Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.

Abstract: Disclosed herein are systems and methods for identifying biomarkers. Biomarker identification can be achieved while increasing efficiency and decreasing data and computation complexity but maintaining accuracy. Such biomarker identification can be achieved via analysis of differential gene expression, such as determined using single cell RNA-sequencing data sets.

Abstract: Prosthetic arm controller systems, as disclosed and discussed herein, include: a first controller unit that is placed or located inside a shoe or a sock of a user or that is integrated into a foot sleeve that slides on to the foot of a user, wherein the first controller unit comprises at least two interactive buttons that the user can engage, a second controller unit that is removably clipped or otherwise removably attached to the side or top of the shoe or the sock, wherein the second controller unit comprises at least one microcontroller with at least one integrated gyroscope, at least one accelerometer, and an onboard wireless protocol antenna that wirelessly communicates at least one command to a prosthetic arm from the first controller unit or the second controller unit, and wherein the at least one command comprises at least one grip command, at least one rotate command, at least one bend command, or a combination thereof.

Abstract: An efficient compact power generator system is provided. The system includes a shaft assembly, upper fan assembly, lower fan assembly, windmill opening assembly, bevel gear assembly, planetary gearset, and generator. The shaft assembly includes upper and lower shafts. The upper fan assembly includes an upper fan. The lower fan assembly includes a lower fan and bearings. The windmill opening assembly includes inlet and outlet openings. The bevel gear assembly includes a top bevel gear, a middle bevel gear, and a bottom bevel gear which are arranged and configured to reverse the direction of the lower fan to synchronize with the upper fan.

Abstract: A method for indentation of physical items may include forming, via an indenter, a plurality of first indents in a first surface of a first physical item, and validating a first material of the first physical item based at least in part on the first indents. The first indents may be disposed within a first defined region of the first surface and arranged in a first encoded pattern corresponding to a first item-specific serialization code for the first physical item.

Abstract: Elastomeric actuators and methods of making the same are provided herein. In some examples, an actuator includes a body comprising a plurality of pairs of frustums, wherein the body is configured to receive a fluid to extend the actuator and to remove the fluid to contract the actuator. In some examples, each pair of frustums includes two thin frustum shells sharing a common base circle diameter.

Abstract: In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for automatically transforming a digital image into a simulated pathology image are provided. In some embodiments, the method comprises: receiving a content image from an endomicroscopy device; receiving, from a hidden layer of a convolutional neural network (CNN) trained to recognize a multitude of classes of common objects, features indicative of content of the content image; receiving, providing a style reference image to the CNN; receiving, from another hidden layer of the CNN, features indicative of a style of the style reference image; receiving, from the hidden layers of the CNN, features indicative of content and style of a target image; generating a loss value based on the features of the content image, the style reference image, and the target image; minimizing the loss value; and displaying the target image with the minimized loss.

Abstract: The present disclosure provides a DC mechanical circuit breaker that can utilize two switches, one of which can generate zero-crossing with an alternate oscillatory circuit for the other one, which can be a conventional zero-crossing-based AC breaker and can be used in the main circuit. This is different from the conventional single-switch commute-and-absorb method currently used. The present disclosure shows that disclosed circuit breaker improves the fault current extinction and significantly reduces the voltage rate-of-change while creating the current zero-crossing faster compared to the available technology. Thus, disclosed circuit breaker is capable of interrupting high DC currents with minimal arc through a less expensive AC circuit breaker. Simulation and hardware results are provided to show the efficiency of the disclosed circuit breaker.

Abstract: Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder.

Abstract: Disclosed herein are CdSeTe photovoltaic devices having interdigitated back contact architecture for use in polycrystalline thin films in photovoltaic devices.

Abstract: A universal bacterial assay and kit for detecting and monitoring changes in concentration of a target analyte in solution. The assay relies on an engineered high affinity protein-based sensor with a detectable label that has high specificity to a target analyte, typically a ligand or metallated complex, and can be used to spectroscopically monitor interaction of the target analyte with a test bacterial strain. The sensors can be in the form of living, transport-deficient bacterial cells expressing the engineered high affinity protein, or in the form of purified proteins themselves. The system can further be used to screen candidate compounds for interference with the binding and uptake of such analytes by bacterial cells, which is useful in investigation of new classes of antibiotics.

