Abstract: Compositions comprising therapeutic oligonucleotide compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided. Methods are described to manipulate and treat the oncogenic deregulation of the TP53-associated apoptosis pathway. Markers for acute myeloid leukemia (AML) and uses thereof are described.

Abstract: A method, a computer readable medium and an apparatus for optimizing a cellular network architecture are disclosed. For example, the method obtains network traffic data for a plurality of different endpoint device types, wherein the network traffic data comprises network traffic data for each of the plurality of different endpoint device types, and predicts a future traffic pattern for one of the plurality of different endpoint device types based on the network traffic data. The method then adjusts a parameter of the cellular network architecture in response to the future traffic pattern predicted for the one of the plurality of different endpoint device types.

Abstract: This invention provides a compound having the structure wherein R1 is H, wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is wherein m is an integer from 0 to 8; R3 is an amino, alkyl, aryl, heteroaryl, diol, piperazine, morpholine, piperidine, triazole, azide or biphenyl, each with or without substitution, branched or unbranched, or and R4 is alkyl, aryl, or heteroaryl, each with or without substitution, branched or unbranched, R2 is H, CH3, or alkyl, aryl, heteroaryl, pyrrole, diazole, or triazole, each with or without substitution, branched or unbranched, or wherein n and q are independently an integer from 0 to 8; A is absent or present and when present is and R6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, or alkyl, aryl or heteroaryl, with or without substitution, branched or unbranched, when R1 is H then R2 is other than H or CH3, and

Abstract: For predicting timing violations, a prediction module predicts a timing violation for a first instruction in a semiconductor device in response to use by the first instruction of a specified sensitized path. The prediction module further mitigates the predicted timing violation.

Abstract: Techniques for sharing a cellular network connection amongst multiple devices over a local area network are provided that reduce cellular network load during crowded events. In an aspect, a devices is configure to perform operations that include scanning an area for another device that has established a first wireless cellular connection with a cellular network device of a cellular network and that enables an indirect connection of the device to the cellular network device via a direct connection of the device to the other device via a local network device. The operations further include, in response to identifying the other device as a result of the scanning, sending a request to the other device to connect to the other device via the local network device and to receive the indirect connection to the cellular network device.

Abstract: A method of electrophoretic movement of particles through a liquid crystal utilizes a direct (DC) or alternating (AC) electric field that is applied along the liquid crystal director (for liquid crystals with a positive dielectric anisotropy) or perpendicular to the director (for liquid crystals with a negative dielectric anisotropy). A perpendicular or tilted orientation of the liquid crystal molecules at the surface of the particle causes distortions, such that the fore-aft (or left-right) symmetry of the particle is broken. The asymmetric orientation of the liquid crystal around the particle allows both charged and neutral particles to be transported, even when the particles themselves are perfectly symmetric (spherical).

Abstract: Shape controlled synthesis of ferroelectric nanocrystals such as barium titanate (BaTiO3) nanocrystals is described. By tuning the molar ratio between the surfactant and the metal precursors, BaTiO3 nanocrystals with different shapes are readily obtained. This provides the nanoscopic ferroelectric building blocks for the fabrication of various electronic devices, as well as for fundamental research in nanoscience and nanotechnology.

Abstract: The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.

Abstract: A nanocomposite material for use as an electromagnetic wave or radio frequency absorber or as a filter to trap or remove heavy metals. The nanocomposite material may be made with a one-pot synthesis, or thermodecomposition process, of magnetic graphene nanocomposites decorated with core-double-shell nanoparticles, wherein the double shell iron nanoparticles may comprise a crystalline iron core, an inner iron oxide layer around the crystalline iron core, and an outermost amorphous Si—S—O compound shell around the iron oxide layer.

Abstract: Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: Small molecule, peptidic hepatocyte growth factors mimics, which act as both mimetics and antagonists, have been generated. These molecules have been shown or predicted to have therapeutic potential for numerous pathologies including dementia (e.g. Alzheimer's) and Parkinson's disease.

Abstract: This disclosure relates generally to sequential state elements (SSEs). More specifically, embodiments of flip-flops are disclosed, along with computerized methods and systems of designing the same. In one embodiment, the flip-flop includes a substrate and subcircuits that are formed on the substrate. The subcircuits provide subfunctions, wherein each of the subcircuits provides at least one of the subfunctions. More specifically, the subfunctions are provided in a sequential logical order by the subcircuits so that the flip-flop provides a flip-flop function. However, the subcircuits are interleaved out of the sequential logical order with respect to a corresponding subfunction provided by each of the subcircuits along a vector defined by the substrate. In this manner, interleaving the subcircuits along the vector of the substrate can provide separation between charge collection nodes without requiring increases in size. Thus, the flip-flop can be more compact and less expensive to manufacture.

Abstract: A method is provided for determining specifications that meet electronic system or integrated circuit product requirements at all stages of the product lifecycle. Early in the product lifecycle design features must be specified. Later in the lifecycle datasheet specifications must be determined and published to customers, and test specifications in manufacturing must be determined. The method includes acquiring data from a test vehicle, fitting the data to a copula-based statistical model using an appropriately programmed computer, and using the statistical model to compute producer- and customer-oriented figures of merit of a product, different from the test vehicle, using the appropriately programmed computer. Different size, fault tolerance schemes, test coverage, end-use (datasheet), and test condition specifications of the product may be modeled. The statistical model is a copula-based and so can take into account dependency among attributes of the product.

Abstract: A method and apparatus for determining an auditory pattern associated with an audio segment. An average intensity at each of a first plurality of detector locations on an auditory scale based at least in part on a first plurality of frequency components that describe a signal is determined. A plurality of tonal bands in the audio segment, wherein each tonal band comprises a particular range of detector locations of the first plurality of detector locations is determined. Corresponding strongest frequency components in the tonal bands are determined. A plurality of non-tonal bands is determined, and each non-tonal band is subdivided into multiple sub-bands. Corresponding combined frequency components that are representative of a combined sum of intensities of the first plurality of frequency components that is in a corresponding sub-band are determined. An auditory based on the corresponding strongest frequency components and the corresponding combined frequency components is determined.

Abstract: A facile method to produce covalently bonded graphene coating on various solid substrates is disclosed in the present invention. According to one embodiment, a combination of graphite, graphene oxide or graphene and silicon compound with or without a metal containing compound in an air free environment is processed at high temperatures to produce covalent carbide bonding among graphene layers and between graphene and substrate surface.

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for forecasting wind farm power generation are disclosed. Via use of a support vector machine (SVM) enhanced Markov model, short-term wind power generation forecasts may be generated. Exemplary approaches accurately account for wind ramp-up and ramp-down, as well as diurnal non-stationarity and seasonality of wind power generation. Via use of the disclosed forecasting approaches, utilities and grid managers can make improved decisions relating to electrical power generation and transmission, thus reducing costs and reducing pollution.

Abstract: The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.

Abstract: The present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.