Patents Assigned to State University
  • Publication number: 20150223377
    Abstract: A new and distinct apricot variety of Prunus armeniaca named ‘NJA152’ is provided. This variety is distinguished from other apricot varieties by its unique combination of a slightly later blooming habit, good production of glossy glabrous fruit with a red blush over a yellow-orange ground color, freestone flesh which has a melting texture and is moderately juicy, and flavor that is sweet-tart and aromatic.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 6, 2015
    Applicant: Rutgers, The State University
    Inventors: Joseph C. Goffreda, Anna M. Voordeckers
  • Publication number: 20150216888
    Abstract: Filarial parasites Brugia, Wuchereria, Loa Loa and Onchocerca cause over 20 million infections worldwide and pose a significant social and economic burden in endemic areas. The invention provides compositions and methods to treat parasitic infections in animals and plants, and to kill and inhibit the replication of parasites in infected hosts. The methods can include administering to a host in need of treatment an effective antiparasitic amount of a composition comprising biodegradable polyanhydride microparticles or nanoparticles that encapsulate antiparasitic agents, optionally in combination with antibacterial agents. Through co-encapsulation of antiparasitic and antibacterial agents into the particles, the invention provides the ability to effectively kill parasitic helminthes, worms, and flukes, with up to a 40-fold reduction in the amount of drug used.
    Type: Application
    Filed: February 4, 2015
    Publication date: August 6, 2015
    Applicant: Iowa State University Research Foundation, Inc.
    Inventors: Bryan Howard Bellaire, Balaji Narasimhan
  • Publication number: 20150216126
    Abstract: Rice plants are disclosed with multiple sources of resistance to herbicides that normally inhibit a plant's acetohydroxyacid synthase (AHAS) enzyme. Besides controlling red rice, many AHAS-inhibiting herbicides also effectively control other weeds that are common in rice fields. Several of these herbicides have residual activity, so that one treatment can control both existing weeds and weeds that sprout later. With effective residual activity against red rice and other weeds, rice producers now have a weed control system superior to those that are currently available commercially.
    Type: Application
    Filed: April 13, 2015
    Publication date: August 6, 2015
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Timothy P. Croughan
  • Patent number: 9096504
    Abstract: Agents of formula: where R1 and R2 vary independently and are acyl, sulfonyl, phosphoryl, alkyl, substituted alkyl, halogen, aryl, arylalkyl, substituted aryl, heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, heterocycle, or heteroatoms; and R3 is H or a member of a ring structure which includes R2, are provided; as are agents of formula: where R1, R2 and R3 vary independently and: R1=OH, OR?, NHR?, NR?R? (with R? R?=alkyl, aryl, heteroaryl, etc); R2=acyl, alkyl, aryl, sulfonyl, etc; R3=alkyl, aryl, substituted aryl, heteroaryl, etc; and R4 and R5 are (independently) H, methyl or alkyl, substituted alkyl, aryl, substituted aryl, etc. Methods of using the agents to treat e.g. cardiovascular disease, stroke, shock, injuries caused by hypoxia, male erectile dysfunction, and Alzheimer's are provided.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: August 4, 2015
    Assignee: Washington State University
    Inventors: Ming Xian, Yu Zhao
  • Patent number: 9096864
    Abstract: The present invention provides tobacco inbred plants NCBEX1F and NCBEX1MS, and NC EX90. The present invention also provides parts of such plants and products made from those parts. The present invention also includes progeny of the provided plants including hybrids.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: August 4, 2015
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Patent number: 9096856
    Abstract: The present disclosure encompasses oligonucleotide aptamers selectively binding a target glycosylated polypeptide or protein, and having biased affinity for the glycan through a boronic acid linked to a nucleosidic base of a nucleotide(s). The disclosure further encompasses methods for isolating an aptamer(s) selectively binding a target glycosylated polypeptide, where, from a population of randomized oligonucleotides that have at least one nucleotide having a boronic acid label linked to a base, is selected a first subpopulation of aptamers binding to the target glycosylated polypeptide or protein. This subpopulation is then amplified without using boronic acid-modified TTP, and amplification products not binding to a target glycosylated polypeptide or protein are selected. The second subpopulation of aptamers is then amplified using boronic acid-modified TTP to provide a population of boronic acid-modified aptamers capable of selectively binding to a glycosylation site of a target polypeptide or protein.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: August 4, 2015
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Binghe Wang, Minyong Li, Zhen Huang, Na Lin
  • Patent number: 9097007
    Abstract: A panel assembly includes a rail, a first panel snap-fit to the rail, a second panel snap-fit to the rail, and a plate coupled to the rail for selectively clamping the panels between the plate and the rail.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: August 4, 2015
    Assignee: North Carolina State University
    Inventor: Kayla L. Geer
  • Patent number: 9096875
    Abstract: The present invention provides bicarbonate containing and/or bicarbonate-producing compositions and methods to induce lipid accumulation in an algae growth system, wherein the algae growth system is under light-dark cycling condition. By adding said compositions at a specific growth stage, said methods lead to much higher lipid accumulation and/or significantly reduced total time required for accumulating lipid in the algae growth system.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: August 4, 2015
    Assignee: Montana State University
    Inventors: Robert Gardner, Brent Peyton, Keith E. Cooksey
  • Patent number: 9096313
    Abstract: An actuator configured to rapidly vary the throat geometry of a microjet nozzle. Varying the throat geometry rapidly changes the characteristics of the microjet produced by the microjet nozzle. The inventive device is capable of producing pulsed flow. In some embodiments it is also capable of producing rapidly variable flow in order to provide active control.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: August 4, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: William S. Oates, Jonathan E. Clark, Farrukh S. Alvi
  • Patent number: 9096544
    Abstract: The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: August 4, 2015
    Assignees: Wayne State University, Department of Veterans Affairs, Sanford-Burnham Medical Research Institute
    Inventors: Joseph A. Fontana, Marcia Dawson, Zebin Xia
  • Patent number: 9095598
    Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: August 4, 2015
    Assignees: The Board of Trustees of the University of Arkansas, Arkansas State University—Jonesboro
    Inventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
  • Patent number: 9095815
    Abstract: A composition is produced by a hydrothermal liquid phase sintering process, and the process includes providing a porous matrix, the porous matrix having a shape, and allowing a component of the porous matrix to undergo a reaction with an infiltrating medium to form a first product, the infiltrating medium including a greenhouse gas, a remainder of the porous matrix acting as a scaffold for facilitating the formation of the first product. The composition includes the first product and the reminder of the porous matrix. The composition has a microstructure that resembles a net-like interconnecting network. The composition maintains the shape of the porous matrix. The composition is free of hydraulic bonds.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: August 4, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Vahit Atakan
  • Publication number: 20150210998
    Abstract: Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods reduce the level of oligomer formation such as homotrimeric E6AP ligase to reduce the enzyme activity. Alternatively, agents are provided that can promote the association of the ligase monomers, thereby increasing the ligase activity. Accordingly, novel therapeutic strategies are provided that are useful for the treatment of pathologies resulting from mutations in the genes encoding the ligases and which adversely increase or decrease a ubiquitination reaction.
