Abstract: Glucose-responsive zwitterionic polymer-insulin-saccharide compositions are provided according to aspects of the present disclosure which include a zwitterionic polymer, an insulin moiety, a saccharide moiety, and a saccharide binding molecule. Methods of use of glucose-responsive zwitterionic polymer-insulin-saccharide compositions according to aspects of the present disclosure include administration to human patients to alleviate conditions, such as diabetes, which are responsive to administration of insulin.
Abstract: Disclosed herein are compounds useful for treating obstructive lung diseases. The compounds are TAS2Rs agonists and may further be used to treat disorders and conditions implicated by TAS2R. In some instances the disclosed compounds can be used to treat asthma.
Type:
Grant
Filed:
September 1, 2021
Date of Patent:
March 25, 2025
Assignees:
University of South Florida, Rutgers, The State University of New Jersey
Inventors:
Stephen Liggett, James Leahy, Donghwa Kim, Steven An
Abstract: The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.
Type:
Grant
Filed:
November 8, 2023
Date of Patent:
March 25, 2025
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Hugh Mason, Andrew Diamos, Mary Pardhe, Brandon Favre
Abstract: Disclosed are a dry calibration device for calibrating fluorescent detectors and methods of making and using such a device to obtain accurate calibration of single site and multiplexed fluorescent detectors. The device comprises slides that use phosphorescent material with neural density filters to replicate varying fluorophore concentrations.
Type:
Grant
Filed:
October 20, 2022
Date of Patent:
March 25, 2025
Assignee:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Jennifer Blain Christen, Joshua Eger, Mark Bailly
Abstract: Described herein are means for generating source models for transfer learning to application specific models used in the processing of medical imaging.
Type:
Grant
Filed:
July 17, 2020
Date of Patent:
March 25, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The present disclosure relates to Betulastatin compounds, pharmaceutical compositions and kits comprising such compounds, and methods for using such compounds or pharmaceutical compositions.
Type:
Grant
Filed:
February 8, 2023
Date of Patent:
March 25, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.
Type:
Grant
Filed:
July 12, 2019
Date of Patent:
March 25, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Inventors:
Douglas Grant McFadden, John Christie, Joseph Blattman, Mohammed Masmudur Rahman, Nancy Yaneth Villa
Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
Type:
Grant
Filed:
September 4, 2018
Date of Patent:
March 25, 2025
Assignee:
The Research Foundation for the State University of New York
Abstract: This discloses that compounds of Formula 1 may be used as antifibrotics because they inhibit type 1 collagen production. In particular, this discloses a pharmaceutical composition containing one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
Type:
Grant
Filed:
November 22, 2022
Date of Patent:
March 25, 2025
Assignee:
Florida State University Research Foundation, Inc.
Abstract: A method of adaptively scanning a selected area that includes selecting an imaging mode, performing a scan of the selected area using the imaging mode, detecting an item of interest, automatically selecting a new imaging mode in response to detecting the item of interest, and performing a scan of the item of interest using the new imaging mode. The imaging mode may determine at least one of a scanning pattern, a scanning speed, and a scanning rate. Spectral data and image data may be gathered and used to detect the item of interest. The method may also include providing a scanning spectrometer system that has a gimbal system configured to provide at least two degrees of freedom to the scanning spectrometer system. The gimbal system may have a spectrometer and a camera each mounted on the gimbal system and configured to gather the spectral data and the image data, respectively.
Type:
Application
Filed:
September 16, 2024
Publication date:
March 20, 2025
Applicant:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: A system implements a modeling (ClassGP) and an optimization (ClassBO) framework that models heterogeneous functions with knowledge of individual partitions within classes, i.e., heterogeneous functions including non-stationary functions which can be divided into locally stationary functions over partitions of input space with an active stationary function in each partition. The framework constructs a class likelihood for the class by combining log marginal likelihoods associated with each partition of the plurality of partitions within the class. The framework aims to improve analysis of systems that are characterized by a discrete and finite number of “classes” of behaviors.
