Patents Assigned to State University
  • TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES
    Publication number: 20210177985
    Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.
    Type: Application
    Filed: February 24, 2021
    Publication date: June 17, 2021
    Applicants: Rutgers, The State University of New Jersey, Georgetown University
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin
  • DIVIDERLESS PLL WITH SAMPLED LOWPASS FILTER STRUCTURE
    Publication number: 20210184686
    Abstract: The present disclosure relates to a phase-lock-loop, which includes a phase detector (PD), a charge pump (CP), a sampled lowpass filter structure, and a voltage-controlled oscillator (VCO) structure. The PD is configured to receive a RF output signal from the VCO structure and a reference signal, and generate detection signals, which indicate a phase relationship between the RF output signal and the reference signal. The CP is configured to receive the detection signals and generate a CP current. Herein, the CP current flows into or out of the sampled lowpass filter structure based on the detection signals. The sampled lowpass filter is configured to provide an oscillator control voltage, which remains constant within a cycle of the reference signal, to the VCO structure based on the CP current. Based on the oscillator control voltage, the VCO structure is configured to tune the RF output signal.
    Type: Application
    Filed: December 14, 2020
    Publication date: June 17, 2021
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventor: Kevin S. Grout
  • ADDITIVE-CONTAINING ALLOY EMBODIMENTS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210180165
    Abstract: Disclosed herein are embodiments of an additive-containing alloy that exhibit improved strength, particularly at high temperatures, creep resistance, thermal fatigue resistance, and oxidation resistance. Also disclosed herein are embodiments of a method for making such additive-containing alloys, including methods whereby the additive component of such alloys can be selectively deposited according to a pre-designed pattern. Such method embodiments facilitate producing programmable alloy embodiments wherein the additive component can be provided in desired regions of the alloy and/or at desired concentrations within the alloy.
    Type: Application
    Filed: February 22, 2021
    Publication date: June 17, 2021
    Applicant: Oregon State University
    Inventors: Somayeh Pasebani, S. Milad Ghayoor Baghbani, Brian K. Paul, Chih-hung Chang, Kijoon Lee, Yujuan He
  • SYSTEMS AND METHODS FOR AUDIO SOURCE SEPARATION VIA MULTI-SCALE FEATURE LEARNING
    Publication number: 20210183401
    Abstract: Various embodiments of a system and methods for audio source separation via multi-scale feature learning are disclosed.
    Type: Application
    Filed: December 14, 2020
    Publication date: June 17, 2021
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Vivek Sivaraman Narayanaswamy, Andreas Spanias, Jayaraman Thiagarajan, Sameeksha Katoch
  • ALPHA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20210179535
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)
    Type: Application
    Filed: February 11, 2021
    Publication date: June 17, 2021
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, Kongzhen Hu, Simon Tong, Matthew Elmes, Su Yan
  • Engineered shell proteins for microcompartment shell electron transfer and catalysis
    Patent number: 11034965
    Abstract: Described herein are bacterial microcompartments shell proteins modified to stably incorporate iron-sulfur clusters. Such bacterial microcompartments shell proteins exhibit redox cycling and confer electron transfer functionality to bacterial microcompartment shells.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: June 15, 2021
    Assignee: Board of Trustees of Michigan State University
    Inventors: Cheryl A. Kerfeld, Clement Aussignargues
  • Protease transition state inhibitor prodrugs
    Patent number: 11033600
    Abstract: Disclosed herein are protease transition state inhibitor/analogue prodrug compounds selected from the group consisting of esters, carbamates, ester phosphates, and pharmaceutically acceptable salts thereof. Compositions containing such prodrugs are also disclosed, along with methods of using such compounds therapeutically or prophylactically against calicivirus, picornavirus, and/or coronavirus infection, as well as other conditions, such as malaria, cancer, stroke, heart attack, neural degeneration, cataracts, and glaucoma through inhibition of the variety of proteases associated with progression of such conditions.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: June 15, 2021
    Assignees: Kansas State University Research Foundation, Wichita State University
    Inventors: Kyeong-Ok Chang, William C. Groutas
  • Zika virus vaccine and methods of production
    Patent number: 11033615
    Abstract: The invention generally relates to a purified inactivated Zika virus (ZIKV), methods for producing the purified inactivated ZIKV, immunogenic compositions and vaccines comprising the purified inactivated ZIKV and methods for the prevention and/or treatment of infection by ZIKV.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 15, 2021
    Assignees: The Government of the United States, As Represented by the Secretary of the Army Fort Detrick, Maryland, The Research Foundation For The State University of New York Syracuse, New York
