Patents Assigned to State University
  • METHODS AND RELATED ASPECTS FOR DETECTING AND QUANTIFYING CHIMERIC ANTIGEN RECEPTOR T CELLS IN SAMPLES
    Publication number: 20250035627
    Abstract: Provided herein are methods of differentiating cell types in a cell population. The methods include removing at least some non-Chimeric Antigen Receptor (CAR)-T cells from a fluidic sample obtained from a subject without centrifuging the fluidic sample to produce a purified fluidic sample. The fluidic sample comprises CAR-T cells and the non-CAR-T cells. The methods also include capturing cells in the purified fluidic sample on a surface that comprises binding moieties that bind at least to the CAR-T cells to produce a captured cell population. In addition, the methods also include distinguishing the CAR-T cells from the non-CAR-T cells in the captured cell population using a trained machine learning model to produce a captured CAR-T cell population data set. Additional methods as well as related devices and systems are also provided.
    Type: Application
    Filed: July 19, 2024
    Publication date: January 30, 2025
    Applicants: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Mayo Foundation for Medical Education and Research
    Inventors: Shaopeng WANG, Nanxi YU, Chao CHEN, Xinyu ZHOU, Januario E. CASTRO, Eider F. Moreno Cortes
  • METHODS FOR MONITORING IMPACT OF MICROBIOTA TRANSFER THERAPY IN AUTISM SPECTRUM DISORDER (ASD)
    Publication number: 20250034656
    Abstract: The present disclosure relates to methods for monitoring effectiveness of a treatment of an autism spectrum disorder (ASD) by analyzing an ASD patient's gut microbiota based on stool samples. Also provided are software for implementing the methods, and kits for performing the methods.
    Type: Application
    Filed: November 30, 2022
    Publication date: January 30, 2025
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Rosa Krajmalnik-Brown, James Adams, Khemlal Nirmalkar
  • METHODS AND COMPOSITIONS FOR THE BIOSYNTHESIS AND USE OF DEMETHYLATED POLYMETHOXY FLAVONES
    Publication number: 20250032446
    Abstract: A novel yeast strain and methods of use thereof for robust biosynthesis of demethylated polymethoxy flavones are disclosed. Also provided are method of administering demethylated polymethoxy flavones for the treatment of obesity and inflammatory a disease.
    Type: Application
    Filed: December 12, 2022
    Publication date: January 30, 2025
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Shiwei SU, Chi-Tang HO, Qingrong HUANG
  • Interactive video surveillance as an edge service using unsupervised feature queries
    Patent number: 12211277
    Abstract: A method for querying data obtained from a distributed sensor network, comprising: receiving sensor data representing an aspect of an environment with a sensor of the distributed sensor network; communicating a representation of the sensor data to a fog node through an automated communication network; determining, by the fog node, a correspondence of a query received through the automated communication network to characteristics of the representation of the sensor data; and selectively communicating, in response to the query, at least one of: the sensor data having the determined characteristics corresponding to the query, an identification of the sensor data having the determined characteristics corresponding to the query, and the data representing the sensor data having the determined characteristics corresponding to the query.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: January 28, 2025
    Assignee: The Research Foundation for The State University of New York
    Inventors: Yu Chen, Seyed Yahya Nikouei
  • Nutrient recovery systems and methods
    Patent number: 12209026
    Abstract: Methods, systems, and apparatuses for anaerobic digestion of waste fibrous material and the recovery of nutrients are provided. Methods, systems, and apparatuses disclosed herein provide mechanisms to release dissolved gases from anaerobic digester effluent. Methods, systems and apparatuses disclosed herein can recover one or more nutrients from anaerobic digested effluent using a range of temperatures, aeration rates, aeration times, pH ranges, and settling times.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: January 28, 2025
    Assignees: DVO, Inc, Washington State University, Andgar Corporation
    Inventors: Quanbao Zhao, Stephen W. Dvorak, Shulin Chen, Craig Frear, Bryan J. VanLoo
  • Antibacterial agents: soluble salts and aqueous formulations of pyronins
    Patent number: 12209082
    Abstract: The invention provides salts of formula Ia, Ib, Ic, or Id: wherein variables are as described in the specification, as well as compositions comprising a salt of formula Ia-Id, methods of making such salts, and methods of using such salts as, e.g., inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: January 28, 2025
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Richard H. Ebright, Yon W. Ebright
  • Antibiofilm formulations
    Patent number: 12208069
    Abstract: Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: January 28, 2025
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, TRIAD NATIONAL SECURITY LLC, DIXIE STATE UNIVERSITY, THE COLLEGE OF NEW JERSEY
    Inventors: Andrew T. Koppisch, Gerrick E. Lindberg, David T. Fox, Joseph Baker, Alexanndra J. Heyert, Rico Del Sesto, Joshua R. Greene
  • Radiation-triggered liposomes
    Patent number: 12208138
    Abstract: The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: January 28, 2025
    Assignee: BOISE STATE UNIVERSITY
    Inventor: Daniel Fologea
  • High density and multiplexed nanopore devices with transverse tunneling junction for biomolecule detection and sequencing
    Patent number: 12209986
    Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: January 28, 2025
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventor: Quan Qing
  • Lapran: a scalable laplacian pyramid reconstructive adversarial network for flexible compressive sensing reconstruction
    Patent number: 12211173
    Abstract: This disclosure addresses the single-image compressive sensing (CS) and reconstruction problem. A scalable Laplacian pyramid reconstructive adversarial network (LAPRAN) facilitates high-fidelity, flexible and fast CS image reconstruction. LAPRAN progressively reconstructs an image following the concept of the Laplacian pyramid through multiple stages of reconstructive adversarial networks (RANs). At each pyramid level, CS measurements are fused with a contextual latent vector to generate a high-frequency image residual. Consequently, LAPRAN can produce hierarchies of reconstructed images and each with an incremental resolution and improved quality. The scalable pyramid structure of LAPRAN enables high-fidelity CS reconstruction with a flexible resolution that is adaptive to a wide range of compression ratios (CRs), which is infeasible with existing methods.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: January 28, 2025
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Fengbo Ren, Kai Xu, Zhikang Zhang
  • Pellet insertion apparatus and related methods
    Patent number: 12207596
    Abstract: Pellet insertion apparatus and methods. In accordance with an example, a method of inserting a pellet in a tree includes extending a taper (108) and an actuator rod (118) into the tree. The actuator rod (118) positioned within a through-bore (110) and extending from a taper distal end (112). The method includes securing the taper (108) in the extended position. The method includes retracting the actuator rod (118). The method includes loading a plug into the through-bore (110) of the taper (108). The method includes moving the actuator rod (118) to a plug insertion position.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: January 28, 2025
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: John C. Wise, Alfred K. Wise
  • Optical elements and systems for reflecting direct beam sunlight while admitting diffuse skylight through building apertures
    Patent number: 12209719
    Abstract: Optical elements and systems are disclosed that can be incorporated into buildings to prevent beam sunlight from entering through apertures of the building while allowing diffuse skylight to enter the building through the apertures. The optical system comprises optical elements configured to admit diffuse skylight through an aperture in the building envelope, while reflecting away the beam sunlight incident on the aperture in the building envelope. The apertures can be, for example, windows in walls or skylights in roofs of the building envelope. The optical system works for both windows in the walls and skylights in the roof, with somewhat different configurations for those two parts of the building envelope.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: January 28, 2025
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventor: Jeffrey Wayne Place
  • Antisense antibacterial compounds and methods
    Patent number: 12209240
    Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: January 28, 2025
    Assignees: Board of Regents, The University of Texas System, Oregon State University
    Inventors: David Greenberg, Bruce L. Geller
  • Fractal-like polymeric particles and their use in diverse applications
    Patent number: 12209203
    Abstract: Fractal-like polymeric particles having a hierarchical, branched structure are disclosed. The particles have fibers with nanometer-scale diameters on their peripheries, which enables a number of unique and highly desirable properties. The particles are fabricated by a method combining phase separation and shear forces of different solutions, in particular a polymer solution. In addition, the particles may be used as coatings, nonwovens, textiles and viscosity modifiers and adhesives, among other applications.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: January 28, 2025
    Assignee: North Carolina State University
    Inventors: Orlin D. Velev, Sangchul Roh
  • Monolithically integrated and densely packed array sensor platform for ultra-low power gas sensing applications
    Patent number: 12210012
    Abstract: The present disclosure presents environmental sensing apparatuses and methods. In one such apparatus, an environmental sensor comprises a substrate and an array of multiple metal oxide materials on the substrate. The multiple metal oxide materials can comprise layers of different metal oxide material, in which the multiple metal oxide materials are deposited on a cross-bar array of heater elements and electrodes and each row in the cross-bar array contains an independently-controlled heater element and each column in the array contains a pair of electrodes. At each crossing of the heater element and the pair of electrodes, one of the multiple metal oxide materials is deposited, and the pair of electrodes and the heater elements are dielectrically isolated from one another at the crossing.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: January 28, 2025
    Assignee: North Carolina State University
    Inventors: Bongmook Lee, Veena Misra
  • Systems and methods for non-destructive isolation, concentration, and detection for unbiased characterization of nano- and bioparticles
    Patent number: 12208400
    Abstract: The present disclosure provides systems and methods for separating one or more analytes within a fluid mixture, and characterizing and/or detecting properties associated with the one or more analytes. In some embodiments, the systems provided herein contain a dielectrophoresis device, such as a gradient insulator-based dielectrophoresis device (g-iDEP). The present disclosure provides systems and methods for separating and characterizing analytes using particle or nanoparticle tracking analysis (NTA). NTA offers various advantages because, particle size and concentration can be calculated in real time, allowing label-free and simultaneous characterization and separation of samples with mixed and unknown analytes.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: January 28, 2025
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Mark Hayes, Mikhail Skliar, Marc Porter, Brennan Copp, Samuel Hayes, Alexis Ramirez
  • Automated Growth System for Floating Aquatic Plants and Method
    Publication number: 20250024800
    Abstract: A hydroponic system for cultivation and harvesting of floating aquatic plants is provided. The hydroponic system includes an arrangement of a plurality of vertically-stacked cultivation trays, each tray containing an amount of fluent media on which floating aquatic plants are able to grow. The hydroponic system also includes a media reservoir in which fluent media is contained and subject to treatment before being circulated to the cultivation trays and a harvesting reservoir for receiving aquatic plants grown in the cultivation trays and harvested from the same. The hydroponic system further includes an automated control system that manages media flow into and from the trays and aquatic plant harvesting from the trays. A method of cultivating and harvesting floating aquatic plants is also provided.
    Type: Application
    Filed: July 19, 2024
    Publication date: January 23, 2025
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Eric Lam, Shawn D. Sorrels
  • METHODS FOR CULTURING MICROORGANISMS IN A LIQUID CULTURE SYSTEM
    Publication number: 20250027074
    Abstract: The present invention provides a method of culturing microorganisms normally grown on a solid in liquid media, methods of use thereof to determine the presence or absence of the microorganism in a sample, and methods of use in a mutation accumulation assay.
    Type: Application
    Filed: July 19, 2024
    Publication date: January 23, 2025
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Stephan Baehr, Wei-Chin Ho, Michael Lynch
  • KEXIN-DERIVED VACCINES TO PREVENT OR TREAT FUNGAL INFECTIONS
    Publication number: 20250025540
    Abstract: A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells.
    Type: Application
    Filed: March 25, 2024
    Publication date: January 23, 2025
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    Inventors: Jay K. Kolls, Michael Zheng, Karen Norris, Heather Kling
  • SYSTEM FOR AUTOMATED PROCESSING OF MASS SPECTROMETRY SAMPLES AND DATA
    Publication number: 20250027917
    Abstract: A system includes a processor, a network interface, an output coupled to the processor, and a memory coupled to the processor. The memory stores an idealized mass spectrogram library including a plurality of idealized mass spectrograms, each associated with an idealized compound, and a reference compound library including a plurality of reference compound identifiers, each associated with a reference structural datum.
    Type: Application
    Filed: July 18, 2024
    Publication date: January 23, 2025
    Applicants: Delaware State University, The United States of America, as represented by the Secretary of Agriculture
    Inventors: Chase Stratton, William Robert Morrison, III, Ebony Murrell, Yvonne Thompson, Konilo Zio