Abstract: An integrated dual-modality microfluidic sensor chip and methods for using the same. In one form, the sensor comprises a patterned periodic array of nanoposts coated with a noble metal and graphene oxide (GO) to detect target biomarker molecules in a limited sample volume. The device generates both electrochemical and surface plasmon resonance (SPR) signals from a single sensing area of the metal-GO nanoposts. The metal-GO nanoposts are functionalized with specific receptor molecules, serving as a spatially well-defined nanostructured working electrode for electrochemical sensing, as well as a nanostructured plasmonic crystal for SPR-based sensing via the excitation of surface plasmon polaritons.

Abstract: A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.

Abstract: A passive authentication method includes, in response to receiving a requested action from a first user, obtaining a set of sensor data and categorizing first sensor data of the set of sensor data into a first modality of a set of modalities. The method includes, for the first modality of the set of modalities, determining a distance value by applying a first modality model to the first sensor data and comparing the distance value to a first verified value of the first user for the first modality. The method includes, based on the comparison, determining a first authentication decision of the distance value. The method includes, in response to the first authentication decision indicating the first sensor data corresponds to the first user, performing the requested action.

Abstract: Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or essential genes, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.

Abstract: Various embodiments of a multi-modal screw propelled excavation craft operable for excavating a material as the craft is propelled along a surface are disclosed.

Abstract: Halide ligand free rhenium complexes are described as well as methods for depositing rhenium-containing films. Some embodiments provide a rhenium complex with a general formula of O3ReO-M-R1R2R3, where M is a group IV element, R1 is selected from H, alkyl, alkenyl, alkynyl, an aromatic ring, or alkoxy, and R2 and R3 are each independently selected from H, alkyl, alkenyl, alkynyl, an aromatic ring, or alkoxy, or R2 and R3 join together to form a ring structure or an oxo group. Some embodiments provide a rhenium complex with a general formula of Re(NR?)3(NHR?), where R? and R? are independently selected from H, alkyl, alkenyl, alkynyl, or an aromatic ring.

Abstract: A testing device for tubular solid oxide fuel cells (SOFC) includes a housing within which the tubular SOFC is mounted. The housing includes suitable inlets and outlets to allow a fuel gas, such as hydrogen, and an oxidant, such as air or oxygen, to interact with the anode and cathode of the tubular SOFC. In addition, the housing is formed of suitable material for placement in a heating device, such as a tubular furnace or a miniature tubular heater. A temperature sensor and computing device may monitor the temperature of the tubular SOFC in order to control the operation of the tubular heating device. In addition, the device provides electrical current collectors for coupling to the anode and cathode of the SOFC, which may be removable and reusable.

Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.

Abstract: The disclosure describes a method for modeling excess base current in irradiated bipolar junction transistors (BJTs). The method includes quantifying defect-related electrostatic effects of a BJT device to help improve accuracy in predicting an irradiated excess base current of the BJT device. The method can be adapted to model the excess base current of a lateral P-type-N-type-P-type (LPNP) BJT device in depleted and/or accumulated surface potential states. The predicted excess base current may be used to qualify or disqualify the BJT device or an electrical circuit including the BJT device for use in a space system(s) as a commercial-off-the-shelf (COTS) component. By modeling the excess base current based on quantifying and utilizing the defect-related electrostatic effects, it may be possible to accurately predict a total-ionizing-dose (TID) response of the BJT device, thus enabling faster and lower-cost qualification of a COTS component(s) for use in the space system(s).

Abstract: The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.

Abstract: A controller hardware in the loop (CHIL) interface is disclosed. The CHIL interface comprises software and hardware that redirects a signal flow, including modulation signals and measurements exchanged between controller logic and a power electronics converter (PEC), to a CHIL port. Accordingly, the CHIL port provides access to the controller logic, at a digital level, throughout phases of the controller's lifetime (i.e., design, installation, maintenance, upgrade). Thus, the CHIL interface facilitates the use of PEC simulators for testing. The CHIL interface can detach the actual PEC from the control logic so testing can be performed with or without an operating PEC and can avoid the need for dedicated and error prone signal conditioning circuitry that is external to the controller.

Abstract: Antiviral protease inhibitors are disclosed, along with related antiviral dipeptidyl compounds, macrocyclic derivatives thereof and methods of using the same to treat or prevent viral infection and disease from coronaviruses, caliciviruses, and picornaviruses.

Abstract: A surgical tool includes opposing jaws, handles and at least one pressure sensor. Another aspect of a surgical tool includes opposing jaws with each having an organ-contacting surface area of at least 50 mm2. A further aspect of a surgical tool includes an electronic controller connected to at least one pressure sensor and automatically adapted to calculate or determine an organ-hardness from a sensor when jaws are moved to an organ-compressing position. In yet another aspect of a surgical tool, a pressure sensor is mounted to a pancreas-compressing surface and a displacement transducer or sensor is mounted to and/or located within a handle coupled to the surface, and an electronic controller is mounted to and/or located within the handle for calculating a hardness of a pancreas and/or other organ.

Abstract: A multi-hypervisor system, comprising: a plurality of hypervisors comprising a first hypervisor and a second hypervisor, at least one of the plurality of hypervisors being a transient hypervisor; and at least one Span VM, concurrently executing on each of the plurality of hypervisors, the at least one transient hypervisor being adapted to be dynamically at least one of injected and removed under the at least one Span VM concurrently with execution of the at least one Span VM on another hypervisor, wherein the at least one Span VM has a single and consistent at least one of memory space, virtual CPU state, and set of input/output resources, shared by the plurality of hypervisors.

Abstract: Methods of synthesizing and isolating facial-tris-homoleptic phenylpyridinato iridium (III) photocatalysts are disclosed. Also disclosed are methods of recovering excess 2-phenylpyridine ligands from said syntheses.

Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Parainfluenza Virus Type 1 (“PPIV-1”), including novel genotypes thereof, all of which are useful in the preparation of immunogenic compositions and vaccines for treating and preventing disease in swine.

Abstract: Disclosed herein are embodiments of a waste management device, and methods of using the same. The waste management device disclosed herein comprises a vessel having a wall that has a hydrophobic material at an inner surface thereof, and the wall is maintained at a temperature that is at least at Leidenfrost temperature for a mixture. The waste management device disclosed herein further facilitates separating one or more liquids from the mixture of liquids.

Abstract: Provided herein is a cell macroencapsulation device composed of hydrogel in a 3D conformation that optimizes encapsulated cell viability and function when transplanted into a vascularized tissue space. The hydrogel macroencapsulation device is intended to reduce or eliminate immune response to the cell graft, while allowing exchange of encapsulated cell-secreted products, such as insulin. Also described herein is an injection-mold and fabrication process to generate the hydrogel macroencapsulation devices for use in the clinic.

Abstract: A composition comprising a bioresponsive (e.g., reactive oxygen species (ROS)-responsive), antibiotic- and/or absorbent-loaded polymeric network is described. In some cases, the composition can release the antibiotic loaded therein in response to ROS or another stimulus related to inflammation. Microneedles, microneedle arrays, and skin patches comprising the composition are also described, as well as methods of treating acne or other inflammatory/infectious skin conditions.

Abstract: A new and distinct Origanum vulgare plant named ‘Pierre’ is disclosed, characterized by very high essential oil content, high carvacrol content, no flowering, broad plant width, and about 16 weeks to maturity.