    Type: Application
    Filed: April 14, 2015
    Publication date: July 30, 2015
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Arthur L. Haas, Virginia P. Ronchi
  • Publication number: 20150211030
    Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
    Type: Application
    Filed: September 6, 2013
    Publication date: July 30, 2015
    Applicant: North Carolina State University
    Inventors: Michael W.W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Pries Lipscomb, Gerrit Jan Schut
  • Patent number: 9090941
    Abstract: The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: July 28, 2015
    Assignees: Cornell Research Foundation, Inc., Sloan Kettering Institute for Cancer Research, Rutgers, The State University of New Jersey
    Inventors: Francis Barany, Yu-Wei Cheng, Philip Paty, Daniel Notterman
  • Patent number: 9093214
    Abstract: Embodiments of magnetorheological systems, devices, and associated methods of control are described below are described herein. In one embodiment, a magnetorheological device includes an magnetorheological fluid, a shaft proximate and mechanically coupled to the magnetorheological fluid, and a magnetic field generator configured to generate a magnetic flux through the magnetorheological fluid along a magnetic flux path. The magnetorheological device also includes a sensor positioned in the magnetic flux path and configured to measure a current value of magnetic inductance of the magnetic flux flowing through the magnetorheological fluid.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: July 28, 2015
    Assignee: Washington State University
    Inventors: Hakan Gurocak, Doruk Senkal, Berk Gonenc
  • Patent number: 9090904
    Abstract: Nucleotide sequences are disclosed that may be used to impart herbicide resistance to green plants. The sources of novel herbicide resistance were originally isolated in mutant rice plants. The sequences impart pre-emergence resistance, post-emergence resistance, or both pre-emergence resistance and post-emergence resistance to multiple herbicides. To date, resistance has been demonstrated against at least the following herbicides: imazethapyr, imazapic, imazapyr, imazamox, sulfometuron methyl, imazaquin, chlorimuron ethyl, metsulfuron methyl, rimsulfuron, thifensulfuron methyl, pyrithiobac sodium, tribenuron methyl, and nicosulfuron. Green plants transformed with these sequences are resistant to these herbicides and to derivatives of these herbicides, and to at least some of the other herbicides that normally inhibit acetohydroxyacid synthase (AHAS), particularly imidazolinone and sulfonylurea herbicides.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: July 28, 2015
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Timothy P. Croughan
  • Patent number: 9091006
    Abstract: The present invention describes a novel process for the conformal coating of polymer fibers of nonwoven substrates. This process is based on modification of polymer fiber surfaces by controlling the degree of etching and oxidation to improve adhesion of initiators to the surface and to facilitate subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increased hydrophilicity, attached ligands or changed surface energy. The invention includes the modified polymer fibers produced by the process described herein.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: July 28, 2015
    Assignees: Pathogen Removal and Diagnostic Technologies, Inc., North Carolina State University
    Inventors: Yong Zheng, Samana Roy Chowdhury, Patrick Vasconcelos Gurgel, Haiyan Liu, Ruben G. Carbonell
  • Patent number: 9089547
    Abstract: Equol (7-hydroxy-3(4?hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5?-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: July 28, 2015
    Assignees: Brigham Young University, Colorado State University Research Foundation
    Inventors: Edwin Douglas Lephard, Trent D. Lund, Robert J. Handa
  • Patent number: 9090945
    Abstract: Methods for predicting a disease free time interval (DFI) for a cancer patient under consideration for initial or further chemotherapy treatment are disclosed. The methods include obtaining a biological sample from a patient and detecting a copy number of chromosome region A1 and/or C2. The mean copy number per cell is correlated with a DFI for the subject. The chemotherapy can include doxorubicin and/or L-asparaginase treatment. Also provided are kits for predicting DFI in a subject with cancer and computer readable storage media for performing the presently disclosed methods.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: July 28, 2015
    Assignee: North Carolina State University
    Inventor: Matthew Breen