Abstract: Disclosed herein are embodiments of a composition comprising at least three layers. Layers one and two each either comprises a sensitizer or an emitter, typically a metal ion or a dye, and the third layer may or may not comprise a sensitizer or emitter. Upon exposure to light, such as infrared light, the composition produces visible and/or UV light. The composition may further comprise a capping moiety, a therapeutic agent, an uptake enhancer, a detection moiety that binds to a desired target, a quenching moiety, or a combination thereof. The composition may be a particle, such as a nanoparticle, or it may be a planar composition. Also disclosed are embodiments of a method for using the composition, including, but not limited to, a method for delivering a therapeutic agent, or a method for detecting a target, such as a biological target.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: Disclosed herein are methods and systems for processing signals from multiple users at an antenna array, and to provide beamforming for transmitting to those multiple users, and more particularly for channel estimation and wireless signal recovery in wireless networks carrying transmissions in the millimeter wave frequency bands to enable such beamforming. Such methods and systems enable MIMO communications at millimeter wave frequencies for multiple users communicating with a MIMO antenna system, such as a massive MIMO multi-antenna system (multi-antenna arrays that consist of hundreds of antenna elements). Such methods and systems may characterize the communications link (i.e., channel) at that frequency band, and directly provide a precoding matrix for beam steering towards a particular user that is in communication with the antenna system.

Abstract: Standard nested virtualization allows a hypervisor to run other hypervisors as guests, i.e. a level-0 (L0) hypervisor can run multiple level-1 (L1) hypervisors, each of which can run multiple level-2 (L2) virtual machines (VMs), with each L2 VM is restricted to run on only one L1 hypervisor. Span provides a Multi-hypervisor VM in which a single VM can simultaneously run on multiple hypervisors, which permits a VM to benefit from different services provided by multiple hypervisors that co-exist on a single physical machine. Span allows (a) the memory footprint of the VM to be shared across two hypervisors, and (b) the responsibility for CPU and I/O scheduling to be distributed among the two hypervisors. Span VMs can achieve performance comparable to traditional (single-hypervisor) nested VMs for common benchmarks.

Abstract: The methods and configurations herein provide for analysis of microplate based assays. Certain aspects include: an optical illumination panel; a plurality of sample wells configured to receive light from the optical illumination panel, and wherein the plurality of sample wells is configured with a first field of view; at least one aperture array configured to isolate directed light therethrough the plurality of sample wells; at least one optical array configured to receive optical information from the plurality of sample platforms, wherein the at least optical array comprises an array of individual microprisms configured with equal apex angles at distal equidistances along a row, wherein the individual microprism apex angles decrease toward the center of the row culminating in at least one flat surface along a center portion of the row; and a detector configured to capture the optical information with a second field of view as provided by the at least one optical array.

Abstract: An example of the composition incudes at least one amino acid sequence from the octarepeat region of hemin that is modified by substituting at least one proline (P) residue in the amino acid sequence. The composition is effective to bind with hemin and for treating hemorrhagic injury.

Abstract: Mapping and localization using image processing of wireless signals is provided. Embodiments of the present disclosure provide a novel approach for high accuracy mapping of an environment around an antenna (or antenna array) coupled to a radio frequency (RF) transceiver through image processing of RF signals. The image processing includes constructing a map of line-of-sight (LOS) and non-line-of-sight (NLOS) objects in the environment by distinguishing NLOS objects and correctly projecting their positions relative to the LOS objects. In some examples, a three-dimensional (3D) image of the environment around the antenna (or antenna array) is produced. Aspects disclosed herein can further provide simultaneous localization and mapping (SLAM) for a wireless device.

Abstract: The instant invention provides near-infrared fluorescent nerve contrast agents and methods of using them.

Abstract: The present invention describes novel pharmaceutical compositions and methods for treatment of diseases, disorders, or conditions characterized by recurrent seizures, particularly, epilepsy. According to the invention, compounds which inhibit the activity or expression of non-receptor Fyn tyrosine kinase can prevent activation epileptic pathophysiology and provide protection from and treatment of epilepsy. Particularly preferred is the class of small molecule Fyn kinase inhibitors such as sacaratinib and its prodrugs, derivatives, analogs and the like.

Abstract: The disclosure relates to a method for decolorization of a dye-colored synthetic polymer, which includes the steps of treating a dye-colored synthetic polymer, such as polyester, with a treatment composition at pH 4 or less, the treatment composition comprising hydrogen peroxide, an iron catalyst, water, and a ketone. The resulting decolorized synthetic polymer is then separated from the treatment composition.

Abstract: Linear actuators are disclosed. The linear actuator comprises a thruster and a stator. The thruster includes a thruster winding, and the stator includes a stator winding. The stator is disposed about the thruster. The linear actuator also includes a sheath disposed about the stator and the thruster. The thruster is configured to translate within the sheath relative to the stator upon application of an electrical current to the stator winding, the thruster winding, or a combination thereof. The stator winding and the thruster winding each comprise a nonpermanent magnet.

