, such as extreme temperatures (heat or cold) and/or drought. Abiotic stress tolerance is enhanced by ectopic expression of a heterologous glutaredoxin. Abiotic stress tolerance (particularly drought) is also enhanced by inhibited function, activity, or expression of an endogenous glutaredoxin. Methods of producing such genetically-modified plants are also disclosed.
Type:
Grant
Filed:
June 9, 2017
Date of Patent:
July 20, 2021
Assignees:
Kansas State University Research Foundation, Baylor College of Medicine
Inventors:
Sunghun Park, Frank White, Jungeun Park, Kendal Hirschi, Ning-Hui Cheng
Abstract: A heterojunction device is provided. The heterojunction device includes a silicon (Si) substrate; and a film of silicon carbide (SiC) deposited on a surface of the Si substrate. The SiC has a Si:C ratio that increases or decreases from a SiC surface in contact with the Si substrate to an opposing SiC surface that is not in contact with the Si substrate.
Type:
Grant
Filed:
April 2, 2018
Date of Patent:
July 20, 2021
Assignee:
Board of Trustees of Michigan State University
Inventors:
Premjeet Chahal, Tim Hogan, Amanpreet Kaur
Abstract: An ultra-low voltage inverter includes a first inverter, a second inverter, and third inverter. The first inverter receives an input from a delay cell and generates an output for a subsequent delay cell. The second inverter is coupled to the first inverter. The third inverter is coupled to the first inverter, wherein outputs of the second and third inverters are coupled to source terminals of a p-type transistor and an n-type transistor of the first inverter, respectively. The ultra-low voltage inverter forms a delay cell, which is a building block of an ultra-low voltage ring-oscillator. A NAND gate is formed using three inverters such that outputs of two inverters are coupled to the p-type transistors of the NAND gate, while an output of the third inverter of the three inverters is coupled to an n-type transistor of the NAND gate.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
July 20, 2021
Assignee:
Oregon State University
Inventors:
Soumya Bose, Matthew Johnston, Tejasvi Anand
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
July 20, 2021
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Neal Woodbury, Stephen Johnston, Phillip Stafford
Abstract: Methods of forming composite materials, composite materials, and articles. The composite materials may include electromagnetic shielding materials. The methods may include providing a mixture of ultra-high temperature ceramic particles and a liquid preceramic precursor, curing the mixture to form a solid mixture, forming particles of the solid mixture, and pressing the particles into a mold.
Type:
Grant
Filed:
February 19, 2019
Date of Patent:
July 20, 2021
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: This work develops a novel microfluidic method to fabricate conductive graphene-based 3D micro-electronic circuits on any solid substrate including, Teflon, Delrin, silicon wafer, glass, metal or biodegradable/non-biodegradable polymer-based, 3D microstructured, flexible films. It was demonstrated that this novel method can be universally applied to many different natural or synthetic polymer-based films or any other solid substrates with proper pattern to create graphene-based conductive electronic circuits. This approach also enables fabrication of 3D circuits of flexible electronic films or solid substrates. It is a green process preventing the need for expensive and harsh postprocessing requirements for other fabrication methods such as ink-jet printing or photolithography. We reported that it is possible to fill the pattern channels with different dimensions as low as 10×10 ?m. The graphene nanoplatelet solution with a concentration of 60 mg/mL in 70% ethanol, pre-annealed at 75° C. for 3 h, provided ˜0.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
July 20, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: A new and distinct cultivar of Berberis plant named ‘NCBT2’ is disclosed, characterized by a semi-compact rounded habit, reddish orange to moderate red spring foliage, deep red to vivid red exterior summer foliage and yellow green interior foliage. The new variety is a Berberis, normally produced as an outdoor garden or container plant.
Type:
Grant
Filed:
June 16, 2020
Date of Patent:
July 20, 2021
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch