Patents Assigned to State University
  • Spin memory encryption
    Patent number: 12201029
    Abstract: A topological spin memory effect, defined as the recovery of magnetic skyrmions or magnetic bubble skyrmions in magnetic thin films after a transition to a dramatically different spin texture, is used for encrypted non-volatile information storage. The storage strategy is based on magnetic skyrmions, that is, topologically protected spin textures comprising chiral domain walls surrounding small (e.g., nanometers to microns in diameter), typically circular, single-domain cores. Systems and methods are described for encrypted non-volatile information storage based on a spin memory effect in magnetic thin films that support skyrmions. Systems and methods encrypt and recover information stored in the form of magnetic skyrmions.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: January 14, 2025
    Assignees: Colorado State University Research Foundation, Bryn Mawr College
    Inventors: Kristen Buchanan, Xiao Wang, Xuemei Cheng
  • Polymerase Chain Reaction Primers and Probes for Mycobacterium Tuberculosis
    Publication number: 20250011883
    Abstract: The present invention relates to novel primers and sloppy molecular beacon and molecular beacon probes for amplifying segments from different genes in Mycobacterium tuberculosis for identifying the presence of M.tb DNA and/or resistance to anti-tuberculosis drugs.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 9, 2025
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David Alland, Soumitesh Chakravorty
  • NANOEMULSION COMPOSITIONS OF TAXOID DRUGS, AND METHODS FOR THE USE THEREOF TO TARGET CANCER CELLS AND CANCER STEM CELLS
    Publication number: 20250009658
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
    Type: Application
    Filed: July 16, 2024
    Publication date: January 9, 2025
    Applicants: TargaGenix, Inc., Research Foundation for State University New York, Northeastern University
    Inventors: James E. EGAN, Iwao OJIMA, Mansoor M. AMIJI, Galina Ivanovna BOTCHKINA
  • CELLULARIZED NERVE REGENERATION GRAFT AND METHODS OF MAKING THE SAME
    Publication number: 20250009938
    Abstract: A cellularized nerve regeneration graft is disclosed that includes an electrospun biodegradable polymer conduit having an exterior surface and an interior luminal space, a plurality of fibroblasts seeded to the exterior surface of the conduit, and a system filling the interior luminal space of the conduit. The system may include a hydrogel matrix or augmented hydrogel matrix and Schwann cells. The cellularized nerve regeneration graft may be used in the repair of peripheral nerve injuries. Methods of making the cellularized nerve regeneration graft are also disclosed.
    Type: Application
    Filed: September 28, 2022
    Publication date: January 9, 2025
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Zhiping Pang, N. Sanjeeva Murthy, Andrew J. Boreland, Jasmine M. Gamboa, Jeremy M. Perrelle
  • SYSTEMS, METHODS, AND APPARATUSES FOR IMPLEMENTING A GENERIC UNIFIED DEEP MODEL FOR LEARNING FROM MULTIPLE TASKS
    Publication number: 20250014721
    Abstract: A generic unified deep model for learning from multiple tasks, in the context of medical image analysis includes means for receiving a training dataset of medical images; training the AI model to generate a trained AI model using a pre-processing operation, a Swin Transformer-based segmentation operation, and a post-processing operation, in which application of a Non-Maximum Suppression (NMS) algorithm generates object detection and classification output parameters for the AI model by removing overlapping detections and selecting a best set of detections according to a determined confidence score for the detections remaining; and outputting the trained AI model for use with medical image analysis.
    Type: Application
    Filed: July 1, 2024
    Publication date: January 9, 2025
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: ZiYu Fan, Jianming Liang
  • TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES
    Publication number: 20250011470
    Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.
    Type: Application
    Filed: February 8, 2024
    Publication date: January 9, 2025
    Applicants: Rutgers, The State University of New Jersey, Georgetown University
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin
  • SYSTEMS AND METHODS FOR A DYNAMIC QUADRUPED WITH TUNABLE, COMPLIANT LEGS
    Publication number: 20250010928
    Abstract: A robot includes four compliant, laminated fiberglass-composite legs that enable tuning passive parallel and series compliance of each leg. The legs of the robot are impactful on the performance of its locomotion for gaits like pronking and trotting, demonstrating the robot's potential for tuning and optimizing leg stiffness for niche and specialized applications.
    Type: Application
    Filed: July 8, 2024
    Publication date: January 9, 2025
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Daniel Aukes, Fuchen Chen
  • METHODS AND RELATED ASPECTS OF RAPID MICROBIAL DETECTION USING INTRINSIC FEATURE TRACKING
    Publication number: 20250012697
    Abstract: Provided herein is a method of detecting microorganisms in liquid samples using image features, such as time profiles of object light scattering intensity and time profiles of object position. Related methods, devices, systems, and other aspects are also provided.
    Type: Application
    Filed: November 14, 2022
    Publication date: January 9, 2025
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Shaopeng WANG, Fenni ZHANG
  • NOVEL RHODANINE DERIVATIVES AND USES THEREOF
    Publication number: 20250011292
    Abstract: Novel rhodanine derivatives and methods for their use are provided herein. The rhodanine derivatives are useful in treating or preventing viral infections, including coronavirus infections (e.g., a SARS-CoV-2 virus infection). The rhodanine derivatives are also useful as photosensitizers for photodynamic therapy in treating or preventing cancer in a subject.
