Abstract: Fabricating a vertical-channel junction field-effect transistor includes forming an unintentionally doped GaN layer on a bulk GaN layer by metalorganic chemical vapor deposition, forming a Cr/SiO2 hard mask on the unintentionally doped GaN layer, patterning a fin by electron beam lithography, defining the Cr and SiO2 hard masks by reactive ion etching, improving a regrowth surface with inductively coupled plasma etching, removing hard mask residuals, regrowing a p-GaN layer, selectively etching the p-GaN layer, forming gate electrodes by electron beam evaporation, and forming source and drain electrodes by electron beam evaporation. The resulting vertical-channel junction field-effect transistor includes a doped GaN layer, an unintentionally doped GaN layer on the doped GaN layer, and a p-GaN regrowth layer on the unintentionally doped GaN layer. Portions of the p-GaN regrowth layer are separated by a vertical channel of the unintentionally doped GaN layer.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.

Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: A variety of applications can include wireless power and voltage regulation for wireless power transfer systems. A receiver can receive power wirelessly from a transmitter to provide an output voltage. The receiver can regulate the output voltage with respect to a window defining an upper threshold and a lower threshold and can generate a first signal in response to the output voltage exceeding the upper threshold voltage and a second signal in response to the output voltage reducing below the lower threshold voltage. The receiver can change its input impedance and control reception of the power in response to the first and second signals. A transmitter can sense current in the power transistors or the coil of the transmitter in response to the change of input impedance of the receiver. The sensed current can be used to modify the current to the output of the transmitter to adjust the transmitted power.

Abstract: A medical system and method for estimating a treatment region for a medical treatment device is provided. The system includes a memory; a processor coupled to the memory; and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region which is an estimate of a treatment region which would have been derived as a result of a numerical model analysis such as a finite element analysis. Advantageously, the estimated treatment region is generated using a fraction of the time it takes to generate the region using the numerical model analysis.

Abstract: A Deep Geometric Moment framework (DGM framework) may be trained to perform an image classification task using a training dataset having a plurality of images. Training the DGM framework may include generating 2D coordinate grids for the plurality of images and computing coordinate bases. The training may further include extracting image features for the plurality of images and computing geometric moments for the image features. Training the DGM framework may include generating predicted affine transformation parameters to transform the 2D coordinate bases into a transformed coordinate grid and generating new coordinate bases and new geometric moments learned from the image features to reconstruct the plurality of images using the transformed coordinate grid. The DGM framework may output an Artificial Intelligence model (AI model) trained to perform the image classification task for an input image.

Abstract: The present disclosure relates to a process for manufacturing an oral pharmaceutical dosage form including: mixing an active pharmaceutical ingredient (API) and surfactant into a blend; feeding the blend into a processor that applies heat and shear forces at a temperature within a range of approximately equal to the melting point of the surfactant to 3° C. below the melting point of the surfactant so as to form API granulates; and formulating the API granulates into a dosage form. The disclosed technology provides a surprisingly effective and economical means for producing high dose solid dosage forms containing poorly soluble APIs with minimal excipient burden.

Abstract: A system and method for the solvent-free fabrication of a battery electrode is disclosed. The method includes forming a dry powder bed on top of a current collector by dispensing an electrode powder directly onto the current collector as a dry powder bed. The method also includes compressing the dry powder bed and the current collector together using a heat-roll press, resulting in an electrode film adhered to the current collector forming the battery electrode. Dispensing the electrode powder may include using a powder dispensing unit having a powder supply sieve suspended within an outer frame by springs and holding the electrode powder, as well as vibrating the powder supply sieve such that the electrode powder passes through the powder supply sieve. The powder supply sieve may have a mesh size such that the sieve holds the electrode powder when the powder supply sieve is motionless.

Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

Abstract: The present application relates to pharmaceutical compositions and to the use of such compositions in the treatment of certain cancers, wherein such compositions positively affect the stress axis and immune system in patients in need of treatment.

Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.

Abstract: Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium. In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.

