Abstract: Disclosed herein are peptides useful for targeting the retina, and may be useful for targeting specific cells in the retina. The peptides may have a Formula I or V: R1—X1—X2—(X3)n—X4—X5—X6—X7—R2?? Formula I R1-Asn-Val-Ser-Ala-Tyr-Pro-Thr-R2?? Formula V. Also disclosed are conjugates and compositions comprising the peptides. The compositions may comprise a desired agent to be delivered to the retina, such as a therapeutic agent and/or an imaging agent. Methods for administering the peptide, conjugates, and/or composition to a subject also are disclosed.
Type:
Application
Filed:
June 13, 2024
Publication date:
October 17, 2024
Applicants:
Oregon State University, Oregon Health & Science University
Inventors:
Marco Herrera, Gaurav Sahay, Renee Ryals
Abstract: Time-synchronized state estimation for reconfigurable distribution systems is challenging because of limited real-time observability. A system addresses this challenge by formulating a deep learning (DL)-based approach for topology identification (TI) and unbalanced three-phase distribution system state estimation (DSSE). Two deep neural networks (DNNs) are trained for time-synchronized DNN-based TI and DSSE, respectively, for systems that are incompletely observed by synchrophasor measurement devices (SMDs) in real-time. A data-driven approach for judicious SMD placement to facilitate reliable TI and DSSE is also developed.
Type:
Application
Filed:
April 17, 2024
Publication date:
October 17, 2024
Applicants:
Arizona Board of Regents on Behalf of Arizona State University, Cornell University
Inventors:
Anamitra Pal, Behrouz Azimian, Lang Tong
Abstract: Provided herein are methods of assessing the presence of microbes in a liquid sample that include assessing an initial integrated scattering intensity of objects (IC0) in the sample and an integrated scattering intensity of the objects at a time t (ICt) from modified images of the liquid sample, and identifying the sample as comprising microbes for (ICt)/(IC0) above a predefined infection threshold TI. Related systems and other aspects are also provided.
Type:
Application
Filed:
June 24, 2024
Publication date:
October 17, 2024
Applicant:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: Systems and methods for simultaneous control of carbon dioxide and nitric oxide and generation of nitrous oxide are provided. In particular, the present invention provides systems and methods utilizing a titania-based photocatalyst to simultaneously control carbon dioxide and nitric oxide levels generated by combustion systems. Additionally, photoreduction of nitric oxide provided by the photocatalyst is used to generate nitrous oxide.
Type:
Grant
Filed:
May 2, 2017
Date of Patent:
October 15, 2024
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.
Type:
Grant
Filed:
June 24, 2022
Date of Patent:
October 15, 2024
Assignees:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Alexander Green, Dana Braff, Melissa Takahashi, Keith Pardee, James J. Collins, Guillaume Lambert, Thomas Ferrante
Abstract: Disclosed herein are methods of determining telomere length using universal reference primers. The reference primer pairs efficiently and reproducibly amplify genomic DNA in any vertebrate species. Kits for determining the length of telomeres or others repetitive regions in a sample are also provided.
Type:
Grant
Filed:
September 22, 2020
Date of Patent:
October 15, 2024
Assignee:
Boise State University
Inventors:
Stephanie F. Hudon, Steven Burden, Eric Hayden, Esteban Palencia Hurtado
Abstract: A training device and methods of using the device are described to train athletes to reduce the incidence of certain types of injuries. The device and methods promote a reduction in knee vulgus and hip internal rotation during typical athletic movements such as jumping, landing, and lateral bounding. The device provides a guide element that serves as a reference line providing feedback to a user on their movements. A user may adjust their joint positions during the movements based upon self-monitoring or feedback from a trainer who observes the user executing movements while wearing the device. The guide element may provide feedback on knee positioning in two axes of movement.
Abstract: Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
Abstract: A method of fabricating a polarization sensor is described. It includes a quarter-wave plate to convert circularly polarized light into linearly polarized light. The quarter-wave plate is realized as a metasurface. The sensor also includes a linear polarizer to analyze the light generated by the quarter wave plate, and a photodetector to receive the analyzed light. The sensor may be combined with other linear polarization sensors to form a sensor capable of complete measurement of the polarization state of incident light.
Type:
Grant
Filed:
May 13, 2022
Date of Patent:
October 15, 2024
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: An ankle support assembly includes a body having a plurality of fabric layers. The body extends along a longitudinal axis. A sealed, inflatable chamber is supported by the body. A valve member is supported by the body and in fluid communication with the chamber. A plurality of retaining members are positioned relative to the chamber. The retaining members are spaced apart from each other. The retaining members are configured to limit expansion of the chamber in at least one direction. The retaining members are positioned relative to the chamber such that the body has a variable stiffness along the longitudinal axis when the chamber is inflated.