    Type: Application
    Filed: October 12, 2022
    Publication date: January 9, 2025
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Binghe WANG, Xiaoxiao Yang, Ming Luo, Mukesh Kumar
  • METHODS FOR THE PRODUCTION OF THERAPEUTIC, DIAGNOSTIC, OR RESEARCH ANTIBODIES
    Publication number: 20250011795
    Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.
    Type: Application
    Filed: July 8, 2024
    Publication date: January 9, 2025
    Applicant: Wayne State University
    Inventors: Kang Chen, Bo Pei
  • MICROFLUIDIC CARTRIDGE AND METHODS OF USE THEREOF
    Publication number: 20250012704
    Abstract: This disclosure provides a microfluidic system (e.g., microfluidic cartridge, microfluidic chip) comprising two or more microfluidic flow channels for impedance-based detection of a biological entity in a sample. The disclosed system enables simultaneous measurements of a sample in two or more microfluidic flow channels to minimize faulty results. It eliminates the need of lysing samples and measuring them multiple times that is more time-consuming, and could introduce some variations across samples and devices.
    Type: Application
    Filed: October 26, 2022
    Publication date: January 9, 2025
    Applicants: RizLab Health, Inc., Rutgers, The State University of New Jersey
    Inventors: Mehdi JAVANMARD, Jianye SUI, Shahriar AZIZPOUR, Zhongtian Lin
  • Digital doping and development of a transparent conductor
    Patent number: 12191412
    Abstract: Compositions, thin films, devices, and methods involving doped oxide semiconductor materials are described. Indium gallium doped zinc oxide (IGZO) with advantageous properties that may be useful as a transparent conductive oxide (TCO) is described. Methods of digital doping to create doped oxide semiconductor materials are described.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: January 7, 2025
    Assignee: Bowling Green State University
    Inventor: Farida Selim
  • Metal organic interactions at hydrothermal conditions
    Patent number: 12187670
    Abstract: Oxidizing a first aromatic compound in the presence of a metal salt to yield a second aromatic compound includes combining the first aromatic compound, the metal salt, and water to yield an aqueous mixture, and heating the aqueous mixture at a temperature exceeding 200° C. to yield a reaction product that includes the second aromatic compound.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: January 7, 2025
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Grant Loescher, Everett Shock, Ian Gould, Hilairy Hartnett, Lynda B. Williams
  • Deep residual inception encoder-decoder network for amyloid PET harmonization
    Patent number: 12186114
    Abstract: Using deep learning, imaging harmonization among images produced with differing PET tracers is achieved. A method may include providing an original PET image of the brain using an original PET tracer, providing a target PET tracer, and converting, using a deep learning neural network, the original PET image into a target PET image simulating the image that would be obtained had the target PET tracer been used.
    Type: Grant
    Filed: May 9, 2024
    Date of Patent: January 7, 2025
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, BANNER HEALTH
    Inventors: Fei Gao, Yi Su, Jay Shah, Teresa Wu
  • Alternating current electrolysis for use in organic synthesis
    Patent number: 12188139
    Abstract: The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: January 7, 2025
    Assignee: Wayne State University
    Inventors: Long Luo, Hien M. Nguyen
  • Donor-acceptor type thermally activated delayed fluorescent materials based on imidazo[1,2-f]phenanthridine and analogues
    Patent number: 12193327
    Abstract: Donor-acceptor type thermally activated delayed fluorescent emitters based on imidazo[1,2-F]phenanthridine and analogues for full color displays and lighting applications.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: January 7, 2025
    Assignee: Arizona Board of Regents on behalf Arizona State University
    Inventors: Jian Li, Zhi-Qiang Zhu
  • Methods for use of soft continuum robotic module
    Patent number: 12186903
    Abstract: A soft continuum robotic module comprises a plurality of inflatable actuators disposed between plates. Via inflation or deflation of one or more of the actuators, the module may extend, contract, twist, bend, and/or exert a grasping force. One or more modules may be combined to form a robotic arm with multiple degrees of freedom.
    Type: Grant
    Filed: February 24, 2023
    Date of Patent: January 7, 2025
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Wenlong Zhang, Pham Huy Nguyen, Zhi Qiao, Sam Seidel, Imran I. B. Mohd, Sunny Amatya
  • Combination taxoid nanoemulsion with immunotherapy in cancer
    Patent number: 12186428
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: January 7, 2025
    Assignees: TargaGenix, Inc., The Research Foundation for the State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor M. Amiji, Iwao Ojima
  • Thermally activated delayed fluorescence chromophores and organic layers including the same
    Patent number: 12187934
    Abstract: A thermally activated delayed fluorescence chromophore of the general structure: wherein Ar1 represents an acceptor tuner ligand and Ar2 represents a donor ligand, wherein the acceptor tuner ligand is a benzene ring at least partially substituted with two or more fluoro atoms and wherein the donor ligand is an optionally substituted carbazole. Organic layers, such as polymers or films, comprising the thermally activated delayed fluorescence chromophores are also disclosed.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 7, 2025
    Assignee: Wright State University
    Inventor: Eric Fossum
  • High-resolution patterning and transferring of functional nanomaterials toward massive production of flexible, conformal, and wearable sensors of many kinds on adhesive tapes
    Patent number: 12186097
    Abstract: Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: January 7, 2025
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Seval Oren, Liang Dong