Abstract: A wireless sensor network is described. The wireless sensor network comprises an interrogator transceiver operable to transmit a first wireless signal at a first RF frequency and to receive a second wireless signal at a second RF frequency to and from a wireless sensor node embedded within a medium. The medium comprises one or more dielectric materials. The wireless sensor node is interrogatable by the interrogator transceiver. The wireless sensor node is operable to receive the first wireless signal at the first RF frequency from the interrogator transceiver and to transmit the second wireless signal at the second RF frequency to the interrogator transceiver. A processor is coupled to a circuit within the interrogator transceiver. The circuit is operable to measure a power level of a received signal, and the processor is operable to correlate the power level of the received signal to a composition of the medium.

Abstract: The invention relates to a method of producing a tendon neotissue from a population of adipose-derived stem cells (ASCs) subjected to mechanical and biological stimulations in a bioreactor system. The tendon neotissues are effective as implants to treat tendon or ligament injury in a subject. The invention also relates to a customized bioreactor useful for producing a tri-dimensional engineered tissue.

Abstract: Compositions and methods useful for the diagnosis and treatment of leaky gut syndrome and IBD including Crohn's disease are disclosed.

Abstract: Disclosed herein is a glass that exhibits high hardness and crack-resistance and can potentially be synthesized using conventional glass manufacturing infrastructure. The glass has high hardness and crack resistance than other commercial glasses. Apart from that, the glass exhibits good glass forming ability and high chemical durability.

Abstract: System and method to improve the linearity of vector matrix multipliers (VMMs) by including (1) delta-sigma modulators that convert the input and output activations into binary pulse trains, (2) charge-domain computation in each SRAM cell that removes the nonlinear dependency on bitline voltage of the result of the multiplication and allows rail-to-rail output swing, and (3) a CMOS switch that transmits input activation to the capacitor in the SRAM cell, which improves linearity by suppressing the switch threshold voltage dependence on input activation voltage.

Abstract: A method for making a catalyst comprises providing an initial compound having a perovskite lattice structure according to formula I M1M2M3O3 ??FORMULA I, where M1 is about 1 relative elemental ratio strontium (Sr); M2 is from greater than 0 to 0.7 relative elemental ratio and is selected from cobalt (Co), scandium (Sc), iron (Fe), nickel (Ni), and titanium (Ti); and M3 is 0.3 to 0.6 relative elemental ratio iridium (Ir). Initial exemplary compounds include SrSc0.5Ir0.5O3 (SSI) and SrCo0.5Ir0.5O3 (SCI). M1 and/or M2 cations are selectively leached from the initial compound to produce a catalyst having substantially increased catalytic performance. Cycling SSI or SCI in an acid produces SSI-H or SCI-H; cycling SSI or SCI in a base produces SSI-OH or SCI-OH. Dual-site metal leaching induced catalytic activity improvement by about 2 orders of magnitude, making reconstructed SrCo0.5Ir0.5O3 among the best-known catalysts for water oxidation in an acidic condition.

Abstract: Aspects of the present disclosure include a robotic wheel that includes a tensegrity structure, an inner hub, an outer hub, and a cable. The tensegrity structure includes multiple rigid rods and multiple elastic cables, and the tensegrity structure defines a longitudinal axis, a first end and a second end. The inner hub is disposed at the first end of the tensegrity structure and the outer hub is disposed at the second end of the tensegrity structure. The cable is in contact with the outer hub, extends through the tensegrity structure parallel to the longitudinal axis, and extends through the inner hub. The cable is operable to retract to transition the tensegrity structure to a collapsed state and to extend to transition the tensegrity structure an expanded state.

Abstract: An optical system, comprises a mirror cage, a light source optically connected to a first side of the mirror cage via a first fiberoptic cable and a first collimator, an energy sensor optically connected to a second side of the mirror cage opposite the first side, a second fiber optic cable optically connected to a third side of the mirror cage via a second collimator, an avalanche photodiode (APD) optically connected to a fourth side of the mirror cage opposite the third side, and a dichroic mirror positioned within the housing at an angle relative to the first side. An automated micropipette electrode guidance system comprises the optical system as above, and a micropipette electrode connected to the optical system via the second fiber optic cable. Related methods are also disclosed.

Abstract: ‘NCORNSP-031SHMG’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its dark red heart shaped leaves, a moderately-compact habit and semi-erect mounding plant architecture. The dark red leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-031SHMG’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-031SHMG’ is shown to be suitable for use as a landscape or containerized plant.