    Inventors: Stephen J. Thomas, Timothy Endy, Kenneth H. Eckels, J. Robert Putnak, Richard Jarman, Rafael De La Barrera
  • Recycled composite materials and related methods
    Patent number: 11034816
    Abstract: Methods of producing particles of fiber and resin from fiber-resin composite materials are disclosed. The particles may be combined with a resin system and optionally combined with fillers, binders or reinforcements to produce new cured solid composite products.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: June 15, 2021
    Assignees: Washington State University, GFSI Group LLC
    Inventors: Hui Li, Karl Englund, Don Lilly
  • Acute pulmonary pressurization device and method of use
    Patent number: 11033702
    Abstract: A system and method for relief of negative lung pressure during acute laryngospasm or upper airway obstruction, providing a non-toxic gas cartridge capable of supplying between 0.5-5 liters of gas during a procedure, a valve adapted to commence and stop gas release, and a trans-cricothyroid cartilage inflation needle for acutely relieving the negative pressure in the chest. The needle may also be used to insert a guidewire to assist in endotracheal tube insertion.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 15, 2021
    Assignee: The Research Foundation for the State University of New York
    Inventors: Mark Stewart, Richard Kollmar, Krishnamurthi Sundaram, Joshua Silverman, Ko Nakase, Hamid Arjomandi
  • Stabilized protein fiber air filter materials and methods
    Patent number: 11033844
    Abstract: Stabilized air filters formed from mats of crosslinked protein-containing fibers are provided. The fibers are formed into a mat with pores that allow air to pass through while physically filtering particulate matter. The protein in the protein-containing fibers also serves to chemically filter polluted air passed through the filter. Specifically, chemical functional groups from the many amino acids that comprise the protein of the protein-containing nanowire react with certain chemical pollutants (e.g., carbon monoxide and formaldehyde) in order to capture or otherwise neutralize the pollutant. Accordingly, the single fiber mat performs two filtering functions. Methods for making the air filters from crosslinked protein-containing nanofibers are also provided.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: June 15, 2021
    Assignee: Washington State University
    Inventors: Wei-Hong Zhong, Hamid Souzandeh, Yu Wang
  • POLYMER-DISPERSED, LIQUID CRYSTAL FILMS AND SYSTEMS FOR SHEAR STRESS MEASUREMENT AND RELATED METHODS
    Publication number: 20210173241
    Abstract: Films, systems, and methods for measuring shear stress are described. In an embodiment, the film comprises an optically transmissive polymer matrix disposed on a substrate; and a liquid crystal dispersed in the optically transmissive polymer matrix, wherein at least a portion of the liquid crystal protrudes from or is exposed on a side of the optically transmissive polymer matrix opposite the substrate.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 10, 2021
    Applicants: University of Washington, Kent State University
    Inventors: Dana Dabiri, John West, Junren Wang
  • Smart Hotel System
    Publication number: 20210173368
    Abstract: In accordance with the present invention, a smart hotel system is provided. In one aspect, the system includes an occupancy sensor and a processor. Another aspect provides an occupancy sensor associated with at least one hotel room and a programmable controller or processor configured to execute instructions stored in a nontransitory computer-readable medium. A further aspect includes programmed software instructions which include obtaining data indicative of occupancy status of the hotel room from the occupancy sensor and displaying the occupancy status of the hotel room. In another aspect, a controller or processor obtains data indicative of a cleaning status of at least one hotel room and displays the cleaning status of the hotel room.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Applicant: Board of Trustees of Michigan State University
    Inventors: Wolfgang BAUER, Natalie MCQUADE, Ryan MULKA, Mitchell LOE, David OSINSKI, Michele WEBER, Jonathan SPIGHT
  • MULTIFUNCTIONAL MANIFOLD FOR ELECTROCHEMICAL DEVICES AND METHODS FOR MAKING THE SAME
    Publication number: 20210175526
    Abstract: A multifunctional manifold for use with electrochemical devices having a spiral cross-section, such as spiral solid-oxide fuel cells, includes an interface that is configured to be placed in operative communication with such devices. The interface includes a fuel interface section and an oxidant interface section that are each configured as spirals. The spiral interface sections also include channels that are configured to be placed in operative communication with corresponding spiral channels of the electrochemical device to deliver operating gases, such as fuel gas and oxidant gas, thereto. In addition to delivering operating gases to the fuel cells, the multifunctional manifold is also configured to act as an electrical current collector and a heat exchanger.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 10, 2021
    Applicant: Kent State University
    Inventors: Yanhai Du, Aliia Mubarak Moh Maar
  • COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210171553
    Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.