Abstract: A communications network system including antenna elements and a processor coupled with the antenna elements, the processor executing instructions to perform operations including establishing a first data communication link over a first frequency band between the CPU and the first AP of a first group of APs, causing the first AP to establish a second data communications link over a second frequency band between the first AP and a first UE, transmitting, via beamforming by the antenna elements, data to the first AP over the first data communications link, the data configured to be relayed via the first AP to the first UE over the second data communications link, obtaining an end-to-end data rate of the data communication between the CPU and the first UE, and achieving a higher end-to-end data rate than the obtained end-to-end data rate by adjusting beamforming vectors.

Abstract: Environmentally friendly, sustainable, and high-performance ultralight composite foams are disclosed. The composite foams are prepared from cellulose nanomaterial, polymeric material, and a crosslinking agent. The fabrication process is simple and uses only water. The composite foams exhibit an elastic strain exceeding the values reported for known nanocellulose-based foams with no reinforcement. The foams exhibit a thermal conductivity superior to that of traditional insulating materials and retain structural integrity after burning.

Abstract: Selective recovery of C2 to C4 hydrocarbons is achieved through the use of a converging-diverging nozzle, or de Laval nozzle. The vapor stream comprising C2 to C4 hydrocarbons is fed into an inlet of a de Laval nozzle having a throat. The vapor stream may have an initial temperature of between 0° C. and 100° C., and an initial pressure of between 200 psig and 500 psig. In the de Laval nozzle, the vapor stream expands after passing through the throat of the de Laval nozzle, producing a vapor stream having reduced temperature and pressure. Then, C2 to C4 hydrocarbons condense from the reduced-temperature vapor stream as liquid droplets, which may be recovered. Fractionation of C2 to C4 hydrocarbons by means of a de Laval nozzle is possible; the technique allows selective recovery of propane from a mixture of propane and ethane.

Abstract: A system for an engine to determine in situ under specified conditions the auto-ignition quality of the fuel used in a compression ignition engine is provided. The system may include an ion current sensor. The ion current sensor may access an engine cylinder for obtaining ion current data. A control unit may be in communication with the ion current sensor for receiving the ion current data. The control unit being configured to determine the auto-ignition quality of the fuel based on features of the ion current data.

Abstract: Disclosed herein is a catalyst which comprises a silica core having an outer surface and a mesoporous silica shell having an outer surface and an inner surface with the inner surface being inside the outer surface of said mesoporous silica shell proximate to and surrounding the outer surface of said silica core. Wherein the outer surface of the mesoporous silica shell has openings leading to pores within the mesoporous silica shell which extend toward the outer surface of said silica core. The catalyst also includes catalytically active metal nanoparticles positioned within the pores proximate to said core, wherein the catalytic metal nanoparticles comprise about 0.0001 wt % to about 1.0 wt % of the catalyst. Also disclosed are methods of making the catalyst and using it to carry out a process for catalytically hydrogenolysizing a polyolefinic polymer.

Abstract: A multifunctional manifold for use with electrochemical devices having a spiral cross-section, such as spiral solid-oxide fuel cells, includes an interface that is configured to be placed in operative communication with such devices. The interface includes a fuel interface section and an oxidant interface section that are each configured as spirals. The spiral interface sections also include channels that are configured to be placed in operative communication with corresponding spiral channels of the electrochemical device to deliver operating gases, such as fuel gas and oxidant gas, thereto. In addition to delivering operating gases to the fuel cells, the multifunctional manifold is also configured to act as an electrical current collector and a heat exchanger.

Abstract: A sterilization system includes a controller, a transformer including a primary side in communication with the controller and secondary side, an ozone generator in communication with the secondary side of the transformer and the controller, and a power source in communication with the controller, wherein the ozone generator ionizes atmospheric oxygen through the application of corona discharge.

Abstract: In an inflatable structure, a plurality of fibers is formed in a cavity of a flexible shell. When structure is inflated, the shell expands and the fibers are tensioned to constrain the flexible shell to have a fiber-constrained shape. When the structure is uninflated, the flexible shell is configured to collapse. The structure is formed by additive manufacturing. The fibers are fused to the shell and can run in various directions in relation to each other and the flexible shell. Fibers can extend obliquely to the shell when tensioned and at crosswise directions in relation to each other to form a nonwoven mesh.