Patents Assigned to State University
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Patent number: 9090907Abstract: A modification of the existing INSM1 promoter region has been discovered that incorporated DNA elements that silence expression of neuronal genes in non-neuronal cells and that has increased the effectiveness and safety of using the INSM1 promoter for tumor treatment. One modification was addition of one or two tandem copies of neuronal restrictive silencer elements (NRSEs) derived either from the mouse nicotinic acetylcholine receptor (nAChR) or the rat superior cervical ganglion 10 (SCG10) promoters. These NRSEs were placed in the expression construct either directly upstream or downstream of the INSM1 promoter sequence. The most effective expression construct was the nAChR NRSE element positioned downstream of the INSM1 promoter. This expression construct increased the tissue specificity of the INSM1 promoter without a significant decrease in its activity. In addition, the modified INSM1 promoter was placed into a viral vector, adenovirus 5.Type: GrantFiled: November 8, 2010Date of Patent: July 28, 2015Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Mary B. Breslin, Michael S. Lan
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Patent number: 9091705Abstract: A high-speed atomic force microscope (HSAFM) is disclosed herein. The HSAFM includes a cantilever, a piezotube, an optical detector, a circuit element, and a feedback controller. The cantilever has a probe, and the piezotube is arranged in proximity to the probe. The optical detector is configured to detect deflection of the cantilever, and the circuit element is abutting a first end of the cantilever and is configured to exert a force on the cantilever to resist deflection of the cantilever. The circuit element is communicably connected to the optical detector by a first feedback loop. The feedback controller is communicably connected to the piezotube and configured to modulate the piezotube along the Z-axis towards and away from the probe. And the feedback controller is communicably connected to the optical detector through a second feedback loop.Type: GrantFiled: May 1, 2013Date of Patent: July 28, 2015Assignee: Boise State UniversityInventor: Byung I. Kim
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Patent number: 9091251Abstract: An actuation apparatus includes at least one magnetic shape memory (MSM) element containing a material configured to expand and/or contract in response to exposure to a magnetic field. Among other things, the MSM element may be configured to pump fluid through a micropump by expanding and/or contracting in response to the magnetic field. The magnetic field may rotate about an axis of rotation and exhibit a distribution having a component substantially perpendicular to the axis of rotation. Further, the magnetic field distribution may include at least two components substantially orthogonal to one another lying in one or more planes perpendicular to the axis of rotation. The at least one MSM element may contain nickel, manganese, and gallium. A polymerase chain reaction (PCR) may be enhanced by contacting a PCR reagent and DNA material with the MSM element.Type: GrantFiled: July 16, 2012Date of Patent: July 28, 2015Assignee: Boise State UniversityInventors: Kari Ullakko, Peter Mullner, Greg Hampikian, Aaron Smith
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Patent number: 9090646Abstract: The invention provides new biotinylated compounds and methods for their use.Type: GrantFiled: December 4, 2013Date of Patent: July 28, 2015Assignee: Rutgers, The State University of New JerseyInventors: Roger A. Jones, Barbara L. Gaffney
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Publication number: 20150201865Abstract: A low back pressure mouthpiece for accurate detection of exhaled nitric oxide (NO) includes a conduit for receiving the exhaled breath from the subject. An oxidizing filter for sample conditioning, wherein the conduit and oxidizing filter operate to produce a back pressure of less than 4 cm H2O; and a device for measuring the level of one or more components of the received exhaled breath.Type: ApplicationFiled: September 27, 2013Publication date: July 23, 2015Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Erica Forzani, Nongjian Tao, Xiaojun Xian, Francis Tsow
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Patent number: 9088049Abstract: A lithium air battery cell includes an anode having lithium, a cathode having a Ag2Mn8O16 catalyst, and an electrolyte comprising a lithium salt. A cathode for a lithium air battery cell and a lithium air battery with a cathode including buckypaper and a Ag2Mn8O16 catalyst are also disclosed.Type: GrantFiled: January 23, 2013Date of Patent: July 21, 2015Assignee: Florida State University Research Foundation, Inc.Inventors: Jian-ping Zheng, Guoqing Zhang
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Patent number: 9085730Abstract: The invention provides a liquid crystal (LC) composition, a LC cell thereof, and a LC device thereof. The LC composition comprises (i) a mixture of two or more nematic liquid crystals, and (ii) at least one chiral dopant. The mixture of the liquid crystals can exist in a blue phase within a temperature range of from about 12-60° C. such as 21-28° C. The LC device can be a blue phase mode liquid crystal display (BPLCD) based on such a room-temperature blue phase LC. The BPLCD requires no alignment, and it exhibits merits such as a fast switching time (e.g. sub-millisecond), a low switching voltage and a large field-induced birefringence, among others.Type: GrantFiled: June 16, 2010Date of Patent: July 21, 2015Assignee: Kent State UniversityInventors: Liang-Chy Chien, Lu Lu, Jeoung Yeon Hwang