Abstract: A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction and a formed using a second knitted portion formed using a second knitting sequence in the machine direction, the second knitted portion comprising at least two strips extending in the machine direction, the at least two strips being detached from one another along their lengthwise edges. The second knitted portion has the same width as the first knitted portion, and the first knitted portion and the second knitted portion alternate sequentially in the machine direction and are formed of a single set of continuous textile strands.

Abstract: A microphone, comprising at least two electrodes, spaced apart, configured to have a magnetic field within a space between the at least two electrodes; a conductive fiber, suspended between the at least two electrodes; in an air or fluid space subject to waves; wherein the conductive fiber has a radius and length such that a movement of at least a central portion of the conductive fiber approximates an oscillating movement of air or fluid surrounding the conductive fiber along an axis normal to the conductive fiber. An electrical signal is produced between two of the at least two electrodes, due to a movement of the conductive fiber within a magnetic field, due to viscous drag of the moving air or fluid surrounding the conductive fiber. The microphone may have a noise floor of less than 69 dBA using an amplifier having an input noise of 10 nV/?Hz.

Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

Abstract: The disclosed technology relates generally to apparatuses comprising conductive polymers and more particularly to tags and tag devices comprising a redox-active polymer film, and methods of using and manufacturing the same. In one aspect, an apparatus includes a substrate and a conductive structure formed on the substrate which includes a layer of redox-active polymer film having mobile ions and electrons. The conductive structure further includes a first terminal and a second terminal configured to receive an electrical signal therebetween, where the layer of redox-active polymer is configured to conduct an electrical current generated by the mobile ions and the electrons in response to the electrical signal. The apparatus additionally includes a detection circuit operatively coupled to the conductive structure and configured to detect the electrical current flowing through the conductive structure.

Abstract: An electronics system may include a substrate, an electronic device bonded to the substrate, a plurality of photoluminescent particles disposed on the electronic device, an illuminator, a sensor, and a control module. The illuminator can illuminate the electronic device. The sensor can capture a first set of positions of the photoluminescent particles on the electronic device when the electronic device is not operating under a load and a second set of positions of the photoluminescent particles when the electronic device is operating under a load. The control module can determine thermomechanical stress on the electronic device based at least in part on a difference between the first set of positions and the second set of positions.

Abstract: A plurality of mobile devices is provided including a first mobile device of the plurality of mobile devices that serves as a relay for communication between a second mobile device of the plurality of mobile devices and a third mobile device of the plurality of mobile devices. The first mobile device is identified as the relay based on a social trust relationship formed between the first mobile device and the second mobile device. A D2D network is formed between the first mobile device and second mobile device. A communication channel is provided to the second mobile device from a second cellular network. A portion of the communication channel is allocated to the second mobile device using the D2D network to improve cellular transmission between the second mobile device and the third mobile device.

Abstract: Position information estimation in a distributed radio frequency (RF) communications system is provided. Embodiments disclosed herein facilitate high-precision estimations of positions, orientations, velocities, and acceleration of network nodes in a distributed RF network. The distributed RF communications system incorporates a series of estimation processes which makes it susceptible to propagation of errors. To ensure robustness of the distributed RF communications system, relative positions of network nodes are tracked by iteratively tracking parameters used for estimating position information. Some embodiments take advantage of Kalman filtering algorithms by leveraging principles directed by physics. At every network node, several filtering algorithms can be employed to synchronize clocks, track delay between multiple-input multiple-output (MIMO) antennas and estimate position and orientation of other network nodes.

Abstract: A single-chain variable fragment (ScFv) derived from anti-c-Met monoclonal antibody MetMAb that specifically binds to c-Met receptor is provided. Also provided are chimeric antigen receptor (CAR) vectors including the ScFv, human T cells transduced with the disclosed CAR vectors, pharmaceutical compositions including the CAR T cells, ScFv fusion proteins, and methods of treating a c-Met-positive cancer or a cancer characterized by overexpression of c-Met in a subject in need thereof by administering an effective amount of the disclosed CAR T cells.

Abstract: Position information estimation in a distributed radio frequency (RF) communications system is provided. Embodiments disclosed herein facilitate high-precision estimations of positions, orientations, velocities, and acceleration of network nodes in a distributed RF network (e.g., including base stations and vehicles, such as aircraft or unmanned aerial systems (UASs)). Modern radio systems must adapt to limited spectral access by reducing spectrum demand and increasing operational efficiency. In this regard, an RF system is provided which simultaneously performs positioning and communications tasks. This system specifically addresses the issue of spectral congestion by employing an extremely efficient positioning strategy and using a joint waveform that simultaneously enables both tasks. This efficiency in turn supports more users in a given frequency allocation.