    Type: Application
    Filed: January 4, 2021
    Publication date: June 10, 2021
    Applicants: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • VACCINE COMPOSITION COMPRISING RECOMBINANT PROTEIN OF STAPHYLOCOCCUS AUREUS ATTENUATED ENTEROTOXIN AND CYTOTOXIN
    Publication number: 20210170010
    Abstract: The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 10, 2021
    Applicants: REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY), Mississippi State University
    Inventors: Dong Chan MOON, Suk Kyung LIM, Keum Chan JANG, Suk Chan JUNG, Hee Soo LEE, Bang Hun HYUN, Hyang Mi NAM, Heui Jin KIM, Keun Seok Seo
  • Methods for generating macrophages with enhanced cancer phagocytosis
    Patent number: 11026972
    Abstract: The present invention relates to compositions and methods variously useful in treating cancer, inhibiting graft rejection, and treating autoimmune disease. The compositions and methods include those in which macrophages are conditioned to down regulate or upregulate the expression or activity of SIRP? or its interaction with CD47.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: June 8, 2021
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Yuan Liu, Zhen Bian, Ke Zen
  • Holistic digital gamma-ray spectroscopy methods and instrumentation for high-throughput high-resolution applications
    Patent number: 11029416
    Abstract: Method of real-time adaptive digital pulse signal processing for high count rate gamma-ray spectroscopy applications includes receiving a preamplifier signal at a pulse deconvolver, the preamplifier signal including resolution deterioration resulting from pulse pile-up. The method further includes generating a deconvoluted signal, by the pulse deconvolver, from the preamplifier signal, the deconvoluted signal having less resolution deterioration as compared to the received preamplifier signal. The method furthermore includes shaping of the deconvoluted signal by a trapezoid filter, the shaping comprising adjusting a shaping parameter of the trapezoid filter for an incoming signal based on a time separation from a subsequent incoming signal.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: June 8, 2021
    Assignee: North Carolina State University
    Inventors: Ayman I. Hawari, Shefali Saxena
  • Systems and methods for feature transformation, correction and regeneration for robust sensing, transmission, computer vision, recognition and classification
    Patent number: 11030485
    Abstract: Embodiments of a deep learning enabled generative sensing and feature regeneration framework which integrates low-end sensors/low quality data with computational intelligence to attain a high recognition accuracy on par with that attained with high-end sensors/high quality data or to optimize a performance measure for a desired task are disclosed.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: June 8, 2021
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Lina Karam, Tejas Borkar
  • Modified cellulose nanocrystals and their use in drilling fluids
    Patent number: 11028307
    Abstract: Bentonite (or other clay) water-based drilling fluids incorporating functionalized cellulose nanocrystals are disclosed. Cellulose nanocrystals are modified with tailored surface charges or tailored levels of salt-tolerant polymer grafting, and combined with bentonite (or other clay) nanoplatelets in an aqueous suspension. Thermal performance of drilling fluids can also be enhanced by surface grafting of thermally functional polymers onto cellulose nanocrystals.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: June 8, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Qinglin Wu, Meichun Li