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Patent number: 9085804Abstract: Described herein are methods for differentiate human cancers comprising using one or more transcribed ultraconserved regions (T-UCR) expression profiles where the association between the genomic location of UCRs and the analyzed cancer-related genomic elements is highly statistically significant and comparable to that reported for miRNAs.Type: GrantFiled: June 5, 2013Date of Patent: July 21, 2015Assignee: The Ohio State University Research FoundationInventor: Carlo M. Croce
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Patent number: 9084423Abstract: Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.Type: GrantFiled: January 8, 2014Date of Patent: July 21, 2015Assignee: North Carolina State UniversityInventors: Christian Melander, John Cavanagh, Robert W. Huigens, III, T. Eric Ballard, Justin J. Richards
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Patent number: 9086596Abstract: A surface-stabilized in-plane switching (SS-IPS) liquid crystal (LCD) cell includes a pair of spaced substrates that include alignment layers disposed thereon. The alignment layers are treated to define a first director orientation. Disposed between the alignment layers is a liquid crystal material that contains polymer fibrils that are disposed upon each of the alignment layers. The polymer fibrils serve to maintain the alignment of the liquid crystal molecules in the first director orientation when no voltage is applied to the LCD cell via interdigitated electrodes disposed upon the alignment layers, thus improving the dynamic response of the SS-IPS LCD cell.Type: GrantFiled: June 27, 2013Date of Patent: July 21, 2015Assignee: Kent State UniversityInventors: Liang-Chy Chien, Jeoung-Yeon Hwang
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Publication number: 20150198169Abstract: A synthetic jet for a stationary vane for a turbo-machine is disclosed. The synthetic jet includes a backside cavity and a jet cavity. The jet cavity includes a frontside cavity adjoining the backside cavity and a jet passage extending from a fluid stream interfacing surface of the airfoil towards the frontside cavity. The jet passage is in flow communication with the frontside cavity. The synthetic jet also includes a disk located between the backside cavity and the frontside cavity. The disk includes a cylindrical disk and a coating on each side of the cylindrical disk. The coating is a piezo electric ceramic material.Type: ApplicationFiled: January 14, 2014Publication date: July 16, 2015Applicants: San Diego State University Research Foundation, SOLAR TURBINES INCORPORATEDInventors: Michael James Cave, Ricardo Benjamin Torres, Gustaaf Bernardus Jacobs
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Publication number: 20150201538Abstract: This invention relates to a new and distinct variety of red raspberry plant (Rubus idaeus L.) named ‘Cascade Harvest’ adapted to the raspberry production area of the Pacific Northwest. ‘Cascade Harvest’ is primarily characterized by suitability for machine harvestability, tolerance to root rot, resistance to raspberry bushy dwarf virus and large, conical fruit that is longer than it is broad.Type: ApplicationFiled: January 13, 2014Publication date: July 16, 2015Applicant: Washington State UniversityInventor: Patrick Peder Moore
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Publication number: 20150196688Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.Type: ApplicationFiled: March 11, 2013Publication date: July 16, 2015Applicant: Colorado State University Research FoundationInventors: Susan P. James, Harold Dean, IV, Lakshmi Prasad Dasi, Marcio H. Forleo, Ketul C. Popat, Nicole R. Lewis, David Alois Prawel
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Publication number: 20150200727Abstract: A method and apparatus includes an optical source for a single order single-sideband suppressed-carrier optical signal with a bandwidth that scales from over 4 gigaHertz or is at least 8 GHz from an optical carrier frequency. In an example embodiment, an apparatus includes a stable laser source configured to output an optical carrier signal at a carrier frequency. The apparatus includes a radio frequency electrical source configured to output an electrical radio frequency signal with a radio frequency bandwidth less than one octave. The apparatus also includes an optical modulator configured to output an optical signal with the optical carrier signal modulated by the radio frequency signal in a plurality of orders (harmonics) of optical frequency sidebands. The apparatus further includes an optical filter configured to pass one single order optical frequency sideband of the optical signal, which sideband does not overlap the sideband of any other harmonic.Type: ApplicationFiled: March 27, 2015Publication date: July 16, 2015Applicants: Montana State University, S2 CorporationInventors: Colton Richard Stiffler, Scott Henry BEKKER, Kristian D. MERKEL, Randy R. REIBEL, William Randall BABBITT, Krishna Mohan RUPAVATHARAM