Type:
Application
Filed:
September 19, 2024
Publication date:
March 20, 2025
Applicant:
Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Mohit Malu, Giulia Pedrielli, Gautam Dasarathy, Andreas Spanias
Abstract: An expanding dowel-pin comprises an upper-collet, inside-conical bore with one or more upper-collet slits. The expanding dowel pin further includes a double-tapered cylinder with tapered cones tapering more narrowly from its middle. The expanding dowel pin further includes a lower collet with a lower-collet, inside-conical bore which has one or more lower-collet slits. The lower collet further includes a lower-collet, inside-straight bore with lower-collet internal screw threads. The upper collet, the double-tapered cylinder, and the lower collet are, in that order, configured to have a bolt pass therethrough. The lower-collet internal screw threads are configured to engage the bolt, such that, when the bolt is rotated a first direction relative to the lower collet, the upper collet and the lower collet are configured to be compressed together by the bolt. The compression by the bolt results in the expansion of the upper-collet and the lower-collet.
Type:
Application
Filed:
September 20, 2023
Publication date:
March 20, 2025
Applicant:
Utah State University Space Dynamics Laboratory
Abstract: Atomically dispersed platinum-group metal-free catalyst and method for synthesizing the same. According to one embodiment, the catalyst is made by a method in which, in a first step, an Mn-doped ZIF-8 catalyst precursor is prepared by reacting a first solution comprising zinc nitrate hexahydrate and manganese chloride dissolved in an acid/water solution with a second solution comprising 2-methylimidazole dissolved in water. Then, in a second step, the Mn-doped ZIF-8 catalyst precursor is thermally activated, i.e., carbonized, to form an Mn—N—C catalyst. Preferably, the thermal activation is performed in a multistep fashion, first at a lower temperature of about 800° C. and then at a higher temperature of about 1100° C. After carbonization, the catalyst material may optionally be subjected to an absorption process, followed by a second thermal activation. The absorption process may involve dispersing the catalyst material in a solution of manganese chloride and urea in hydrochloric acid and isopropanol.
Type:
Grant
Filed:
September 1, 2021
Date of Patent:
March 18, 2025
Assignees:
The Research Foundation for the State University of New York, Giner, Inc.
Inventors:
Gang Wu, Hui Xu, Mengjie Chen, Fan Yang
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
Type:
Grant
Filed:
January 2, 2024
Date of Patent:
March 18, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA.
Abstract: Processing algae includes liquefying algae to yield a mixture including biocrude oil, biochar, and an aqueous component, and treating the biochar to yield a nutrient composition including ammoniacal nitrogen and phosphate.
Type:
Grant
Filed:
January 27, 2023
Date of Patent:
March 18, 2025
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Inventors:
Shuguang Deng, Peter Lammers, Kodanda Phani Raj Dandamudi, Mark Seger
Abstract: A dynamic capacitive sensor configuration is disclosed which imposes minimal force and resistance to motion on the moving electrode. Moving electrodes avoid adverse effects of large bias voltages such as pull-in instability, despite arbitrary levels of compliance. This configuration facilitates incorporation of highly compliant and thin electrode materials that present the least possible resistance to motion. This type of material is particularly useful for sensing sound. A large bias voltage can be applied without influencing its motion, e.g., 400 V. The electrical sensitivity to sound is high, e.g., approximately 0.5 volts/pascal, two orders of magnitude greater than typical acoustic sensors.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
March 18, 2025
Assignee:
The Research Foundation for The State University of New York
Abstract: The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.
Type:
Grant
Filed:
December 3, 2019
Date of Patent:
March 18, 2025
Assignees:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, The Board of Regents for Oklahoma State University
Inventors:
Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell
Abstract: A method of removing contaminants from a solution comprises passing a solution including one or more contaminants through a first cell comprising a first anode chamber and a first cathode chamber, passing a slurry comprising a flowing electrode material through the first anode chamber and the first cathode chamber while applying an electric potential between the first anode chamber and the first cathode chamber to transport anions from the solution to the first anode chamber and to transport cations from the solution to the first cathode chamber, the flowing electrode material comprising a MXene material, wherein M is a metal and X is one or both of carbon and nitrogen, and passing the slurry through a second cell to desorb the anions and cations from the flowing electrode material. Related systems for removing contaminants from a solution, and related methods are disclosed.
Type:
Grant
Filed:
December 3, 2020
Date of Patent:
March 18, 2025
Assignees:
Battelle Energy Alliance, LLC, Boise State University
Inventors:
Tedd E. Lister, Luis A. Diaz Aldana, Naqsh E. Mansoor, David Estrada