Type:
Grant
Filed:
June 15, 2021
Date of Patent:
October 15, 2024
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: Hands-free walking devices and methods of constructing the same are described herein. The devices can include a receiving member to receive a portion of a patient's leg above a patient's knee and one or more hinges connected to the receiving member. One or more vertical members can be each connected to one of the hinges. A ground-contact member can be connected to the vertical members. The receiving member can transfer at least a portion of the patient's weight through the vertical members to the ground-contact member. The hinges can rotate about an axis about which the patient's knee also rotates while walking to support a natural gait.
Abstract: Systems, computer-implemented methods, and computer program products to facilitate end to end integration of dialogue history for spoken language understanding are provided. According to an embodiment, a system can comprise a processor that executes components stored in memory. The computer executable components comprise a conversation component that encodes speech-based content of an utterance and text-based content of the utterance into a uniform representation.
Type:
Grant
Filed:
March 18, 2022
Date of Patent:
October 15, 2024
Assignees:
International Business Machines Corporation, The Ohio State University
Inventors:
Samuel Thomas, Vishal Sunder, Hong-Kwang Kuo, Jatin Ganhotra, Brian E. D. Kingsbury, Eric Fosler-Lussier
Abstract: Principles of the present disclosure present an advanced control algorithm related to improving maximum power point tracking of a renewable energy system such as a solar photovoltaic system through load management, which estimates optimum load switch points, minimizes unsuccessful switches, and maximizes renewable energy such as photovoltaic energy delivered to loads.
Type:
Grant
Filed:
May 24, 2023
Date of Patent:
October 15, 2024
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: The invention relates to a method of preparing titanium dioxide-coated nanostars. Titanium precursors are hydrolyzed into crystalline TiO2 polymorphs at low temperatures, allowing the delicate morphology of the nanostars to be preserved while maintaining their desirable photocatalytic properties.
Type:
Grant
Filed:
June 14, 2023
Date of Patent:
October 15, 2024
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors:
Laura Fabris, Fuat E. Celik, Supriya Atta, Ashley M. Pennington
Abstract: A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.
Type:
Grant
Filed:
July 14, 2023
Date of Patent:
October 15, 2024
Assignees:
The Regents of the University of California, Arizona Board of Regents on Behalf of Arizona State University
Inventors:
Gaurav Sant, Laurent G. Pilon, Bu Wang, Narayanan Neithalath, Zhenhua Wei, Benjamin Young, Gabriel D. Falzone, Dante Simonetti
Abstract: Various implementations include a method of decreasing oxygen saturation levels in a patient, including securing a leg and foot of the patient to a splint having a leg supporting portion, a foot supporting portion, and an inflatable device. The leg supporting portion includes a leg support body and leg support surface. The foot supporting portion includes a foot support body and foot support surface. The inflatable device rotates the foot support surface relative to the leg support surface from a first position to a second position. The angle between a leg longitudinal axis and a foot longitudinal axis is less in the second position than in the first position. The method further includes inflating the inflatable device to rotate the foot support surface from the first position to the second position and maintaining the second position to decrease oxygen saturation levels in the patient.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
October 15, 2024
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: Organic light emitting devices (OLEDs) are described, the OLEDs comprising an anode; a cathode; and an organic region, disposed between the anode and the cathode, comprising a first complex and a second complex; wherein when a voltage is applied across the anode and cathode at room temperature, the OLED emits a luminescent radiation that comprises one or more luminescent radiation components resulting from the formation of at least one exciplex; wherein the exciplex is formed by at least one of the following aggregate types: 1) at least one aggregate within the first complex, and at least one aggregate within the second complex; 2) at least one aggregate between the first and the second complex; and 3) both 1 and 2.
Type:
Grant
Filed:
September 14, 2023
Date of Patent:
October 15, 2024
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A method of forming a monocrystalline nitinol film on a single crystal silicon wafer can comprise depositing a first seed layer of a first metal on the single crystal silicon wafer, the first seed layer growing epitaxially on the single crystal silicon wafer in response to the depositing the first seed layer of the first metal; and depositing the monocrystalline nitinol film on a final seed layer, the monocrystalline nitinol film growing epitaxially on the final seed layer in response to the depositing the monocrystalline nitinol film. The method can form a multilayer stack for a micro-electromechanical system MEMS device.
Type:
Grant
Filed:
August 12, 2022
Date of Patent:
October 15, 2024
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A new and distinct cultivar of Euonymus plant named ‘NCEA1’ is disclosed, characterized by plants with compact, rounded habits, good fall color, low fruit production, and greatly reduced fertility. The new cultivar is a Euonymus, suitable for ornamental garden purposes.
Type:
Grant
Filed:
February 28, 2024
Date of Patent:
October 15, 2024
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren H. Touchell, Andra Windorf Nus, Irene Palmer, Nathan P. Lynch