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Patent number: 9078886Abstract: The present invention features, inter alia, pharmaceutically acceptable compositions that include metyrapol as the sole pharmaceutically active agent; compositions that include metyrapol and at least one additional pharmaceutically active agent; compositions in which the agent targeting the HPA axis is, itself, new or modified (e.g., a bi-specific antibody designed to traverse the blood-brain barrier or a known compound redesigned by, for example, conjugation to a substance that traverses the blood-brain barrier); and compositions in which the agent targeting the HPA axis is newly formulated in such a way that it fails to significantly inhibit cortisol production in the adrenal gland. For example, the composition can be formulated to include a dosage that is too low to reduce plasma cortisol levels or formulated to preferentially affect the skin.Type: GrantFiled: June 16, 2011Date of Patent: July 14, 2015Assignees: Embera Neurotherapeutics, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Nicholas E. Goeders, Barbara S. Fox, Glenn Guerin
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Patent number: 9081023Abstract: Analyte sensors, methods for producing and using analyte sensors, methods of detecting and/or measuring analyte activity, detecting pH change, and/or, controlling the concentration of an analyte in a system, are disclosed. Embodiments of the analyte sensors according to the disclosure can provide an accurate and convenient method for characterizing analyte activity, detecting pH change, controlling the concentration of an analyte in a system, and the like, in both in vivo and in vitro environments, in particular in living cell imaging.Type: GrantFiled: August 21, 2014Date of Patent: July 14, 2015Assignee: Georgia State University Research FoundationInventors: Jenny Jie Yang, Shen Tang
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Patent number: 9080942Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.Type: GrantFiled: December 14, 2011Date of Patent: July 14, 2015Assignee: The Research Foundation for State University of New YorkInventors: Chuan-Jian Zhong, Jin Luo, Lingyan Wang, Jun Yin, Susan Lu
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Patent number: 9081100Abstract: A neutron detection system may include a neutron detector including a plurality of neutron detection devices, a plurality of discrete neutron moderating elements, wherein each of the neutron moderating elements is disposed between two or more neutron detection devices, the plurality of neutron detection devices and the plurality of discrete neutron moderating elements disposed along a common axis, a control system configured to generate a detector response library, wherein the detector response library includes one or more sets of data indicative of a response of the detector to a known neutron source, receive one or more measured neutron response signals from each of the neutron devices, the one or more measured response signals response to a detected neutron event, and determine one or more characteristics of neutrons emanating from a measured neutron source by comparing the one or more measured neutron response signals to the detector response library.Type: GrantFiled: October 29, 2012Date of Patent: July 14, 2015Assignees: The Curator of the University of Missouri, Kansas State University Research FoundationInventors: Steven L. Bellinger, Anthony N. Caruso, Brian Cooper, William L. Dunn, Ryan G. Fronk, Douglas S. McGregor, William H. Miller, Eliot R. Myers, Thomas M. Oakes, Philip B. Ugorowski, John K. Shultis, Timothy J. Sobering, Cory B. Hoshor
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Patent number: 9082011Abstract: A method of assessing the identity of a person by one or more of: internal non-visible anatomical structure of an eye represented by the Oculomotor Plant Characteristics (OPC), brain performance represented by the Complex Eye Movement patterns (CEM), iris patterns, and periocular information. In some embodiments, a method of making a biometric assessment includes measuring eye movement of a subject, making an assessment of whether the subject is alive based on the measured eye movement, and assessing a person's identity based at least in part on the assessment of whether the subject is alive. In some embodiments, a method of making a biometric assessment includes measuring eye movement of a subject, assessing characteristics from the measured eye movement, and assessing a state of the subject based on the assessed characteristics.Type: GrantFiled: June 3, 2013Date of Patent: July 14, 2015Assignee: Texas State University—San MarcosInventor: Oleg V. Komogortsev
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Patent number: 9080258Abstract: A melt-spun highly oriented and crystalline thermoplastic filament or fiber having a tenacity of at least about 10 g/d, an elongation less than about 15-%, and a modulus of at least about 130 g/d. A method of making highly oriented and crystalline thermoplastic filaments has been developed that comprises extruding a thermoplastic polymer to form at least one molten filament. The at least one molten filament is introduced into a horizontal liquid isothermal bath. The bath is maintained at a temperature between the glass transition temperature and the melting temperature of the thermoplastic polymer. The bath increases the tension along the molten filament to form at least one partially oriented and low crystalline filament. The partially oriented filament is drawn to form the highly oriented and crystalline filament.Type: GrantFiled: July 9, 2010Date of Patent: July 14, 2015Assignee: North Carolina State UniversityInventors: John A. Cuculo, Richard Kotek, Peng Chen, Mehdi Afshari, Ferdinand Lundberg